Synonym: YKL128C, PMU1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PMU1_pd | Subfamily PMU1 | 52-284 | 4.9e-147 | 477.8 | In-house | 1-233 (233) | alignment | ||
Range on Protein: 52-284
Range on HMM: 1-233/233.0
HYKLLILARHGQGYHNAAILRYGMEKWDAYWSLLSGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKQLGMLPHVFFSSPMRRCLETFIESWTPVLAET
|||||||.|||.||||.|||.|||||.||||.||||||.||.||||||.||||||||||||||||||||||||.||||||..||.|||..||...|||||
hykllilvrhGeGyhnlailkyGmekldaywallsgdengeildskltslGkdqvrrtGsnvllpmakqlGmlehvffsstlrraletalesfeavlaet
QELPAGTKISTRIIEGLRETLGSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLSSEEKFISL
||||||||.||||||.|||||||||||||||.|..||||||.|.|||||||||||||.|||||||..|||||..|.|||||..||||...|||||||..|
qelpagtkvstriieslretlGshtcdkrvarsaivdeyqdlslesghtvhwqyvPdlPeddelwktdhretkveldkrtlatlfelaadlsseekfval
TCHSGVIQSVLRNLQHPPIYNLDTGKVVAVVVE
..||.|..|.||.|.|..|||||||||||.|.|
vthssvllsllraldhlriynldtGkvvalvle
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 56-277 | 1.2e-25 | 83.2 | In-house | 3-209 (240) | alignment | ||
Range on Protein: 56-277
Range on HMM: 3-209/240.0
LILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESWTPVlaetqelp
|.| |||. ..||. . .| | |. ||.||. |.|..| |. . ...|||..|...| .
lyLvRHGesewnaegrlqg..................wtDvpLtelGreqaralgerLadl.....gikfdlvysSpllRaiqTaeiiaeal........
aG--TkISTRIIEGLRETlgSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELFN
| . . .. ..||| .. .. . ... ...... .. .. ..| . .|||.| . |. |.. .| |. | ||..
.glpl.lpvvvdprlrEr..dfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleella
QLSSEEKFISLTCHSGVIQSVLRNLQHPPIYN-----LDTGK
. ..| . . .|.||| ..|. | . |. ...|
ralkpgknvlvVsHggvirallayllglpleeilrlnipngs
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 54-279 | 3.2e-25 | 81.9 | In-house | 4-214 (241) | alignment | ||
Range on Protein: 54-279
Range on HMM: 4-214/241.0
KLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFieswTPVLAETqE
| |.| |||. ..||. . .| | |. ||.||. |.|..| ..||. . ...|||..|...| .....
krlyLvRHGesewnaegrlqg..................wtDvpLtelGreqaralgerl.....adlgikfdavysSpllRaiqTa....eiiaeal.g
LPagtKISTRIIEGLRETlgSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELFN
|| .. .. ..||| .. .. . ... ...... .. . . | . .|.|.| |. |.. .| |. | ||..
lp...llpvvvdprlrEi..dfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleella
QLSSEEKFISLTCHSGVIQSVLRNLQHPP-----IYNLDTGKVV
.| ..| . . .|.||| ..|. | . | .||..| |.
rllldgknvlvVsHggvirallayllglpleellrlnlpngsvt
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 54-283 | 4e-24 | 77.9 | In-house | 3-221 (249) | alignment | ||
Range on Protein: 54-283
Range on HMM: 3-221/249.0
KLLILARHGQGYHNAAilrygmekwdaywsllsgDEHGEWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQE
| |.| |||. ..||. . . |||| ||.||. |.|..| . |.||. .....|||..|...| . ..|.| .
krlyLvRHGetewnae..................grfqgwlDspLtelGreqaralgeal.....kelgipfdavysSplkRAiqT....aeiileelgl
LPagtkISTRIIEGLRET-LGSHT-CDKRVAHSMAVDEYQDFST----------ESGHTVHWQYVPDYPE---DDELWLPDHRETCAEMDKRTLNGLFEL
. .. ..||| .|. . ..| .... .|.. . . |. .........|| |..|. | . |. |.. .| |..| ||
dk....lpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleel
FNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVVV
...|. ... . . .|.||. ..|. | . .. ||..| .. ...
larllkdggnvliVaHggvlrallayllglsledilrlnlpngsitvlel
|
|||||||||
0049178 | Phosphoglycerate mutase-like | 54-283 | 2.1e-22 | 72.4 | In-house | 4-216 (243) | alignment | ||
Range on Protein: 54-283
Range on HMM: 4-216/243.0
KLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFieswtpvlaetQE
. |.| |||. ..||. . .| |.|| ||.||. |.|..| ..||. . ...|||..|...| .
trlyLvRHGetewnaegrlqg..................wtDspLtelGreqAralgell.....aelglkfdavysSplkRaiqTa...........ei
LP------AgtkISTRIIEGLREtLGSHTCDKRVAHSMAV---DEYQDFSTESGHTVH---WQYVPDYPEDDELWLP----DHRETCAEMDKRTLNGLFE
. . .. ..||| .. .... . . .| .|.. . . . ... . . . .|. |.|... |. |.. .| |. | |
ilealglpl...lpvvvdprLrE.rdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpalee
LFNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVVV
|...|. ..| . . .|.||| ..|. | . |. ||..| |. . .
llaellhdgktvlvVaHggvirallalllglpleellrlnlpngsvtvlel
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 54-282 | 7.5e-22 | 70.6 | In-house | 3-216 (247) | alignment | ||
Range on Protein: 54-282
Range on HMM: 3-216/247.0
KLLILARHGQGYHNAailrygmekwdaywsllsGDEHGEWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETqe
| |.| |||. ..|| . . |||. ||.||. | ...| . |.||. . ...|||..|...| . ..|..
krlyLvRHGetewna..................egrfqgwlDvpLtelGreqakalgell.....kelglpfdavysSpllRAiqT....aeiileal..
lpA-GtKISTRIIEGLREtLGSHTCDKRvAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELF
.. .. ..||| .. .... . .. . ..|... . .. . | . ...||.| . |. |.. .| |. | ||.
..gls.llpvvvdprLrE.rdyGalegl.tkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleell
NQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVV
..| ... . . .|.||. ..|. | . .. ||..| .. ..
arllkdgenvlvVsHggvlrallayllglsledilrlnlpngsitvle
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 56-260 | 7.8e-20 | 64.4 | Pfam-A | 2-157 (158) | alignment | ||
Range on Protein: 56-260
Range on HMM: 2-157/158.0
LILARHGQGYHNAAILrygmekwdaywsllsgdeHGEWLDSKLTPLGKDQVRRTGSNvllpmAKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQelp
|.|.|||. ..|.. . .| |..||. |..|.|..| |. . ......||..|...| ....|.| .
lylvRHGesewnkegr..................lqgwsdvpLtekGreqarelgkk.....LkradlpidavytSplkRaiqT....aeilleeld...
agtkISTRIIEGLRETLGsHTCD---KRVAHSMAVDEYQDFSTesghtVHWQYVPDypeddelwlpdHRETCAEMDKRTLNGLFELFNqLSSEEKFISLT
| ... ..||| ... |. .... .||. . . .... |. . |. |.. .|. . | ||.. .... . ..
....ipiikeprLrerdf.geweglpkeevkeefpeeyekwkr.....dkkefrpp...........egesladvyeRvapfleelie.akdkgenvliv
CHSGVIQS
.| ||...
sHggvlra
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 56-260 | 7.8e-20 | 64.4 | In-house | 2-157 (158) | alignment | ||
Range on Protein: 56-260
Range on HMM: 2-157/158.0
LILARHGQGYHNAAILrygmekwdaywsllsgdeHGEWLDSKLTPLGKDQVRRTGSNvllpmAKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQelp
|.|.|||. ..|.. . .| |..||. |..|.|..| |. . ......||..|...| ....|.| .
lylvRHGesewnkegr..................lqgwsdvpLtekGreqarelgkk.....LkradlpidavytSplkRaiqT....aeilleeld...
agtkISTRIIEGLRETLGsHTCD---KRVAHSMAVDEYQDFSTesghtVHWQYVPDypeddelwlpdHRETCAEMDKRTLNGLFELFNqLSSEEKFISLT
| ... ..||| ... |. .... .||. . . .... |. . |. |.. .|. . | ||.. .... . ..
....ipiikeprLrerdf.geweglpkeevkeefpeeyekwkr.....dkkefrpp...........egesladvyeRvapfleelie.akdkgenvliv
CHSGVIQS
.| ||...
sHggvlra
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 51-281 | 1.8e-19 | 62.5 | In-house | 5-195 (211) | alignment | ||
Range on Protein: 51-281
Range on HMM: 5-195/211.0
RHYKLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESWTPVlae
... |.| |||. ..||. . .| |||. ||.||. |.|..| . |. .....|||..|...| . .
llmtrlyLvRHGetewnaegrlqg..................wldvpLtelGreqaralgealadl.....glpfdavysSpllRaiqTaeiileal...
tqelpaG-TKISTRIIEGLREtlgshtCDKRVAHSMAVDEYQDFSTESGHTVHWQY----VPDYpeddelwlpdhrETCAEMDKRTLNGLFELFNQLSSE
| ... .. ..||| .| . . . ..| ... | . .. . |. |. |.. .| |. | ||...| ..
......glpllpvevdprlrE......rdfgalegltleeiaekypeelvawlrdpydfrppgg............EsladvvaRvlpaleellarllkd
EKFISLTCHSGVIQSVLRNLQH-----PPIYNLDTGKVVAV
.. . . .|.||. ..|. | . . .||..| |. .
genvlvVsHggvlrallayllglsleellrlnlpngsvtvl
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 55-279 | 1.9e-19 | 62.5 | In-house | 3-181 (202) | alignment | ||
Range on Protein: 55-279
Range on HMM: 3-181/202.0
LLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLlpmakqlGMLPHVFFSSPMRRCLETFIESWTPVlaetqel
|.| |||. ..|.. . .| .||. ||.||. |.|..| .. |. . ...|||..|...| .
rlyLvRHGetewnvegrlqg..................dldvpLtelGreqaralgerla.......glpfdavysSpllRaiqTaeiiaeal.......
pagtKISTRIIEGLRETLGSHTcdkrvahsmavdeyQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLssEEKFISLTCH
... .. ..||| . . ..| . . ... .. |. . | . |. |.. .| |. | ||...| ... . . .|
....glpvivdprlrEidfgal..............egltleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl..dggnvlvVsH
SGVIQSVLRNLQHPPIYN------LDTGKVV
.||. .|. | . .. . |..| |.
ggvlrallayllglsledllrlrklpngsvt
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 56-281 | 2.9e-16 | 52.0 | In-house | 2-173 (219) | alignment | ||
Range on Protein: 56-281
Range on HMM: 2-173/219.0
LILARHGQGYHNAailrygmekwdaywsllSGDEHGewlDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFIESwtpvlaetqelp
|.| |||. ..|. | | || ||..|. |.|..| |.||. . ...|||..|...|
lyLvRHGetewnv.................egrlqg...dspLterGreqaralgerl.....kdlglpfdavysSpllRaiqTaeii............
agtKISTRIIEGLREtlgshtcdkrvahsMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNqlsseEKFISLTCHS
... .| ..||| . ... . | . . . . . .|. . |.. |. |.. .| |. | ||.. .. . . .|.
...glpveidprLrE..............idfgdlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella.....genvlvVsHg
GVIQSVLRNLQH-----PPIYNLDTGKVVAV
|||. .|. | . . .||..| |. .
gvirallayllglsleeilrlnlpngsvtvl
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 56-282 | 3e-16 | 52.0 | In-house | 2-174 (219) | alignment | ||
Range on Protein: 56-282
Range on HMM: 2-174/219.0
LILARHGQGYHNAailrygmekwdaywsllSGDEHGewlDSKLTPLGKDQVRRTGsnvllPMAKQLGMLPHVFFSSPMRRCLETFIESwtpvlaetqelp
|.| |||. ..|. .| | |. ||..|. | |..| ..||. . ...|||..|...|
lyLvRHGetewnl.................egrlqg...dvpLterGreqaralg.....ealadlgipfdavysSpllRaiqTaeii............
agtKISTRIIEGLRETLGSHTCDkrvahsmavdeyqdFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELfnqlsSEEKFISLTCHS
... .| ..||| . . ... .. . .. . .|. . | . |. |.. .| |. | || ... . . .|.
...glpveidprLrEidfgdleg..............ltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleel.....edgenvlvVsHg
GVIQSVLRNLQHPPIY-----NLDTGKVVAVV
|||. .|. | . |. ||..| |. .
gvirallayllglpleeilrlnlpngsvtvle
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 55-279 | 2.8e-14 | 45.6 | In-house | 3-173 (191) | alignment | ||
Range on Protein: 55-279
Range on HMM: 3-173/191.0
LLILARHGQGYHNAAilrygmekwdaywS---LlsgdehgewlDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESwtpvlaet
|.| |||. ..||. |. ||.||. |.|... |. . ...|||..|...|
rlyLvRHGetewnae.............grlqg..........dvpLtelGreqaralaellael.....glkfdavysSpllRarqTaeii........
qelpagtKISTRIIEGLRETLGSHTcdkrvahsmavdeyQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNqlsseEKFISL
... .. ..||| . . | . ..... . .|. . |.. |. |.. .|.|. | ||.. .. . .
.......glpvevdprlrEidfgdw..............egltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella.....ggnvlv
TCHSGVIQSVLRNLQHPPIY-----NLDTGKVV
.|.|||. .|. | . |. ||..| |.
VaHggvirallayllglpleellrlnlpngsvt
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 56-270 | 6.5e-12 | 37.7 | In-house | 3-149 (171) | alignment | ||
Range on Protein: 56-270
Range on HMM: 3-149/171.0
LILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmakqlgmLPHVFFSSPMRRCLETFIESWtpvlaetqelp
|.| |||. ..|.. . .| |.|. ||.||. |.|..| .....|||..|. .| .
lyLvRHGetewnlegrfqg..................wtdvpLtelgraqaralgell..........pfdavysSpllRArqTaelil...........
agtkISTRIIEGLRETLGSHTCDKRVAHSMAVDEYqdfstesghtvhwqyvpdYPEDDELWLPDHRETCAEMDKRTLNGLFELFnqlsseeKFISLTCHS
.. .. ..||| .... .| . . |. . | |. |.. .| |. | || . . . .|.
....lpvivdprLrErdfGawegltldeiaakype..................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHg
GVIQSVLRNLQHPPI
||| ..|. | . ..
gvirallalllglsl
|
|||||||||
0049059 | Phosphoglycerate mutase-like | 54-267 | 2e-06 | 20.1 | In-house | 45-343 (435) | alignment | ||
Range on Protein: 54-267
Range on HMM: 45-343/435.0
KLLILARHGQ----------------------GYHNaailrygmekwdaywsllsgDEHGEWLD-------SKLTPLGKDQVRRTGSNVL-----LpMAK
.. .|.||| |.| ...... | . |||||..| ...| | . .
qvqvlfRHGaRtPtsklikklealwekllslltypn....................gplsflndwnyplgageLTplGreqayelGkrlrkrYgfL.ynp
QlgmlPHVFFSSPMRRCLETFIESWTPVLAET-------QELPAGTKISTRIIEGLRETLGSHTCDKRVAHS---MAVDEYQDFSTESGHTVHWQYVPDY
. ....||...|.|.. . . . |. . . .. . .. || . .|.. . . .| ||.... .|. . .. | .
d....evyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtlpydscpafdellkellasdeflelflerilkllqellpgl
P--EDDELWLPDH---------------RETCAEMDKRTLNGLF---------------------------ELFNQLSS---------------------
.| |.|.| | ... |. |. |....| .
gltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfp
-EEKFISLTCHSGVIQSVLRNLQH
. |.. .| . |...| |.
ldlklylyfaHdttiapllsaLgl
|
|||||||||
0047369 | Phosphoglycerate mutase-like | 53-268 | 4.9e-06 | 19.1 | In-house | 45-346 (438) | alignment | ||
Range on Protein: 53-268
Range on HMM: 45-346/438.0
YKLLILARHGQGYHNAA-----------ILRYGMEKWDAY-------WSLLSGDehgewldskLTPLGKDQVRRTGSNVL-----LpmakqlgmLPH---
.. .|.||| . . .. .. ... . ... |. |||||..|.. | | |.
kqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagq.........LTplGreqayelGkrlrkrYglL........npedvl
VFFSSPMRRCLETFIE------------SWTPVLAEtqelPAGTKISTRIIEGLRETLGSHTCDKR---VAHSMAVDEYQDFSTESGHTVHWQYVP--DY
...||...|.|.. ...| | . |. . . . | .|.| .|... . .| ||.... ... . .. | ..
yvrssdvdRtlqSAqaflaGlfppegtgelapilwq....pipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnl
PEDDELWLPDH--RETCAEMD-------------KRTLNGLF---------------------------ELFNQLSS----------------------E
. .| |.| |. .|.| .. . |. | |... | . .
tpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPld
EKFISLTCHSGVIQSVLRNLQHP
|.. .| . |...| |.
lklylyfaHdttiaallsaLglf
|
|||||||||
subfamily_STS_pd | Subfamily STS | 95-266 | 8e-06 | 17.4 | In-house | 52-198 (245) | alignment | ||
Range on Protein: 95-266
Range on HMM: 52-198/245.0
DSKLTPLGKDQVRRTGSNVLlpmakQLGMLPHVFFSSPMRRCLETFieswTPVLAETQelpagTKISTRIIEGLRETLgsHTCDKRVAHSMAVDEYQDFs
|. || |. | . .| . | . |. ... |.||. ||..| ...| ... || .. .|| | | . ..| . . . .| . |
DpPlterGviqAkllgraLl.....eagikiehifcSPslrciqTa....aailkglg.....kkikikvepgllewl..kldrkpipellspeelkkf.
tesGHTVHWQYVPDYPEDDELWlpdhRETCAEMDKRTLNGLFELFNQLsSEEKFISLTCHSGVIQSVLRNLQ
. . .| | . . |.. |. .|. . . |.... .|.. | . | .... |.|.
...fpqidedYkpvlslselks....keseeelyeRikkvvkeiiekv.pedgniliVahaatldalsrqll
|
|||||||||
0048439 | Phosphoglycerate mutase-like | 55-142 | 9.9e-06 | 18.2 | In-house | 12-101 (391) | alignment | ||
Range on Protein: 55-142
Range on HMM: 12-101/391.0
LLILARHG------------QGYHNAailrygmekwdaywsllsGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKqLGMLPH---------VFFSSPM
. .|.||| ....| .|.. .. |||||..|.. .| . ||.|| ..||..
vqvlfRHGaRtPtssypnkldpllnk..................llpngpcglgeLTplGreqlyelGrrlrkrYvd.lgllpskytlnpsevyvrssdv
RRCLETFIE
.|.|..
dRtlqSAqa
|