Gene ALP-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP003_AA protein Get Run
SpurP003_AA_26-502 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 28-498 1.7e-193 634.3 In-house 3-469 (472) alignment 
Range on Protein: 28-498
Range on HMM: 3-469/472.0
AEFWNQEAQDSLKEAIRLTeRNVNTAKNIVLFLGDGMSIETLTAARILKGQLAGGLGEDAKLAVEDFPHFGLAKTYSTNKQVPDSAATATAYLCGVKTKT
|.||...||..||||..|. .| ..|||..|||||||...|.||||||||||.|.|||.|.||.|.||..||.||||..|||||||||||||||||||..
akfwlkkaqeelkealelq.snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

GVLGVDDRVERGDCVSSLGGEVKSILEMAQEAGKSVGFVTTTTLTHASPGALYAKVPDRKWQSDMDIPRGERNLGCVDMAQQFV---SNNNIQVALGGGR
|..|||..|||.|| .| | ||.||||.|..|||..|.||||..||||| .|||.|..|.|.||...|. ... ||.|.|||..   ......| |||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

MKFMSRINRDPEYPSMpGSRIDGRNLIQEWinnKPDQDRAHYVWNEADFNKIDPEQTDYLLGLFEYSLMKFDIRRdnDTGGEPSIAEMTDKAIRILSKNP
 ||... ..|.||... |.| ||||||.||   . ....|.||.|.......|...||.|||||. | .|..|.|  |. .|||..|||.||...||||.
kkflpktvkdseyekk.gerkDgrnLieew...ekekknakyvenrkelenvdksktdrllGlfadshlkyeidr..dekeePsLkemtekAlevLskne

NGFFLFVEGGRIDHGHHFGVANLALTETVAMDKAIDVALGLVDTEETLVMVTSDHAHTFKMAGYSARGNPILGKSD-GRSTDLGSYTTVGYMNGPGAIIS
||||||||||||||.|| . |. ||.||...|.|...|| |.|.|.||..||.||.||...|||. ||..||| ..  .|.|  .|||. |.||||.  .
nGffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelt

SLSYRLlGRRPPVTDANTGRPFYLPQAVVPTFLETHGGDDVAIFAIGPMSHLVHGVHEQNYVSHVMQRAACIGYY
. ...  |.|  .|.|.|... |. ||.||.  |||||.|||..| ||.|||..||.||....|||..|||.| .
esdlee.gerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclgea
0037220 Alkaline phosphatase-like 27-502 5.6e-152 496.9 In-house 8-475 (479) alignment 
Range on Protein: 27-502
Range on HMM: 8-475/479.0
DAEFWNQEAQDSLKEAIrLTERNVNTAKNIVLFLGDGMSIETLTAARILKGQLAGGLGEDAKLAVEDFPHFGLAKTYSTNKQVPDSAATATAYLCGVKTK
.. .... |.  | .|. |.  | ..|||..||.||||...|.|||||..||| |||||. .||...||. ||.||||....|.||||.|||...|||| 
llllllllalallllal.llllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKtn

TGVLGVDDRVERGDCVSSLGGEVKSILEMAQEAGKSVGFVTTTTLTHASPGALYAKVPDRKWQSDMDIPRGERNLGCVDMAQQFVSNNNIQVALGGGRMK
 |..|||  |.|..| ..|| .|..|||.|.||||..|.||||..|||.|.|.||.|..|.|..|....  . . || |.|.|.| .....| |||||  
ngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilGGGrky

FMSRINRDPEYPSM---PGSRIDGRNLIQEWINNKPDqdrAHYVWNEADFNKIDP-EQTDYLLGLFEYSLMKFDIRRdnDTGGEPSIAEMTDKAIRILSK
|..    ||||..    .| | |||.|..|. . |..   ..||.| ......|. ...|.|||||..| ..... |  |. .|||.||||.||...|||
flpkgtldpeydlelllggkrldgrdlleeakekkkg...ytyvtnreeldaldlgsnvdkllGlfadshlpyeldr..daseePsLaemtekAldlLsk

NPNGFFLFVEGGRIDHGHHFGVANLALTETVAMDKAIDVALGLVDTEETLVMVTSDHAHTFKMAGYSARGNPILGKSDGRSTDLGSYTTVGYMNGPGAII
|..||||.||||||||..| . | .||.|..|.|.|...|| ... ..|||.||.|| |.. . ||..||||||| ..|  .|  .|||. | ||||  .
ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgfll

SSLSYRLLgrrppvTDANTGRPFYLPQAVVPTFLETHGGDDVAIFAIGPMSHLVHGVHEQNYVSHVMQRAACIGYYADNC
.   .  |      | ..|  ...| .|.|..  ..|.|.||...|.||...|..||.|.... ||. .|...|..   .
lldlrldl......tllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglgllevll
Alk_phosphatase Alkaline phosphatase 53-495 2.4e-139 455.4 Pfam-A 1-421 (421) alignment 
Range on Protein: 53-495
Range on HMM: 1-421/421.0
AKNIVLFLGDGMSIETLTAARILKGQLAGGLGEDAkLAVEDFPHFGLAKTYSTNKQVPDSAATATAYLCGVKTKTGVLGVDdrvergdcvsSLGGEVKSI
|||..|..||||.  |.||||.||.| .| |||.. ||.. .|. ||.|||...|||.|||||||||.||||| .|..|||          . | ||||.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LEMAQEAGKSVGFVTTTTLTHASPGALYAKVPDRKWQSDMDIPRGERNLGCVDMAQQFVSNN-NIQVALGGGRMKFMSRINRDPeyPSMPGSRIDGRNLI
||.|..||||.| |||| .|||.| ||.|.| .|||..|.. .   .. |. |.|.| .... .|.| ||||| .|. . ..|.   .  | | ||||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

QEWinnkpDQDRAHYVWNEADFNKIDPEQ-TDYLLGLFEYSLMKFDIRRDNDTggEPSIAEMTDKAIRILSKNPNGFFLFVEGGRIDHGHHFGVANLALT
.|.      .  ..||.. ....|   |. ...|||||. . .|... ||...  |||..|||..||..||||..||||.|||.||||..| . |  ||.
eea.....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdeke..ePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgals

ETVAMDKAIDVALGLV-DTEETLVMVTSDHAHTFKMAGYSARGNPILGKSDGRS-TDLGSYTTVGYMNGPGAIISSlsyrllGRRPPVTDANTGRPFYLP
|.|..|.|.. || .    .||||.||.||.|.| ..||..||. | | .   . .|  ... . | ||.|| ..       | |. || .....  |  
EvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrk

QAVVPTFLETHGGDDVAIFAIGPMSHLVHGVHEQNYVSHVMQRAACI
.. |.   |.|.|.|||.|| ||...||.||.||... .|.. |...
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 53-495 2.4e-139 455.4 In-house 1-421 (421) alignment 
Range on Protein: 53-495
Range on HMM: 1-421/421.0
AKNIVLFLGDGMSIETLTAARILKGQLAGGLGEDAkLAVEDFPHFGLAKTYSTNKQVPDSAATATAYLCGVKTKTGVLGVDdrvergdcvsSLGGEVKSI
|||..|..||||.  |.||||.||.| .| |||.. ||.. .|. ||.|||...|||.|||||||||.||||| .|..|||          . | ||||.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LEMAQEAGKSVGFVTTTTLTHASPGALYAKVPDRKWQSDMDIPRGERNLGCVDMAQQFVSNN-NIQVALGGGRMKFMSRINRDPeyPSMPGSRIDGRNLI
||.|..||||.| |||| .|||.| ||.|.| .|||..|.. .   .. |. |.|.| .... .|.| ||||| .|. . ..|.   .  | | ||||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

QEWinnkpDQDRAHYVWNEADFNKIDPEQ-TDYLLGLFEYSLMKFDIRRDNDTggEPSIAEMTDKAIRILSKNPNGFFLFVEGGRIDHGHHFGVANLALT
.|.      .  ..||.. ....|   |. ...|||||. . .|... ||...  |||..|||..||..||||..||||.|||.||||..| . |  ||.
eea.....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdeke..ePsLkemtevAiklLsknekGFFLlVEGsrIDhaaHendavgals

ETVAMDKAIDVALGLV-DTEETLVMVTSDHAHTFKMAGYSARGNPILGKSDGRS-TDLGSYTTVGYMNGPGAIISSlsyrllGRRPPVTDANTGRPFYLP
|.|..|.|.. || .    .||||.||.||.|.| ..||..||. | | .   . .|  ... . | ||.|| ..       | |. || .....  |  
EvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrk

QAVVPTFLETHGGDDVAIFAIGPMSHLVHGVHEQNYVSHVMQRAACI
.. |.   |.|.|.|||.|| ||...||.||.||... .|.. |...
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Metalloenzyme Metalloenzyme superfamily 308-387 7.1e-06 15.7 Pfam-A 124-202 (252) alignment 
Range on Protein: 308-387
Range on HMM: 124-202/252.0
SIAEMTDKAIRILSKNPNGfFLFVEGGRIDHGHHFGVANLALTETVAMDKAIDVALGLVDTEETLVMVTSDHAHTFKMAG
| .|.|||... | |. .  |..|    .|   | | .. .     |.|...   |  |. |..|...|.||    .| .
sakeitdkllealekgkyd.fvvvnlantDmvGHtgdveakvkaieavDerlkelldavekeddlliitADHgnaeemkd