Gene PPQ1 in Saccharomyces cerevisiae

Synonym: CNA2, YML057W, CMP2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP073_AA protein Get Run
ScerP073_AA_257-537 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP1C_pd Subfamily PPP1C 260-537 2.5e-140 459.5 In-house 3-280 (282) alignment 
Range on Protein: 260-537
Range on HMM: 3-280/282.0
SKKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLR
.|.|.. ... ||. .. .||||.|.||.||.|.||.|.|||.|||..||||... ||.|...|||||||||||||.|||||.|||.|||||..|.|.||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRG
||||||.....||||||||||.|.|.||.|.||||.|||||....||.|||||.||.|....||.|..||...||.||..|||||||| .|..|||||||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRA
||.||.|..| .|..|...|||.|.|.||||||||||....||.||||||||||.| |||.||.. ...||..|||..
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
subfamily_PPZ_pd Subfamily PPZ 238-535 1.9e-134 440.9 In-house 1-293 (300) alignment 
Range on Protein: 238-535
Range on HMM: 1-293/300.0
LDIDVAIEKLLQVGESREITktskkKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNS
.|||  |.|||. | . . |     ||  ..  ||  ||..|||.||.||.|| |  ..|.|||||||..||||..   |.|  .|||||||||||||.|
vdideiiqklldagyaakrt.....knvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqs

LETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGL
|||||||||||||| .|||.|||||| ||||..||||||||||   |.|| ||| |||||||||.  ||||||||.|| |  | .| .|.||||.|. ||
letillllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfgl

VTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKP
. |||||||     .| .|.||||| . |  .  |  || |||. | |||||||||||  . .||.|||||||||| ||||||||. |..|||||| |
indllwsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 261-537 3e-121 397.1 In-house 18-295 (298) alignment 
Range on Protein: 261-537
Range on HMM: 18-295/298.0
KKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRG
||     .. ... .. .|..|| .|..|. ..||||| ||.|||..||||... .| | |.||||||||||||...||.|.|||.||.||..|||.|||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESANVTKMYGFYDECKRRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRG
||| . . ..||||.|||||  | .... | ||||.|||.|.| ..|.|.|||.|. |. ..|. .. ||.| .|. |..||||.||. .|..|.|| ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

VSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRA
||..| . .| |.. |.. ||. |.| || ||||||| ||.|||||||.|||.| |  |||.|   ...|||.|||. 
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 238-538 1.3e-113 372.2 In-house 1-296 (299) alignment 
Range on Protein: 238-538
Range on HMM: 1-296/299.0
LDIDVAIEKLLQVGESREITKTSKKKNfpfhswEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNS
||.|  . |||.|| | .   .| |..      |.| .|  |...|..|..|| ..|||.|.||.|||. |||||.. .| | |.|.||||||||||.. 
ldvdellskllnvgmsekrltksvkeq......elqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqn

LETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESG
||.| ||||.||||...|||||||||   . ..||||.||..|  |...| .| | |...||. .|  .|.|.|||.|| |... |. ...|| | |.  
lelitlllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnps

LVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPR
|  ||||.|||  | ||  | ||||| | .  | | . ... ||. | | ||.||||||| ||.||||||| |||.| |  |.| |   ..|.| .||| 
lgidllwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt

AL
. 
pk
0045823 Metallo-dependent phosphatases 259-537 3.9e-110 361.6 In-house 35-325 (473) alignment 
Range on Protein: 259-537
Range on HMM: 35-325/473.0
TSKKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFML
   ||.. ..  ..  ... |.||. ..|.||.|...| |.||.|||. ||||.|.. | |......||||.|||| .|||...|||..|||| .|.|.|
ehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfll

RGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTD------
|||||..... .|||.||. .... .....|......|||||.| .||..||||.||||. ..||... || .||..||..|||||||...  |      
rGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddgdgllrlr

-WSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKK------FVTIFSAPNYCGEFHNWGAVMSVTTGMmCSFELLKPRA
 .  . ||..|.|... | .|. |...||| ||| .|..|||.. ..|       .|.||||||||...|..||. .. .. .|| ...|  
ffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsp
PP2Ac_SM00156 269-535 2.4e-109 357.6 In-house 3-269 (271) alignment 
Range on Protein: 269-535
Range on HMM: 3-269/271.0
SWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVT
. |.  .. ...||. ....|....||. ||||.|||..||||.|.| |.|....|.|||||||||..|.|.||||...||.| .....||||||| .|.
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

KMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRN
|.|||..|.||. .......| ..|. |||||....||.|.|||.||.|. ...|.|. |. ..||.||..|||||||. .. ... . ||.|..|... 
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFgeda

VLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKP
| .|. |....|| |.|.||..||||||.|| ||||||||||.||.| .||..| .....|.|.||.
vkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 271-536 6.5e-107 349.8 In-house 10-275 (280) alignment 
Range on Protein: 271-536
Range on HMM: 10-275/280.0
EIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKM
.|. .  . ..|.. | |.. ..||..|.||.|||..||||...  . | |.||||||||||||.  || |||||.||..| .||..|||||| ... . 
didrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrk

YGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVL
|||.||.||| | .... | .....|||.|..  .|.|.|||.|..|  .... .. || | ... | .||||.||. .|| |.|| ||||. | . .| 
ygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifganvvk

DFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPR
|.. |.. ||| ||| ||.||||||| ||.||.||||.|.|||.|  ||. |  ... |||.||| 
dltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
0049330 Metallo-dependent phosphatases 258-537 6.4e-106 346.8 In-house 21-300 (309) alignment 
Range on Protein: 258-537
Range on HMM: 21-300/309.0
KTSKKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFM
.   .| . ..  |. |....|.||....|.||.|...| |.||.|||. ||||.|.. |.|......||||.|||| .|||..||||..|..| ||.|.
ielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfl

LRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSEND
||||||..... .|||.||..|......|..|.|....|||||.| .||.|||||.||||. ..||... ||..||. ||..|||||||.| . .. .|.
lrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnp

RGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRA
||....|    | .|. |...||| ||| .|..||..|. .|..|.||||||||...|.|||. .. ....|| |..|  
rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvp
PPP_1 270-522 4.1e-105 343.8 In-house 4-264 (264) alignment 
Range on Protein: 270-522
Range on HMM: 4-264/264.0
WEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTK
 |.. .. ...|.. ....||.....|.|.||.||||.|||.. | .| ...||||||||||||||.|.|..||||..|.||....|.|||||||..|||
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

MYGFYDECK-RRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLL-------WSDPDPQVTDWSENDRGVS
.|||..|.. .. |....|...|||..|||||.|..||..||||.||.|. ..||.|. | |..||.| ..|||       .||.. | . .....||..
vygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGag

YTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSV
|.|.|. . .|. |....||.| |.|.|.||||....|.||||||.||. |..|.||....
ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PPP_3 271-534 6.7e-104 339.7 In-house 6-270 (271) alignment 
Range on Protein: 271-534
Range on HMM: 6-270/271.0
EIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKM
|.. .. ...||. ....|....||..|.||.|||..|||.. | .| ...|.||||||||||||.|||..||||..||||......|||||||....|.
elkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkv

YGFYDECK-RRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNV
|||..|.. .. ..||.|.. .||..|||||.|..|...||||.||... ..||.|  |....||.|...|||.|... . . .....||....|... .
YgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFgpdvt

LDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLK
 .|. | |..||.| | ..|.|||.....| ||.|||||||....| ||...... ....|..|.
eefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 267-535 1.3e-103 339.3 In-house 8-282 (284) alignment 
Range on Protein: 267-535
Range on HMM: 8-282/284.0
FHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVP------SDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRG
..  |.  .|| |||.| ...  | ..||.|.|||.||||.||| .|.| | |       ...|||||||||||  |.| |.||..||... |. |.|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGV
||||  | . |||| |||.| | .....|   ||..||.|....||.|.||||| || |.||..|. ||.|||. |...|| |.||. .|. . | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKP
  .| .. | .|. |||.||..| | || ||||||| .|.||||||| |||...| .||..| . ...|| .|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
0053225 Metallo-dependent phosphatases 261-536 8.1e-99 323.6 In-house 16-291 (293) alignment 
Range on Protein: 261-536
Range on HMM: 16-291/293.0
KKKNFPFHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRG
 .... .. .|. |....|.||....|.||.|...| |.||.||.. |||..|.. | |......||||.|||| .|||...|||..|..|.||...|||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHESANVTKMYGFYDECKRRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDpQVTDWSENDRG
|||..... .|||.||..|.. ....|....|....|||||.| .||..||||.||||. ..||... ||..||. ||..||||||||  ...|  . ||
NHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrg

VSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPR
....|    ||.|. |...||| ||| || |||...  .| ||.||||||.|...|.|||. . .|....| |..|.
lgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 279-536 1.2e-93 306.7 In-house 35-295 (297) alignment 
Range on Protein: 279-536
Range on HMM: 35-295/297.0
AREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECK
| ..| .| ... ..|||||.||.|||| ||||...  | |  .||||||||||||. |.|||.|||.||.|.  |.|.||||||   | |.||||.||.
aldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecq

RRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISP---DLHDMKQIEKVARPTDIPEsGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCA
.|  | ...  | |||| |||. .| .||.|.|||.||   .   .. . |. |.|.  | .||.||||.||   .. . ||.||    | . .||. |.
kryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadllwadpisglsgfmenqrgagcgfgrdavlklcs

KFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPR
.||.||. | | ||.||||||| .|.||||||| |||.| |  |.||.   . ||||.|.| 
efkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 271-542 1.6e-93 306.2 In-house 7-280 (284) alignment 
Range on Protein: 271-542
Range on HMM: 7-280/284.0
EIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKM
... . .|| .|| .|| |.  ..||...||.|||| ||||..   |.|  .|||||||||||||  |||||||..||. . . ||||||||| . . |.
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRLS-SKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPES-GLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRN
||||.||.||     |.. |  || ..||.|.. ..|.|.|||.|  |... |.  . || | ||   |  |.|||||      |  | ||||| |    
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRALKNKK
.  .  ... ||..| | ||.||||||| ...||||||| |||.| |  ||| |   ..||| .|.||    ..
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 270-537 3.6e-92 301.6 In-house 11-278 (281) alignment 
Range on Protein: 270-537
Range on HMM: 11-278/281.0
WEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTK
 ||. . .... || .. .|  ...||.||||.|.||||| |...| | .... ..|||||||||..|||...||...||.|.|. ..|||||| |.| |
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

MYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNV
.|||| ||. .   ..|  |   || ||..| |. .. |.|||.||.|  . .. .  .| . .. ||| ||||.|||..| .| .  ||.|.|| |  |
iygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknvv

LDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRA
 | | ... .|| |.| || |||| .. .|..|.||.||||  ..| .||. |   .  |.  | | .
ddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_PPP4C_pd Subfamily PPP4C 270-533 3.5e-91 298.4 In-house 19-282 (288) alignment 
Range on Protein: 270-533
Range on HMM: 19-282/288.0
WEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTK
 |.. .| .||||....  . |...|. | ||.||||.|||...|..|   .||||||||.||||..|.||.||||..|..| |.  ..|||||| ..|.
eevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq

MYGFYDECKRRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDpQVTDWSENDRGVSYTFSKRN
.||||||| |.  |..||.. ..||. |.|||||..||||||||.||... . .|  . | ...|..| ..|||||||. ... |.   ||  | | .. 
vygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylfgsdv

VLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELL
| .|... ...|| | | .| .|| .  ..| .|..||||||    |  |.. .   .   |...
veqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 268-537 5.3e-91 297.5 In-house 11-283 (287) alignment 
Range on Protein: 268-537
Range on HMM: 11-283/287.0
HSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANV
   .|  .  ...||.   |.||...|||..|||.|||..|||||..  | .....||||||||||| .||| .|||...||.|  .  .||||||  ..
sdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkki

TKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPES--GLVTDLLWSDPDPQVTDWSEN-DRGVSYTF
 |.|||..| ||. .....| | |||. ||| |... .|.|.||||||.|. ..... . .||   .   ||. ||||.||. .      |  |..|  |
nklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvf

SKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRA
 |..| |.. |.. |||.| | |.|.||.|.. |. ||.|||| |.||  | |||. |.  .  ||  |||  
GkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 322-536 1.5e-89 293.3 In-house 101-315 (317) alignment 
Range on Protein: 322-536
Range on HMM: 101-315/317.0
TNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMK
 .|||||||||||  |.| ..||...|..| |. |.||||||| .| . |||| |.|.| |......|  .||.|||.|....||.|.||||| .| |.|
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMS
|..|. ||.|||. |...|| |.|||..|. . |  || .  | .. | .|. |...||..|.| |||||||||| .|.|||||||.|||...| .||.|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VTTGMMCSFELLKPR
| . ...|...|.| 
vdkklkisinvlrpe
subfamily_PPP2C_pd Subfamily PPP2C 268-535 2.8e-87 285.6 In-house 18-285 (290) alignment 
Range on Protein: 268-535
Range on HMM: 18-285/290.0
HSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANV
.  |.. .| .|.||. ..  .  ...|. |.||||||| ||| ..|. |   ||||||||||||||  |.||. || . |..||.   .||||||| ..
eesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqi

TKMYGFYDECKRRLS-SKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDpQVTDWSENDRGVSYTFSK
|..||||||| |. . ..|||.| |.|. |||.|.....|||.|||.|| .. . .|... |  ..|. | ..|||||||| . . |.  .||  ||| |
tqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagytfgk

RNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKP
    .|  . .. || | | .| .||..   .. ||||||||||    | .|.. .   .  ||   .|
disekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_PPP3C_pd Subfamily PPP3C 272-527 1.9e-81 267.1 In-house 46-314 (452) alignment 
Range on Protein: 272-527
Range on HMM: 46-314/452.0
IQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMY
.. |  .| ... ...|||...||| |.||.|||| |||......| |..|.|||||||||||  |.|..| |.. ||.|....|.||||||.  .|. .
alkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyf

GFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVT------DWSEN-DRGVSYTF
 | .||| . | .|...... |..|||||..... .|||||.||.......|.|. |  ..|.||.. |||||||  .        ....|  || || .
tfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfy

SKRNVLDFCAKFKFDLILRGHMVVEDGYEFFAR------KKFVTIFSAPNYCGEFHNWGAVMSVTTGMM
| . | .|  | ..  |.| | . ..||. . .         .|.||||||.. ..| .||. . .  |
sykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 268-536 3.3e-81 265.5 In-house 17-289 (290) alignment 
Range on Protein: 268-536
Range on HMM: 17-289/290.0
HSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANV
   .|  |  ...||.   |.||...||| .|||.|||...||| ..  | | . ..|||||||||| .|||  |||.||||.|  .  .||||||  .|
sdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv

TKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTD--IPESGLVTDLLWSDPDPQV--TDWSENDRGVSYT
 ..|||..|  |. .|..||.. |||. |.| | .. ||.|.|||||....  . .. . .|      . ||. ||||.||. .   |   .  |..|  
nrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvv

FSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPR
| |. . |.. |. ..||.| | | |.|..|   || ||.|||| |.|.  | ||.. |.  .  |.  ||||
fgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_PPP6C_pd Subfamily PPP6C 270-526 3.4e-80 262.3 In-house 18-274 (290) alignment 
Range on Protein: 270-526
Range on HMM: 18-274/290.0
WEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTK
 ... .| .  ...|.. ..  ...|. |.||.|||| ||. ... .|   ||.|.||||.||||  ||||. .||. |.|| |.  .||||||| ..|.
ndlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitq

MYGFYDECKRRL-SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDpQVTDWSENDRGVSYTFSKRN
.|||||||...  ....|| ...||. |..||||.....|||||.|||.. ..||. . | ..||. | ..||.||||. .| .|.  .||  | | .. 
vygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylfgskv

VLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGM
. .|..  ...|| | | .||.|....  .|.||..||||||    |  ..... .  
tkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledae
subfamily_PPG1_pd Subfamily PPG1 271-525 1.3e-78 257.3 In-house 18-285 (300) alignment 
Range on Protein: 271-525
Range on HMM: 18-285/300.0
EIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKM
 .. .... .|.....  . ....|. ||||||||| |.| |.|. |   ||||||||||||||  |.||| ||.. |..|     .||||||| ..|..
tvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqv

YGFYDECKRRL--SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPD---------PQVTD--WSEND
|||| || |.    |.||| . ..|. | |||||...|.|||||.||.   . ||  . |  ..|. | ..|||||||.         |.     . . .
ygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsq

RGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTG
||  |.. |  |. |  . ... |.| | .. .||. .  .|  |..||||||    |  ... .   
rgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 271-538 2.2e-78 256.5 In-house 10-277 (280) alignment 
Range on Protein: 271-538
Range on HMM: 10-277/280.0
EIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKM
||  |      ||...  |   .|||||.||.| |..|. |.. | |   . . .||||||||| . .| ..||.| ||.|.|  ..||||||. .| |.
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVL
|||| ||. .    .|  |  .|| .|....|  ...|.|||.||.| ..  | .. || .  . ||. |||||||  .   |  . ||.|| | |  | 
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

DFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRAL
. |  .. |||.|.| ||.||||..| ....|.|| |||| .| |  ||. . . .  ||. | |  |
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipppl
subfamily_PPP5C_pd Subfamily PPP5C 270-524 2e-75 246.8 In-house 37-296 (322) alignment 
Range on Protein: 270-524
Range on HMM: 37-296/322.0
WEIQLICYHAREIFLNQPTLLRLQAP----IKVVGDVHGQFNDLLRILKLSGVPSDTN-YLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHES
  .  |  .|.|.. ..|.|. .. .    . | ||.|||| ||| |..| |.||..| ||| ||.||||  |.|.||.||..|. | ..||. ||||||
kyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhes

ANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGI-SPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTdWSENDRGVSYT
 |. |.||| .|.| . ..|| ..| .||| |||| .|..|.. ||||. | |   .... |. | .. ||.||. .||||||...    |.  |||. .
dnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanG.rspskrGvgvq

FSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTT
|       |. . ...||.| | | |.|||.    | .|.||||||| .  | ||......
fGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrg
PPP_2 296-487 3e-74 242.0 In-house 1-197 (198) alignment 
Range on Protein: 296-487
Range on HMM: 1-197/198.0
IKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECK-RRLSSKVWKMFVDVFN
..|.||.|||..|||.. | .. .....||||||||||||.|||..||||..|..|......|||||||..|.|.|||..|.. .. ..||.|.. .||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

TLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLL----WSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMV
.|||||.|..|...||||.|.... ..||.|  |....||.|...|||    .|||. . . .... ||....|... . ... |.|..||.| | |
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 269-525 1.5e-73 240.7 In-house 22-281 (307) alignment 
Range on Protein: 269-525
Range on HMM: 22-281/307.0
SWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVT
  |.. . | |. ||  . .|. .. |  ||||.|||||||. .. | | | .| |.| |||||||  |||.||||..||| | .|  .|||||| | | 
keefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

KMYGFYDECKRRL---SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFS
| ||||.||   .     ..| .|  .|| ||..|.|  ||.|.|||.|| |  . .. .  .|   |  |.| |.||.|||| | .|    ||  .|| 
kkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfg

KRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTG
   . | | ..  .||.| | .. |||  .. .|..|||||| ||  ..| |.|. |   
tnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdet
PPP_4 296-487 6.6e-71 231.4 In-house 1-196 (197) alignment 
Range on Protein: 296-487
Range on HMM: 1-196/197.0
IKVVGDVHGQFNDL-LRILKLSGVPS-DTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVF
. ||||.|||..|| |..||..| || ...|.||||||||||.|||..||||..|..|......|||||||......|||..|.... .....|.. |||
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIP-ESGLVTDL-LWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMV
..|||||.|..|...||||.|..|.....||...|....| |...  || ||||| .. . .... ||....|... . .|. | ...||.|.| .
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 267-534 4.5e-70 229.2 In-house 6-298 (302) alignment 
Range on Protein: 267-534
Range on HMM: 6-298/302.0
FHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGV-----------PSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNF
... |. |.. .  | . .. || .. .|. .|||.||||.||.|||.                |   ..|||||||||..|.| | |....|. |. |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FMLRGNHESANVTKMYGFYDECKRRLSS----KVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARP-TDIPESGLVTDLLWSDPD---
 .||||||.  .   ||| .| . ||.     ..|. | .||  .||||.. .||.|||||||| |. ...|.|. || ... |  | .|||..||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

-----PQVTDWSEN-DRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLK
     ..  .. .|  ||.|..| .  | |.| .. ..||.|.|...  |. ||| ||..||||||.|  |  | |||. | |    |   |.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 267-534 7.4e-70 228.5 In-house 7-299 (302) alignment 
Range on Protein: 267-534
Range on HMM: 7-299/302.0
FHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGV-----------PSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNF
... |. |.. .  | . .. || .. .|. .|||.||||.||.|||.                |   ..|||||||||..|.| | |....|. |. |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FMLRGNHESANVTKMYGFYDECKRRLSS----KVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARP-TDIPESGLVTDLLWSDPD---
 .||||||.  .   ||| .| . ||.     ..|. | .||  .||||.. .||.|||||||| |. ...|.|. || ... |  | .|||..||    
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

-----PQVTDWSEN-DRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLK
     ..  .. .|  ||.|..| .  | |.| .....||.|.|...  |. ||| ||..||||||.|  |  | |||. | |    |   |.
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 289-539 4.5e-68 222.7 In-house 2-259 (263) alignment 
Range on Protein: 289-539
Range on HMM: 2-259/263.0
LLRLQAPIKVVGDVHGQFNDLLRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSS-----
|| |||||...|| |||.||||||..  |  . |.|||||||||||  ||| |.||.  |.    ....||||||   . | |||. | |.|.       
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIPE-SGLVTDLLWSDPDPQVTDWSEND-RGVSYTFSKRNVLDFCAKFKFDLI
 |.. | .||. .||.||.  .|.|.|||||| |. . .|  .  | .  .   |  ||||.||. .   .  |  | .|  | |..| |.| ..  |||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

LRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSFELLKPRALK
.| | ||| || ||| ....|.|||  |  |. |. ||. |   .  ||  |||  ..
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedfe
PPP_5_Dcr2 296-487 7.3e-68 221.5 In-house 1-198 (199) alignment 
Range on Protein: 296-487
Range on HMM: 1-198/199.0
IKVVGDVHGQFNDLLRILKLSG-VPS-DTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRR-LSSKVWKMFVDV
. |.||.|||..||| ||   |  || ...|.||||||||||.|||..||||..|..|......||||||. .....|||..|....  ..|..|.. ||
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVARPTDIP-ESGLVTDL-LWSDPDPQVTD-WSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMV
|. |||||.|..|...||||.||........||..|...|| |.|   || ||||| ..... . .. ||....|..... .|. | ...|| |.| .
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 323-538 3.5e-66 216.6 In-house 121-336 (339) alignment 
Range on Protein: 323-538
Range on HMM: 121-336/339.0
NYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTKMYGFYDECKRRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQ
 |||||||||||  |.| ..|| . |. | |  ..|||||||  |   |||| | . |  ..... | ..|| .|..|.|.. |.|.|||||  |  ..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IEKVARPTDIPESGLVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSV
.  . || .||. |..||| |.||||    .    || |. |    .  |  |. .....||| |||||||||  ...|||||||||||.  |  ||.|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

TTGMMCSFELLKPRAL
   .  | ....| . 
dkklkisinvfrpesr
subfamily_PPPLV_pd Subfamily PPPLV 274-519 4.3e-49 160.4 In-house 4-272 (290) alignment 
Range on Protein: 274-519
Range on HMM: 4-272/290.0
LICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRIL----KLSGVPSDTNYLFLGDYVDRGKNSLETILLLLCYKIKYKDNFFMLRGNHESANVTK
 .|  | .|....  || |..|. |.||.||...||  .     ..  . . ...||||||||||. |.| |  ||  |. |   ...||||||   |..
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

MYGFYDECKRRLS---SKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIEKVA-----RPTDIPESGLVTDLLWSDPDPQVT----------
 . .. |.. .      .||. | .||..|||||.|..|.||||.||    .   .|  .       . ||  . |  |.|||||. .            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-DWSEND-RGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFhNWGAV
  . .|| || .. ||.  .  |  .   . .|| | | | |...  . . .|.||. .|||   |  |.
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaal
Metallophos Calcineurin-like phosphoesterase 295-487 2.5e-42 138.4 Pfam-A 2-198 (200) alignment 
Range on Protein: 295-487
Range on HMM: 2-198/200.0
PIKVVGDVHGQFNDL----LRILKLSGVPSDTNYLFLGDYVDRGKNSLETILLL--LCYKIKYKDNFFMLRGNHESANVTKMYGFYDECK----------
.| |.||.||...||    |..||. . .  ...|||||.||||..|.||. ||  |..|.......|.||||||| .... |||..|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------RRLSSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISPDLHDMKQIekvarptdipesglvtdllwsdpdpqvtdws
                         .|  ... .. ..|. |||.|..  ||...||..|...    .|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

endrgVSYTFSKRNVLDFCAKFKFDLILRGHMV
      |. |..... ... | . ||.||||  
.....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 256-428 1.7e-38 125.3 In-house 23-201 (383) alignment 
Range on Protein: 256-428
Range on HMM: 23-201/383.0
ITKTSKKKNfPFHSWEIQLICYHAREIFLNQPTLLRLQA----PIKVVGDVHGQFNDLLRILKLSGVPSDTN-YLFLGDYVDRGKNSLETILLLLCYKIK
. .. |.|.  .|.  . || . |.... . | . |...     . | ||.||...||| ||   |.||  | |.| ||.|||||.|.| .|.||.. . 
lieafkekk.llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllv

YKDNFFMLRGNHESANVTKMYGFYDECKRRL---SSKVWKMFVDVFNTLPLAAIIQDKIFCVHGGISpDLHDMKQIEKVAR
|  .... |||||   .   |||  | . .    ..|. ... |||  ||||..|..||. |||||| |  |.. ..|..|
ypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 267-320 3.9e-16 52.1 In-house 9-62 (317) alignment 
Range on Protein: 267-320
Range on HMM: 9-62/317.0
FHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPS
|.. |.  .|| |||.| ..|  |.|.||...|||.||||.||| .|.| | | 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_PPP7C_pd Subfamily PPP7C 437-530 5.5e-16 51.2 In-house 236-329 (383) alignment 
Range on Protein: 437-530
Range on HMM: 236-329/383.0
LVTDLLWSDPDPQVTDWSENDRGVSYTFSKRNVLDFCAKFKFDLILRGHMVVEDGYEFFARKKFVTIFSAPNYCGEFHNWGAVMSVTTGMMCSF
 | |.|||||  .   ...  ||    |      .. .|....|..| |    .||||   || .||||| ||  |  | || . ... ..  .
qvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpri
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 267-320 1.1e-12 40.7 In-house 11-64 (339) alignment 
Range on Protein: 267-320
Range on HMM: 11-64/339.0
FHSWEIQLICYHAREIFLNQPTLLRLQAPIKVVGDVHGQFNDLLRILKLSGVPS
| . |.  .|..|||.   .| .|.|.||| |.||.||||.||| .| . | | 
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_YNL217W_pd Subfamily YNL217W 296-416 1.7e-10 33.8 In-house 12-139 (235) alignment 
Range on Protein: 296-416
Range on HMM: 12-139/235.0
IKVVGDVHGQFNDLLRILK--LSGVPSDTNYLFLGDYVDRGKNSLETILLLlcykikYKDNFFMLRGNHESANVT-----KMYGFYDEC----K-RRLSS
. ||||||| ...|...|.    |   .   ...|| ...| .|.|.. ..       ||.   ..|||| . .      |.   ...     |   | |
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

KVWKMFVDVFNTLPLA-AIIQDKIFCVHGGISPD
|. |  ..    |. .  |  |... ||.|..| 
klskadmeyarelgfsldipsdellvvhaGlvpg