Gene PFK26 in Saccharomyces cerevisiae

Synonym: YIL107C, PFK26

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP034_AA protein Get Run
ScerP034_AA_392-634 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 174-395 1.3e-89 289.4 Pfam-A 4-222 (223) alignment 
Range on Protein: 174-395
Range on HMM: 4-222/223.0
LISKEDSGSKLVIVMVGLPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFAKEhglkDQDSKFFEPKNADSTRLRDKWAMDTLDELLDYLLEGSGSV
 ..|... ||||||.|||||.||..|..||.|.|... ...||||||..||...|.    ..|..||.|.|.....||.|.|...|..||.|| |..|.|
stvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavka....lsdaeffrpdneealklreklalaalkdllkylneeegqv

GIFDATNTSRERRKNVLARIRKRSphLKVLFLESVCSDHALVQKNIRLKLFG-PDYKGKDPESSLKDFKSRLANYLKAYEPIE--DDENLQYIKMIDVGK
.|||||||.|||||..|.......  ||||||||||||......||... .. ||||.|..|...|||..||.|| |.|||..  .||.|.|||.|||||
aifDAtNttrerRklilefveenn..lkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgk

KVIAYNIQGFLASQTVYYLLNFNLA
.....|.||.|.|..||||||..|.
slvvnnvqgylqsrivyyllNihlk
subfamily_PFKFB_pd Subfamily PFKFB 391-612 1.3e-79 258.3 In-house 1-196 (198) alignment 
Range on Protein: 391-612
Range on HMM: 1-196/198.0
NFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARqreifyqnlmqqkknnentdGNIYnDFFVWTSMRARTIGTAQYFnedDYPIK
|  |..|.|...|.||||.|..|||||.|.||.|| ..||.| |||..                     |.. .. ||||...||| ||...   ..| .
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike....................enlk.elrvwtselkrtiqTaell...glpke

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLGYFMNLSMGIIANLDVP
|.|.||||.||..||.|| |||..|||||..|.|||.|||||  .||||.|...||.|||.||||...|||||.|. |.|.||.|....|.  ...|.||
qwkaLdeldaGkcdgltyeeikekfpeefkerkkdkyryryp..rgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvp

LHCVYCLEPKPYGITWSLWEYD
||.|..|.|..||....|...|
lhtvikltpvaYgckvellkld
0039931 Phosphoglycerate mutase-like 398-634 2.6e-50 163.1 In-house 1-210 (219) alignment 
Range on Protein: 398-634
Range on HMM: 1-210/219.0
QIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFyqnlmqqkknnentdgniyndFFVWTSMRARTIGTAQYFnedDYPIKQMKMLDE
.....| ||.|.|| ||. |.|.||.|| . |. | .......  |                     . |..|   |.| ||...   ..|..... | |
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpf.....................davysSpllRaiqTaeii...glpveidprLrE

LSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGigGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCL
...||..|.|..||....|||......|...||.||  |||..||..|..|...||.. ..|||...|  | |||| |...||.  |..|..| ..|..|
idfgdlegltleeiaekypeelaawlrdpydyrppg..gEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtvl

EPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEV
|....|... |. . .  |.. ... ..|...... .
elddggwvlvllnltshlddllrlllltlelllllll
0035570 Phosphoglycerate mutase-like 398-630 7.3e-50 161.7 In-house 1-206 (219) alignment 
Range on Protein: 398-630
Range on HMM: 1-206/219.0
QIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQReifyqnlmqqkknnentdgniYNDFFVWTSMRARTIGTAQYFnedDYPIKQMKMLDE
.....| ||.|.|..||. |...||.|| . |. | ...|...                     .. ..|..|   |.| ||...   ..|..... | |
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlg.....................ipfdavysSpllRaiqTaeii...glpveidprLrE

LSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCL
...||..|.|..||.. .|||. ... |...||.|  ||||..||..|..|...|||. ..|||...|  | |||| |...|... |..|..| ..|..|
idfgdlegltldeiaekypeelaawlrdpydyrpp..ggEsladvvaRvlpaleeled.genvlvVsHggvirallayllglpleeilrlnlpngsvtvl

EPKPYGITWSLWEYDEASDSFSKVPQTDLNTTR
|....|..|.|. ... |    ..... |....
eldggggkwvlvllndtshlelllellllslll
0036777 Phosphoglycerate mutase-like 397-613 6.1e-44 142.8 In-house 3-231 (247) alignment 
Range on Protein: 397-613
Range on HMM: 3-231/247.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYFNE----DDYPIK
......| ||.|.|..||. |  ...||..| . || | ......   |                      .|..|.  |.| ||... |    . .|..
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfd.....................avysSpllRAiqTaeiilealglsllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELERI----EDNVLII
... | |.. |...|.|..||.. .|||. ... |.. ||.|                         ||||..||..|..|...|| .     ..|||..
vdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvV

THRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDE
.|  | |||| |...||.. |..| .| .....|| ...| .|.|. ...
sHggvlrallayllglsledilrlnlpngsitvleldddgklwvleslnd
0053607 Phosphoglycerate mutase-like 397-609 9.7e-43 138.2 In-house 2-187 (191) alignment 
Range on Protein: 397-609
Range on HMM: 2-187/191.0
RQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFYQnlmqqkknnentdgniyndffVWTSMRARTIGTAQYFnedDYPIKQMKMLD
..... | ||.| |. ||. |...||..| . |. | ...|..   |                       |..|   |.. ||...   ..|..... | 
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfda.....................vysSpllRarqTaeii...glpvevdprlr

ELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYC
|...||..|.|. |.....|||......|.| ||.|  ||||..||..|..|...|| . ..|||...|  | |||| |...|..  . .|..| ..|..
Eidfgdwegltleelaekypeelaawlrdpldyrpp..ggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsvtv

LEPKPYGITWSLW
||....|... |.
lelddggwvlvll
0051064 Phosphoglycerate mutase-like 397-613 2.7e-42 137.7 In-house 4-232 (241) alignment 
Range on Protein: 397-613
Range on HMM: 4-232/241.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQ----YFNEDDYPIK
..... | ||||.|. ||. |  ...||..| . |. | ...|..   |                       |..|   |.| ||.    ... ...|..
krlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfd.....................avysSpllRaiqTaeiiaealglpllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELERI----EDNVLII
... | |.. |...|.|..||.. ||||. ..  |.| .|.|.                        ||||..||..|..|.. || .     ..|||..
vdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvV

THRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDE
.|  | ||||.|...|.   . .|..| ..|..|| ...| ...|. ...
sHggvirallayllglpleellrlnlpngsvtvleldddgkrvvlvllnd
0043909 Phosphoglycerate mutase-like 397-606 2.8e-41 133.9 In-house 3-228 (249) alignment 
Range on Protein: 397-606
Range on HMM: 3-228/249.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYFNE----DDYPIK
..... | ||.|.|. ||. |  .|.||..| . |. | .......  |                      .|..|   |.| ||... |    | .|..
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfd.....................avysSplkRAiqTaeiileelgldklpve

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQK-----------------------------DKLRYRYPGigGESYMDVINRLRPVITELERI----E
... | |.. |...|.|..||.. .|||. ...                              |.| .|.||  |||..||..|..|...|| .     .
vdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppg..gEsladvvaRvlpaleellarllkdg

DNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITW
.||||..|  | |||| |...||.  | .| .| .....||....|  .
gnvliVaHggvlrallayllglsledilrlnlpngsitvlelddggkpv
0049178 Phosphoglycerate mutase-like 397-609 3.3e-41 133.9 In-house 4-226 (243) alignment 
Range on Protein: 397-609
Range on HMM: 4-226/243.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYF----NEDDYPIK
..... | ||.| |. ||. |  .|.||..| . |. | ...|..   |                       |..|   |.| ||...    . . .|..
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfd.....................avysSplkRaiqTaeiilealglpllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG---------------------IGGESYMDVINRLRPVITELERI----EDNVLIITH
... | |.. |...|.|. ||. ..|||. ... |.. .|.|                       ||||..||..|..|.. || .     ...||...|
vdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaH

RVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLW
  | |||| ....|... ...|..| ..|..|| ...|..   .
ggvirallalllglpleellrlnlpngsvtvlelddggwvlvsl
0048955 Phosphoglycerate mutase-like 398-612 3.4e-41 134.0 In-house 2-228 (240) alignment 
Range on Protein: 398-612
Range on HMM: 2-228/240.0
QIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYF----NEDDYPIKQ
.... | ||||.|. ||. |  ...||..| . |. | ...|..   |                       |..|   |.| ||...    . . .|. .
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfd.....................lvysSpllRaiqTaeiiaealglpllpvvv

MKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELER----IEDNVLIIT
.  | |.. |...|.|..||...||||....  |.| .|.|.                        ||||..||..|..... || .     ..|||...
dprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVs

HRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYD
|  | ||||.|...|.   |..|..| ..|..|| .... ... ... 
Hggvirallayllglpleeilrlnipngsvtvlelddglvslndtshl
0036887 Phosphoglycerate mutase-like 397-609 1.6e-40 131.2 In-house 2-195 (202) alignment 
Range on Protein: 397-609
Range on HMM: 2-195/202.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQreifyqnlmqqkknnentdgniyNDFFVWTSMRARTIGTAQYFNED-DYPIKQMK
......| ||.|.|| ||. |  ...||..| . |. | ...|                         . . |..|   |.| ||... |  ..|.....
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlagl.......................pfdavysSpllRaiqTaeiiaealglpvivdp

MLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERI--EDNVLIITHRVVARALLGYFMNLSMGIIANLD-VP
 | |.. |...|.|..||.. .|||. ... |.. .|.|  ||||..||..|......|| .   ..|||...|  | |||| |...||.  . .|. .|
rlrEidfgalegltleeiaekypeelaawlrdpydfrpp..ggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklp

LHCVYCLEPKPYGITWSLW
 ..|..|| ...|... |.
ngsvtvlelddggwvlvll
0037864 Phosphoglycerate mutase-like 393-609 4.6e-39 126.3 In-house 4-207 (211) alignment 
Range on Protein: 393-609
Range on HMM: 4-207/211.0
NLADRQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYQnlmqqkknnentdgniyndffVWTSMRARTIGTAQYF----NEDD
||. ......| ||.|.|. ||. |  ...||..| . |. | ...|..   | .                     |..|   |.| ||...    . . 
nllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfda.....................vysSpllRaiqTaeiilealglpl

YPIKQMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERIE----DNVLIITHRVVARALLGYFMNLSMG
.|..... | |.. |...|.|..||.. .|||. ... |.. .|.|  ||||..||..|..|.. || .      .|||...|  | |||| |...||. 
lpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrpp..ggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle

IIANLDVPLHCVYCLEPKPYGITWSLW
 . .| .| ..|..|| ...|... ..
ellrlnlpngsvtvlelddggwvlvsl
0050036 Phosphoglycerate mutase-like 398-599 3.5e-33 106.6 In-house 2-167 (171) alignment 
Range on Protein: 398-599
Range on HMM: 2-167/171.0
QIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIarqreifyqnlmqqkknnentdgniyNDFFVWTSMRARTIGTAQYFNeddYPIKQMKML
.... | ||.| |. ||. |  .. ||..|.. |. | ...                          .  .|..|.  |.. ||...    .|. ... |
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell..........................pfdavysSpllRArqTaelil...lpvivdprL

DELSAGDYDGMTYPEIKNNFPEefekrqKDKLRYRYPGIGGESYMDVINRLRPVITELErieDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVY
 |.. |...|.|. ||.. .||       ..  ....  ||||..||..|..|.. ||    .|||...|  | |||| ....||.  | .|..| ..|.
rErdfGawegltldeiaakype......wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpngsvl

CLEP
.|| 
vlel
His_Phos_1 Histidine phosphatase superfamily (branch 1) 398-572 1.1e-30 99.7 Pfam-A 1-158 (158) alignment 
Range on Protein: 398-572
Range on HMM: 1-158/158.0
QIWITRSGESEDNVSGRIGGNSH--LTPRGLRFAKSLPKFIARqreifyqnlmqqkknnenT----DGniyndffVWTSMRARTIGTAQYFNE-DDYPIK
.....| |||| | .||. |.|.  ||..| . |..| | ..|                       |        |.||   |.| ||....|  |.||.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..................adlpida.......vytSplkRaiqTaeilleeldipii

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELE---RIEDNVLIITHRVVARAL
. . | |...|...|....|.|..||||.||...|| ..|.|  .|||. ||..|..|...||    . ..||||..|. | |||
keprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrpp..egesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 398-572 1.1e-30 99.7 In-house 1-158 (158) alignment 
Range on Protein: 398-572
Range on HMM: 1-158/158.0
QIWITRSGESEDNVSGRIGGNSH--LTPRGLRFAKSLPKFIARqreifyqnlmqqkknnenT----DGniyndffVWTSMRARTIGTAQYFNE-DDYPIK
.....| |||| | .||. |.|.  ||..| . |..| | ..|                       |        |.||   |.| ||....|  |.||.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..................adlpida.......vytSplkRaiqTaeilleeldipii

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELE---RIEDNVLIITHRVVARAL
. . | |...|...|....|.|..||||.||...|| ..|.|  .|||. ||..|..|...||    . ..||||..|. | |||
keprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrpp..egesladvyeRvapfleelieakdkgenvlivsHggvlral
AAA_33 AAA domain 185-344 1.4e-11 35.0 Pfam-A 1-140 (143) alignment 
Range on Protein: 185-344
Range on HMM: 1-140/143.0
VIVMVGLPATGKSFITNKLSRFLNyslyyCKVFNVGNTRRKFAKehglKDQDSKFfepknaDSTRLRDKwAMDTLDELLDYLLEGSGSVgIFDATNTSRE
....||||..|||.  ..| . |      . . .  . ||. ..    .||.|.       |.||.... . ..| .|.   |.  .|| |.||||.|||
lvllvGlpGsGKstlaerllkklg.....yvrlsqdtlrrrlfg....tdqqslt......dytrvlkr.lyqilnklarkalsagrsv.ivdatnlsre

RRKNVLARIRKRSPHLKVLFLEsvcSDHALVQKNIRLKLFGPDYKGKDPESSLKDFKSRL
.|. ...  .. .   ....||    . .. ..... .    |.. . ||. |.... |.
erarfvklakrlgvpvrivyle...vpeetlaeRlakRerngddrsevpeealdrmlarf
AAA_17 AAA domain 185-282 4.2e-09 27.9 Pfam-A 1-78 (121) alignment 
Range on Protein: 185-282
Range on HMM: 1-78/121.0
VIVMVGLPATGKSFITNKLSRFLNYSLYYCKV-FnvgntrrkfaKEHGLKDQDSKFFEPKNADSTRLRDKwaMDTL---DELLDYLLEGsgsvgifdatn
||. .| |..|||.....|.. |..  ...   .          .| |||  | ...| |.||  .|..   .| |   .. |.....|           
viaitGppGsGKsTlakeLaerlglpvlslddll..........reeglkelddgereskdadadllaai..ldglaakkdtlswvidg...........

tS
 .
.a
AAA_18 AAA domain 186-285 9.2e-06 15.0 Pfam-A 1-87 (129) alignment 
Range on Protein: 186-285
Range on HMM: 1-87/129.0
IVMVGLPATGKSFITNKLSRFLnyslyyckvfnvGNTRRKFAKEHGLKDQDSKFfePKNADSTRLRDKWAMDTLDELLDYLL-EGSGSVGIFDATNTSRE
|. .| |..||. ....|.. |            |   |..|||.|| . . ..   ....| .|. .  .  ||.| ..   .. |.. |.| . .  |
IlitGtpGsGKtTlakeLaerl............gdvlrdlakeegleeevddk..idtkeskeldedkldelldkleeneselaegenviidghlaele

R
.
l