Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPP6C_pd | Subfamily PPP6C | 2-53 | 3.9e-31 | 101.2 | In-house | 73-124 (290) | alignment | ||
Range on Protein: 2-53
Range on HMM: 73-124/290.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
...|||||||||||||||||||||||.||||.|||||||||||||||||| |
vflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfyde
|
|||||||||
subfamily_PPP4C_pd | Subfamily PPP4C | 1-53 | 5.8e-26 | 84.4 | In-house | 73-125 (288) | alignment | ||
Range on Protein: 1-53
Range on HMM: 73-125/288.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. |||||||.||.||| ||.||...||||.|.|||||||||||||||| |
ylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfyde
|
|||||||||
subfamily_PPP2C_pd | Subfamily PPP2C | 1-53 | 7.7e-26 | 83.9 | In-house | 74-126 (290) | alignment | ||
Range on Protein: 1-53
Range on HMM: 74-126/290.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||||||.|| | | .|| ....||..|||||||||||||||||.|
ylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvygfyde
|
|||||||||
PPP_3 | 1-53 | 6.7e-25 | 80.6 | In-house | 59-111 (271) | alignment | |||
Range on Protein: 1-53
Range on HMM: 59-111/271.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.| ||.||||..|||... ||.|| |.|....|||||||||||..||||. |
YlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqinkvYgFkke
|
|||||||||
PPP_1 | 1-53 | 2.4e-24 | 79.0 | In-house | 58-110 (264) | alignment | |||
Range on Protein: 1-53
Range on HMM: 58-110/264.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.| ||.||||..|.|... ||.|| |.|... ||||||||||.|.||||. |
YlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvygFkkE
|
|||||||||
subfamily_PPG1_pd | Subfamily PPG1 | 1-53 | 4.9e-24 | 78.1 | In-house | 71-123 (300) | alignment | ||
Range on Protein: 1-53
Range on HMM: 71-123/300.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.||||.||.|| . |..|| ..| || ||||||||||||||||||.|
ylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyte
|
|||||||||
PPP_2 | 1-53 | 7.3e-23 | 74.3 | In-house | 29-81 (198) | alignment | |||
Range on Protein: 1-53
Range on HMM: 29-81/198.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.| ||.||||..|||... ||.|| ..|....||||||||.....||||. |
ylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkke
|
|||||||||
PP2Ac_SM00156 | 1-53 | 1.1e-22 | 73.4 | In-house | 58-110 (271) | alignment | |||
Range on Protein: 1-53
Range on HMM: 58-110/271.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
... ||.||||..|.|. . |..|| ..|...|||||||||......|||. |
yvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnkiygfeee
|
|||||||||
PPP_4 | 2-53 | 9.4e-22 | 71.0 | In-house | 32-83 (197) | alignment | |||
Range on Protein: 2-53
Range on HMM: 32-83/197.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
. ||.||||..|||... || || ..|...|||||||||......|||. |
vflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkke
|
|||||||||
0045823 | Metallo-dependent phosphatases | 2-53 | 2.4e-21 | 69.1 | In-house | 101-152 (473) | alignment | ||
Range on Protein: 2-53
Range on HMM: 101-152/473.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.. ||.||||..|||.. .|| || |.|....|||||||.|.....|||..|
vflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgde
|
|||||||||
subfamily_PPP1C_pd | Subfamily PPP1C | 1-53 | 5e-21 | 68.1 | In-house | 67-119 (282) | alignment | ||
Range on Protein: 1-53
Range on HMM: 67-119/282.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| |||| . ||..| |.|... |||||||| .|...|||| |
ylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGfyde
|
|||||||||
PPP_5_Dcr2 | 3-53 | 9.6e-21 | 67.7 | In-house | 33-83 (199) | alignment | |||
Range on Protein: 3-53
Range on HMM: 33-83/199.0
LQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
||.||||..|||... || || ..|....|||||||..|....|||. |
FlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftke
|
|||||||||
0049330 | Metallo-dependent phosphatases | 3-53 | 1.1e-20 | 67.2 | In-house | 89-139 (309) | alignment | ||
Range on Protein: 3-53
Range on HMM: 89-139/309.0
LQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
. ||.||||..|||....|| || ..||...|||||||.|.....|||..|
flGDlvdrGpdslevlllllalkllypdnvfllrGNHElrllnglygfgde
|
|||||||||
0053225 | Metallo-dependent phosphatases | 2-53 | 3.1e-20 | 66.0 | In-house | 80-131 (293) | alignment | ||
Range on Protein: 2-53
Range on HMM: 80-131/293.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.. ||.||||..|||....|| ||...||..||||||||.......|||..|
vflGDlvdrGpdslevlelllalkllypdnvvllrGNHElmllnglygfgde
|
|||||||||
subfamily_Cele-PPP-Subfam1_pd | Subfamily Cele-PPP-Subfam1 | 1-53 | 6.3e-20 | 64.6 | In-house | 103-155 (317) | alignment | ||
Range on Protein: 1-53
Range on HMM: 103-155/317.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .|.| . |..|| ..||...||||||||| . . |||| |
ylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyre
|
|||||||||
subfamily_Cele-PPP-Subfam4_pd | Subfamily Cele-PPP-Subfam4 | 1-53 | 1.8e-18 | 59.6 | In-house | 81-133 (298) | alignment | ||
Range on Protein: 1-53
Range on HMM: 81-133/298.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| ..||. . ||. |.|.|....||||||| .| .||||| |
ylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainrvyGfyee
|
|||||||||
subfamily_Cele-PPP-1A_pd | Subfamily Cele-PPP-1A | 1-53 | 2.3e-18 | 59.6 | In-house | 71-123 (284) | alignment | ||
Range on Protein: 1-53
Range on HMM: 71-123/284.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .|.| | |...| ..||...||||||||| . . |||| |
ylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyle
|
|||||||||
subfamily_PPP5C_pd | Subfamily PPP5C | 1-53 | 7.2e-18 | 57.7 | In-house | 96-148 (322) | alignment | ||
Range on Protein: 1-53
Range on HMM: 96-148/322.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||||||| .|.|. ||..| .|... | |||||| .. ..||| ||
ylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfege
|
|||||||||
subfamily_PPP3C_pd | Subfamily PPP3C | 1-51 | 2.4e-17 | 55.9 | In-house | 98-148 (452) | alignment | ||
Range on Protein: 1-51
Range on HMM: 98-148/452.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFY
.|. ||.|||||.|.|. |..|| ..|... |||||||.| .|. . |
ylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfk
|
|||||||||
subfamily_Cele-PPP-1B_pd | Subfamily Cele-PPP-1B | 1-53 | 4.5e-17 | 55.1 | In-house | 122-174 (339) | alignment | ||
Range on Protein: 1-53
Range on HMM: 122-174/339.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .|.| | .|| .|||| ||||||||| . |||| |
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyre
|
|||||||||
subfamily_PPZ_pd | Subfamily PPZ | 1-53 | 1.6e-16 | 53.7 | In-house | 82-134 (300) | alignment | ||
Range on Protein: 1-53
Range on HMM: 82-134/300.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| |||| || | |.|. ..||||||| ..|.||||| |
ylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvygfyde
|
|||||||||
subfamily_Cele-PPP-4D_pd | Subfamily Cele-PPP-4D | 1-53 | 1.8e-16 | 53.3 | In-house | 80-132 (297) | alignment | ||
Range on Protein: 1-53
Range on HMM: 80-132/297.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .|.|| ||. | ||| ..||||||| . .||||| |
ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyee
|
|||||||||
subfamily_Cele-PPP-Subfam2_pd | Subfamily Cele-PPP-Subfam2 | 2-53 | 2.1e-16 | 53.0 | In-house | 66-117 (281) | alignment | ||
Range on Protein: 2-53
Range on HMM: 66-117/281.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.. ||.|||| |||.. |.||| ...||||||||||| .. ..|||| |
vflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyve
|
|||||||||
subfamily_Cele-PPP-Subfam3_pd | Subfamily Cele-PPP-Subfam3 | 1-53 | 2.7e-16 | 52.3 | In-house | 67-119 (287) | alignment | ||
Range on Protein: 1-53
Range on HMM: 67-119/287.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| ||| |..|| ..| .. ||||||| ..| ..|||. |
ylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkee
|
|||||||||
subfamily_Cele-PPP-4B_pd | Subfamily Cele-PPP-4B | 1-53 | 2.8e-16 | 52.6 | In-house | 81-133 (299) | alignment | ||
Range on Protein: 1-53
Range on HMM: 81-133/299.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
||. ||.|||| ||. | || | |.|.|. .|||||| | .||||| |
flflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyee
|
|||||||||
Metallophos | Calcineurin-like phosphoesterase | 5-53 | 2.5e-15 | 50.3 | Pfam-A | 39-89 (200) | alignment | ||
Range on Protein: 5-53
Range on HMM: 39-89/200.0
GDFVDRGYYSLETFTRL--LTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
||.|||| .|.||. .| | || ..|....||||||||......|||. |
GDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflle
|
|||||||||
subfamily_Cele-PPP-4C_pd | Subfamily Cele-PPP-4C | 1-53 | 3.1e-15 | 49.0 | In-house | 63-115 (280) | alignment | ||
Range on Protein: 1-53
Range on HMM: 63-115/280.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| . || ||. |...|.....|||||| .| . |||. |
ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkde
|
|||||||||
subfamily_Cele-PPP-3B_pd | Subfamily Cele-PPP-3B | 1-53 | 3.5e-15 | 48.8 | In-house | 73-125 (290) | alignment | ||
Range on Protein: 1-53
Range on HMM: 73-125/290.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
||. ||.|||| ||| |. .| ... .. ||||||| |.. ..|||. |
flflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkee
|
|||||||||
subfamily_Cele-PPP-4A_pd | Subfamily Cele-PPP-4A | 1-53 | 2.8e-14 | 46.2 | In-house | 60-112 (284) | alignment | ||
Range on Protein: 1-53
Range on HMM: 60-112/284.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| . ||| |.. | ||.....|||||| | ..|||| |
ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyee
|
|||||||||
subfamily_Cele-PPP-2B_pd | Subfamily Cele-PPP-2B | 2-53 | 5.7e-14 | 45.2 | In-house | 64-115 (280) | alignment | ||
Range on Protein: 2-53
Range on HMM: 64-115/280.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.. ||.|||| .| . |. || .. ||| |||||||. . ..|||| |
mflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyve
|
|||||||||
subfamily_Cele-PPP-5_pd | Subfamily Cele-PPP-5 | 1-52 | 4e-13 | 42.2 | In-house | 74-125 (302) | alignment | ||
Range on Protein: 1-52
Range on HMM: 74-125/302.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYG
|.. ||.||||. |.| . ...|| .| . .|||||||.. | ||| .
fvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfre
|
|||||||||
subfamily_Cele-PPP-3A_pd | Subfamily Cele-PPP-3A | 1-53 | 4.1e-13 | 42.6 | In-house | 37-89 (263) | alignment | ||
Range on Protein: 1-53
Range on HMM: 37-89/263.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .||| |..|| .| .. ||||||| . | . |||. |
ylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhae
|
|||||||||
subfamily_Cele-PPP-Subfam5_pd | Subfamily Cele-PPP-Subfam5 | 1-52 | 4.6e-13 | 42.0 | In-house | 75-126 (302) | alignment | ||
Range on Protein: 1-52
Range on HMM: 75-126/302.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYG
|.. ||.||||. |.| . ...|| .| . .|||||||.. | ||| .
fvflGdyvdrGsksieciclvfalkvlyptnyillrgnhetkainfaygfre
|
|||||||||
subfamily_PPPLV_pd | Subfamily PPPLV | 1-53 | 8.1e-13 | 41.3 | In-house | 58-110 (290) | alignment | ||
Range on Protein: 1-53
Range on HMM: 58-110/290.0
FLLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.|. ||.|||| .|.| . ||.|| .| ...||||||| . ... . ..||
llflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykge
|
|||||||||
subfamily_Cele-PPP-2A_pd | Subfamily Cele-PPP-2A | 2-53 | 2.5e-12 | 39.6 | In-house | 78-129 (307) | alignment | ||
Range on Protein: 2-53
Range on HMM: 78-129/307.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFYGE
.. ||.|||| |||. |.| | .|. ||||||||| .. . |||| |
vftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyee
|
|||||||||
subfamily_PPP7C_pd | Subfamily PPP7C | 2-51 | 3.8e-11 | 35.3 | In-house | 96-145 (383) | alignment | ||
Range on Protein: 2-51
Range on HMM: 96-145/383.0
LLQGDFVDRGYYSLETFTRLLTLKAKFPDRIVLLRGNHESRQITQVYGFY
.. ||||||| |.| ||.| .| . | ||||| . |||
vfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfi
|