Gene PFKFB in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP168_AA protein Get Run
SpurP168_AA_271-484 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 273-468 7e-99 321.2 In-house 1-197 (198) alignment 
Range on Protein: 273-468
Range on HMM: 1-197/198.0
NIHIIPRTIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKG
|||. ||.|||.|||||..|..||||||..|.|||..|...|.......||..|.||||.||||.|||. ...  |||| |||||||.|||||||||.. 
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

HPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELER-QKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNI
.||||. |..||..||||.||||.|||.||||||.|||| |.|||.|.|| |.|.||||.|||. .||||||.|||||||||||||||.||...|..
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
6PF2K 6-phosphofructo-2-kinase 50-277 1.6e-89 289.1 Pfam-A 6-222 (223) alignment 
Range on Protein: 50-277
Range on HMM: 6-222/223.0
MPSLHKPHAVIVMVGLPARGKTYIAKKLARYLNWIGINTKVFNVGEYRRKAVSGEISHDFFRHDNAEAYKIRLQCAKEALEDMANWLD-EDGEVAVFDAT
...|.. . |||.|||||||||||.||| |||.|.|..|||||||.|||.||. . . .|||.||.|| |.| ..|..||.|....|  |.|.||.||||
vknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAt

NTTRDRRQTILEFLGERHiklikfllnvfiFLVFLCESVCDDPVTVQSIIREVKLNSPDYYDIDKERAIRDFLQRIEHYKETYQSLSDDHDRNLSYIKII
||||.||..||||. |..            . |.. ||||.|.  ... |.||||.|||| | ..| ||.|||.|.|.|...|..|.|..|..|||||.|
NttrerRklilefveenn............lkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvi

NVGDRFLVNKVSGHIQSRVVYYLMNIHII
.|| ...||.|.|..|||.||||.|||  
dvgkslvvnnvqgylqsrivyyllNihlk
0035570 Phosphoglycerate mutase-like 280-484 1.4e-59 193.4 In-house 1-205 (219) alignment 
Range on Protein: 280-484
Range on HMM: 1-205/219.0
TIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEFAL
..||.||||...| .||. ||..|.|||. ..| |||... ....  .|..| |.|..|||  |.. .|... | |.|.|...|||..||.. .|||.|.
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

RDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNIPAVDTHRPRPD
. .|...||.| |||..|.|||..|...|||...||||..|.||.|.||||.|. . .|...|..| ..|..|.. ..|.... |.||. .. ... .. 
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllell

ECNTN
 ....
llsll
0039931 Phosphoglycerate mutase-like 280-483 1.7e-59 193.0 In-house 1-204 (219) alignment 
Range on Protein: 280-483
Range on HMM: 1-204/219.0
TIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEFAL
..||.||||...| .||. ||..|.|||. ..| |||... ..|.   |..| |.|..|||  |.. .|... | |.|.|...|||.|||.. .|||.|.
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

RDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNIPAVDTHRPRPD
. .|...||.| |||..|.|||..|...||....||||..|.||.|.||||.|. . .|...|..| ..|..|.. ..|...... |. .  |..|... 
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllll

ECNT
 ...
tlel
0053607 Phosphoglycerate mutase-like 278-462 1.9e-53 173.0 In-house 1-185 (191) alignment 
Range on Protein: 278-462
Range on HMM: 1-185/191.0
PRTIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEF
....|| ||||...| .||. ||..|.|.|. . | |.|..  ..|.  .|..| |.|..|||  |.. .|... | |.|.|...|||.||... .|||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVE
|.. .|...||.| |||..|..||..|...|| ...||||..|.||.|.||||.|. . .||..|..| ..|..|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv
0036777 Phosphoglycerate mutase-like 278-469 4.1e-53 172.7 In-house 2-232 (247) alignment 
Range on Protein: 278-469
Range on HMM: 2-232/247.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....||.||||...|..||. |  |..|.|.|. . . |||......|.  .|..| |.|..|||  |    .   . ..... | |.| |...|||..|
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

IQKGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDE
|.. .|||.... .|...||.                         | |||..|.|||..|...|| ..     .||||..|.||.|.||||.|. . ..
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

LPYLKCPLHTVIKLTPVAYGCRVETVTLNIP
...|..| .....|.  ..| ..  ..|| .
ilrlnlpngsitvleldddgklwvleslndt
0037864 Phosphoglycerate mutase-like 272-463 1.5e-51 167.0 In-house 1-206 (211) alignment 
Range on Protein: 272-463
Range on HMM: 1-206/211.0
MNIHIIPRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCD
|.........||.||||...|..||. |  |..|.|.|. . | |||..  ..|.   |..| |.|..|||  |    .   . .|... | |.| |...
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

GLTYEEIQKGHPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAY
|||.|||.. .|||.. . .|....|.| |||..|.|||..|...|| ..     .||||..|.||.|.||||.|. . .||..|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCRVET
|.....
gwvlvs
0051064 Phosphoglycerate mutase-like 278-469 1.8e-51 167.7 In-house 3-233 (241) alignment 
Range on Protein: 278-469
Range on HMM: 3-233/241.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTAS----SID---VAIEQWKSLDELDAGVCDGLTYEE
....|| |||||..| .||. |  |..|.|.|. ..| |||... ....  .|..| |.|..|||      ..   . ..... | |.| |...|||.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQKGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDE
|.. .|||......|....|.                         | |||..|..||..|.. || ..     |||||..|.||.|.||||.|. . .|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLKCPLHTVIKLTPVAYGCRVETVTLNIP
|..|..| ..|..|.  ..|.||  |.|| .
llrlnlpngsvtvleldddgkrvvlvllndt
0043909 Phosphoglycerate mutase-like 278-461 9.2e-51 164.9 In-house 2-228 (249) alignment 
Range on Protein: 278-461
Range on HMM: 2-228/249.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....|| ||||...|..||. |  |..|.|.|.   | |||........  .|..| |||..|||  |    .   . .|... | |.| |...|||..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQKGHPEEFALRDQ-----------------------------DKFHYRYPMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDK
| . .|||.... .                             |....|.| |||..|.|||..|...|| ..     .|||...|.||.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

NSDELPYLKCPLHTVIKLTPVAYGCRV
. .....|..| .....|.. ..|. |
sledilrlnlpngsitvlelddggkpv
0049178 Phosphoglycerate mutase-like 278-463 1.4e-50 164.5 In-house 3-225 (243) alignment 
Range on Protein: 278-463
Range on HMM: 3-225/243.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....|| ||||...|. ||. |  |..|.|.|.   | |||......|.   |..| |||..|||  |    .   . ..... | |.| |...|||..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQKGHPEEFALRDQDKFHYRY-----------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDELP
|.. .|||.... .|....|.                       | |||..|..||..|...|| ..     |.|||..|.||.|.|||..|. . .||.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVIKLTPVAYGCRVET
.|..| ..|..|.   .|.....
rlnlpngsvtvlelddggwvlvs
0036887 Phosphoglycerate mutase-like 278-463 2.6e-49 159.8 In-house 1-194 (202) alignment 
Range on Protein: 278-463
Range on HMM: 1-194/202.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMStqNLQDLKVWTSRLKRTVQTASSI----DVAIEQWKSLDELDAGVCDGLTYEEIQK
....||.||||...|..||. |  |..|.|.|. . | |||...  .|.   |..| |.|..|||  |    .. ..... | |.| |...|||.|||..
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

GHPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQ---KNVLVICHQGVMRCLLAYFLDKNSDELPYLK-CPLHTVIKLTPVAYGCRVET
 .|||.| . .|....|.| |||..|.|||......|| ..   .||||..|.||.|.||||.|. . ..|..|. .| ..|..|.  ..|.....
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
0048955 Phosphoglycerate mutase-like 280-460 3.3e-49 160.2 In-house 2-221 (240) alignment 
Range on Protein: 280-460
Range on HMM: 2-221/240.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTAS----SID---VAIEQWKSLDELDAGVCDGLTYEEIQ
..|| |||||..| .||. |  |..|.|.|. ..| |||... ....  .|..| |.|..|||      ..   . ....  | |.| |...|||..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

KGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELE-----RQKNVLVICHQGVMRCLLAYFLDKNSDELP
. .|||..|. .|....|.                         | |||..|..||..... ||      ..|||||..|.||.|.||||.|. . .|..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YLKCPLHTVIKLTPVAYGCR
.|..| . |..|.   .. .
rlnipngsvtvlelddglvs
0050036 Phosphoglycerate mutase-like 280-452 7.4e-42 134.8 In-house 2-165 (171) alignment 
Range on Protein: 280-452
Range on HMM: 2-165/171.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMstqnlQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEef
..|| ||||...| .||. |  | .|.|.|. . | |||..     .   |..| |.|..|||  | . ..... | |.| |...|||..||.. .||  
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

alRDQDKFHYRYPMGESYQDLVARLEPVIMELErqKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKL
  ...|......| |||..|..||. |.. ||   .||||..|.||.|.|||..|. . .|...|..| ..|. |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 280-427 8e-38 122.8 Pfam-A 1-158 (158) alignment 
Range on Protein: 280-427
Range on HMM: 1-158/158.0
TIYLTRHGESMHNQNGRIGGDAN--LSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDV----AIEQWKSLDELDAGVCDGLTYEEIQKGH
..||.||||| .|..||. |. .  |.|.|.   |.||.... ..|.  .|.||.|||..||| ..       |.. . | |.|.|...||..||... .
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELE----RQKNVLVICHQGVMRCL
|||.. ...||...|.| |||..|...|..|...||     ...|||...|.||.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 280-427 8e-38 122.8 In-house 1-158 (158) alignment 
Range on Protein: 280-427
Range on HMM: 1-158/158.0
TIYLTRHGESMHNQNGRIGGDAN--LSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDV----AIEQWKSLDELDAGVCDGLTYEEIQKGH
..||.||||| .|..||. |. .  |.|.|.   |.||.... ..|.  .|.||.|||..||| ..       |.. . | |.|.|...||..||... .
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELE----RQKNVLVICHQGVMRCL
|||.. ...||...|.| |||..|...|..|...||     ...|||...|.||.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
AAA_33 AAA domain 59-168 9.3e-12 35.5 Pfam-A 1-98 (143) alignment 
Range on Protein: 59-168
Range on HMM: 1-98/143.0
VIVMVGLPARGKTYIAKKLARYLNWIGINTKVfnvgeyRRKAVSGeishdfFRHDNAEAYKIRLQCAKEALEDMANWLDEDGEVAVFDATNTTRDRRQTI
....||||. ||.. |..|.. | .. ... .       |... |        ... . |  .|. . ..|...| .  ..|  ...||||..|..|. .
lvllvGlpGsGKstlaerllkklgyvrlsqdt......lrrrlfg......tdqqsltdytrvlkrlyqilnklarkalsagrsvivdatnlsreerarf

LEFLGERHIK
.... . . .
vklakrlgvp
subfamily_TIGAR_pd Subfamily TIGAR 281-432 1.1e-11 36.8 In-house 3-174 (222) alignment 
Range on Protein: 281-432
Range on HMM: 3-174/222.0
IYLTRHGESMHNQNGRIGGD--ANLSERGWSYSRSLGEYMSTQNLQdlKVWTSRLKRTVQTASSI--------DVAIEQWKSLDELDAGVCDGLTYEEIQ
... ||||.. |... . |     |||.|     .... .| ....   . .| |.|. |||. |        . |.|. | | | . ||  | ...|..
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

KGHPEEFalrdqdKFHYR-YPMGESYQDLVARLEPVIMEL-----ERQ------------KNVLVICHQGVMRCLLAYFL
.    .       ...    . ||| . | .|| . . ||     ...             .|||..|. ..| ||....
ellkaag......nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlh
subfamily_PGAM_pd Subfamily PGAM 280-347 1.7e-11 35.9 In-house 2-71 (248) alignment 
Range on Protein: 280-347
Range on HMM: 2-71/248.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAI
.. | ||||| .|.. .. |  ||.|||.| .  . .|...  .||.  .|.||.|||..||.. |  ..
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileel
AAA_17 AAA domain 59-168 1.8e-10 32.3 Pfam-A 1-91 (121) alignment 
Range on Protein: 59-168
Range on HMM: 1-91/121.0
VIVMVGLPARGKTYIAKKLARYLNWIgintkVFNVGE-YRRKAVSgEISHDFFrhdnaEAYKIRLQCAKEALEDMANwlDEDGEVAVFDAtnttrdrrqt
||. .| |. ||...||.||..|...     |.. .. .|....  |. ....     |.. . ..  .. |...|.   .|... |.|           
viaitGppGsGKsTlakeLaerlglp.....vlslddllreeglk.elddger.....eskdadadllaaildglaa..kkdtlswvidg..........

ileflgE---------RHIK
                 ...
......aleveldlrleead
subfamily_TFC7_pd Subfamily TFC7 280-425 5.6e-08 23.6 In-house 2-171 (255) alignment 
Range on Protein: 280-425
Range on HMM: 2-171/255.0
TIYLTRHGE-------SMHNQNGR-IGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----------DVAIEQWKSLDELDaGVC
|||..|||          ...  . |  |. |||||   .. |..|... .|.   . .| |.| ..|. .|          |  . .|   |.    . 
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrP.vil

DGLTYEEIQKGHPEEFAlRDQDKFHYRYPMGESYQDLVARLE---PVIM-----ELERQKNVLVICHQGVMR
. ...|...| .|.    .| .      . ||. ..|  |..   || .     . . .. .|.. |   . 
ePasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatki
subfamily_STS_pd Subfamily STS 298-427 1.4e-07 23.2 In-house 50-193 (245) alignment 
Range on Protein: 298-427
Range on HMM: 50-193/245.0
GGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEqWKSLDELDAGVCDGLTYEEIQ-K--GHPE---EFALRDQDKF---HYR
  |  |.|||   .. ||.... ....   .. |   |..|||. |  ...  |   ... |... | ... . .   .||   .| .. . ..   .  
ksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsl

YPM--GESYQDLVARLEPVIMEL----ERQKNVLVICHQGVMRCL
...  .||...|..| . |. |.    ....|.|.. |   .  |
selkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal
0053031 Phosphoglycerate mutase-like 279-343 2.8e-07 23.3 In-house 5-87 (342) alignment 
Range on Protein: 279-343
Range on HMM: 5-87/342.0
RTIYLTRHG----ESMHNQNGRI-----GGDANLSERGWSYSRSLGEYMSTQ---------NLQDLKVWTSRLKRTVQTASSI
..|.|.|||    .|... . ..      |.  |...|.  .. ||... .          | ....|..|   ||.|.| ..
qvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaf
0049059 Phosphoglycerate mutase-like 279-343 1.1e-06 21.0 In-house 45-143 (435) alignment 
Range on Protein: 279-343
Range on HMM: 45-143/435.0
RTIYLTRHGE--------------------SMHNQNGR---------IGGDANLSERGWSYSRSLGEYMST-----QNLQDLKVWTSRLKRTVQTASSI
....|.|||.                    .... ||          . |.  |...|.   . ||...        | ....|..|   ||.|.| . 
qvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqaf
KTI12 Chromatin associated protein KTI12 59-114 5.4e-06 15.7 Pfam-A 3-51 (270) alignment 
Range on Protein: 59-114
Range on HMM: 3-51/270.0
VIVMVGLPARGKTYIAKKLARYLNWIGINTKVFNVGEYRrkavsgeISHDFFRHDN
 .|. |||. ||. .||.||..|.  |..  | .  ...       |..| ... .
LvvltGlPssGKstvakeLakaleeegrsvvvisdeslg.......iekdsykdsk
0047369 Phosphoglycerate mutase-like 280-342 7e-06 18.6 In-house 47-143 (438) alignment 
Range on Protein: 280-342
Range on HMM: 47-143/438.0
TIYLTRHGE----------------SMHNQNGRIGGD-------------ANLSERGWSYSRSLGEYMSTQ----NLQDL-KVWTSRLKRTVQTASS
...|.|||.                 . | .....|.               |...|.   . ||... .     | .|. .|..|   ||.|.| .
vqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqa
AAA_28 AAA domain 60-146 9.1e-06 12.1 Pfam-A 2-79 (163) alignment 
Range on Protein: 60-146
Range on HMM: 2-79/163.0
IVMVGLPARGKTYIAKKLARYlnwigiNTKVFnvGEYRRKAVSGEIshdFFRHDNAE----AYKIRLQCAKEALEDMANWldEDGEVAVFD
||..| |  ||| ....||..      ...|.   |. |. .. .    . ......    . ...... ...||. |.   ..... ..|
ivitGgpstGKTtlleaLaar......gypvv..pEvarevleekl...akgeealpweedllafaeavleaqleqeaaa..aaskllfcD
subfamily_PGAM_pd Subfamily PGAM 383-438 9.8e-06 17.0 In-house 141-200 (248) alignment 
Range on Protein: 383-438
Range on HMM: 141-200/248.0
DKFHYRYPMGESYQDLVARLEPVIME-----LERQKNVLVICHQGVMRCLLAYfLDKNSDE
.. . ..|  || ...|.||.||. |     ....|.||.. | ...|.|| . |.. |||
elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkv.legisde