Gene PPZ1 in Saccharomyces cerevisiae

Synonym: YDR075W, PPH3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP051_AA protein Get Run
ScerP051_AA_359-658 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPZ_pd Subfamily PPZ 361-660 3.1e-215 706.1 In-house 1-300 (300) alignment 
Range on Protein: 361-660
Range on HMM: 1-300/300.0
IDIDETIQKLLDAGYAAKRTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETIL
.||||.|||||||||||||||||||||.|||||||||||.||.||.||||||.|||||||||||.||||||||||||||.||||||||||||||||||||
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLL
||.||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALK
|||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpldsaalk
subfamily_PPP1C_pd Subfamily PPP1C 378-655 1.9e-138 453.4 In-house 3-280 (282) alignment 
Range on Protein: 378-655
Range on HMM: 3-280/282.0
KRTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLR
|..|.| ||..|| ... |||||.|||| ||||. |||||||.|||| |||||| ..|.||.||||||||||||||||||||.||..||||||||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERG
||||.|...|.|||||||||| .||.||||.|.||.|||||.|. ||.|||||||| |.|...||.. ||..||. ||. ||||||| .. ..|..|.||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLD
||. ..| ...|||.|. .||..|||.|||||||||..| |||||||||||||||| |||.||.| ||.||..| | .
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 362-655 2e-127 417.3 In-house 2-295 (298) alignment 
Range on Protein: 362-655
Range on HMM: 2-295/298.0
DIDETIQKLLDAGYAAKRTKNvCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILL
..|| . ..| .. ..|.  . ..|.... ... .|..|| .|.||.|. .|.|. ||.|||| |||||| |.||||..||||||||||||.|.||.|.|
evdellievlsvslsekkltk.vikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivl

LFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLL
|..||.|||.|||||||||||. . ||||||.|||||  .......| |.||.|||.|...|.|.|.|||||. |.|.|..|.. ||.| ..  | .|||
llaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidll

WSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLD
|.||... ..|..|.||||. . . .....|.|.  |||.||| || |||||| .. |||.||||.|||.|||  |||.|.| | .|||.| | .
wadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 361-655 1.3e-119 391.9 In-house 1-295 (299) alignment 
Range on Protein: 361-655
Range on HMM: 1-295/299.0
IDIDETIQKLLDAGYAAKRTKNvCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETIL
.|.|| . |||. |.. ||  . ..|..|. ..|  |...|.||.||||. .|....||.|||| ||||.| | |||| .|.||||||||||.| ||.| 
ldvdellskllnvgmsekrltk.svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelit

LLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDL
||.|.||||||.||.|||||||  . ||||||.||..|    ..|  | |.|...||. .....|.|.|||||| |...| .|.. || | |.  |  ||
lllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidl

LWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLD
||.|| .|  .|  | ||||| . .  ... ..... |||.||| ||.|||||| .. |||.|||| |||.|||  |.| | | |.|.| .| | .
lwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
0045823 Metallo-dependent phosphatases 370-658 5e-113 371.2 In-house 37-328 (473) alignment 
Range on Protein: 370-658
Range on HMM: 37-328/473.0
LldagyaakrTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKY
|         .|.  |. ...|... .|.||. ..|.|||||... ..||.|||. |||||. |.||||. ...||||.|||| .|||...||...||||
l.........kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkiky

PENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPtDSPN
|.|.||||||||..... .|||.||. .. ...... |.. ...|||||.. |||..||||||| |...|.||.. || ..||.||. ||||||| ....
pgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.wedd

E--------WEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRS------LVTVFSAPNYCGEFDNWGAVMSVSEGLlCSFELLDPLD
         .. . ||..|.... |...||.|.|.||..|.| .|..|||...|..      ..||||||||||...|..||. ..|.| .|| ..||..
gdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp

SAA
   
hpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 383-653 3.2e-110 360.7 In-house 4-274 (280) alignment 
Range on Protein: 383-653
Range on HMM: 4-274/280.0
VCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHEC
 |.|. .| ..  | ..|.. | ...|.  ||...||.|||| ||||||....||| .||||||||||||.| || ||||..||..||.||..||||||.
acikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

ANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCY
... | |||.||.||| . .... | . ...|||.|.|.|.|.|.|||||. | |.|......|| | .|  | .||||.|| .    | .| ||||. .
isinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvif

NKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
 .  .... .|.  ||..| | ||.|||||| |. ||||||||.|.|||||  ||. |.|.|  |||.| |
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
PP2Ac_SM00156 386-653 4.1e-109 356.8 In-house 2-269 (271) alignment 
Range on Protein: 386-653
Range on HMM: 2-269/271.0
KNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANV
...|.|... ...||. ....|.|.|.|| .|||.|||. |||||. . |.||...|.|||||||||.||.|.|||||..||.|||...|||||||. .|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKV
...|||..|.||. . .|.. | ..|. |||||.|  ||.|.|||||| |.|.|.||.. |. . |. ||. |||||||... .... . ||.|. ... 
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

AINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
|...||.|. ..|..|||.||..||||| |..|||.|||||||.||.| .||..|...| .|.|.|..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
0049330 Metallo-dependent phosphatases 360-657 1.2e-108 355.8 In-house 6-302 (309) alignment 
Range on Protein: 360-657
Range on HMM: 6-302/309.0
PIDIDETIQKLLDAGYAAKrTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETI
|....| |..|||. .    .| ..|. .|.|... ||.||..|.|.||||| .. ..||.|||. |||||. |.||||. ...||||.|||| .|||..
pllllelilslldlliell.lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

LLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDL
|||...|..||.|.||||||||.......|||.||..|. ....|. |.|....|||||.. |||.|||||||| |...|.||.. ||...|..||..||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSA
|||||..  ... .| ||......  |...||.|.|.||..|.| .|..||..| |..|.||||||||||...|.|||. ..|.|..|| |..|..  
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
PPP_1 386-640 7.1e-108 352.9 In-house 2-264 (264) alignment 
Range on Protein: 386-640
Range on HMM: 2-264/264.0
KNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANV
...|. ... |..|.. ... |||.| .....||.|||. |||.||...|..|..|||||||||||||.|.|..|||...|.|||...||||||||...|
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TRVYGFYDECK-RRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLL-------WSDPTDSPNEWEDNERG
|.||||..|.. .... .|.||. |.|..|||||.. .||..||||||| |...|.||.. | |.||. | ..|||       .||.... . .....||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSV
..|...| ...|||.|....|..|||.|.|.||||...|..||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 385-651 3.1e-104 340.8 In-house 2-269 (271) alignment 
Range on Protein: 385-651
Range on HMM: 2-269/271.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECAN
|..||. ... |..||. ....|.|.| ||...||.|||. |||.||...|..|...||||||||||||.|||..|||...|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VTRVYGFYDECK-RRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYN
...||||..|.. .. . |..|.. ..|..|||||.. .|...||||||| ..|.|.|..  |...||. |.. |||.|..... . .| ..||..... 
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELL
. . ..||.|  ..|..||| ..|.|||...|...||||||||||....| ||.....| | ..|..|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 385-653 1.8e-100 329.1 In-house 8-282 (284) alignment 
Range on Protein: 385-653
Range on HMM: 8-282/284.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFP------PSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRG
||..|....|..|||.|  ..  ||.  |||||||.|||. ||| |.   |.|       ...|||||||||||  |.| |.|||.||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGV
|||   | . |||| |||.|   .....|  .||..||.|.|. ||.|.|||.|  | ..... .. ||.|.|| |.| || |.||  . . ... .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
   . . |...||.|| .||| ||| || |||||| || |||.|||| |||..|| .||..|.| |..|| .| |
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 389-663 2.3e-100 328.7 In-house 7-283 (284) alignment 
Range on Protein: 389-663
Range on HMM: 7-283/284.0
EILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRV
..  . ..| .||  || |.|   |..|.||.|||. |||||| | |||  .|||||||||||||. ||||||||.||. .|. ||.|||||||. . ..
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRCNI-KIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDF-GLINDLLWSDPTDSPNEWEDNERGVSYCYNKVA
||||.||.|| |   ....|   | ..||.|.|  .|.|.|||.| .|. . ..| . || | |.   |  |.||||||.  . |. | ||||| .   |
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

INKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLDSAALKQVM
. |.|...  ||| ||| ||.|||||| .| |||.|||| |||.|||  ||| | . |.||| .| |    | ...|
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarrrmm
0053225 Metallo-dependent phosphatases 379-653 1.3e-99 326.2 In-house 16-290 (293) alignment 
Range on Protein: 379-653
Range on HMM: 16-290/293.0
RTKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRG
  ....|. .|.|.....|.||....|.||||| .. ..||.||.. |||.|. |.||||.....||||.|||| .|||...||...|..||.|..||||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHECANVTRVYGFYDECKRRC-NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTdSPNEWEDNERG
|||..... .|||.||..|.  . ..|. ..|....|||||.. |||..||||||| |...|.||.. ||...|..||..|||||||.   ..|  . ||
NHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrg

VSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
......  |. .||.|.|.||..|.| || |||... |..||||||||||.|...|.|||. ..|||...| |..|
lgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 364-653 9.1e-98 320.2 In-house 3-294 (297) alignment 
Range on Protein: 364-653
Range on HMM: 3-294/297.0
DETIQKLLDAGYAAKRTKNVcLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLF
|. |  .| |    |   .| . .. .|..   | ..| .| |..|.  |.|..||.|||. |||||| . |.||..||||||||||||. |.|||.||.
dsiiidvlsasthekllskv.iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

CYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLN---SMDEIRHVVRPTDVPDfGLINDL
.||.|.| |.|||||||||  | .|||||.||..|   .... .| | || |||. ..| ||.|.||||||.|    ..| .|.. |.|.  . .|. ||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadl

LWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
||.||      . .|.||    . . |. |   .| .||||||| ||.||||||  | |||.|||| |||.|||  |.||. | | ||||.| |
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 385-655 2e-94 308.7 In-house 10-283 (287) alignment 
Range on Protein: 385-655
Range on HMM: 10-283/287.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECAN
.....||..  |..||.   |.|||.  |..||||.|||..||||.| ..| .|  .||||||||||| .||| .||||..||.||..  |||||||. .
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

VTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDF--GLINDLLWSDPTDSPNEWEDN-ERGVSYC
. ..|||..| ||. . ...|.| | |. ||| |.|. .|.|.|||.|| |.|.|... . .||   .   ||. ||||.||.   .  | |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLD
. |  ....|.|.. ||. ||| |.|.||.|. |. |||||||| |.||  | |||. ||. |  ||  | | |
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 382-651 8.2e-93 303.7 In-house 5-274 (281) alignment 
Range on Protein: 382-651
Range on HMM: 5-274/281.0
NVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHE
.| . ..|| ..  ... || .. .| |. .|...|||.|.|. || |||   | .|   ..|||||||||.||||...|||..||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYC
 |.| ..|||| ||. .. ...|  |   || ||..| .| .. |.|||||| | ..||.|   .| . .| ||..||||.||... .||    ||.|. 
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELL
. |  ...   ... .|. ||| || |||| .. | |.||||.||||  . | .||. | | |  |.  |
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_PPP4C_pd Subfamily PPP4C 383-651 2.8e-91 298.7 In-house 14-282 (288) alignment 
Range on Protein: 383-651
Range on HMM: 14-282/288.0
VCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHEC
  .|..|. ..| |||||.. .  . ..  || . ||.|||. |||.||   |  |. |||||||.||||. |.||.||| ..|..||..  |.|||||.
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhes

ANVTRVYGFYDECKRR-CNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPnEWEDNERGVSYC
 ..|.|||||||| |.  ....|.   . |. |.||||. |||||||||||| ....|||| . | ..||. | . ||||||| |    |    ||  | 
rqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagyl

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELL
. . ....| .. ...|.|||| .| .|| .  .....||.||||||    |  |.. . | |   |...
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP2C_pd Subfamily PPP2C 381-653 2.9e-88 288.8 In-house 13-285 (290) alignment 
Range on Protein: 381-653
Range on HMM: 13-285/290.0
KNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNH
.   |...|. ..| ||.||. ..  . |.. || ..||||||. ||| ||   |  | .||||||||||||  |.||. || . |..|.|   .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ECANVTRVYGFYDECKRR-CNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSpNEWEDNERGVS
|  ..|.|||||||| |.  | ..|| | | |. |||.|.| ..|||.|||||| ....|.||.. |  .||. | . ||||||| |  . |   .||  
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.ggwgisprgag

YCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
| . |   .|| .. |. |. ||| .| .||..  || .||.|||||||    | .|.. . . |  ||   ||
ytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 440-653 1.4e-85 280.2 In-house 101-314 (317) alignment 
Range on Protein: 440-653
Range on HMM: 101-314/317.0
SNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMD
..|||||||||||  |.| ..|||..|..||.. ||||||||  .| . |||| |.|.| . .....|  .||.|||.|.|. ||.|.|||.|  | ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

EIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMS
.. .. ||.|.|| |.. || |.||  . . ... .|| .  . . |...||.|. .||| ||| |||||||||.|| |||.||||.|||..|| .||.|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VSEGLLCSFELLDP
| . | .|...| |
vdkklkisinvlrp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 385-653 1.6e-85 279.6 In-house 16-288 (290) alignment 
Range on Protein: 385-653
Range on HMM: 16-288/290.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECAN
.....||.|  |..||.   |.|||.  |. ||||.||| ..||| | . |.||  ..|||||||||| .|||  ||||||||.|...  |||||||. .
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

VTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTD--VPDFGLINDLLWSDPTD-SPNEWED-NERGVSY
| |.|||..|  |. . ..|| . | |. |.| | |. ||.|.|||.|. ..| . .. . .|      | ||. ||||.|||    .  .    |..| 
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

CYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
 . | .....|.|....|. ||| | |.|..|  |. |||||||| |.|.  | ||.. ||| |  |.  | |
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP3C_pd Subfamily PPP3C 383-642 3.6e-81 266.2 In-house 39-311 (452) alignment 
Range on Protein: 383-642
Range on HMM: 39-311/452.0
VCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHEC
  |.....|.|  .| ... ....|||.. |. ..||.|||. |||.||   | | |..|||||||||||  |.|..| |.. ||.||...|||||||||
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

ANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWE-------DNE
  .|  . | .||| . . .........|..|||||.. .. .|||||||| ..|.|.|... |  ..| .|.. |||||||..  .| .       .. 
rhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFND------RSLVTVFSAPNYCGEFDNWGAVMSVSE
|| || |.  |. .||.|  .  . ||| . ..||. ...       ||.|.||||||.. ..| .||. . .
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP6C_pd Subfamily PPP6C 384-643 3.2e-80 262.4 In-house 14-273 (290) alignment 
Range on Protein: 384-643
Range on HMM: 14-273/290.0
CLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECA
 | .|.. ..| .  ...| . ..  .| || ..||.|||. ||. || . |  | ..|.||||.||||  ||||. .|.. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

NVTRVYGFYDECKRR-CNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPtDSPNEWEDNERGVSYCY
..|.||||||||...  | . || ... |. |..|||. ....|||||||| .. .|.|| . | ...|  | . ||.|||| .  ..|.  .||  | .
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

NKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEG
 .   ..|..   ..|.|||| .||.|.... | .||||.||||||    |  ....... 
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaleda
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 385-653 1.4e-79 260.5 In-house 6-274 (280) alignment 
Range on Protein: 385-653
Range on HMM: 6-274/280.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECAN
.   ||. |      ||. .  | |   |.|..||.| || |. |||   |  |  . .||||||||| | .| ..|||| ||.| .  .|||||||  .
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

VTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNK
| ..|||| ||. .  . .|  |   || .|...... ...|.|||||| |  .| || . || .  | ||. ||||||||.  . |  . ||.|| . |
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

VAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDP
  ...  . .  ||. ||| ||.||||..  | |.|||| |||| .| |  ||. .   |  ||. | |
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_PPG1_pd Subfamily PPG1 380-645 1.1e-76 251.0 In-house 9-287 (300) alignment 
Range on Protein: 380-645
Range on HMM: 9-287/300.0
TKNVCLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGN
 |   | .  . ... | .|.....  . |.  || .|||||||. |.| .|   |  | .||||||||||||  |.||| || . |..||    |||||
qkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgn

HECANVTRVYGFYDECKRRC--NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPT-------DSPNE
||  ..|.||||| || |.   | ..|| . . |. | ||||.  .|.||||||||   |.|.|. . |  .||. | . |||||||        | |..
hesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdr

----WEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLL
    .   .||  |.| |  ..|||..  .. . ||| .. .||. . |  | ||.||||||    |  ... . | . 
egqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekde
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 385-644 2.4e-76 249.9 In-house 20-282 (307) alignment 
Range on Protein: 385-644
Range on HMM: 20-282/307.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECAN
  ..|. ..  .|. || |. .|... ||. .|||.|||. ||. .|   | || . |.| |||||||  |||.|||||.||| ||||  ||||||| | 
ytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiar

VTRVYGFYDECK---RRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYC
| . ||||.||     .|  .||  |   || ||..|..| ||.|.|||||| |  .||.|   .|   |  |..||.||.||  |  ||    ||  . 
vnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgft

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGL
.    |.   ...| .|. ||| .. |||  .  | |.|.|||| ||  . | |.|. | | |
fgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 385-641 3.1e-75 246.1 In-house 6-287 (302) alignment 
Range on Protein: 385-641
Range on HMM: 6-287/302.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFT----------KCGFP-PSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENF
....|.|... .  | .  . .| |.|||| ||||.|||. ||.|...          |  .   |. ..|||||||||..|.| | |.|..|. ||.|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECANVTRVYGFYDECKRR----CNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRP-TDVPDFGLINDLLWSDPTD--
 |||||||.  .   ||| .| . |       .||. | ..|  .||||.|  ||.|||||.|| |.|...|....|| ..| .  | .|||..||.|  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

-------SPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVS
        |.  ... ||.|...|. |.... ......|. |||...  |. || |. |.|.||||.|  | || |||. | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 384-641 4.9e-75 245.5 In-house 6-288 (302) alignment 
Range on Protein: 384-641
Range on HMM: 6-288/302.0
CLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFT----------KCGFP-PSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPEN
 ....|.|... .  | .  . .| |.|||| ||||.|||. ||.|...          |  .   |. ..|||||||||..|.| | |.|..|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECANVTRVYGFYDECKRR----CNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRP-TDVPDFGLINDLLWSDPTD-
. |||||||.  .   ||| .| . |       .||. | ..|  .||||.|  ||.|||||.|| |.|...|....|| ..| .  | .|||..||.| 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

--------SPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVS
         |.  ... ||.|...|. |.... ......|. |||...  |. || |. |.|.||||.|  | || |||. | 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
PPP_2 414-605 6.7e-74 240.9 In-house 1-197 (198) alignment 
Range on Protein: 414-605
Range on HMM: 1-197/198.0
VKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECK-RRCNIKIWKTFIDTFN
|...||.|||. |||.||......|...||||||||||||.|||..|||...|..||....|||||||...|..||||..|.. .. . |..|.. ..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

TLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVPDFGLINDLL----WSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMV
.|||||.. .|...||||||. ....|.|..  |....|. |...|||    .|||... . .. ..||....... .....|.|. ..|..||| |
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_PPP5C_pd Subfamily PPP5C 383-642 2e-71 233.6 In-house 32-297 (322) alignment 
Range on Protein: 383-642
Range on HMM: 32-297/322.0
VCLKNNEILQICIKAREIFLSQPSLLELSPP----VKIVGDVHGQYGDLLRLFTKCGFPPSS-NYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLR
  |..  .|.| ..|.|.. ..|||.|.. .    . . ||.|||. ||| .| . | | ..  ||| ||.||||  |.|.||.|...|. ||..||| |
kklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsr

GNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVL-NSMDEIRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEdNER
||||  |. ..||| .|.| . . |. . | ..|| |||| ..  |.. |||||      ..|..|.. | .. |. ||. .|||||| ...  ..  .|
GnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrsp.skr

GVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSV-SE
||.  .     .|||.. ...|. |.| | |.|||. .| .|.||||||||| . .| ||.... ..
GvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgd
PPP_4 414-605 1.6e-70 230.1 In-house 1-196 (197) alignment 
Range on Protein: 414-605
Range on HMM: 1-196/197.0
VKIVGDVHGQYGDLLRLFTKCG-FPP-SSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTF
| .|||.|||. |||  ..|.| .|. ...|.||||||||||.|||..|||...|..||....|||||||.......|||..|.... . .|.|.. |.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVP-DFGLINDL-LWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMV
..|||||....|...||||||. |.|.|.|... |....| . ....|| |||||... . .....||..... . ...|||.| ...|..|.| .
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 414-605 2.3e-68 223.1 In-house 1-198 (199) alignment 
Range on Protein: 414-605
Range on HMM: 1-198/199.0
VKIVGDVHGQYGDL-LRLFTKCGFPP-SSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRR-CNIKIWKTFIDT
| ..||.|||..|| |.|| ..|.|. . .|.||||||||||.|||..|||...|..||....|||||||. .....|||..|....  . ||.|.. |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVP-DFGLINDL-LWSDPTDSPNE-WEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMV
|. |||||....|...||||||| ..|....... |....| . |  .|| |||||.|. .. .. .|||....... ...|||.| ...|..|.| .
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 407-655 7.7e-67 218.7 In-house 2-257 (263) alignment 
Range on Protein: 407-655
Range on HMM: 2-257/263.0
LLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNI-----
||||  |..|.|| |||| ||||.|  ||    ..||||||||||| .||| |.|||  |.  | ...|||||||   . . |||. | |.| .      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIRHVVRPTDVP-DFGLINDLLWSDPTDSPNEWEDNE-RGVSYCYNKVAINKFLNKFGFDLV
 ... | . |. .||.|||. .|.|.|||.|| |.|.|.|| .  | .    . |  ||||.||    . .| |. | .|  . |  .. . ...  ||.
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGLLCSFELLDPLD
 ||| ||| || || || |.|||||  |  |. |. ||. | . |  ||  | | |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 441-653 1.1e-63 208.4 In-house 121-333 (339) alignment 
Range on Protein: 441-653
Range on HMM: 121-333/339.0
NYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDE
 |||||||||||  |.| ..|| . |. ||.  .|||||||   |   |||| | . | . .... | . || .|..|..   |.|.|||.|  | |...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRHVVRPTDVPDFGLINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSV
.  . || ..|| |.. || |.||  . . ..   || |. .   |.  ||.|. ...| | | |||||||||. | |||.||||||||. ||  ||.|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

SEGLLCSFELLDP
 . |  | ... |
dkklkisinvfrp
subfamily_PPPLV_pd Subfamily PPPLV 391-639 4.8e-49 160.2 In-house 3-274 (290) alignment 
Range on Protein: 391-639
Range on HMM: 3-274/290.0
LQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLR---LFTKCGF-PPSSNYLFLGDYVDRGKQSLETILLLFCYKIKYPENFFLLRGNHECANVT
| .| .| .|....  ||||  |. ..||.||.| ||      . . |     ...||||||||||. |.| |  |.  |. ||  ..|||||||   |.
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

RVYGFYDECKRRCN---IKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVL------NSMDEIRHVVRpTDVPDFGLINDLLWSDPTDS----------
  . .. |.. .      ..|..| ..|..|||||..  |.||||.|.           ....| . ..  |.    |  |.||||| .           
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk.ddidgaplaldilwsdpaedrdlslrgelv

-PNEWEDN-ERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFdNWGAVMS
 .. . ||  || .. . . |...||.. . . | ||| | | |... ..  |.||||. .|||   |  |.. 
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalil
Metallophos Calcineurin-like phosphoesterase 413-605 5.2e-41 134.1 Pfam-A 2-198 (200) alignment 
Range on Protein: 413-605
Range on HMM: 2-198/200.0
PVKIVGDVHGQYGDL----LRLFTKCGFPPSSNYLFLGDYVDRGKQSLETILLL--FCYKIKYPENFFLLRGNHECANVTRVYGFYDECK----------
.. ..||.||.. ||    |.|. ... ..  ..|||||.||||. |.||. ||  ...|...| ..||||||||. ... .|||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRCNIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVLNSMDEIrhvvrptdvpdfglindllwsdptdspnewe
                         . . ...  . ..|. |||.|.| |||...||.||. ..| | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dnergVSYCYNKVAINKFLNKFGFDLVCRAHMV
      |. ... | .|.|.| | |||.|.|  
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 358-542 1.2e-35 115.9 In-house 12-197 (383) alignment 
Range on Protein: 358-542
Range on HMM: 12-197/383.0
KKPIDIDeTIQKLLDAgyaAKRTKnvCLKNNEILQICIKAREIFLSQPSLLEL----SPPVKIVGDVHGQYGDLLRLFTKCGFPPSSN-YLFLGDYVDRG
. |.. |  ..||..|    |. |   |. . .|.|  .|.... . |.. ..    |  | . ||.||.  ||| .. | |.| ..| |.| ||.||||
slpltkd.evekliea...fkekk..llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrG

KQSLETILLLFCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC---NIKIWKTFIDTFNTLPLAAIVAGKIFCVHGGLSPVlNSMDEIR
|.|.| .|.|... . ||....| |||||   .   |||  | . .    . || ... | |  ||||...  ||. ||||.|    ... . 
kesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelld
subfamily_PPP7C_pd Subfamily PPP7C 555-644 2.2e-16 52.6 In-house 236-325 (383) alignment 
Range on Protein: 555-644
Range on HMM: 236-325/383.0
LINDLLWSDPTDSPNEWEDNERGVSYCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMSVSEGL
 . |.|||||      . .  ||    .     .|.|.|....|. |.|    .||||  |. ..|.||| ||  |  | || . ... |
qvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 384-440 2.4e-15 49.5 In-house 8-64 (317) alignment 
Range on Protein: 384-440
Range on HMM: 8-64/317.0
CLKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSS
 .|..|....| .|||.| ..|  |||  ||.||||.|||. ||| |.   |.| ||
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwplss
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 385-440 3.1e-10 32.7 In-house 11-66 (339) alignment 
Range on Protein: 385-440
Range on HMM: 11-66/339.0
LKNNEILQICIKAREIFLSQPSLLELSPPVKIVGDVHGQYGDLLRLFTKCGFPPSS
.   |. ..| .|||.  |.| .|.|  |. ..||.|||. ||| ..   |.| ||
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwplss
subfamily_YNL217W_pd Subfamily YNL217W 416-533 2.4e-08 26.7 In-house 14-138 (235) alignment 
Range on Protein: 416-533
Range on HMM: 14-138/235.0
IVGDVHGQYGDLLRLFT--KCGFPPSSNYLFLGDYVDRGKQSLETILLLfcykikYPENFFLLRGNHECANVT------RVYGFYDE--CKRRCNI--KI
.|||||| | .|..|.   . |  .    ...|| ...| .|.|.. ..        ..   ..|||| . .       .  |. .    ..   .  |.
vvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfleskl

WKTFIDTFNTLPLA-AIVAGKIFCVHGGLSP
 |  ..    |. .  | . ... ||.||.|
skadmeyarelgfsldipsdellvvhaGlvp