Gene PTC7 in Saccharomyces cerevisiae

Synonym: YHR076W, PTC7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP031_AA protein Get Run
ScerP031_AA_70-343 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPTC7_pd Subfamily PPTC7 82-343 3.3e-96 314.5 In-house 4-252 (252) alignment 
Range on Protein: 82-343
Range on HMM: 4-252/252.0
DSIRSPTGEDNYFVTSNNVHDIFaGVADGVGGWAEHGYDSSAISRELCKKMDEIStalaeNSSKETLLTPKKIIGAAYAKIRDEKVVKVGGTTAIVAHFP
 ..|. .|||.|||.|.. .|.. |||||||||...|.|.|..||||.|.....|     ..||.. |.|.... |||.....|||...|..||..... 
kgkrqkageDayfvsseksadvl.gvADGVggWrsvGiDpsefsreLmkacekls.....keskaeelkPvelleaayqelleekvpvlGssTacivvld

SNG-KLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEmlkeaerRGSKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFL
..  |||.||||||.. |.|..|.||..|.|.. ||.||||||.||.       |..|.||..|..||..||..||.|||.|||||..||...|.|. .|
ksdkklesanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapeg.......regkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileil

KDNAARTNDELQLLSQKFVDNVVSLSKDPNYPSVFAQEiSKLTGKNYSGGKEDDITVVVVRVD
|.........|| |..|.......||.||.| |.|||. .| .|...||||.|||||||..|.
kelkeseksslqslakklaekarelsldpeyespfaqk.akkngleasGGKpDDitvvvavvs
PP2C_SIG_SM00331 71-342 2.8e-59 193.3 In-house 1-217 (217) alignment 
Range on Protein: 71-342
Range on HMM: 1-217/217.0
DRDDLIYQKLKDSIR-SptgEDNYFVTSNNVHDIFAGVADGVGgwaeHGYDSSAISRELCKKMDEISTALaenssKETLLTPKKIIGAAYAKirdeKVVK
|...||.|....... |   .|.|.|...| ..... ||||.|    .|....|.|..|.....|....      .|.  ..|....|.|..    |..|
ddggliaqyyeeatqvs...GDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee....keek

VGGTTAIVAHF-PSNGKLEVANLGDSWCGVFRDSKLVFQTKFqtvgfNAPYQLSIIPEEMlkeaerrgskyilntprdADEYSFQLKKKDIIILATDGVT
 ...|...|.. .|.|||..||.|||.. ..||.|||...|.     .....|...||..                  .|.....|.|.|...|.|||.|
gmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.....vegaplGlepevs..................vdirelelekgdllllytDGlt

DN-----IATDDIELFLKDNAartNDELQLLSQKFVDNVVSLSKDPNYpsvfaqeiskltgknysggkEDDITVVVVRV
..     .|....|..|.|..   ..|.| |.||.|.....|.|..|.                    |||||||||.|
earsekgfaeerleeiledlv...dseaqelaqkiveellelakgsng....................eDdiTvvvvkv
PPM_PTC7_SpoIIE 96-343 5.6e-53 173.1 In-house 26-230 (230) alignment 
Range on Protein: 96-343
Range on HMM: 26-230/230.0
TSNNVHDIFAGVADGVGgwaeHGYDSSAISRELCKKMDEISTALAEnssketllTPKKIIGAAYAKI----RDEkvVKVGGTTAIVAH-FPSNGKLEVAN
 ......... |.|..|    ||.........|.....|...| .|        .|..|........    .||  ....|.||.||. .||.|||.|||
ekssggrlalvvgdvdG....hGgraalamgllrtalrelafagle........kpeeilrrlnlalaadlede..psssgaTavvalidpstgklyvan

LGDSWCGVFRDSKlvfQTKFQTVGFNAPYqLSIIPEemlkeaerrgskyilntpRDADEYSFQLKKKDIIILATDGVTDNIA-TDDIELFLKDNAARTND
.|||.. ..||..   ......|....|. |.|.|.                  |........|...|...|.||||... . |.|.||| ||.......
aGdsppllvrddg...gererivagglps.lGilpg..................rvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilas

----E---LQLLSQKFVDNVVSLskdpnypsvfaqeiskltgkNYSGGKEDDITVVVVRVD
    .   .| |.....|.....                    ...|..|||||..|||||
dglwdvlspqelvdlvrdelekp....................aaeglleDDitllvvrvd
SpoIIE Stage II sporulation protein E (SpoIIE) 100-343 2.5e-47 153.2 Pfam-A 2-193 (193) alignment 
Range on Protein: 100-343
Range on HMM: 2-193/193.0
VHDIFAGVADGVGgwaeHGYDSSAISRELCKKMDEISTALAEnssketlltPKKIIGAAYAKIRDEKVVKVGGTTAIVAH-FPSNGKLEVANLGDSWCGV
 ......|.|.||    ||.....|...|.....|..|| .|         |........... ..   .. ..||..|. .||.||||.||.|.... .
dgrlalvvgDvvG....hGleAalimgllrsalrelatagle.........paevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppll

FRDSKlvfQTKFQTVGFNAPyqLSIIPEemlkeaerrgskyilntpRDADEYSFQLKKKDIIILATDGVTDNIaTDDIELFLKDNAARTND--E---LQL
.|...   .|||..|....|  |.|.||                  .|..|...||...|...|.|||||..  ..| ||| |........  |   |. 
vrpdg...gtkfllvstglp..lGilpe..................adyeeaelqlepgdllllyTDGvtEar.dpdgelfgkerllallaeaegeslee

LSQKFVDNVVSlskdpnypsvfaqeiskltgkNYSGGKEDDITVVVVRVD
|....|.....                     ..||..|||||..|.|||
lldalveelle.....................lgsgeleDDitllvlrvd
SpoIIE Stage II sporulation protein E (SpoIIE) 100-343 2.5e-47 153.2 In-house 2-193 (193) alignment 
Range on Protein: 100-343
Range on HMM: 2-193/193.0
VHDIFAGVADGVGgwaeHGYDSSAISRELCKKMDEISTALAEnssketlltPKKIIGAAYAKIRDEKVVKVGGTTAIVAH-FPSNGKLEVANLGDSWCGV
 ......|.|.||    ||.....|...|.....|..|| .|         |........... ..   .. ..||..|. .||.||||.||.|.... .
dgrlalvvgDvvG....hGleAalimgllrsalrelatagle.........paevlerlnealarnleeeerfatavlaeydpstgkleyanaGhpppll

FRDSKlvfQTKFQTVGFNAPyqLSIIPEemlkeaerrgskyilntpRDADEYSFQLKKKDIIILATDGVTDNIaTDDIELFLKDNAARTND--E---LQL
.|...   .|||..|....|  |.|.||                  .|..|...||...|...|.|||||..  ..| ||| |........  |   |. 
vrpdg...gtkfllvstglp..lGilpe..................adyeeaelqlepgdllllyTDGvtEar.dpdgelfgkerllallaeaegeslee

LSQKFVDNVVSlskdpnypsvfaqeiskltgkNYSGGKEDDITVVVVRVD
|....|.....                     ..||..|||||..|.|||
lldalveelle.....................lgsgeleDDitllvlrvd
0049733 PP2C-like 86-342 4.7e-34 110.8 In-house 15-233 (235) alignment 
Range on Protein: 86-342
Range on HMM: 15-233/235.0
SPTGEDNYFVtsnnvHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENSSKETLLTPKKIIGAAYAKIRdekVVKVGGTTAIVAHFPsNGK
 ...|| ..|     . ....||||.||.|  .. |. . . |.. . | ..   |.. ....|.  . . . . . .    . ..||||.|| .  .||
rkvneDavlv.....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp...elagmgtTavvalld.ggk

LEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLkeaeRRG-----SKYILNTPRDADEYSFQLKKKDIIILATDGVTDNIATDDIELFL
| |||.|||.. ..|| |||. |. ... .. ..|  | .....    |       .... ... ..| ....|.. |...||.||..|..  ..|  .|
lyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeivdll

KDnaartnDELQLLSQKFVDNVVSlskdpnypsvfaqeiskltgknysGGKEDDITVVVVRV
..      ..|. . .. |. ...                        .|. |.|||||||.
rs......ldleeaaerlvelala........................rggrDNiTvvvvrl
0034914 PP2C-like 85-343 5.7e-31 100.6 In-house 31-291 (295) alignment 
Range on Protein: 85-343
Range on HMM: 31-291/295.0
RSPTGEDNYFVTSN----NVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEIstalaENSSKETLLTPKKIIGAAYAKI--------RDEKVVKVGG
|... || ..|  |    . . ...||.||.||.|   . |. . ..|.. . ..      ... ..| ......  |. ..        .... . ..|
rrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.....lllltlsledieealrkaflaadeellelallrpelagsG

TTAIVAHFpSNGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAERRGS----------------------KYILNTPrDADEY
|||.||..  ..|| |||.||| . ..|. .||. |. ... ..  ..  . ....     . |.                       .. ..| | . .
tTavvali.rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllslllleplvsaeP.dvtvl

SFQLKKKDIIILATDGVTDNIATDDIELFLKDNAArTNDELQLLSQKFVDNVVSlskdpnypsvfaqeiskltgknysGGKEDDITVVVVRVD
...|.. |...||.||..|..  ..|  ..... | ....|. .... || ...                        .|. |.|||||||..
eltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAla........................rgsrDNiTvvvvrln
PPM_PTC7_SpoIIE_motif 246-343 2.5e-28 91.6 In-house 1-81 (81) alignment 
Range on Protein: 246-343
Range on HMM: 1-81/81.0
DADEYSFQLKKKDIIILATDGVTDNIaTDDIELFLKDNAARTND--E---LQLLSQKFVDNVVSlskdpnypsvfaqeiskltgkNYSGGKEDDITVVVV
|.||..||||..|...|.|||.|... ..|.|||.|....|..|  |   ||.|..|.||.|..                     |.||..|||||..|.
dydeaefqLkpgdvllLyTDGltEar.dsdgelfgkeellrladraegkslqeladklvdevle.....................ngsgereDDitllvl

RVD
|||
rvd
PPM_PTC7 88-336 6.8e-27 87.5 In-house 6-256 (259) alignment 
Range on Protein: 88-336
Range on HMM: 6-256/259.0
TGEDNYFVTSNNVHDIFAGVA--DGVGGWAEHGYDSSAISRELCKKMDEIST-ALAENSSKETLLTPKKIIGAAYAK----IRDEK-----VVKVGGTTA
.  ..........| ..|...  .|   .|.... .....||..|...|. . .|.|..|.|.|  ..|..  ....    .. ..     . . .|.||
safqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGstA

IVAHFPSNGkLEVANLGDSWCGVFRDSKLV--FQTKFQTVGFNAPYQLSIIPEEMLKEaeRRGSKYILntprDADEYSFQLKKKDIIILatdGVTDNIAT
.|| . ..  |.|||.||| . ..|. . |  ........  .  ..... . .. ..  ..| ..       |  ..|. .....      ...  .|.
vvalitgsk.lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv..gngrvngv....lavsRafGdfelkpket...eeqlvsae

DDIElfLKDNAARtNDELQLLSQKFVDNVVSLSKDPNYPSVFAQ-EISKLTGKNYSGGKEDDIT
.||.    .. .. .. | |.|....|.| .     ...|.... . .... |... .......
Pdis..stkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargse
PP2Cc_SM00332 85-209 2.7e-11 36.4 In-house 20-147 (274) alignment 
Range on Protein: 85-209
Range on HMM: 20-147/274.0
RSPTGEDNYFVTSN---NVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTA---LAENSSKET-LLTPKKIIGAAYAKIRDEkvvKVGGTTAIV
.  ..|| ..|. .   .    | ||.|| || .   . |. . . |.... . ..      |.  |.  | | ..|  ..  | ...      |.||.|
wrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen...alsGstavv

AHFpSNGKLEVANLGDSWCGVFRDSKLVFQTK
|.. ....| |||.||| . ..|..| |  ..
all.kkedlyvanvGDSravlcrngkavqlsv
PPM_PTC7_motif 261-311 6.1e-11 35.7 In-house 1-51 (51) alignment 
Range on Protein: 261-311
Range on HMM: 1-51/51.0
ILATDGVTDNIATDDIELFLKDNAARTNDELQLLSQKFVDNVVSLSKDPNY
|||.||..|... ...  ...|. . .....| ...| ||. ..  ...|.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2Cc_SM00332 237-340 2.7e-10 33.1 In-house 195-274 (274) alignment 
Range on Protein: 237-340
Range on HMM: 195-274/274.0
SKYILNTPRDADEYSfqLKKKDIIILATDGVTDNIATDDIELFLKDNAARTndelqllsqkfvdnvvslskDPNYPSVFAQEISKLTGKNysGGKEDDIT
..|| ..|    .     ......|||.||..|..  ...  ....  |..                      | |. .|... ... ..  ||.||.||
epyitaepdvkvvtl..tsedeflilaSDGlwdvlsnqevvdivrkllakg....................ktndpqeaaelldeeairr..ggseDniT

VVVV
||||
vvvv
subfamily_PPM1L_pd Subfamily PPM1L 90-202 1.7e-08 27.1 In-house 20-135 (269) alignment 
Range on Protein: 90-202
Range on HMM: 20-135/269.0
EDNYFV---TSNNVHDIFAGVADGVGGWAEHGYDSSAISRELCKKMDEISTALAENS--SKETLLTpKKIIGAAYAKIRDEKV-VKVGGTTAIVAHFpSN
|| . .    .|...  | .| || ||     .  . ..... .|. |. ..  ..   . ..||| ..|. . .  .   |.  .. ||||..|   ..
edrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfskllt.deilsvdekllekakraediaGttalialv.qe

GKLEVANLGDSWcGVFRDS
 .| |||.|||  ||. | 
sdlivanvGdsr.Gvlydk
PP2C_2 Protein phosphatase 2C 90-287 2.7e-08 26.3 Pfam-A 13-198 (212) alignment 
Range on Protein: 90-287
Range on HMM: 13-198/212.0
EDNYFVTSNNVHDIFAgVADGVGGwAEhgyDSSAISRELCKKMDEISTALAENSSKE-TLLTPKKIIGAAY--------AKIRdEKVVKVGGTTAIVAHF
.| ... ...  ...| ||||.|  |.    |   .| ... . |  ..| |..|.. .  . ..|  ...        |. . .. .|  .|| ..| .
qDalaireasdgwlla.VADGaGs.ak...rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavi

PSnGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAerrgskyilntprdaDEYSFQLKKKDIIILATDGVTDNIATDD-IELF
 . |.. ....||. . |.. .. | .   . .|  |    .. .|.  .|                .  ...|.. | ..| |||| |......  . .
tp.geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............rirrlklepgdalllmTDGvsdslrkeepfrel

LKDNAART
|..  .. 
laelletl
PP2C_2 Protein phosphatase 2C 90-287 2.7e-08 26.3 In-house 13-198 (212) alignment 
Range on Protein: 90-287
Range on HMM: 13-198/212.0
EDNYFVTSNNVHDIFAgVADGVGGwAEhgyDSSAISRELCKKMDEISTALAENSSKE-TLLTPKKIIGAAY--------AKIRdEKVVKVGGTTAIVAHF
.| ... ...  ...| ||||.|  |.    |   .| ... . |  ..| |..|.. .  . ..|  ...        |. . .. .|  .|| ..| .
qDalaireasdgwlla.VADGaGs.ak...rSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq.qeelkdyatTlllavi

PSnGKLEVANLGDSWCGVFRDSKLVFQTKFQTVGFNAPYQLSIIPEEMLKEAerrgskyilntprdaDEYSFQLKKKDIIILATDGVTDNIATDD-IELF
 . |.. ....||. . |.. .. | .   . .|  |    .. .|.  .|                .  ...|.. | ..| |||| |......  . .
tp.geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...............rirrlklepgdalllmTDGvsdslrkeepfrel

LKDNAART
|..  .. 
laelletl
PP2C Protein phosphatase 2C 97-202 3.6e-07 23.0 Pfam-A 29-130 (255) alignment 
Range on Protein: 97-202
Range on HMM: 29-130/255.0
SNNVHDIFAGVADGVGGWAEHGYDSSAISrelckkmdeisTALAENSSKETLLTPKKIIGAAYAK-IRDEK-------VVKVGGTTAIVAHFPSNGkLEV
| . .  | .|.||.||   . |... .            . |.|..|...|   .|..  .... ...|.            |.||.|| . ..  | |
sgkssvaffavfdghggreaakyarehle...........eilkeqksflelekvekalrksfladtdeelksskantepsksGstavvalirgkk.lyv

ANLGDSWCGVFRDS
||.||| . ..|..
AnvGDSravLcrkd
PP2C Protein phosphatase 2C 97-202 3.6e-07 23.0 In-house 29-130 (255) alignment 
Range on Protein: 97-202
Range on HMM: 29-130/255.0
SNNVHDIFAGVADGVGGWAEHGYDSSAISrelckkmdeisTALAENSSKETLLTPKKIIGAAYAK-IRDEK-------VVKVGGTTAIVAHFPSNGkLEV
| . .  | .|.||.||   . |... .            . |.|..|...|   .|..  .... ...|.            |.||.|| . ..  | |
sgkssvaffavfdghggreaakyarehle...........eilkeqksflelekvekalrksfladtdeelksskantepsksGstavvalirgkk.lyv

ANLGDSWCGVFRDS
||.||| . ..|..
AnvGDSravLcrkd
NLBH Neuraminyllactose-binding hemagglutinin precursor (NLBH) 233-303 9.2e-06 11.4 Pfam-A 100-166 (258) alignment 
Range on Protein: 233-303
Range on HMM: 100-166/258.0
ERRGSKyILNTpRDADEYSFQLKKKDIIILATDGVTdnIATDDIELFLKDNAARTNDELQLLSQKFVDNVV
|..| | .|.  .|..| |.. |||  ..|| ||       .|.   .|.. |  ..|. ..|  ||   .
ekkGYk.vlrf.kDkkelsvdqkkkaylvlaldGev..aileDlkrtvkekdaldkeevvdissGfvklnf