Gene PPH21 in Saccharomyces cerevisiae

Synonym: YDR436W, PPZ2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP013_AA protein Get Run
ScerP013_AA_58-354 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 68-355 1.1e-182 598.8 In-house 2-289 (290) alignment 
Range on Protein: 68-355
Range on HMM: 2-289/290.0
NQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRY
..||..||.|..|..|.|..|..||..| ..|. |.||.....|||.||||||||||||||||||| .|||||||.||||||||||||||..|||.||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRG
..|||||||||||||||||||||||||||||.|||||.|||||||.|.|||||..||||||||||.|.|.|..|.|.|.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRP
||||||||||.|||.|.||.||.||.|.|||||||||||||.|||..|||||||||||||||||||||.|.|......|||.||..| 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_PPP4C_pd Subfamily PPP4C 69-349 3.9e-145 475.5 In-house 2-282 (288) alignment 
Range on Protein: 69-349
Range on HMM: 2-282/288.0
QLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYP
.||. ||.| .|| ..|..| .||. | ..|  | ||. .. |||.|||.||||.|||||||.|| .|.|||||.||.||||.|||||   |.|.|||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

HRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGG
 |||..|||||||||||||||||||||||||||||.. |..|||....|..|.||||.|||||| |.|.|..| ..| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|..||||||. ||.||.||||..||..||.|||||||||| .  ...|.|..||||||||||| |||.|.||. ...|  .
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP6C_pd Subfamily PPP6C 70-347 8.6e-137 448.0 In-house 2-279 (290) alignment 
Range on Protein: 70-347
Range on HMM: 2-279/290.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||.|||  .||. |.|.|. .||.. .|.|  | ||.|.. |||.|||.||||.||.|||. ||  |||.|.|.||.|||||||.||...|...|..||.
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGW
|||.|||||||||||||||||||||.|||.||.|| .|..|| ..|.|..|....|.|||||| ..|.||.| ..| ||.||.|..|||.||||.|   |
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

GISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
 .||||||. ||. |...|.|.|.|.||.||||||.||. .  ....||..||||||||||| |.|........|.. 
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereak
subfamily_PPG1_pd Subfamily PPG1 70-350 1.4e-123 405.0 In-house 1-294 (300) alignment 
Range on Protein: 70-350
Range on HMM: 1-294/300.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||. .|.| |.| | |  |  |..   ..|  | ||. |. |||. |||||||.|.||.|||||..|||||||.|||||||.|||||.| |...|.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| | ..||| .|..|||. ..|..|..|.|.|||||| . .|||.. |.|..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
      || |  . .|.||||...|.|| |.| ..||.  | |||||..|||    .. . |..|||||||||||.|.|.|. |...| |  |.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvye
0045823 Metallo-dependent phosphatases 63-354 2e-119 392.2 In-house 23-326 (473) alignment 
Range on Protein: 63-354
Range on HMM: 23-326/473.0
NNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVA
 . .. .||..|||| |.. |.|.|. .|...| ..| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. .| |
illglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlellla

MKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSD
.|..||.....||||||.|.....|||.||.|.|| .......| ..... |..|....||.. |||||| ....||.||..| .|.|..|...||||||
lkikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsd

PDDRGG--------WGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQN------VVTIFSAPNYCYRCGNQAAIMEVDENHnRQFLQ
|..  |        .| ||||||..||.|. |.| . |.| || |.|. |.||| . .  .      ..|.|||||||.|.|| ||....||.  ..| |
PweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiq

YDPSVR
.|||  
fdpsph
PPP_3 83-350 1.3e-116 381.3 In-house 2-270 (271) alignment 
Range on Protein: 83-350
Range on HMM: 2-270/271.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQ
|||.....|.|.. ..|. |.|.  |. |||.|||.|||..|||||||.|||.|.|.|||.|||||||..|.|.. .|.|.|..||.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGFTFG
|..||||..|.|.|.|...|.|.....|...|..||.|.|....|||||| |...||...|.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
.||.|.|...|.|.||.|||.|..|||   |...|||.|||||||.|..|..||....|.....| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
PPP_1 84-338 3.6e-116 380.1 In-house 2-264 (264) alignment 
Range on Protein: 84-338
Range on HMM: 2-264/264.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
.|. .|.|.|.....|..|||.. .. ..|.|||.||||.|||.|||.|||.|.|||||.|||||||..|||.. .|.|.|..||.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|..|....|..||.||..|..||.|.||...||||||.....||.|...| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEV
||..||.||.|.|...|.|.||.|||....||| . ....|||||||.||.....|..|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
0049330 Metallo-dependent phosphatases 59-352 5.3e-113 370.1 In-house 6-299 (309) alignment 
Range on Protein: 59-352
Range on HMM: 6-299/309.0
PLELNNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVS
|| | .  .. ||..||.| |.  |||... .|. .|...| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. 
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

YLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDL
.| |.|..||.....||||||.|.....|||.||.||||| |..|..|.|.....|..|....||.| |||||| . ..||.|||.| .|.|..|..|||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPD-DRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
|||||. .| |.. .|||.|..|| .. |.| ..|.|.|| |.|..|..|| . ......|.|||||||.|.||..|..|.||.....||...|.
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepv
PP2Ac_SM00156 84-351 3.1e-108 353.9 In-house 2-269 (271) alignment 
Range on Protein: 84-351
Range on HMM: 2-269/271.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
|. .|..|.. . ..|. |.|.  .. |||..||.|||..|||.|.. .|..|...|.|.|||||||..|.|....|.|.|..|| ....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGFTFGQ
...|||..|. ||| .......|...|...|..||||.||.|.||||||..|..|..|.|.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|. ..| ..|.|.|| |||..|.||| . .....||||||||||....|.||...|..| . .. |...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
0053225 Metallo-dependent phosphatases 67-352 2.9e-107 351.3 In-house 6-291 (293) alignment 
Range on Protein: 67-352
Range on HMM: 6-291/293.0
INQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVR
.  ||..||.| ..  |||... .|. .| ..|  | |. ... .....||.||...|||.|... | .|.....|.||.||||..|.|.. .| |.|..
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDR
||.....||||||.......|||.||.|||||.|..|....|.....|..||...||.. |||||| . ..||.||.|| ...|.||...||||||||..
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

GGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ||..|.||.|..|| .. ..| ..|.| || |.||.|..|| . .....||.||||||..|.||..|....||. ...| ...|.
sgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP1C_pd Subfamily PPP1C 81-347 2.4e-104 341.5 In-house 8-274 (282) alignment 
Range on Protein: 81-347
Range on HMM: 8-274/282.0
EPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHES
  |.| .. .|.|.| ..|. .  .  .. ||.|.||.|||..||| ||...|  |..||||.|||||||  |.||.  |.|.|..||... .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFT
 .|...||||||| |.|..  .||.||| |...|..||||.||.|.|||||| .. ..|.|...|  |||..| .|||||||||. . ||. . ||  ||
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
||.|| |.| . |||.|| ||||.| .|| .  ....||.||||||| . .|..|...|||.   .| 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 65-352 5.3e-98 320.7 In-house 6-294 (298) alignment 
Range on Protein: 65-352
Range on HMM: 6-294/298.0
TNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMK
  |..| . ... . .. ..|.|| .|...| ....  . .  .. |...|||.|||. ||| ||. .|  ||.||||.||||||| ...|..  |.| |
llievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllayk

VRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPD
|.||... .||||||  .| .|||||.|| |.| | .... | |.|. .|.|||. ..|.|.|||||......||.|||.| .. ..|    ||||.||.
vkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpe

D-RGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
.   ||  . ||....||.|| ... .. |. |..||||.| .|| .  ....|||||||.|| .  | ||.|.|||.    |  . |.
navkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_PPP3C_pd Subfamily PPP3C 63-349 2.2e-89 293.3 In-house 21-319 (452) alignment 
Range on Protein: 63-349
Range on HMM: 21-319/452.0
NNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVA
..|.. .|.   ||. |   |.|...... ..| ..|. |...  .. |.|..||.||||.|||.||..||   .|.|||.||||||||.|.|.| || |
detgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylya

MKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSD
.|. ||... .||||||.| .|. . | .||  || | .|...... || .|..||.... .|.|||||| |...|....|.| .|.|. ||.|||||||
lkiaypstlfllrGnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsd

PDDRGGWGI--------SPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQ------QNVVTIFSAPNYCYRCGNQAAIMEVDENHNrQFLQ
| .. |           |.||  . ..   . .| ..|||  | |||.   .||   ..        ..|.||||||.    |.||......|   .  |
PledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm.nirq

Y
.
f
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 82-354 6.1e-88 287.9 In-house 23-296 (299) alignment 
Range on Protein: 82-354
Range on HMM: 23-296/299.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 . |... .||..| .|.  .  .  .. |. .|||.|||. ||| .|.. |  ||.|.||.|||||||   .|... |...|..||.|. .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
 | .|||||.|| ..| |. .| .| | |...|.| |. ..|.|.|||||| ..|.||.|.|.| |. |      ||||.|||.   .|    ||  . |
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVR
|||| ..  .. |. |.|||||.| .|| .  ....||||||| || .  | ||||.||||    |  . |. .
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 78-353 1.8e-84 276.2 In-house 3-276 (280) alignment 
Range on Protein: 78-353
Range on HMM: 3-276/280.0
SKCepLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
 .|  . | |. |. .   ..|. .. .  .. ||..|||.|||. ||| ||.  .  ||.||||.||||||| . .| .  |.| ||||| .. |||||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGA
||  .| . |||.||. |.| | .... | .|.| .|..|||  .|.|.|||||. . ..|...|| |  . ..|    ||||.||. .  ||. ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSV
   ||..|  .. .  |. |||| ||.| .|| .  ....||.||||.|.    |.||.. |||.    |    |..
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
subfamily_PPP5C_pd Subfamily PPP5C 57-355 4e-84 275.4 In-house 8-312 (322) alignment 
Range on Protein: 57-355
Range on HMM: 8-312/322.0
SKPLELNNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVP----VTICGDVHGQFHDLLELFKIGG-PCPDTNYLFMGDYVDRGY
   || ..  .. ... .|.. | . | .  .... ..| ..|. .  .  |...    .|.|||.||||.|||..|.. | | ..  ||| ||.|||| 
gpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGs

YSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPM-IETIDQVRELNRIQEVP
.|||..  |...|. ||... . |||||| .. ..||| .|.  || ...| ..||..|...|.. ....|.. .||||      |.|..|...| .. |
fsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqpp

HEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEV-DENHNRQFLQY
.|| ...||||||... | . | || |..|| ||...| ..|.|.|| |.|.. .|||  .|. ...|.||||||| . ||..|.... ..... .| ..
eegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktf

DPSVRP
.    |
eavehp
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 83-347 6.9e-81 264.8 In-house 8-278 (284) alignment 
Range on Protein: 83-347
Range on HMM: 8-278/284.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPC------PDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRG
|.| .. .||  | ...  |.  . |..||.|.||.|||| ||| |... |         ...|||.||||||| .|.| .. | |.|...|.....|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRG
||||| . . |||| || ..| | .....|   |  .|..|.|..||.|.|||.|  .  ..|. .|.|  ..|  | ..|| |.||. .  |.  ||||
nhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
|| .||..  ..|... .| |. ||||.||.|| .  ....||||||| || .  | ||...|||.    | 
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasft
PPP_2 112-303 2.7e-80 261.7 In-house 1-197 (198) alignment 
Range on Protein: 112-303
Range on HMM: 1-197/198.0
VTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFD
||.|||.|||..|||.||| |.|.|...|||.|||||||..|.|.. .|.|.|..||.....|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQL
..|..||.|.|....|||||. |...||... .| .|.|.||...||     |..........  | ||||..||.||.|.. ..|.|.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 78-346 1.3e-78 257.3 In-house 18-289 (297) alignment 
Range on Protein: 78-346
Range on HMM: 18-289/297.0
SKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
  .. ..|. | .|  .|.||.. ....  .| |. .|||.|||| ||| ||. ||  | .||||.||||||| .|.||.  |.| ||..|  . .||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMI---ETIDQVRELNRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..| |  ..  | |.|...|.| |. .||.|.||||||..    |.| .|...| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQF
||||  ||.|   .     .| |..||||.| .|| .   ...||||||| || .  | ||.| .||. .  |
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 86-352 6.1e-78 254.9 In-house 11-277 (281) alignment 
Range on Protein: 86-352
Range on HMM: 11-277/281.0
DDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
...  . ...  ..  |...  |. |... ||.|.||.|| .||.. |  |.. ..|.|||||||  |.|..  | ..|.||..|| .||||||  .. .
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

VYGFYDECLRKYGSaNVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGFTFGQDV
.|||| ||  |||  ..|  |   |. .||.||..... |.|||||| . ..|..|.  .  . .. | . ||||.|||... .|  | ||..||||..|
iygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

SEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ..   . .. || ||||.|..||     ....|.||.||||    | ||.. |||. . ..... |.
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
PPP_4 112-303 6.6e-76 247.7 In-house 1-196 (197) alignment 
Range on Protein: 112-303
Range on HMM: 1-196/197.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKyGSANVWKMFTDL
||..||.|||..|| |.|.|.|  | ....|.|.|||||||..|.|.. .|.|.|..||.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||. .|..|......| .|.| .|. ..|| |||||  .  |.  | ||||..||.|| |.| ..|.|.|| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 112-303 9.6e-75 243.9 In-house 1-198 (199) alignment 
Range on Protein: 112-303
Range on HMM: 1-198/199.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDL
||.|||.|||..|| |.||| |  | ....|.|.|||||||..|.|.. .|.|.|..||.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||| |..|.......| .|.| ..| ..|| |||||  .  | .  | ||||..||.|| |.| ..|.|.|| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 80-351 2.2e-74 243.0 In-house 7-281 (287) alignment 
Range on Protein: 80-351
Range on HMM: 7-281/287.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
 . .|..|.  . . . ..|.  . .  .. |.||.||.|||..||| .|.  |  |...|||.|||||||  |.| . .| ..|..||... .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PR
 ..| ..|||..|  ||..  ...| | |.|...|. | |...|.|.|||.|| ....|... |.. .     .|| . ||||.||.     ..     |
vkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkir

GAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
.    ||. . ... .. |..|| |||... ||||.  ....||.|||| |. .  | .|.. |..  . .| .  |
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_PPZ_pd Subfamily PPZ 82-351 6.5e-74 242.1 In-house 24-293 (300) alignment 
Range on Protein: 82-351
Range on HMM: 24-293/300.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 | .... ..|. | ...  . ..  .. .| | ||||||. ||| ||   |  | .||||.|||||||  |.||.  |.. |..||  . .||||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
..|.|||||||| |.    ..|| | | |. .|..|.|  ||||.||||||.....|..| . |  .||  | . ||||||| |    |    ||  . .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
 .   ..|     . |..||| .| .|| .  ....||.|||||||    |  |.| | |     |   ||
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 138-351 2.4e-72 236.8 In-house 101-314 (317) alignment 
Range on Protein: 138-351
Range on HMM: 101-314/317.0
TNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETI
 .|||.||||||| .|.| |. |.|.|..||.....|||||||| . . |||| |. ..| ||.....|   |  .|..|.|..||.|.|||.|  .  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQVRELNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIM
.|. .|.|  ..|  | ..|| |.||| .  |.  |.||||. ||..  ..|... || |. ||||.|..|| .  ....|||||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EVDENHNRQFLQYDP
.||.. .  .  . |
svdkklkisinvlrp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 85-349 1.4e-71 234.3 In-house 5-271 (284) alignment 
Range on Protein: 85-349
Range on HMM: 5-271/284.0
EDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQIT
 .||  |   |..... .  .  .| |. ||||.|||| ||| ||   |    .||||.||||||| . .||.  |.| || .| .. .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGFTFGQ
..||||.|| |.|    |.. |  .|  .|.|||| ..|.|.|||.| |.. . |.| ..|  . |    .  |.||||| . . ||    ||  . || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|   ..    .. |. ||||.| .|| .  .. .||||||| || .  | ||.| |..|    |.  
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 74-350 9.5e-67 218.0 In-house 4-287 (290) alignment 
Range on Protein: 74-350
Range on HMM: 4-287/290.0
IEHLSK---CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHR
|||| |    . .|..|.  . . . ..|.    .  .. |..| ||.|||. .||. |.  |  |. ..||.|||||||  |.|   .|  .|.||...
iehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskk

ITILRGNHESRQITQVYGFYDECLRKYGSaNVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNR--IQEVPHEGPMCDLLWSDPDD--R
. .|||||| |.. ..|||..|  || || ..||.. |.|. ... | |..||.|.|||.|. ||. . .. |..  ..   .|| . ||||.||.    
vhllrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkd

GGWGI-SPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
    .   |.    ||... ... ..  |||| |||..  ||...  ....||.|||| |. .  |  ||..| | .. ..    
dtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 80-352 2.3e-65 213.8 In-house 3-275 (280) alignment 
Range on Protein: 80-352
Range on HMM: 3-275/280.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
|. ..  ..  . .|   ..  | |.   . |. . ||.| |..|.  || . |  |. . .|.|||||||   .| .  |...|.||  || .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGF
.  . ..|||| ||  ||| . .|  |   |. .|...|. ....|.|||||| .  .| .|.. |  |    | . ||||||| ..| ||  | ||  .
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ||. | ||  .. .. || ||||.| .||     . ..|.|| |||| .  | ||.. .. | .  | |  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 97-352 5.1e-64 209.4 In-house 34-292 (307) alignment 
Range on Protein: 97-352
Range on HMM: 34-292/307.0
DVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRK
 ..  |  .  |. |. . ||.|||| ||...| . |  |.| |.| |||||||  |.|..  |...|. ||. | .||||||  .. . ||||.||.  
tifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvts

YG--SANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDVSEQFNHTND
      ..| .|   |. .||.||.  ||.|.|||||| .  .|..|.  .    |  | . |.||.|||     |  | ||.||||| .| ..  .   
ipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlg

LSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. || ||||....||     ....|||||| ||    |  ... |||    | . . |.
veliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 139-342 3.1e-57 187.2 In-house 121-324 (339) alignment 
Range on Protein: 139-342
Range on HMM: 121-324/339.0
NYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETID
 |||.||||||| .|.| |  | |.|. || || .|||||||| .   |||| |   .|  |.... | ..|. ||. |...| |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QVRELNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIME
|.  ..|  |.|  | . || |.|||    |.  | ||| | ||      | .  || .. | ||.| .|| .   . .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDENH
.|.. 
idkkl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 83-342 5.7e-57 186.2 In-house 6-290 (302) alignment 
Range on Protein: 83-342
Range on HMM: 6-290/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 83-342 8.8e-57 185.6 In-house 7-291 (302) alignment 
Range on Protein: 83-342
Range on HMM: 7-291/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 108-351 1.1e-55 182.1 In-house 5-255 (263) alignment 
Range on Protein: 108-351
Range on HMM: 5-255/263.0
INVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSAN----VW
.. |. |||| |||. ||| .|.  | .  |.|||.||||||| .|.| .  |...|.  |... .|||||| . | . |||. |  ...   .    |.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGFTFGQDVSEQFNHTNDLSLIAR
. | ..| |.|. |.| ..|.|.|||.|| ....|..| .    |  .  |. |||||.||.     |. |   |     ||.   ... .  |. || |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|||.|  |||.  .. ..|.|||  |     | ||.. |..  .  |.|  |
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_PPPLV_pd Subfamily PPPLV 90-342 2.2e-55 181.0 In-house 4-279 (290) alignment 
Range on Protein: 90-342
Range on HMM: 4-279/290.0
RLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLL----ELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
 ||..|||.|  ||.. ... |. . ||.||...||      |...|     ...||.||||||| .||| ..||.|.|| || .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGSA--NVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVREL----NRIQEVPHEGPM-CDLLWSDPDDR------------
 . .. |.  |.|    .||. |.. ||..|..| .|.|.|| |.|.   | |  ..  .    .|...  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRcGNQAAIMEVDENH
 |    . || |  |..|  |.| . |.|| . |||.   .|.   ..  ..|.||. .||    |.||.. ||...
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk
Metallophos Calcineurin-like phosphoesterase 111-303 5.8e-42 137.2 Pfam-A 2-198 (200) alignment 
Range on Protein: 111-303
Range on HMM: 2-198/200.0
PVTICGDVHGQFHDL----LELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYL--VAMKVRYPHRITILRGNHESRQITQVYGFYDECL----------
.....||.||...||    |.|.||..... ...||.||.|||| .| ||  .|   . |...|...  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVrelnriqevphegpmcdllwsdpddrggwgi
                       ....  ... .. . |.. |. ||||.||.. ||.||.  .. |.                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFTFGQDVSEQFNHTNDLSLIARAHQL
    ... || |. | .   ... |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 67-245 1.7e-37 122.1 In-house 17-201 (383) alignment 
Range on Protein: 67-245
Range on HMM: 17-201/383.0
INQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINV----PVTICGDVHGQFHDLLE-LFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLV
 ..... ||.. . . |    |. . . | .||.  .|.. ..      ||.|||.||.. |||  |.| | | .. .|.| ||.||||  ||| .  |.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

AMKVRYPHRITILRGNHESRQITQVYGFYDECLRKY--GSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIEtIDQVRELNR
|. . ||. . . |||||   .   |||  |   ||   .... ... |.| ..|...|.|.||. .|||.| . . .. . ...|
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkier
subfamily_PPP7C_pd Subfamily PPP7C 255-352 5.9e-22 70.9 In-house 237-335 (383) alignment 
Range on Protein: 255-352
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. |.|||||   .| .  . ||.|  || ||.... .  .|.|. |.|.  .||| ..|...|.||||| ||     |. | . . .. . ...||  |
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-133 7.7e-11 34.7 In-house 9-59 (317) alignment 
Range on Protein: 83-133
Range on HMM: 9-59/317.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
..| ... ||  | ...  |.  . ...||||.||.||||.||| |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_YNL217W_pd Subfamily YNL217W 111-184 1.2e-08 27.7 In-house 11-80 (235) alignment 
Range on Protein: 111-184
Range on HMM: 11-80/235.0
PVTICGDVHGQFHDLLELFK--IGGPCPDTNYLFMGDYVDRGYYSVETVSYLvamkvrYPHRITILRGNHESRQIT
 . . ||||| . .|.||..  |||  ..   ...|| ...|  |||.|||.        .    ..||||   . 
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 83-133 2.3e-06 19.9 In-house 11-61 (339) alignment 
Range on Protein: 83-133
Range on HMM: 11-61/339.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
.   ..| ||. | ...  |  .  .. |. . ||.|||| ||| .. . |
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng