Gene CYR1 in Saccharomyces cerevisiae

Synonym: CDC35, FIL1, HSR1, SRA4, TSM0185, YJL005W, CYR1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP037_AA protein Get Run
ScerP037_AA_1337-1624 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PP2C Protein phosphatase 2C 1374-1617 6.3e-62 202.4 Pfam-A 2-255 (255) alignment 
Range on Protein: 1374-1617
Range on HMM: 2-255/255.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN-GADVANL-SY--ADLL
||......| ..... .... ||...  ....|. . ...|.. .|....| .|. .  . ... |||.|.|. ... .|. .  ... .. .   ... 
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsk

SGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLP----HIHASPDISVVTLT
||....|..||||||. ||.||..|.|.........||..| |....|.|||. .||.|. ||.. |...||||.| |.| |    ...|.||...|.||
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklt

KADEMLIVATHKLWEYMDVDTVCDIARENSTD---PLRAAAELKDHAMAYGCTENI
. ||.||.|.. ||.... ....|..|.. ..   | .|| || |.|.|.|...||
eedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 1374-1617 6.3e-62 202.4 In-house 2-255 (255) alignment 
Range on Protein: 1374-1617
Range on HMM: 2-255/255.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN-GADVANL-SY--ADLL
||......| ..... .... ||...  ....|. . ...|.. .|....| .|. .  . ... |||.|.|. ... .|. .  ... .. .   ... 
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsk

SGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLP----HIHASPDISVVTLT
||....|..||||||. ||.||..|.|.........||..| |....|.|||. .||.|. ||.. |...||||.| |.| |    ...|.||...|.||
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklt

KADEMLIVATHKLWEYMDVDTVCDIARENSTD---PLRAAAELKDHAMAYGCTENI
. ||.||.|.. ||.... ....|..|.. ..   | .|| || |.|.|.|...||
eedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 1374-1617 2.8e-61 200.2 In-house 2-259 (259) alignment 
Range on Protein: 1374-1617
Range on HMM: 2-259/259.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN--GADVANL----SyAD
|. ...|.|  .... .... .| ..  ....|. .  ..|....|....| .|. .  . ..| || .|.| .... .|. .   ... ..    . ..
dggasafqgfrksmedahialanless.sgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseant.ep

LLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN---NGKLDGVVDVSRAVGFFDLLP------HIHASPDI
. ||.. .|..|.|.||. ||.||..|.|.........||..| |....|.|||...||.|.   ||.. ||..||||.| |.| |      ...|.|||
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi

SVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTD--PLRAAAELKDHAMAYGCTENI
|...... ||.||.|...||.... ....|..|..  .  | .|| .| |.|.|.|...||
sstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
0034914 PP2C-like 1338-1624 3.7e-52 170.0 In-house 3-290 (295) alignment 
Range on Protein: 1338-1624
Range on HMM: 3-290/295.0
PDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRG-NDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIRQLERY---GDETDDNIK
.... ...|... | .. .|.|||.. |.|..   . ... ..   ..| .|... |  .     ||.......... ..|...||..    ......|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhg.....Ghaaaevasellvelllellekllllltlsledie

TALRFSFLQLNKEINGMLNSVdngadvanlsYADLLSGACSTVIYIRGKKLFAANLGDCMAILSkNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKL
.||| .||....|.  .. .           . .. ||.. .|..|||.||. ||.||. |.|. .|| .. ||. | |. ..|.|||. .||.|..| .
ealrkaflaadeellelallr..........pelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavshgrv

DGVVDVSRAVGFFDLL---------PHIHASPDISVVTLT-KADEMLIVATHKLWEYMDVDTVCDIAREN---STDPLRAAAELKDHAMAYGCTENITIL
 ||  |.||.|.|||.         |...| ||..|..|| . |..|..|.. ||.... ....||.|..   ..|.  || || |.|.|.|...|||..
ngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvv

CLAL
.. |
vvrl
PP2Cc_SM00332 1354-1621 6.9e-46 149.8 In-house 8-273 (274) alignment 
Range on Protein: 1354-1621
Range on HMM: 8-273/274.0
NGMRYGVadTLGQRDYVSSRDVTFERFR--GNDDECLLCLHDSknqnaDYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGML
.|..||.  .  |   .| .|... ...   ..|  . .. |        |......|..   ..|...|.   || .|... ||. .||....||. . 
lglsygk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

NSVDNGAdvanlsyadLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGdYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL--
.|  .            |||.. .|.......|. ||.||. |.|..|.     |...| | . .|..||. .||.|..|...|.  |||| | ..|   
qskelen.........alsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkkn

-----PHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENS-----TDPLRAAAELKDHAMAY-GCTENITILC
     |.| | ||..|||||..||.||.|.  ||.... ..|.|| |.        || .||..| ..|... |...|||...
kklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1358-1623 7.9e-32 103.5 In-house 8-252 (255) alignment 
Range on Protein: 1358-1623
Range on HMM: 8-252/255.0
YGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIRQLERYGDetddNIKTALRFSFLQLNKEIngmlnsvdng
 | .|..|.|  .  . | .  ||...|| ...| |        |.. ...  .   |||   |. .      | . .|. .. ...  |          
vgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhg.....Graaakfaseelykilaelldlnna....nPvkslkkaykeistqi..........

advanlSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNG----KLDGVVDVSRAVGFFDLLPHIH
      |      |. .....| ..| . ||.||  ..|....|  . |.  | |.. .| .||.  || | ..    ...| . ||||.|   | |.. 
......serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvv

ASPDIS-VVTLTKADEMLIVATHKLWEYMDVDTVCDIAReNSTDPLRAAAELKDHAMAYGCTENITILCLA
. ||.|  .. .| |. ||.|   .|. .  .  ..|.  ...|| .|| .|.|.|   | |.||... . 
pdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva.gisdpekaaeklrdlayssGstdnisvivik
Guanylate_cyc Adenylate and Guanylate cyclase catalytic domain 1662-1836 8.9e-32 96.3 Pfam-A 4-173 (184) alignment 
Range on Protein: 1662-1836
Range on HMM: 4-173/184.0
PPTGNLAMVFTDIKSSTFLWELF-PNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTP---TSGLTWCLSVQLKLLDAQwPEEITSVQdgcqv
... .....|.||...| |..   | .. .......  ....|. .|.|.||| |||.|||. .|   .. . ......|.||.|   |. .. .     
esydevtilFadIvgftalssehepeelvkllnelitrfdelldekgvykvktiGdaymvasglpeekaahaaklaelaLdlleal.eevaieek.....

tdrngniiyQGLSVRMGIHWGCPVPELD-LVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFN-----KIMKYHERVVKG
         .||..| ||| |  | ...  .. |.|. |  || |.|.. ....|.|..|.  |.  .     .. .  |  |||
.........eglklrvGihtGtvvagviGakkprydvfGntVnlAsrmestgkkgkiqvseetyellkeeeqfeltergevevkg
subfamily_PPM1A_pd Subfamily PPM1A 1354-1624 1.4e-30 99.6 In-house 10-280 (282) alignment 
Range on Protein: 1354-1624
Range on HMM: 10-280/282.0
NGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIR--QL--ERYGDETDDNIKTALRFSFLQLNKEING
||.||||. . | |     . ..  .. .  |  .  ..|        |......| .   . ...  .|  .   ....|..| ||| .||.|...|..
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHa.....GsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

MLNSVDNGaDVAnlsyadllsGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL
. .....  | .         |. .... .. |.|. |||||. |.|..| |  . ||. | |.. .| .||.  || | .....|   ||||.| ... 
lstdlkta.dks.........GsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeyk

P---------HIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIAREN---STDPLRAAAELKDHAMAYGCTENITILCLAL
          .. |.|.. ..  .. |. |..|   .|. .. ..|....|..   .... . |..| |.|.  | ..|...| ...
eeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
0049733 PP2C-like 1402-1623 9.2e-27 87.0 In-house 37-232 (235) alignment 
Range on Protein: 1402-1623
Range on HMM: 37-232/235.0
GHNISRIVRDIYDKILIRQLERygdETDDNIKTALRFSFLQLNKEINGMlnsvdngadvANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKnNG
||. ........ ..|...|..    .  ....||| .||..|...  .          |  |.    .|.. .|....|.||. ||.||. |.| . .|
ghaagevasellvetllellle...lllldleealrkaflaaneallel..........alaspelagmgtTavvalldggklyvanvGDsrayllr.dg

DYQTLTKQHLPTKREEYERIRISGGYVnngKLDGVVDVSRAVGffDLLPHihasPDISVVTLTKADeMLIVATHKLWEYMDVDTVCDIAREnsTDPLRAA
  . ||. | |. ..|..||.  ||.|      |.  ..||.|  ||| .    ||..|..|.. | .|..|.  ||.... ....|. |.  .|.  ||
klvqltedhspvnelerqriitaggav...rvpgrlaltralG..dlllk....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldleeaa

AELKDHAMAYGCTENITILCLA
 .| ..|.|.| ..|||.... 
erlvelalarggrDNiTvvvvr
subfamily_PHLPP_pd Subfamily PHLPP 1403-1623 9.4e-25 79.9 In-house 39-244 (246) alignment 
Range on Protein: 1403-1623
Range on HMM: 39-244/246.0
HNISRIVRDIYDKILIRQLERygdetDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSyadllsgaCSTVIYIRGKKLFAANLGDCMAILSKNNGd
...|... ..  ..|  ....     | | .  ... .|. ....    . .   | .  .          ..|   .  .|  |. | . |.| .|.  
eelssllqrlmkdvlkeevqk.....dkneeeymkntllvaqrklGeaGeklgsaallilir........hdkvdPaksfsLevAsvGtlqavliRngk.

YQTLTKQHLpTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENsTDPLRAA
  .|.|..   ...|..||.   .... ..|..||.  .| .|.. | | .  .| .. |.||. ||.|||  ..||| ...| . .  |..  ||| ||
klrlsksyv.iekdelkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrke.edplvaA

AELKDHAMAYGCTENITILCLA
  | | | .||.......| . 
kklvdlaqsygaadsvsvlvvr
subfamily_PPM1E_pd Subfamily PPM1E 1467-1622 6e-23 74.4 In-house 99-260 (265) alignment 
Range on Protein: 1467-1622
Range on HMM: 99-260/265.0
DLLSGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVNN---GKLDGVVDVSRAVGFFDLLPHIHASPDISVVTL
 | ||. . |. |....|. | |||  |.| .. |.  .|.| | | . .| .||   || | .    . .||. ||||.|  .| |.. . .|.. |.|
klksGstavvvliekdqlyvaWlGDsqallvrk.geavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaevel

TKADEMLIVATHKLWEYMDVDTVC----DIARENSTDPLRAAAELKDHAMAYGCTENITILCL
....|.||.|.  ||. .. ..|.    . ......|  ..| .| ..|   | ..|||..  
dgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv
subfamily_PPM1K_pd Subfamily PPM1K 1417-1623 1.5e-22 73.0 In-house 53-257 (263) alignment 
Range on Protein: 1417-1623
Range on HMM: 53-257/263.0
LIRQLERYGdETDDNIKTALRFSFLQLNKEINGMLNSVDNGAdvanlsyADLLSGACSTVIYIR-GKKLFAANLGDCMAILSKnNGDYQTLTKQHLPTKR
| . |.|.  | ...... |. .|..|.|...  |.     |         | ||. .||  .| |..|  |.|||  ||| . ||. . ||. | | ..
lekilkrll.ekekdleivlknafeeldkklkrylefsvaea.......ellssGttatvsllrdGtelvlaslGdsrailcr.nGkakkltrdhdPele

EEYERIRISGGYVNNG-----KLDGVVDVSRAVGFFDLLPH-IHASPDISVVTLT-KADEMLIVATHKLWEYMDVDTVCDIAReNSTDPLRAAAELKDHA
|| |||. .|| |.       ...|.. ..|..| .|| .. . | |.   . .  .|| .|.. |  .   ..   .||. |   .|| .||  | . |
eekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr.lchdpeeaahalteqa

MAYGCTENITILCLA
. ||. .| |.. . 
lqygsednatavvvp
subfamily_ILKAP_pd Subfamily ILKAP 1471-1591 1.2e-21 70.1 In-house 114-240 (293) alignment 
Range on Protein: 1471-1591
Range on HMM: 114-240/293.0
GACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQ-----TLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL-PHIHASPDISVVTLT
|.  ||. .  . |. |||||  |.| ... . .     .|||.| |.| || .||. .||.|..|.. ||..|||..|        . . ||.. ..||
GstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLt

KADEMLIVATHKLWEYMDVDTVCDIAR
. |  ...|   ||. ...| | . . 
endlfvvlaCdGLwkvfsadevvkfil
PPM_PTC7_SpoIIE 1375-1616 1.6e-21 70.2 In-house 3-229 (230) alignment 
Range on Protein: 1375-1616
Range on HMM: 3-229/230.0
VTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQlerygDETDDNIKTALRFSFlQLNKE-INGMLNSVDNG--AD---VanlsyaDL
. . ...|  .... .... .| ..  ... ...|  ..|   .|.       .   ..||||    . . |  .  |.  .    ||          . 
ggasaaqgarksmedahispanseks.sggrlalvvgdvdGhGgra.....alamgllrtalrela.faglekpeeilrrlnlalaadlede......ps

LSGACSTVIYIRGKK--LFAANLGDCMAILSKNNGDyqtltkqhlptkreEYERIrISGGYVN----NGKLDGVVDVSRAVGFFDLLP---HIHASPDiS
 |||. .|..|.. .  |  ||.||. ..|....|               | |||  .|| .     .|   ||. ||.| | . ||.    . |.|| .
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.t

VVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTDPlrAAAELKDHAMAYGCTEN
. ....  ||.||.|. .||.... . ..|..|..  .|  || .|............
sdgelfgkdeflilasdglwdvlspqelvdlvrdelekp..aaeglleDDitllvvrv
subfamily_PPM1G2_pd Subfamily PPM1G2 1418-1614 3.2e-21 68.5 In-house 75-270 (287) alignment 
Range on Protein: 1418-1614
Range on HMM: 75-270/287.0
IRQLERYGDETDDNIKTALRFSFLQLNKEINGMlnsvdngadvanLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGdYQTLTKQHLPTKREE
|. ...  . ........|. .||....|.                . .|  .|. ..|. |. .||. || ||  |.||..    ..|.  | |.. .|
ikkiakkksfkegaleqilkdafletDeellkd............eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeese

YERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPH---------IHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENS---TDPLRAAAELK
 .||  .||.|. ..  |.. .|||.| |    .         . | ||. |  |.. || |..|   .|. .  ..|.|. ||.    ... . . || 
kkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell

DHAMAYGCT
|...|  . 
dkclapdss
subfamily_PPM1G_pd Subfamily PPM1G 1470-1595 5.3e-21 68.1 In-house 296-430 (473) alignment 
Range on Protein: 1470-1595
Range on HMM: 296-430/473.0
SGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFD-----LLPH----IHASPDIS
||.  .|. ...|||. || ||. ..||.| |    |   | |   .| |||.  || |. .|...| ...|||.| .       ||.    | | ||| 
sGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

VVTLTKADEMLIVATHKLWEYMDVDTVCDIARENST
| |||..|| |..|.  .| .|. . | |  |.. .
vltlteedeFlvlAcDGiWnvmesqevvdfvraklk
subfamily_PPM1L_pd Subfamily PPM1L 1363-1624 5.4e-20 64.8 In-house 12-266 (269) alignment 
Range on Protein: 1363-1624
Range on HMM: 12-266/269.0
TLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRqlerygdetDDNIKTALRfsfLQLNKEINGMLNSVDNGAdVAN
 ||.|. .  |    |  . . .| .....| .  .    .  ...|..|..|..           | . . ..    .. .| ..  . |||.   . .
vlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel.........dadkentep...infsklltdeilsvdekl.lek

LSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NG--KLDGVVDVSRAVGFFDLLPH--IHASPD
.  |  ..|. . .  .....|  ||.||   .|  ..|    |. .| | . .|  ||. .||..  .|  .. ||. .|||.| . |  .  . |.||
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd

ISVVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLAL
|    | .   |.||.|.  ||. .  .  .  ..|.  .|   |  |  ..   |...|||.| . |
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
Ad_cyc_g-alpha Adenylate cyclase G-alpha binding domain 368-418 4.5e-16 44.5 Pfam-A 2-50 (52) alignment 
Range on Protein: 368-418
Range on HMM: 2-50/52.0
EATTPTIETpisCKPSLFRLDTNLEDVTDI-TKTVPPTAVNSTLNSTHGTET
|..||| |.   ...|.|.|||||.|...| ||. |.|...|.|......|.
etitptdee...eegsvfsLDTNLsdMeGIltkpePltPtdsslindgesek
subfamily_PP2D1_pd Subfamily PP2D1 1479-1591 2.3e-15 49.3 In-house 185-303 (492) alignment 
Range on Protein: 1479-1591
Range on HMM: 185-303/492.0
IRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYV----NNGKLDGVVDVSRAVGFF---DLLPHIHASPDISVVTLTKADEMLI
.    |. || |.  |.| .. |   .||..| |  ..| .|.. .|. |    .||. .|..|. | .|..   .|   .   | .  |.|..|. .|.
eelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflv

VATHKLWEYMDVDTVCDIAR
.|.  ||| .. . |  ...
lAsnGlWevlseeevlsLvk
subfamily_PDP_pd Subfamily PDP 1411-1523 1.2e-14 47.2 In-house 94-209 (398) alignment 
Range on Protein: 1411-1523
Range on HMM: 94-209/398.0
DIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEI-NGMLNSVdNGADVANlSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDY----QT
. . . | ..|..  . . ...| ||. .||.| |.| .  |... .. .... . .  |||||... .|.|..|. || ||| |.| .....      .
klslselskylqelleaevekvkealkkaFlklDkdistealkkl.kekslre.allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavk

LTKQHLPTKREEYERIRI
|.|..  . .|| |||. 
LskdqtadneeEveRikk
PPM_PTC7_motif 1571-1617 1.1e-13 44.5 In-house 1-51 (51) alignment 
Range on Protein: 1571-1617
Range on HMM: 1-51/51.0
IVATHKLWEYMDVDTVCDIARENSTD----PLRAAAELKDHAMAYGCTENI
| |.. ||.... ....|..|.. ..    | .|| .| |.|.|.|.. ||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
subfamily_PPM1D_pd Subfamily PPM1D 1418-1537 4.8e-13 41.9 In-house 61-178 (309) alignment 
Range on Protein: 1418-1537
Range on HMM: 61-178/309.0
IRQLERYGDETDDNIKTALRFSFLQLNKEingMLNSVDNGADVANLSYAdlLSGACSTVIYIRGKKLFAANLGDCMAILSKNNG-----DYQTLTKQHLP
|.. . .  . .... .|.| .||.....   | .. .. .  ..  ..   .|.  .|. ||..||. |. ||  ..|....        ..|||.| |
ikkqkkflssepedvleAireaflathea...mkkkleeWpktksglls..taGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkP

TKREEYERIRISGGYVNNGklDGVV
 . || |||. .|| | .    || 
espeekerieelGGevaak..sGvk
RA Ras association (RalGDS/AF-6) domain 677-744 6.4e-13 36.6 Pfam-A 2-76 (93) alignment 
Range on Protein: 677-744
Range on HMM: 2-76/93.0
HYAIRIFNTDDT----FTTLSCTPATTVEEIIPALKRKFNI-TAQGNFQI--SLKVGKLSKILRPTSKPILIERK
.. .|.. .|..    ..|..... ||..|.| || .||.. . ......  ||. |.  ..| .. ||  | ..
sgvlrVytedgkpgttyktilvsstttaqeVieallekfgledspedyaLveslerggeervLsddekplqiqlq
LRR_8 Leucine rich repeat 865-921 1.8e-12 36.5 Pfam-A 3-61 (61) alignment 
Range on Protein: 865-921
Range on HMM: 3-61/61.0
LVSLELQRNFIRKVPN-SIMKLSNLTILNLQCNELESLPA-GFVELKNLQLLDLSSNKF
| .| |..| ....|. |  .||||. |.|..|.|.|...  |  |..|. |.||.|..
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 1087-1125 5.7e-12 34.9 Pfam-A 1-39 (44) alignment 
Range on Protein: 1087-1125
Range on HMM: 1-39/44.0
TKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDF
|.| .|. ..|... .||||..|..|.||.| .|.| |.
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl
LRR_4 Leucine Rich repeats (2 copies) 1066-1104 1.3e-10 30.6 Pfam-A 3-41 (44) alignment 
Range on Protein: 1066-1104
Range on HMM: 3-41/44.0
LEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPP
||.| |..||.. || |...|..|  |....|... ...
LevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 933-989 6.3e-10 28.3 Pfam-A 2-61 (61) alignment 
Range on Protein: 933-989
Range on HMM: 2-61/61.0
NLLQIDLSYNKIQSLPQ-STKYLVKLAKMNLSHNKLNFIGD--LSEMTDLRTLNLRYNRI
||  .||| |.....|. | |.| .| ...||.|.|. | .  .. .. || |||..||.
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 1088-1143 9.3e-10 27.8 Pfam-A 2-60 (61) alignment 
Range on Protein: 1088-1143
Range on HMM: 2-60/61.0
KLVFLSVARNKLEYIPPEL-SQLKSLRTLDLHSNNIRDFVDGM-ENL-ELTSLNISSNA
.|  | . .|.|..||..  ..|..|..|||..||.    ... ..|  |..||.|.| 
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr
LRR_8 Leucine rich repeat 1211-1269 2.7e-09 26.3 Pfam-A 2-61 (61) alignment 
Range on Protein: 1211-1269
Range on HMM: 2-61/61.0
SITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAEL-SNLSQLSVFDVGANQL
...||.||.|.|.... ..  ..|.||.| |..|   |...|. ..| .|.  ..  |.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 1190-1226 4.2e-09 25.8 Pfam-A 2-40 (44) alignment 
Range on Protein: 1190-1226
Range on HMM: 2-40/44.0
NLKVLNLSYNNFSDVSH--MKLESITELYLSGNKLTTLS
||.||.||.|| .|...   .| . ..|.||.|... ||
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_4 Leucine Rich repeats (2 copies) 957-993 5.9e-09 25.3 Pfam-A 3-40 (44) alignment 
Range on Protein: 957-993
Range on HMM: 3-40/44.0
LAKMNLSHNKLNFIGD-LSEMTDLRTLNLRYNRISSIK
| . .||.|..  ..  |. ...|.|||| .|.||...
LevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
LRR_4 Leucine Rich repeats (2 copies) 864-903 1.9e-08 23.7 Pfam-A 2-41 (44) alignment 
Range on Protein: 864-903
Range on HMM: 2-41/44.0
KLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPA
.| .| |..| | ..|... .|.||. |||. | ...|.|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_8 Leucine rich repeat 1041-1099 6e-08 22.0 Pfam-A 2-61 (61) alignment 
Range on Protein: 1041-1099
Range on HMM: 2-61/61.0
NMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEI-SKLTKLVFLSVARNKL
| ..| |.. .|..|| . . .|| |..| |. |||.... |. ..|..|  |..  |.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_4 Leucine Rich repeats (2 copies) 909-949 6.2e-08 22.0 Pfam-A 1-41 (44) alignment 
Range on Protein: 909-949
Range on HMM: 1-41/44.0
KNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQ
.||. ||||.|.    |...  ..|| ...||.|.|..|..
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 1235-1275 3.5e-07 19.7 Pfam-A 2-41 (44) alignment 
Range on Protein: 1235-1275
Range on HMM: 2-41/44.0
SLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKyNISN
.|..| |..|.  .||.||.||..| . ..  |..  ..|.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpis.dlsa
LRR_4 Leucine Rich repeats (2 copies) 998-1033 5.1e-07 19.1 Pfam-A 2-40 (44) alignment 
Range on Protein: 998-1033
Range on HMM: 2-40/44.0
NLQNLFLTDNRISNFED---TLPKLRALEIQENPITSIS
||. | |..|.|.. .     ||.|. | .. |||...|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 1451-1535 5.9e-07 22.3 In-house 64-155 (292) alignment 
Range on Protein: 1451-1535
Range on HMM: 64-155/292.0
LN-SVDNGADVANLSYADLLSGACSTVI-YIR-GKKLFAANLGDCMAILSK--NNGDYQ--TLTKQHLPTKREEYERIRISGGYVNNGKLDG
|.  .| .| . .|     .|.. ..|   .| ...|. ||.||  |.| .     ||.   |...| |   .| .||. .||.|.  .. |
llrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg
LRR_8 Leucine rich repeat 957-1009 8.1e-07 18.4 Pfam-A 3-61 (61) alignment 
Range on Protein: 957-1009
Range on HMM: 3-61/61.0
LAKMNLSHNKLNFIGD--LSEMTDLRTLNLRYNRISSIKTNA----SNLQNLFLTDNRI
| . .||.|.| .|..  .. .. |..|.|..|...|| ..|     .|. |.| .||.
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 1189-1222 1.3e-06 17.7 Pfam-A 25-61 (61) alignment 
Range on Protein: 1189-1222
Range on HMM: 25-61/61.0
VNLKVLNLSYNNFSDVSH---MKLESITELYLSGNKL
 |||||.||.|| . .|     .|.|..||.||||.|
snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl