Gene GLC7 in Saccharomyces cerevisiae

Synonym: SAL6, YPL179W, PPQ1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP025_AA protein Get Run
ScerP025_AA_4-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 21-300 8.7e-162 529.9 In-house 2-281 (282) alignment 
Range on Protein: 21-300
Range on HMM: 2-281/282.0
SKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFIL
||.|..|.|.|.||..|..|||.|...||||||||||.||.|||||||.|||||||..|.|||||||||||||||||||||||.||||||||||||.|.|
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDR
|||||.|||||||||||||||||.|||||||||.|||||.||..||||.|.||||||.|.|.||||...||...|. |||||||||||||...|||||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQK
|||||||.|||..||||.|..||.|||||||||||||.||||||.|||||||||||||||..||||.||.||||||||.|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_PPZ_pd Subfamily PPZ 6-299 1.6e-140 460.8 In-house 1-295 (300) alignment 
Range on Protein: 6-299
Range on HMM: 1-295/300.0
VDVDNIIDRLLEVR-GSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
||.|.||..||.    .|  ..| |...||  .| ||| .|. || ||||  ..|| ||.|||| ||||||   |||| .||||||||||||||||||| 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLL
|||.||||||||||.|||||||| . |.|||||||||| |||.|||| | || ||.|||.  ||||.|||||| ||||..||.|.||||.||.||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQ
||||      | .|.||||. .    .|.||.|  ..|.|||| |||||||||  | |||.|||||||||||| ||.||| | |||||..| | .
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpld
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 7-301 1.4e-138 453.9 In-house 2-297 (298) alignment 
Range on Protein: 7-301
Range on HMM: 2-297/298.0
DVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
.||... ..|.|  |.      ..|...  |...|..|| ||. |.|..||||.|||||||| ||||||. .||||..||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFILRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLW
||||.|||.|||.|||||||..|||.||||.|||||| ...|...| | || ||..|.| ..|.|||||||. |.|..|.|.. ||.| ..  |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQKS
.||.. . ||.|| ||||..|| |||. .|.| |..|..|||||| ||||||....|||.||||.|||.|||. |.|.||| | .||..|||..|.
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 6-302 3.7e-132 433.1 In-house 1-298 (299) alignment 
Range on Protein: 6-302
Range on HMM: 1-298/299.0
VDVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
.|||... .||.|  |.      ..|.|.. ||. |.|.|..|. |||.||||..|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.|
ldvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitl

LLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLL
||..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.. .|  .|.|||||||| |....|.| . || | |.  |  |||
llcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidll

WSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQKSL
|.|||. ...|  | ||||. ||.|||.  ... |..|..||||||.||||||....|||.|||| |||.|||. |.| ||| |.|.|..|||..|||
wadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 30-300 2.8e-121 397.0 In-house 7-277 (280) alignment 
Range on Protein: 30-300
Range on HMM: 7-277/280.0
EENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
.| .|  .  | . |.  |  ..|..||...|||.|||| ||||||.  .|||..||||||||||||.| || |.||||||..||.||.|||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPD
|| |||.||.||||. .|.. | . .. ||..|..  .|.|||||||..| |........|| | .|  |  ||||.||.... ||.|| ||||  || .
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

VVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQK
||. . .| |..||.| ||||.||||||....|||.||||.|.|||||. |.. ||| |  ||..|||| .
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
0045823 Metallo-dependent phosphatases 22-300 1.3e-118 389.5 In-house 36-326 (473) alignment 
Range on Protein: 22-300
Range on HMM: 36-326/473.0
KPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILR
    .  |.|.....|...|..|. |.| ||||...| ..||||||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||.|.|.||
hlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllr

GNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPdKDIVG-------
||||.. .| .|||.||. ..|...|.. | .....||.||.|..||...||||||||....|||.. || .||| |||.|||||||  .. |       
GNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlr

-WSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQ------LVTLFSAPNYCGEFDNAGAMMSVDESLlCSFQILKPAQK
 .  . ||....||||.|..||.| .. ||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .|| | .||....|.. 
ffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
PP2Ac_SM00156 30-298 1.4e-117 384.6 In-house 2-270 (271) alignment 
Range on Protein: 30-298
Range on HMM: 2-270/271.0
EENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
...|.. |......|. ... |.|..||. ..||||||..|||||.| .|.|||..|.|||||||||.||.|.|.||.|.||.|||....||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPD
|.||||..|.||.|. .... |...|..||.||..|.||.||||||||.|.|...||.. |. ..|. |||.|||||||...  |.. . ||.|..||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

VVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPA
.|..||.| ...||.|||.||..|||||....|||.|||||||.||.|..|...|...| .|.. ||..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
0049330 Metallo-dependent phosphatases 5-300 4.1e-117 383.5 In-house 6-301 (309) alignment 
Range on Protein: 5-300
Range on HMM: 6-301/309.0
PVDVDNIIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
|......| .||..  ... ... |.|.|...|. ||..|....|.||||...| ..||||||..|||||.|  ||||| ...||||.|||| .|||...
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLL
||||.|..||.|.|.||||||.. .|..|||.||..|.|...||. |.|....||.||.|..||.|.||||||||....|||...||..||. |||||||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdll

WSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQK
||||. .. |. .|.||....||...|.|||.| ...||.|.|..|..||..| ...|.|.||||||||...|.||.. .||.|..||....|.. 
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
PPP_1 30-284 1.1e-116 381.7 In-house 2-264 (264) alignment 
Range on Protein: 30-284
Range on HMM: 2-264/264.0
EENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
||.|.. |..|..... |...|||....|..|||||||..|||.||..||..||.|||||||||||||.|.|...||||.|.|||...|.||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLL-------WSDPDKDIVGWSENDRG
...|||..|.. ..|. ...||.||.|..||.||.|||||...||||||.|....|||...| |..|. | |||||       .||....  ......||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSV
....||.||...||||....||.|||.|.|.||||..||..||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 29-296 1.9e-116 380.8 In-house 2-270 (271) alignment 
Range on Protein: 29-296
Range on HMM: 2-270/271.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
|.|||.. |..|...|. |...|.|..||...|||||||..|||.||..||..||..||||||||||||.|||...||||.|||||.....||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||.||||....||||||...|..||..  |....|. |.|.|||.|.....  |.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

PDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILK
|||...||.|....||.|||...|.|||.. ....||.|||||||....||||.....|.| ..|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 29-297 1.2e-113 372.3 In-house 8-282 (284) alignment 
Range on Protein: 29-297
Range on HMM: 8-282/284.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFP------PESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRG
|.|.|.  || .|| .| |... ||.|||.||.||||||. ||| |..  |.|       |..|||||||||||  |.| | ||.|||...|.. |.|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.|||||.| || ...|. .. ||.||||.|...|| |.||.....|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKP
  .||.. |..||.| ...|. |||||| ||||||. |.|||.|||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 32-301 6.7e-109 356.7 In-house 6-277 (284) alignment 
Range on Protein: 32-301
Range on HMM: 6-277/284.0
NEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINR
...  |  .| ||| |||.|.| ..||.||||||||. ||||||.  |||  .|||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYNI-KLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVG-LLCDLLWSDPDKDIVGWSENDRGVSFTFGPD
|||||.||.||||   ....|   |  .|..|.. ..|.|||||.|  |. . |.| . || | |.   |  |.||||| .   ||  | ||||. || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

VVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQKS
 . ..|.. ...|. ||||||.||||||..|.|||.|||| |||.|||| |.| |.. |.||| .|.| .| 
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkki
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 8-298 8.5e-108 353.1 In-house 2-295 (297) alignment 
Range on Protein: 8-298
Range on HMM: 2-295/297.0
VDNI-IDRLLEVRGSKPGQQVDLEENeIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL
||.| || |      |.  .|  ||  .  |   | ..| .|  ..|..||||.|||||||. ||||||  ||.|| .||||||||||||. |.||| ||
vdsiiidvlsasthekllskviteer.vlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivll

LAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSP---DLNSMEQIRRVMRPTDIpDVGLLCD
||||.|.| |.|.|||||||  .|..||||.||..||. .... .| | || ||.. .| .||.||||||||   .  ... .|.. |.|.    .|..|
laykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvad

LLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPA
|||.||   . |. ||.||    || | | .   . ...|.|||||||.||||||. |.|||.|||| |||.|||. |.||.|| | |||.||.|.
llwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 11-298 1.9e-107 351.9 In-house 4-291 (293) alignment 
Range on Protein: 11-298
Range on HMM: 4-291/293.0
IIDRLLEVRGSKPGQQVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYK
.| .||..  .   ... | |.|...|. .|..|..|.|.||||...| ..|||||...|||.|.|. |||||....||||.|||| .|||...||||.|
lilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalk

IKYPENFFILRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPD
..||.|...||||||.. .| .|||.||..|.| . .||. ..|....||.||.|..||...||||||||....|||...||..||. |||.||||||||
llypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd

kDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPA
 .. ||  . ||....||...| |||.| ...||.|.|||| |||... ...|||.||||||.|...|.||.. .||.|...|....| 
.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP2C_pd Subfamily PPP2C 28-300 1.7e-104 342.1 In-house 16-288 (290) alignment 
Range on Protein: 28-300
Range on HMM: 16-288/290.0
DLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 |||.|.. || ||. |. |.  . |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   |||||||  
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDkDIVGWSENDRGVSFTF
 | ..||||||| |.| | ..|| ||| |..||..|..||.|||.|||||| ......|| . |  ..|. | |||||||||| |  ||.  .||  .||
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagytf

GPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQK
| |. ..| ......|| ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .|| .
gkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP4C_pd Subfamily PPP4C 29-299 4.8e-104 340.6 In-house 16-286 (288) alignment 
Range on Protein: 29-299
Range on HMM: 16-286/288.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
..|.|.. ||.||| |....  . ....|. .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  ..|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDkDIVGWSENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |..|||||.||||.||||||.......|| . | ...|. | |||||||||. |. ||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfg

PDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQ
 |||..| ...|.||||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. |.
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-299 1.3e-100 329.2 In-house 6-278 (281) alignment 
Range on Protein: 27-299
Range on HMM: 6-278/281.0
VDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHEC
|.. ..||  .  ....|| ..  | |...||.. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... ..|||||| 
vqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhei

ASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTF
||.|.||||| ||. .| ..||  |  ||| |||.| |.... ||||||||.| .....|   .| . .| ||. ||||.|||..  .| .  ||.||||
asvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQ
| .||.   .. ..||| |||||| |||| .| |.|.|.||.||||  . ||.|.. |||.|  |.. | || 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 84-298 4e-99 324.7 In-house 101-315 (317) alignment 
Range on Protein: 84-298
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSME
..|||||||||||  |.| . ||.|.|..||.. |.||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.|||||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.||||||.|.|| |.|||... |. |  || .. ||.. |..||.| |..|. |||||||||||||. |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDESLLCSFQILKPA
||. | .|...|.| 
vdkklkisinvlrpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 29-299 2e-97 318.5 In-house 10-283 (287) alignment 
Range on Protein: 29-299
Range on HMM: 10-283/287.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
.....|  .  |...|.   | |||.||||.|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  .||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDV--GLLCDLLWSDPDKDIVGWSEND-RGVSFT
||..|||..| ||... .|.|.| | |. ||. |.....|.|||||.||.|.|..... . .||   .   ||  ||||.||.||  .   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQ
||  .|. .|.| |..|| |||.|.|.||.|. ...|||.|||| |.||  | ||.. |..||  ||  ||| .
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_PPP6C_pd Subfamily PPP6C 29-295 8.9e-95 310.1 In-house 15-281 (290) alignment 
Range on Protein: 29-295
Range on HMM: 15-281/290.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
| ||... ||..   .....  .  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  .||||||.  
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPdKDIVGWSENDRGVSFTFG
| ..|||||||...| | . || .|. |. |.|||||||...|.|||||||.. ..||| . | ..||  | .|||.|||| .|.  |.  .||  . ||
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylfg

PDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQIL
  |.. |.. ....|||||||.||.|.... . .|||..||||||    |  ........   .....
skvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_PPP3C_pd Subfamily PPP3C 28-287 1.5e-89 293.8 In-house 40-312 (452) alignment 
Range on Protein: 28-287
Range on HMM: 40-312/452.0
DLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 |||...  . ..| ... |.. |||.|||| ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...|.||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWS------EN-DR
 .   . | .||| .|. .........|..||.||..... .|.||||||...|...|... |  ..|  |.||||||||| .|    .      .|  |
hlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSK------RQLVTLFSAPNYCGEFDNAGAMMSVDES
| |. ..   | .||||.|.  | |||.. ..||. . |        |.||||||||.. ..| .|.. ... 
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 34-298 1.6e-88 289.8 In-house 11-275 (280) alignment 
Range on Protein: 34-298
Range on HMM: 11-275/280.0
IRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIY
|  .     .||...  | | |||||. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  ..||||||  |.|.||
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiy

GFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNR
||| ||. .| . ||  |  ||| .|....| ....||||||||.|  .. || . || .  | ||| ||||||| .   ||  . ||.|. ||  ||..
gfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveq

FLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPA
  .  ...|| ||||||.||||... |.|.|.|| |||| .| || |.. ..  |  ||| | | 
acksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPG1_pd Subfamily PPG1 29-300 3.4e-87 285.5 In-house 14-298 (300) alignment 
Range on Protein: 29-300
Range on HMM: 14-298/300.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECAS
| |  .. |. | . ...|.  . |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    .||||||   
lpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrq

INRIYGFYDECKRRY--NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPD---------KDIVG--W
| ..|||| || |.|  | ..|| .|. |. | .||||||.|.|.||||||.  |..||. . |  ..|. | |.|||||||.          |  |  .
itqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhf

SENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQK
 . .||  ...| |||..||...||. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . | .
vvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 28-298 1.2e-86 283.4 In-house 15-289 (290) alignment 
Range on Protein: 28-298
Range on HMM: 15-289/290.0
DLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECA
 .....|  .  |...|.   | |||.|||| | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  .||||||. 
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevr

SINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTD--IPDVGLLCDLLWSDPDKDIVG--WSENDRGVS
 .||.|||..|  |. . .||| . | |. |.. | ...||.|||||.|....| | .. . .|      | ||  ||||.||..|       .  |..|
kvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrais

FTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPA
  || .... .|.|  ..|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |||  |. .||| 
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP5C_pd Subfamily PPP5C 35-285 2.1e-86 282.9 In-house 40-295 (322) alignment 
Range on Protein: 35-285
Range on HMM: 40-295/322.0
RYLCSKARSIFIKQPILLELEAP----IKICGDIHGQYYDLLRLFEYGGFPPES-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASI
  . ..|.... |.| |.|.. .    . .|||||||.|||| .||  | | |.  ||| ||.||||  |.|.| .||..|. ||..||. |||||  ..
lkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnm

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGL-SPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKdIVGWSENDRGVSFTFGP
|..||| .|.| .|. |. . ||. || ||.| .|.||.. .|||| | |  .....|.. | .. |. |||..||||||..   | |.  |||...|||
nklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGp

DVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVD
|| ..||.....||| |.|.| |.|||.  . .|.|.||||||| . .| ||.... 
dvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlr
PPP_2 58-249 4.1e-84 274.2 In-house 1-197 (198) alignment 
Range on Protein: 58-249
Range on HMM: 1-197/198.0
IKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFN
...|||.|||..|||.||..|...||..||||||||||||.|||...||||.|..||.....||||||....|..|||..|.. .... |..|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLL----WSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQV
.||.||.||||....|||||.......||..  |....|. |.|.|||    .|||...  ..... ||....|||||....|.|....||.|||.|
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 58-249 4.2e-81 264.7 In-house 1-196 (197) alignment 
Range on Protein: 58-249
Range on HMM: 1-196/197.0
IKICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCF
. ..||||||..|| |.|...||.|. |..|.||||||||||.|||...||||.|..||.....||||||..|.|..|||..|...... ...|...|.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIP-DVGLLCDL-LWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQV
..||.||.||||....|||||..|.|...|.|. |....| . ....|| ||||| ..  |.... ||....|||||...||.|....||.|.|..
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-296 6e-79 258.4 In-house 18-290 (307) alignment 
Range on Protein: 27-296
Range on HMM: 18-290/307.0
VDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHEC
..   .|.  .  .|..||  .  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  .|||||| 
iqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhei

ASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVS
| .|. ||||.||     .   ..|  |  ||| |||.|.|  ||.|||||||| |  ....|   .|   |  |.. |.||.|||  .. |    ||  
arvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsg

FTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILK
|||| .|..   ..  .||| ||||.. |||  .| |.|.|.|||| ||  . |||... |||.|      . 
ftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 85-299 3.4e-78 256.1 In-house 121-335 (339) alignment 
Range on Protein: 85-299
Range on HMM: 121-335/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQ
 |||||||||||  |.| . || | |. ||.  ..||||||  |.|  |||| | . ||. .|.. | . || .|..|.|.. |.|||||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRVMRPTDIPDVGLLCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || .|||||.| || |.|||    |.    || || |||  .  ||.| |.... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DESLLCSFQILKPAQ
|. |  | ....|  
dkklkisinvfrpes
PPP_5_Dcr2 58-250 2.6e-77 252.3 In-house 1-199 (199) alignment 
Range on Protein: 58-250
Range on HMM: 1-199/199.0
IKICGDIHGQYYDL-LRLFEYGGFPP-ESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDC
. .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||.....||||||. ..|.||||..|.... .. |..|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIP-DVGLLCDL-LWSDPDKDIVG-WSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVV
|..||.||.||||....||||||...|.|..... |...|| . |  .|| ||||| ..  | . .. ||....|||||...||.|....||.|.|...
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 51-299 3.3e-73 239.6 In-house 2-257 (263) alignment 
Range on Protein: 51-299
Range on HMM: 2-257/263.0
LLELEAPIKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNI-----
||||.|||.|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ....||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRPTDIPDV-GLLCDLLWSDPDKDIVGWSEND-RGVSFTFGPDVVNRFLQKQDMELI
 ... | . |. .|..||. ..|.|||||.|| |.|...|| .  | .      | |||||.||.||  |.  |  | .|  ||   |. . .. |..||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKPAQ
 ||||||| || ||. |.|.|.|||  |  |. |  |.. |.. |  ||  ||| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 26-297 7.9e-71 231.7 In-house 3-299 (302) alignment 
Range on Protein: 26-297
Range on HMM: 3-299/302.0
QVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKY
. .....|.  |...  . . |.  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvly

PENFFILRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRP-TDIPDVGLLCDLLWSDP
|.|. .||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.|.|||.|| |.|.|.|... || ... .  |  |||..||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

-DKDIVG-------WSE-NDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILKP
 | . .        . . . ||.|..|    |. . .. ...|| ||||..  |. ||....|.|.||||.|  | || ||.. ||     | ..|..
ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 26-296 2.1e-70 230.3 In-house 4-299 (302) alignment 
Range on Protein: 26-296
Range on HMM: 4-299/302.0
QVDLEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYG------------GFpPESNYLFLGDYVDRGKQSLETICLLLAYKIKY
. .....|.  |...  . . |.  | |. .|. | ||||||. ||.|.. .             .|  .. ..|||||||||..|.| |||..|.|. |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysf.ssdkfvflGdyvdrGsksieciclvfalkvly

PENFFILRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIRRVMRP-TDIPDVGLLCDLLWSDP
|.|. .||||||. .||  ||| .| . |.      ..|. | ..|  .|.||.. |||.|.|||.|| |.|.|.|... || ... .  |  |||..||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

-DKDIVG-------WSE-NDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLLCSFQILK
 | . .        . . . ||.|..|    |. . .. ...|| ||||..  |. ||....|.|.||||.|  | || ||.. ||     | ..|.
ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPPLV_pd Subfamily PPPLV 37-287 1.6e-58 191.4 In-house 5-278 (290) alignment 
Range on Protein: 37-287
Range on HMM: 5-278/290.0
LCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLL----RLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRI
||..|  |....  ||||..|. . ||.||.| ||      |.  |     ...||||||||||. |.| |. ||| |. ||  ...||||||  |.   
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

YGFYDECKRRYNIKL---WKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNS------MEQIRRVMRpTDIPDVGLLCDLLWSDPDKDI-----------
. .. |.. ..  .|   |..|...|. ||.||.||.|.||.|.|.     .      ...|   ..  ||    |  |.|||||..|            
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk.ddidgaplaldilwsdpaedrdlslrgelvln

VGWSEND-RGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAgAMMSVDES
 |. .|| || .  |. | ...||...... . |||.| | |...  | .|.|.||. .|||  ..| |.. ||..
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkk
Metallophos Calcineurin-like phosphoesterase 57-249 4.3e-46 150.7 Pfam-A 2-198 (200) alignment 
Range on Protein: 57-249
Range on HMM: 2-198/200.0
PIKICGDIHGQYYDL----LRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFILRGNHECASINRIYGFYDECK----------
.| ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..| ||||||. ..|  |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRYNIKLWKTFTDCFNCLPIAAIIDEKIFCMHGGLSPDLNSMEQIrrvmrptdipdvgllcdllwsdpdkdivgws
                         ... . .  . ..|..||..|..| ||...||.||....| ..|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

endrgVSFTFGPDVVNRFLQKQDMELICRAHQV
      |. ||||... .|.| .. |..|.|. 
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-189 9.5e-39 126.2 In-house 65-200 (383) alignment 
Range on Protein: 57-189
Range on HMM: 65-200/383.0
PIKICGDIHGQYYDLLRLFEYGGFPPE-SNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRY---NIKLWKTFT
 . .|||.||.  ||| ..   |.| |  .|.| ||.|||||.|.| ...|||. . ||..... |||||   .|  |||  | . .|   . |. ... 
evtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlle

DCFNCLPIAAIIDEKIFCMHGGLSpDLNSMEQIRRVM
| |  ||.|..|||||. .|||.| |  ..| . .. 
dvfawlplatlidekilivhGGis.dktdlelldkie
subfamily_PPP7C_pd Subfamily PPP7C 200-289 4.2e-21 68.1 In-house 237-326 (383) alignment 
Range on Protein: 200-289
Range on HMM: 237-326/383.0
LCDLLWSDPDKDIVGWSENDRGVSFTFGPDVVNRFLQKQDMELICRAHQVVEDGYEFFSKRQLVTLFSAPNYCGEFDNAGAMMSVDESLL
. |.||||| ..   ...  ||    ||||| ...||| ...|. |.|.   .||||  .....|.||| ||  |  | || . . ..| 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdlt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 29-82 1.1e-17 57.1 In-house 9-62 (317) alignment 
Range on Protein: 29-82
Range on HMM: 9-62/317.0
LEENEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPP
..|.|.  || .|| .| |.|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 32-83 6.2e-12 38.2 In-house 14-65 (339) alignment 
Range on Protein: 32-83
Range on HMM: 14-65/339.0
NEIRYLCSKARSIFIKQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPE
 |.  || .|| .   .||.|.||||| . ||||||. ||| ...  |.|  
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_YNL217W_pd Subfamily YNL217W 59-178 2.1e-08 26.9 In-house 13-139 (235) alignment 
Range on Protein: 59-178
Range on HMM: 13-139/235.0
KICGDIHGQYYDLLRLFE--YGGFPPESNYLFLGDYVDRGKQSLETICLLlaykikYPENFFILRGNHECASINR------IYGFYDE--CKRRYNI--K
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.. ..        ..   ..|||| . . .        |. .    ..   .  |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

LWKTFTDCFNCLPIA-AIIDEKIFCMHGGLSPD
| |  ..    |. .  |  .... .|.||.| 
lskadmeyarelgfsldipsdellvvhaGlvpg