Gene PTC2 in Saccharomyces cerevisiae

Synonym: YER089C, PTC2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP024_AA protein Get Run
ScerP024_AA_2-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 4-293 1.1e-133 437.6 In-house 1-287 (287) alignment 
Range on Protein: 4-293
Range on HMM: 1-287/287.0
ILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINT
.||.||..|||.|.|..||..| .||||.|..|||.||||...|.|||....|....||||||||||.|.|.|........|||.||.| ..|.|.|..|
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DVKLLQDPVMKEDHSGCTATSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKL
| .||.|  .|....|.||...|.....  |...||||||.||...||.||||.||||. .|||.||.||.||||..|||||||||||.||||||.| |.
DeellkdeklkdesaGstavvvlikeek..lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

GPEEQIVTCVPDILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALL
.|||||||.|||.| ..|| ..|||..||||||||.||....||||.  |..|..|.||.....| |.||... ||.|||||..|.|.||
kpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
PP2C Protein phosphatase 2C 24-276 1.4e-86 283.2 Pfam-A 3-252 (255) alignment 
Range on Protein: 24-276
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN-TDVKLLQDPVM-KEDHSGC
.| ...||.|.||||.||...|   .|.|...||...|||||| ..|.|..... |||.|||||.|. .. .||...| . || .| ..  . ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNPklgpeEQIVTCVPDILE
||...|.....  | . |.||||.||....||| .|..||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||. .
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTE
..|... |||.|||.||.||.|..|..||||.  | ..|...|.. ...| ..|. .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 24-276 1.4e-86 283.2 In-house 3-252 (255) alignment 
Range on Protein: 24-276
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN-TDVKLLQDPVM-KEDHSGC
.| ...||.|.||||.||...|   .|.|...||...|||||| ..|.|..... |||.|||||.|. .. .||...| . || .| ..  . ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNPklgpeEQIVTCVPDILE
||...|.....  | . |.||||.||....||| .|..||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||. .
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTE
..|... |||.|||.||.||.|..|..||||.  | ..|...|.. ...| ..|. .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
PPM_PTC7 24-276 2.2e-85 279.2 In-house 3-256 (259) alignment 
Range on Protein: 24-276
Range on HMM: 3-256/259.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN--TDVKLLQDPVM-KEDHSG
.| .|.||.|.||||.||...|.  .|.||..||...|||||| ..|.|..... |||.|.||| |. .| .||...| .  || .| ..  . ....||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

CTATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE---MDRVNGNLALSRAIGDFEFKSNPKlgpEEQIVTCVPD
.||...|...|.  | . |.||||.||...|||. .|..||||.. .|..|| .|.|.|.   . ||||.||.|||.||||.|....   ||| |.. ||
stAvvalitgsk..lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePd

ILEHSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGkTLNEISSRIIDVCCAPTTE
| .. .|.. |||.|||.||.||....|..||||.  | .. ...|.. ...| ..|. .|
isstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargse
0034914 PP2C-like 3-292 3e-78 255.4 In-house 2-290 (295) alignment 
Range on Protein: 3-292
Range on HMM: 2-290/295.0
QILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDkdHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-------KSFHEGNLPRA
..||.|.... ..|    |. .| . .||.|.|.||...  .|.|.  .  .....|.|||||| ..||.. . .||.| |.        .. . .. .|
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieea

LIDTFINTDVKLLQDPVM--KEDHSGCTATSILVskSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIG
|...|...| .||.  ..  . ..||.||. .|.   .| |...|.|||| || ..| .. |..||||.  .|. ||..|.|.| ..||||.||..||.|
lrkaflaadeellelallrpelagsGtTavvali..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalG

DFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCApttegtGIGCDNMSIVVVAL
||..| ...| ..|..|...||.  ..|... |.|..||.||.||.|.....||.|.  |..|..|.|.. ...| . |      . ..||...||| |
dfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
PP2Cc_SM00332 14-290 1.4e-75 247.2 In-house 2-274 (274) alignment 
Range on Protein: 14-290
Range on HMM: 2-274/274.0
SHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLtksDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG----NLPRALIDTFINTDVKLLQ
| || ..  ..|...||||| |||| |.  ...     ..  .|.|.||||||..||... .|..|.|.|.......    .  .|| . | .|| ..|.
sesgsnlglsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeile

DPVMKED---HSGCTATSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPklGPE
.  .||.    ||.||...|..| .  |.. |.|||| ||...|.|..||.||||  ..|..|| .| |.|| .||||.||.|||.||...| |   ...
eeqskelenalsGstavvallkked..lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klk

EQIVTCVPDILEHSLdYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK--TLNEISSRIIDvCCAPTtegtGIGCDNMSIVVV
|...|. ||.  ..|  . |||.|||.||.||.|..|. ||.|.  |..||     |.. .... .....    | ..||...|||
epyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaellde.eairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 15-292 3.6e-74 242.6 In-house 5-280 (282) alignment 
Range on Protein: 15-292
Range on HMM: 5-280/282.0
HSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLtksDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFH--------EGNLPRALIDTFINTDVK
... .    .|. .|||||..|||.|.   ..       . .|. .||||.|..||.|. ....| . |.....        . ..  || . |...| .
sqaegnglrygvssmqgwrvemEDahtvvaslg...alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

LLQDPVMKE--DHSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLG
. ..   ..  |.||.||...|||  .. |.. |.||||.||. .|.|. |..||||. ..|| || .|.|.| ..||||.||.|||.||.|.|......
irelstdlktadksGsTavtvlvs..ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekk

PEEQIVTCVPDILEHSLDYDRDeFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEgtgigcDNMSIVVVAL
.||| |. .|..   . . . | |..|||||||| |.... |.||.  |. .. |.|......| .    ..      ||.|..||..
aeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
subfamily_PPM1G_pd Subfamily PPM1G 117-292 1.5e-60 198.5 In-house 295-470 (473) alignment 
Range on Protein: 117-292
Range on HMM: 295-470/473.0
HSGCTATSILVSKsqNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMD-RVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPD
 ||.||. .|. .  . |.  ||||||.||. .|.|  ||.||||    |..|| .| | |..| |||| | ||||.||. .|.| .|...||... .||
dsGttAvvaLlke..kklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPD

ILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK--TLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVAL
|  . |  . |||..|||||||....||. || |.  |..|.  .|.||  ...| | || |.| | |||||....| |
ikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
0049733 PP2C-like 24-291 1.6e-50 164.6 In-house 5-232 (235) alignment 
Range on Protein: 24-291
Range on HMM: 5-232/235.0
FGLCAMQGW-RMSMEDSHILepnvltksdkdHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-KSFHEGNLPRALIDTFINTDVKLLQDPVMK--EDHSG
.| . ..|. |  .||....           ........|||||. ..|.. . .||.|.|. ..... .| .||...|  ..  ||.  .     ...|
vgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

CTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVemdRVNGNLALSRAIGDFEFKsnpklgpeeqivtcvPDILEH
.||. .|.   .. |.. |.|||| .| .||..  |..||.|.   |. ||..|.|.|   ||.| |||.||.||...|               ||. ..
tTavvalld..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvl

SLDYDRdeFVILACDGIWDCLTSQDCVDLVHLglregKTLNEISSRIIDVCCApttegtGIGCDNMSIVVVA
 |. .   |..||.||.||.|.... |||..      ..|.|. .|... ..|      . |.||...||| 
elepgd..flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvr
subfamily_PPM1E_pd Subfamily PPM1E 26-292 1.9e-47 154.7 In-house 8-262 (265) alignment 
Range on Protein: 26-292
Range on HMM: 8-262/265.0
LCAMQGWRMSMEDSHILEPN--VLTK-SDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLpRALIDTFINTDVKLLQDPVMKEDHSGCTA
. |... |  ||| |.  ..   | . .|....||...|||||| . |.|  ... | | .|....|  . .|| ..| .|| ..||  . .. .||.||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklksGsta

TSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFV---EMDRVNGNLALSRAIGDFEFKsnpklgpeeQIVTCVPDILEH
 ..|..|.|  |  .  |||...|  .|.|  |   |||    ||.|| .|.|.|   .. ||||.|..|||||| . |         . |.  .|. | 
vvvliekdq..lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvaev

SLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK-TLNEISSRIIDVCcapTTEGTGigcDNMSIVVVAL
.|| . .|..||||||.|| .. .. |.||.  |..|. .|.|..  ...     . .|     ||...||| |
eld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaa...keagss...Dnitvvvvfl
PPM_PTC7_SpoIIE 24-263 4.7e-47 153.7 In-house 3-214 (230) alignment 
Range on Protein: 24-263
Range on HMM: 3-214/230.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKvaEYCGNKIVEILQEQKsFHEGN-LPRALIDTFIN--TDVKLLqdpvmkEDHSGC
.| .|.||.| ||||.||...|.  .|...  ...|..|||||     .. . . ..|.|.. |.... .  .|.... .  .| .        ...||.
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede......psssga

TATSILVSKSQNLLVCGNAGDSRTVLATDgNAKalsydhkptlasEKSRIvAADGFVE----MDRVNGNLALSRAIGDFEFKSnpklgpEEQIVTCVPDi
||. .|.  |.. | . |||||. .| .| ...            |. || .| |...     .||.|.||.|.|.||. ..       ....|.. || 
TavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.

LEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGktlneIS
 .. .....|||.|||.||.||.|..|..||||   | .      ..
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aa
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 25-250 8.5e-43 139.5 In-house 9-221 (255) alignment 
Range on Protein: 25-250
Range on HMM: 9-221/255.0
GLCAMQGWRMSMEDSHILEPNVLTKSDKDHiafYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPvmkeDHSGCTATS
| . | | | .|||. ..  .   |||.|.   | .|||||| . |... ...  ||.|    .. |  ..| ... ...... . |     . |.||.|
gfsdmiGrrptmedelviyGsfrdksdedy...yalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp....kfiGttaas

ILVSKsqNLLVCGNAGDSRTVLA-TDGNAKALSYDHKPTLASEKSRIVAADGFVEMD----RVNGNLALSRAIGDFEFksNPklgpeeqIVTCVPDILEH
.|. .  .  .  | |||| ||.  || || ||.||||.  ||. || .. |.|  .    ||||.||.|||.||  .  .|        |.  ||. . 
vliie..dkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfl..eP.......fvvpdPdlsqs

SLDYDRDEFVILACDGIWDCLTSQDCVDLVH
   . .|.|.||||||||| .. .. |..| 
leiskkdkflilacdGiwdlisdeeaveiva
subfamily_PPM1L_pd Subfamily PPM1L 27-255 2e-41 135.1 In-house 10-238 (269) alignment 
Range on Protein: 27-255
Range on HMM: 10-238/269.0
CAMQGWRMSMEDSHILEPNVltkSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ----KSFHEG----NLPRALIDTFINTDVKLLQDPVMKEDHS
 ...| |  |||  ..| ..   ..| .. |...||||||   ||.. ...|. ....    .. .|     |  . | |  .  | |||.    .|| .
ysvlGrrprmedrfeieedi...knktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedia

GCTATSILVSKSQnlLVCGNAGDSRTVLA-TDGNAKALSYDHKPTLASEKSRIVAADGFVEMD---RVNGNLALSRAIGDFEFKsnpklgpEEQIVTCVP
|.||   ||..|.  |.  | |||| ||  ..|.|  ||.||||    |. ||  | ||. ..   ||.| || |||.||. .|       ....|   |
Gttalialvqesd..livanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadp

DILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLRE
|||   ||  . ||.|||.||.||... .. |  ..  | |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
subfamily_ILKAP_pd Subfamily ILKAP 29-255 1.8e-39 128.6 In-house 12-245 (293) alignment 
Range on Protein: 29-255
Range on HMM: 12-245/293.0
MQGWRMSMEDSHILEPNVLTK--SD---KDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-----KSFHEGNLPRALIDTFINTDVKLLQDPVMKED--
 .| |  |.|.|..  .. ..   .     ....|..||||.| . .|.. .|. . . |.      | .| .. ..|.|.| .|| ..|.    ..   
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvW

HSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAK------ALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSnpkLGpeeqiV
  |.|||..||   .|.|  .| |||..||.   ..       .|. ||.|.   |. ||  | |.|. .||.| |  ||.||| .||.   ||     |
kdGstatvvlvl..dnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....v

TCVPDILEHSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLRE
...||.    |. . | ||.|||||.|. .. .. |. .   | .
istPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvled
subfamily_PPM1K_pd Subfamily PPM1K 49-266 6.3e-36 116.8 In-house 25-238 (263) alignment 
Range on Protein: 49-266
Range on HMM: 25-238/263.0
KSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKsFHEGNLPRALIDTFINTDVKLLQDPVM-----KEDHSGCTATSILVSKSQNLlVCGNAGDSR
|  .... ....||||.|.  |... .|. .||.. .  .| .|   | ..| . | || .   .     ..  || |||  |. . ..| |  . ||||
keldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtel.vlaslGdsr

TVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEM-----DRVNGNLALSRAIGDFEFKSNpklGpeeqiVTCVPDILEHSLDYDRDEFVILACDGIWD
..|  .|.|| |. ||.| |  || || ||.|.||.      .||| ||..|..||...|.    |     |   |.  .  .|...| |..|  ||| .
ailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry...G.....viatPetkslkvdhaadsflvlitdgisf

CLTSQDCVDLVHLGLREgktlNEISSRI
 ..||.  |||.|        .| .. .
vvnsqelcdlvrlchdp....eeaahal
subfamily_PPM1D_pd Subfamily PPM1D 28-292 2.4e-32 105.2 In-house 8-307 (309) alignment 
Range on Protein: 28-292
Range on HMM: 8-307/309.0
AMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHE---GNLPRALIDTFINTDVKLLQD----PVMKED-H--
| || |  |||   .  .   .. . . || ..|||||| . |..  ..... ...|| |      .. .|. ..|..|  .. .     |  |.     
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllst

SGCTATSILVSKsqNLLVCGNAGDSRTVLATDGN------AKALSYDHKPTLASEKSRIVAADGFVEMD----RV---------NGN--------LALSR
.| ||. ... .  . |  .. |||..||... .      || |  ||||   .|| ||  . | | .     ||         ||.        ||..|
aGttasvviirr..eklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaR

AIGDFeFKSNPKLgpEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDV---CCAPTTEGTGIGCDNMSI
..||. .  | |   .| .|  .||. .. || ....|.||| ||.|..||..| |..|.     ... .| |. .  .   .   ...   . .||.|.
slGDl.Wsynaks..gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsv

VVVAL
.|| |
ivvil
subfamily_PPM1G_pd Subfamily PPM1G 5-115 1.4e-30 99.8 In-house 2-107 (473) alignment 
Range on Protein: 5-115
Range on HMM: 2-107/473.0
LSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHilepNVLTKSDKDhIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTD
||.| ..|||. .. . ...|  |||||| |.||.|    |..|. |.| .......|||||..||.|. .|. ..|..||...||.. .|| ..|.. |
lskpkvekesedesneelsygasamqGwrvsqEDah....ncitdlded.tslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD

VKLLQDPVMKE
 || .. ..||
eklkaeeslke
subfamily_KAPP-like_pd Subfamily KAPP-like 31-292 5.8e-27 87.4 In-house 7-266 (266) alignment 
Range on Protein: 31-292
Range on HMM: 7-266/266.0
GWRMSMEDSHILEPNVLTKSD---KDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ---KSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATS
|  . ||| ..    .| . .     .||....|||| |  .|.   . . ..|...      ..|  .       ..  .| ..  . . .. |.||| 
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatl

ILVSK--SQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKSNpKLGpeeqiVTCVPDILEH
 || .   | .| ..| ||| . |.   ..  ||.||| .  .|| ||   ||     .  |.|| ||.|||.||   |    .|     ..  | . ..
alvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfikel.niG.....lisepyvsnr

SLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCaptteGTGIGCDNMSIVVVAL
 |    |.|.|.| ||.|| .. .| .. |.    ...| ....| ....       ..    ||.|..|| |
illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletai.....qsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-292 4e-23 74.7 In-house 6-276 (276) alignment 
Range on Protein: 31-292
Range on HMM: 6-276/276.0
GWRMSMEDSHILEPNVLTKSD---KDHIAFYGIFDGHGGAKVAEYC----GNKIVEILQE-Q---KSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSG
|  . ||| ..    .| . |     .||....|||| |  .|.       ...  .|.  .      ..|  .       ..   | ... . . .. |
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeG

CTATSILVSK--------SQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKSNpKLGpeeq
.|||  || .         |  | ..| ||| . |.   ..  ||.||| |  .|| ||   ||     .  |.|| ||.|||.||   |    .|    
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfikel.niG....

iVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCaptteGTGIGCDNMSIVVVAL
 ..  | . .. |    |.|.|.| ||.|| .. .| .. |.    ...| ....| ....       ..    ||.|..|| |
.lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletai.....qsikakdnvsvivvkl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-198 8.3e-18 57.9 In-house 19-186 (292) alignment 
Range on Protein: 54-198
Range on HMM: 19-186/292.0
HIAF-YGIFDGHG--GAKVAEYCGNKI-VEILQEQKsfHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNlLVCGNAGDSRTVLAT-
 ..|   ..||||  | |||..  ... ||.|.  .  .  .|. ||.   ...  || .  . .  ... ...   |   .. |.  | ||||..|   
altflaavldGhGvnGdkvaqlaedtlevelleltr..qlqelsealllrildiaakldkltidaresattavvcarvrddra.lilanvGdsrallgrc

----DGNAKALSYDHKPTLASEKSRIVAADGFVE-----------MDRV------NGNLALSRAIGDFEFK
    | . . || ||||    |..|| .| |.||             ||      .|.||||||.||| ..
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlf
subfamily_PDP_pd Subfamily PDP 106-267 1.1e-16 53.9 In-house 141-326 (398) alignment 
Range on Protein: 106-267
Range on HMM: 141-326/398.0
KLLQDpVMKEDHSGCTATSILVSKSQnlLVCGNAGDSRTVLAT---DG--NAKALSYDHKPTLASEKSRIVAAD------GFVEMDRVNGNLALSRAIGD
| |.. ...   || .|.  |... .  |   |.||.|.||..   .|  .|..|| |.  . ..| .|| ..         .  .|. |.|. .|| ||
kslre.allvalsGacallaliegte..lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGd

FEFKSNPKLGP---EE------Q--------IVTCVPDILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRII
...| . .|     |.      .         .|  |....| |   .| |..|| ||.||.|.... |.||.  | . |. ......  
vryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklr.endkFLvlatDGLwdllsneevvslVgehlakkkekepvkveea
PPM_PTC7_motif 230-277 1.9e-16 53.3 In-house 1-49 (51) alignment 
Range on Protein: 230-277
Range on HMM: 1-49/51.0
ILACDGIWDCLTSQDCVDLVHLGLR-EGKTLNEISSRIIDVCCAPTTEG
|||.||.||.|..|..||||. .|  .|....|......| ..|. .| 
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseD
subfamily_PP2D1_pd Subfamily PP2D1 129-385 1.9e-15 49.6 In-house 185-414 (492) alignment 
Range on Protein: 129-385
Range on HMM: 185-414/492.0
KSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVE----MDRVNGNLALSRAIGdfeFKSNPKLgpeEQIVTCVPDILEHSLDyD
. . .|   |||. . ||  .|.|. |  .| |    |..|.  | . |     . .||| |   | .|   .  .|||   .. | . | .    || .
eelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLG...nyGdpkL...kksvipePkttsvkld.e

RDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEiSSRIIDvccapttegtgigcDNMSIVVVALLKEgEDVAQWSDRMKSKAHRTSVRSFADKrrr
.. |..||  |.|. |. .. . ||.  |.  |   . .  . |               ... |    | |  .. . | |.......  |.|  |    
aaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvr.aenvpd..............sdvttvgedylgE.leakklsaryentgfdkfvtseidl...

vfsyyDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENL
     | .. .. ... . . .. .. ..| .   ..   |     .   . |.|..||. 
.....daaegdesnlqklfsynelsevkedaddereglseanskkeityneedtdksaees
Subfamily Dicty-PPM1L-like 95-200 2.9e-12 39.1 In-house 192-295 (305) alignment 
Range on Protein: 95-200
Range on HMM: 192-295/305.0
ALIDTFINTDVKLLQDPVMKEDhsGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADG-----FVEMDRVNGNLALS
||....   . .||.    | |  . .   .   . ..|||  .|.|.. |||||| ...|||....    |. |.   ..     | |. || ...|..
alynygellvnrllkksrskGd..knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavk

RAIGDfefksN
| .||     |
rgsgD.....n
PP2C_SIG_SM00331 49-291 5.1e-12 38.8 In-house 24-216 (217) alignment 
Range on Protein: 49-291
Range on HMM: 24-216/217.0
KSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHegnlpRALIDTFINTDVKLLQDpvMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLAT
 .....  .. ..||.|. . |. .  .... |.|. | .      .| ... ...  . .    .|.....|.. .|.  |.. |   |||||| .| .
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr

DGNAKALSYDhkptlaseksrivaadgfvemdrvngnlalsraigdfefKSNPKLGPEEQIVtcvpdILEHSLDYDRDEFVILACDGIWDCLTSQ----D
||. .    |                                       .. . || |...      . ...|... .....|. ||...  ...    .
dgklveilkd.......................................vegaplGlepevs.....vdirelelekgdllllytDGltearsekgfaee

CVDLVHLGLReGKTLNEISSRIIDVCCAPTTEGTGigCDNMSIVVVA
 . ..   |  . .. |....|..  .. ...  |   |....||| 
rleeiledlv.dseaqelaqkiveellelakgsng..eDdiTvvvvk
subfamily_PPM1H_pd Subfamily PPM1H 95-170 1.3e-09 30.4 In-house 139-210 (404) alignment 
Range on Protein: 95-170
Range on HMM: 139-210/404.0
ALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPtlASEKSRI
|| . |.. | .. ..    ... |||| . ||   .. |   |||||| .| . .. ..|| |. |  ..|. |.
alesaflemDeqiarereayrikGGCtalvalvl..lgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl
subfamily_PP2D1_pd Subfamily PP2D1 23-84 1.3e-08 27.0 In-house 2-62 (492) alignment 
Range on Protein: 23-84
Range on HMM: 2-62/492.0
AFGLCAMQ--GWRMSMEDSHILEPNVLTKSDKdhiAFYGIFDGHGGAKVAEYCGNKIVEILQEQ
|.|.|  .   |. .||| . |  . . . ..   .|.||.||. ||  || . ... |.| |.
avGiCedknsrWKskmeDkrtlqdyfgndvns...cFfgiyDGynGataAeiaakelhevllee
subfamily_PHLPP_pd Subfamily PHLPP 54-250 2.3e-08 26.2 In-house 26-213 (246) alignment 
Range on Protein: 54-250
Range on HMM: 26-213/246.0
HIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHeGNLPRALIDTFINTDVKLLQdpvmKEDHSGCTATSILV--SK----SQNLLVCGNAGDSRTVLA
. | ||.|||.   ....   . . ..|.|. .    |    .  |.. .  || .    . .. | .|  ||.  .|    .   |   . |   .||.
vealyGlfdGdrneelssllqrlmkdvlkeevqkd.kneeeymkntllvaqrklGe....aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavli

TDGNAKALSYDHKPTLAsEKSRIVAADGFVEM-DRVNGNLALSRAIGDFefKSNPKLGPEeqivtcvPDILEHSLDYDrDEFVILACDGIWDCLTSQDCV
 .|.   ||  ..     | .||  | ....  ...|| .. .| .| .     | . |.       | . |  |  . ||..|.  . .|. |  .. |
Rngkklrlsksyviekd.elkrikeakaiitednkingviestrllGyt..flfPvvlPk.......phvrevlLteq.dellivGnkalWevlsideav

DLVH
. |.
eavr
PPM_PTC7_SpoIIE_motif 218-291 6.3e-08 26.2 In-house 4-79 (81) alignment 
Range on Protein: 218-291
Range on HMM: 4-79/81.0
EHSLDYDRDEFVILACDGIW-------DCLTSQDCVDLVHLGlrEGKTLNEISSRIIDVCCApttEGTGIGCDNMSIVVVA
|.....  .. ..|..||..       .... .. ..|..    |||.| |.. ...| . .    | |   |.....|. 
eaefqLkpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlr
Subfamily Dicty-PPM1L-like 24-82 2.7e-07 22.7 In-house 9-64 (305) alignment 
Range on Protein: 24-82
Range on HMM: 9-64/305.0
FGLCAMQGWRMSMEDSHIlepNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQ
..| . .. |   || .    . ..  ....  ..|.||||.| . |||   |.|||. 
yelyvsansrkyqedrnk...vkislessqelslfGvfdGhnGdiaaeyvkkklveivn
subfamily_PPM1H_pd Subfamily PPM1H 180-253 3.6e-07 22.3 In-house 275-351 (404) alignment 
Range on Protein: 180-253
Range on HMM: 275-351/404.0
DRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSL---DYDRDEFVILACDGIWDCLTSQDCVDLVHLGL
 |. . .. .| .|| | |   .      ....||..    |   . ..|. .||| ||.|| |. ..   .|.  |
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevl
subfamily_TAB1_pd Subfamily TAB1 37-108 2.7e-06 19.4 In-house 9-83 (333) alignment 
Range on Protein: 37-108
Range on HMM: 9-83/333.0
EDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIV-EILQEQK--SFHEGNLPRALIDTFINTDVKLL
...|  | .|.. . ....  |..|||. |.|.|..  ...| |.|.||   ...| .  . |   | ... |.|
kedhevedkvflfktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfl