Gene ALP-4 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP004_AA protein Get Run
SpurP004_AA_37-454 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 40-342 6.8e-122 398.1 In-house 2-303 (472) alignment 
Range on Protein: 40-342
Range on HMM: 2-303/472.0
SPDFWNSQARSSIEQALGLEVNTKPAKNVIVFVGDGMDVSTVVSSRIRQGQQAGVEGVSNVLAWDAFPHGGLVKTYSTDAQAADSASTSTAIFGGVKTKD
|..||...|......|| |. |.| |||||.|.||||.|||| ..|| .||..|  | .. ||.. ||. ||.||||.|.|..|||.|.||...||||. 
sakfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

GVLGLDDDAKRGDCASATGNEVASNLHLAHAEGKATGFVTSDSVTGATVAALYAHSPERDWQSDADIPRK--QEECNDLAYQLI--MENDFINVILGGGR
|..|.|....|.||....|.|| | |. |...|||||.||. .|| |. |.||||...|.|.||...|..  .|.|.|.|.|||  .......|||||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

QEFLPTRVEDPEYYDVtGRREDGNNLIGQWqgEKEASSSHYVWNKEDFDNVEPTTTDYLLGLFEPGRMQYGADRaaDGAGEPSLAEMTEKAIKVLGRDED
..|||..|.|.||..  |.|.||.||| .|  ||| ....||.|.....||....||.|||||......| .||  | ..||||.||||||..|| ..|.
kkflpktvkdseyekk.gerkDgrnLieew..ekekknakyvenrkelenvdksktdrllGlfadshlkyeidr..dekeePsLkemtekAlevLsknen

GFFLVVE
||||.||
GffLfVE
0037220 Alkaline phosphatase-like 38-454 1.6e-109 357.0 In-house 6-469 (479) alignment 
Range on Protein: 38-454
Range on HMM: 6-469/479.0
GQSPDFWNSQARSSIEQALGLEVNTKPAKNVIVFVGDGMDVSTVVSSRIRQGQQAGVEGVSNVLAWDAFPHGGLVKTYSTDAQAADSASTSTAIFGGVKT
 ... ... .|   . .|| | .|.. |||||.|.||||.||||   || .||  |  |. ..||.| ||. |||||||.|.. .|||...||.. ||||
llllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKt

KDGVLGLDDDAKRGDCASATGNEVASNLHLAHAEGKATGFVTSDSVTGATVAALYAHSPERDWQSDADIPRKQ--EECNDLAYQLImENDFINVILGGGR
  |..|.| |..|..| . .||.|.. | || . |||||.||. ..| || ||.|||...|.|..|....  .  ..|.| |.||.  .. ..|||||||
nngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlv.lgsgldvilGGGr

QEFLPTRVEDPEYYDV---TGRREDGNNLIGQWQGEKEAssSHYVWNKEDFDNVEP-TTTDYLLGLFEPGRMQYGADRaaDGAGEPSLAEMTEKAIKVLG
. |||. . ||||...   .|.| || .|. ...  |.    .||.|.|..|.... ...|.|||||... ..|  ||  | ..|||||||||||...|.
kyflpkgtldpeydlelllggkrldgrdlleeakekkkg..ytyvtnreeldaldlgsnvdkllGlfadshlpyeldr..daseePsLaemtekAldlLs

RDEDGFFLVVEM----------------------------------------------------LSNFVCHVTIGIVDDQESADRLPYTTLTYLNGPGGV
....||||.||                                                     |.. . . .|  . ..  .| ||||||.| |||| .
kndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgllldglpyttllyangpgfl

NVQTNwanngnRRDYSGVDTESRTWQQDAIIPLEAETHGGADVPVYAQGPWSHMFAGVHEQNYIAHAVRHAACLD
 . ..      | |.. ..| .....| | .... ..|.| ||||||.||....| ||.|...|||....|..|.
llldl......rldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglg
Alk_phosphatase Alkaline phosphatase 65-342 1.4e-77 251.9 Pfam-A 1-262 (421) alignment 
Range on Protein: 65-342
Range on HMM: 1-262/421.0
AKNVIVFVGDGMDVSTVVSSRIRQGQQAGVEGVSNvLAWDAFPHGGLVKTYSTDAQAADSASTSTAIFGGVKTKDGVLGLDddakrgdcasATGNEVASN
|||||...|||| ||||   |. ..|..|  |    || |..|. || |||..|.| .|||.|.||   ||||  |..|.|           .|.|| | 
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LHLAHAEGKATGFVTSDSVTGATVAALYAHSPERDWQSDADI--PRKQEECNDLAYQLIMENDFINVILGGGRQEFLPTRVEDPeyYDVTGRREDGNNLI
|. |...||.|| ||  .|| || |||.||. .|.|..||.    .|.| ..|.|.||| ..  |.|.|||||.|||||  .|.  .. .| | || |||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

GQWqgekEASSSHYVWNKEDFDNVEPTT-TDYLLGLFEPGRMQYGADRaaDGAGEPSLAEMTEKAIKVLGRDEDGFFLVVE
 ..     . ...||...... ...    ...|||||..| ...  .|  | . ||||.||||.|||.| ..|.||||.||
eea....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkveler..dekeePsLkemtevAiklLsknekGFFLlVE
Alk_phosphatase Alkaline phosphatase 65-342 1.4e-77 251.9 In-house 1-262 (421) alignment 
Range on Protein: 65-342
Range on HMM: 1-262/421.0
AKNVIVFVGDGMDVSTVVSSRIRQGQQAGVEGVSNvLAWDAFPHGGLVKTYSTDAQAADSASTSTAIFGGVKTKDGVLGLDddakrgdcasATGNEVASN
|||||...|||| ||||   |. ..|..|  |    || |..|. || |||..|.| .|||.|.||   ||||  |..|.|           .|.|| | 
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LHLAHAEGKATGFVTSDSVTGATVAALYAHSPERDWQSDADI--PRKQEECNDLAYQLIMENDFINVILGGGRQEFLPTRVEDPeyYDVTGRREDGNNLI
|. |...||.|| ||  .|| || |||.||. .|.|..||.    .|.| ..|.|.||| ..  |.|.|||||.|||||  .|.  .. .| | || |||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

GQWqgekEASSSHYVWNKEDFDNVEPTT-TDYLLGLFEPGRMQYGADRaaDGAGEPSLAEMTEKAIKVLGRDEDGFFLVVE
 ..     . ...||...... ...    ...|||||..| ...  .|  | . ||||.||||.|||.| ..|.||||.||
eea....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkveler..dekeePsLkemtevAiklLsknekGFFLlVE
subfamily_AP_pd Subfamily AP 353-456 8.8e-34 107.6 In-house 367-469 (472) alignment 
Range on Protein: 353-456
Range on HMM: 367-469/472.0
IGIVDDQESADRLPYTTLTYLNGPGGVNVQTNWANnGNRRDYSGVDTESRTWQQDAIIPLEAETHGGADVPVYAQGPWSHMFAGVHEQNYIAHAVRHAAC
.|. ....|||.||||||.| |||| .. ...... |.|.|.. ..||.......|..|||.||||| || |||.||.||.. ||.||..|||....|||
lglakesksadelpyttlsyangpgyeltesdlee.gerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaac

LDAA
|..|
lgea
Alk_phosphatase Alkaline phosphatase 354-453 9.6e-20 61.4 Pfam-A 328-421 (421) alignment 
Range on Protein: 354-453
Range on HMM: 328-421/421.0
GIVDDQESADRLPYTTLTYLNGPGGVNVQtnwannGNRRDYSGVDTESRTWQQDAIIPLEAETHGGADVPVYAQGPWSHMFAGVHEQNYIAHAVRHAACL
|..  ... |. ... ..| ||.|    .      |.| . .  .. ...... . ..|. |.|.| ||.|.|.|| .....||.||..||. .  |..|
glaaakktkdgkakklilygngegakved......garenvtaeealekiyrkrsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 354-453 9.6e-20 61.4 In-house 328-421 (421) alignment 
Range on Protein: 354-453
Range on HMM: 328-421/421.0
GIVDDQESADRLPYTTLTYLNGPGGVNVQtnwannGNRRDYSGVDTESRTWQQDAIIPLEAETHGGADVPVYAQGPWSHMFAGVHEQNYIAHAVRHAACL
|..  ... |. ... ..| ||.|    .      |.| . .  .. ...... . ..|. |.|.| ||.|.|.|| .....||.||..||. .  |..|
glaaakktkdgkakklilygngegakved......garenvtaeealekiyrkrsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel