Gene ALP-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP002_AA protein Get Run
SpurP002_AA_21-490 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 22-490 1.3e-202 664.3 In-house 2-470 (472) alignment 
Range on Protein: 22-490
Range on HMM: 2-470/472.0
DAAFWNNQARDSIQKALERELNIGEAKNIIFFLGDGMSVPTVTAARIRQGQLKGETGEENILAWETFPHVGLIKTYNTDAQVPDSAGTATAFFSGIKTKS
.|.||...|......|||.. |  .|||.|.||||||.| ||||||| .||||||.|||. ||.|.||.|||.|||..|.||||||.||||...|.||..
sakfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

GVVGIDDRVEYADCESGLGGEVDSVLVNAHNIGKATGVISTARITHATPAATYAHVAKRDWEVDTEMIEDGEdGKGCKDIALQLI--EDNPFIKVILGGG
|..|.|..||. |||.  | ||||.| .|.. |||||...|.|.|||.||..|||||.|.|| |.|. ...|  .|||||| |||  | . ...||||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeae.kegckdiaqQLieeevgkeldvilGGG

RRMFYNNTELDPEDPSDrGNRTDGRNLIEEWQNGKTNARYVWNKEQFDAIDEDTTDYLFGLFEDSHMRYASESEEGNDPSLASMTEKAIKMLQKEEKGFF
|..|...|. |.|.... |.|.|||||||||.. |.||.||.|.......|...||.|.|||.|||..|. . .| ..|||. |||||...|.|.|.|||
rkkflpktvkdseyekk.gerkDgrnLieewekekknakyvenrkelenvdksktdrllGlfadshlkyeidrdekeePsLkemtekAlevLsknenGff

LAVEGGRIDHAHHAGNAYNALGDAIAMSDAVAMALEMTSDSDTLIVVTADHAHTMSIGGYPDRGNKILGLAG-YFGSDDLPFTTLGYLNGPGAEEVRQSY
| |||||||||||...|..|| .......||..|||.|...||||||||||.||..| |||.||..|||||     .|.||.||| | ||||.|. ....
LfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyeltesdl

SDtGMRPNLTEIDTEDKDYLQQAIVPLSSESHGGDDVAIYATGPMAHLFHGVQEQSYIAHVMRNAGCYDETD
.. | | .|||..||.|||..||.|||..|.|||.|||.||.||..||..||.|||.|||||..| |..|..
ee.gerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
0037220 Alkaline phosphatase-like 22-490 1.2e-157 515.5 In-house 8-472 (479) alignment 
Range on Protein: 22-490
Range on HMM: 8-472/479.0
DAAFWNNQARDSIQKALERELNIGEAKNIIFFLGDGMSVPTVTAARIRQGQLKGETGEENILAWETFPHVGLIKTYNTDAQVPDSAGTATAFFSGIKTKS
.. .....|   .  ||   || . |||.|.|.||||.|.||||||| .|||.|..|||..||...||.|||.|||..|..|.|||..|||...|.||  
llllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKtnn

GVVGIDDRVEYADCESGLGGEVDSVLVNAHNIGKATGVISTARITHATPAATYAHVAKRDWEVDTEMIEDGEDGKgCKDIALQLIeDNPFIKVILGGGRR
|..|.|  |.. .|.. || .|...|  |   |||||...|.|||||||||.||||| |.|| |...   | . . ||||| ||.  .  ..|||||||.
gaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleag.ckdiatqlv.lgsgldvilGGGrk

MFYNNTELDPEDPSD---RGNRTDGRNLIEEWQNGKTNARYVWNKEQFDAIDE-DTTDYLFGLFEDSHMRYASESEEGNDPSLASMTEKAIKMLQKEEKG
.|.....||||....   .| |.|||.|.||... |....||.|.|..||.|  ...|.|.|||.|||. |. . .  ..|||| |||||...|.| .||
yflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldrdaseePsLaemtekAldlLskndkG

FFLAVEGGRIDHAHHAGNAYNALGDAIAMSDAVAMALEMTSDSDTLIVVTADHAHTMSIGGYPDRGNKILGLAGYFGSDDLPFTTLGYLNGPGAEEVRQS
||| |||||||||.||..|. |||...|...||..|||...|.|||.|||||| |...|.||.|||| ||||....  |.||.||| | ||||   . . 
FfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgflllldl

ysdtgmRPNLTEIDTEDKDYLQQAIVPLSSESHGGDDVAIYATGPMAHLFHGVQEQSYIAHVMRNAGCYDETD
      |..|| ..| ....||.| |...|..|.|.||..||.||.|.||.||.|...||||...| ...  .
......rldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglglle
Alk_phosphatase Alkaline phosphatase 47-485 2.2e-146 478.6 Pfam-A 1-420 (421) alignment 
Range on Protein: 47-485
Range on HMM: 1-420/421.0
AKNIIFFLGDGMSVPTVTAARIRQGQLKGETGEENiLAWETFPHVGLIKTYNTDAQVPDSAGTATAFFSGIKTKSGVVGIDdrveyadcesGLGGEVDSV
|||.|...||||.|.||||||. ..| ||..|||  || ...|.||| |||..|.||.|||.||||. .|.||  |..|.|            | || ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LVNAHNIGKATGVISTARITHATPAATYAHVAKRDWEVDTEMiEDGEDGKGCKDIALQLIEDNPFIKVILGGGRRMFYNNTELDPedPSDRGNRTDGRNL
|  |.. ||.||...|.|.|||||||..||||.|.|| |...  .    .|.|||| |||. .  |.|.|||||. |..... |.   ..|| |.|||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnl

IEEWqnGKTNARYVWNKEQFDAIDEDT-TDYLFGLFEDSHMRYASESEEGNDPSLASMTEKAIKMLQKEEKGFFLAVEGGRIDHAHHAGNAYNALGDAIA
|||.   |. ..||...... .  |.  ...|.|||.|...... | .| ..|||. |||.|||.|.|.|||||| |||.|||||.|...|..||.....
ieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEvve

MSDAVAMALEMT-SDSDTLIVVTADHAHTMSIGGYPDRGNKILGLAGYFG-SDDLPFTTLGYLNGPGAEEVRqsysdtGMRPNLTEIDTEDKDYLQQAIV
. .||. |||.. ....||.||||||.|..|||||. ||..| |||     .|  ... . | ||.||.         |.|.|.|. .. .| | ... |
fdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrkrsav

PLSSESHGGDDVAIYATGPMAHLFHGVQEQSYIAHVMRNAGC
.|.|| |.|.|||..| ||.|.|..||||| .||.|. .| .
gltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaale
Alk_phosphatase Alkaline phosphatase 47-485 2.2e-146 478.6 In-house 1-420 (421) alignment 
Range on Protein: 47-485
Range on HMM: 1-420/421.0
AKNIIFFLGDGMSVPTVTAARIRQGQLKGETGEENiLAWETFPHVGLIKTYNTDAQVPDSAGTATAFFSGIKTKSGVVGIDdrveyadcesGLGGEVDSV
|||.|...||||.|.||||||. ..| ||..|||  || ...|.||| |||..|.||.|||.||||. .|.||  |..|.|            | || ||
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LVNAHNIGKATGVISTARITHATPAATYAHVAKRDWEVDTEMiEDGEDGKGCKDIALQLIEDNPFIKVILGGGRRMFYNNTELDPedPSDRGNRTDGRNL
|  |.. ||.||...|.|.|||||||..||||.|.|| |...  .    .|.|||| |||. .  |.|.|||||. |..... |.   ..|| |.|||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnl

IEEWqnGKTNARYVWNKEQFDAIDEDT-TDYLFGLFEDSHMRYASESEEGNDPSLASMTEKAIKMLQKEEKGFFLAVEGGRIDHAHHAGNAYNALGDAIA
|||.   |. ..||...... .  |.  ...|.|||.|...... | .| ..|||. |||.|||.|.|.|||||| |||.|||||.|...|..||.....
ieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgalsEvve

MSDAVAMALEMT-SDSDTLIVVTADHAHTMSIGGYPDRGNKILGLAGYFG-SDDLPFTTLGYLNGPGAEEVRqsysdtGMRPNLTEIDTEDKDYLQQAIV
. .||. |||.. ....||.||||||.|..|||||. ||..| |||     .|  ... . | ||.||.         |.|.|.|. .. .| | ... |
fdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrkrsav

PLSSESHGGDDVAIYATGPMAHLFHGVQEQSYIAHVMRNAGC
.|.|| |.|.|||..| ||.|.|..||||| .||.|. .| .
gltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaale
Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase 295-397 1.2e-06 17.6 Pfam-A 162-270 (365) alignment 
Range on Protein: 295-397
Range on HMM: 162-270/365.0
GNDPSLASMTEKAIKMLQKEEKGFFLAVEGGRIDHAHH-AGNAYNALGDAIAMSDAVAMALEMTSDSD-----TLIVVTADHAHTMSIGGYPDRGNKILG
 ..| .   .....|.| .||.  .|.|.   .|...|  |.    . ||..  | .   |  . |..     |.|....||  .  .  .  . |..|.
esepkvdtilsdvakrlleeerpdlllvylselDsvgHkfgpdspevedalrrvDraigeLlealdergllentniilvSDHGmadvlnkkvidlnellr

LAGYFGSDD
|.|..  |.
legllklde
Metalloenzyme Metalloenzyme superfamily 301-372 2.6e-06 17.2 Pfam-A 126-196 (252) alignment 
Range on Protein: 301-372
Range on HMM: 126-196/252.0
ASMTEKAIKMLQKEEKGfFLAVEGGRIDHAHHAGNaYNALGDAIAMSD-AVAMALEMTSDSDTLIVVTADHAH
. .|.|....|.|..   |. |    .| . |.|. ..|  .||   | .... |.  ...|.|...||||  
keitdkllealekgkyd.fvvvnlantDmvGHtgd.veakvkaieavDerlkelldavekeddlliitADHgn