Gene PFKFB in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP168_AA protein Get Run
SpurP168_AA_271-484 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PFKFB_pd Subfamily PFKFB 273-468 7e-99 321.2 In-house 1-197 (198) alignment
Range on Protein: 273-468
Range on HMM: 1-197/198.0
NIHIIPRTIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKG
|||. ||.|||.|||||..|..||||||..|.|||..|...|.......||..|.||||.||||.|||. ...  |||| |||||||.|||||||||.. 
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeikek

HPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELER-QKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNI
.||||. |..||..||||.||||.|||.||||||.|||| |.|||.|.|| |.|.||||.|||. .||||||.|||||||||||||||.||...|..
fpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv

6PF2K 6-phosphofructo-2-kinase 50-277 1.6e-89 289.1 Pfam-A 6-222 (223) alignment
Range on Protein: 50-277
Range on HMM: 6-222/223.0
MPSLHKPHAVIVMVGLPARGKTYIAKKLARYLNWIGINTKVFNVGEYRRKAVSGEISHDFFRHDNAEAYKIRLQCAKEALEDMANWLD-EDGEVAVFDAT
...|.. . |||.|||||||||||.||| |||.|.|..|||||||.|||.||. . . .|||.||.|| |.| ..|..||.|....|  |.|.||.||||
vknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAt

NTTRDRRQTILEFLGERHiklikfllnvfiFLVFLCESVCDDPVTVQSIIREVKLNSPDYYDIDKERAIRDFLQRIEHYKETYQSLSDDHDRNLSYIKII
||||.||..||||. |..            . |.. ||||.|.  ... |.||||.|||| | ..| ||.|||.|.|.|...|..|.|..|..|||||.|
NttrerRklilefveenn............lkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvi

NVGDRFLVNKVSGHIQSRVVYYLMNIHII
.|| ...||.|.|..|||.||||.|||  
dvgkslvvnnvqgylqsrivyyllNihlk

0035570 Phosphoglycerate mutase-like 280-484 1.4e-59 193.4 In-house 1-205 (219) alignment
Range on Protein: 280-484
Range on HMM: 1-205/219.0
TIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEFAL
..||.||||...| .||. ||..|.|||. ..| |||... ....  .|..| |.|..|||  |.. .|... | |.|.|...|||..||.. .|||.|.
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa

RDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNIPAVDTHRPRPD
. .|...||.| |||..|.|||..|...|||...||||..|.||.|.||||.|. . .|...|..| ..|..|.. ..|.... |.||. .. ... .. 
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndtshlelllell

ECNTN
 ....
llsll

0039931 Phosphoglycerate mutase-like 280-483 1.7e-59 193.0 In-house 1-204 (219) alignment
Range on Protein: 280-483
Range on HMM: 1-204/219.0
TIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEFAL
..||.||||...| .||. ||..|.|||. ..| |||... ..|.   |..| |.|..|||  |.. .|... | |.|.|...|||.|||.. .|||.|.
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa

RDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVETVTLNIPAVDTHRPRPD
. .|...||.| |||..|.|||..|...||....||||..|.||.|.||||.|. . .|...|..| ..|..|.. ..|...... |. .  |..|... 
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnltshlddllrllll

ECNT
 ...
tlel

0053607 Phosphoglycerate mutase-like 278-462 1.9e-53 173.0 In-house 1-185 (191) alignment
Range on Protein: 278-462
Range on HMM: 1-185/191.0
PRTIYLTRHGESMHNQNGRIGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEEF
....|| ||||...| .||. ||..|.|.|. . | |.|..  ..|.  .|..| |.|..|||  |.. .|... | |.|.|...|||.||... .|||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypeel

ALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAYGCRVE
|.. .|...||.| |||..|..||..|...|| ...||||..|.||.|.||||.|. . .||..|..| ..|..|..  .|....
aawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlv

0036777 Phosphoglycerate mutase-like 278-469 4.1e-53 172.7 In-house 2-232 (247) alignment
Range on Protein: 278-469
Range on HMM: 2-232/247.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....||.||||...|..||. |  |..|.|.|. . . |||......|.  .|..| |.|..|||  |    .   . ..... | |.| |...|||..|
mkrlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae

IQKGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDE
|.. .|||.... .|...||.                         | |||..|.|||..|...|| ..     .||||..|.||.|.||||.|. . ..
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled

LPYLKCPLHTVIKLTPVAYGCRVETVTLNIP
...|..| .....|.  ..| ..  ..|| .
ilrlnlpngsitvleldddgklwvleslndt

0037864 Phosphoglycerate mutase-like 272-463 1.5e-51 167.0 In-house 1-206 (211) alignment
Range on Protein: 272-463
Range on HMM: 1-206/211.0
MNIHIIPRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCD
|.........||.||||...|..||. |  |..|.|.|. . | |||..  ..|.   |..| |.|..|||  |    .   . .|... | |.| |...
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

GLTYEEIQKGHPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKLTPVAY
|||.|||.. .|||.. . .|....|.| |||..|.|||..|...|| ..     .||||..|.||.|.||||.|. . .||..|..| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCRVET
|.....
gwvlvs

0051064 Phosphoglycerate mutase-like 278-469 1.8e-51 167.7 In-house 3-233 (241) alignment
Range on Protein: 278-469
Range on HMM: 3-233/241.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTAS----SID---VAIEQWKSLDELDAGVCDGLTYEE
....|| |||||..| .||. |  |..|.|.|. ..| |||... ....  .|..| |.|..|||      ..   . ..... | |.| |...|||.||
mkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltlee

IQKGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDE
|.. .|||......|....|.                         | |||..|..||..|.. || ..     |||||..|.||.|.||||.|. . .|
iaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglplee

LPYLKCPLHTVIKLTPVAYGCRVETVTLNIP
|..|..| ..|..|.  ..|.||  |.|| .
llrlnlpngsvtvleldddgkrvvlvllndt

0043909 Phosphoglycerate mutase-like 278-461 9.2e-51 164.9 In-house 2-228 (249) alignment
Range on Protein: 278-461
Range on HMM: 2-228/249.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....|| ||||...|..||. |  |..|.|.|.   | |||........  .|..| |||..|||  |    .   . .|... | |.| |...|||..|
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkae

IQKGHPEEFALRDQ-----------------------------DKFHYRYPMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDK
| . .|||.... .                             |....|.| |||..|.|||..|...|| ..     .|||...|.||.|.||||.|. 
iaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgl

NSDELPYLKCPLHTVIKLTPVAYGCRV
. .....|..| .....|.. ..|. |
sledilrlnlpngsitvlelddggkpv

0049178 Phosphoglycerate mutase-like 278-463 1.4e-50 164.5 In-house 3-225 (243) alignment
Range on Protein: 278-463
Range on HMM: 3-225/243.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----D---VAIEQWKSLDELDAGVCDGLTYEE
....|| ||||...|. ||. |  |..|.|.|.   | |||......|.   |..| |||..|||  |    .   . ..... | |.| |...|||..|
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkae

IQKGHPEEFALRDQDKFHYRY-----------------------PMGESYQDLVARLEPVIMELERQ-----KNVLVICHQGVMRCLLAYFLDKNSDELP
|.. .|||.... .|....|.                       | |||..|..||..|...|| ..     |.|||..|.||.|.|||..|. . .||.
iaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleell

YLKCPLHTVIKLTPVAYGCRVET
.|..| ..|..|.   .|.....
rlnlpngsvtvlelddggwvlvs

0036887 Phosphoglycerate mutase-like 278-463 2.6e-49 159.8 In-house 1-194 (202) alignment
Range on Protein: 278-463
Range on HMM: 1-194/202.0
PRTIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMStqNLQDLKVWTSRLKRTVQTASSI----DVAIEQWKSLDELDAGVCDGLTYEEIQK
....||.||||...|..||. |  |..|.|.|. . | |||...  .|.   |..| |.|..|||  |    .. ..... | |.| |...|||.|||..
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiae

GHPEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELERQ---KNVLVICHQGVMRCLLAYFLDKNSDELPYLK-CPLHTVIKLTPVAYGCRVET
 .|||.| . .|....|.| |||..|.|||......|| ..   .||||..|.||.|.||||.|. . ..|..|. .| ..|..|.  ..|.....
kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl

0048955 Phosphoglycerate mutase-like 280-460 3.3e-49 160.2 In-house 2-221 (240) alignment
Range on Protein: 280-460
Range on HMM: 2-221/240.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTAS----SID---VAIEQWKSLDELDAGVCDGLTYEEIQ
..|| |||||..| .||. |  |..|.|.|. ..| |||... ....  .|..| |.|..|||      ..   . ....  | |.| |...|||..||.
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

KGHPEEFALRDQDKFHYRY-------------------------PMGESYQDLVARLEPVIMELE-----RQKNVLVICHQGVMRCLLAYFLDKNSDELP
. .|||..|. .|....|.                         | |||..|..||..... ||      ..|||||..|.||.|.||||.|. . .|..
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

YLKCPLHTVIKLTPVAYGCR
.|..| . |..|.   .. .
rlnipngsvtvlelddglvs

0050036 Phosphoglycerate mutase-like 280-452 7.4e-42 134.8 In-house 2-165 (171) alignment
Range on Protein: 280-452
Range on HMM: 2-165/171.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMstqnlQDLKVWTSRLKRTVQTASSIDVAIEQWKSLDELDAGVCDGLTYEEIQKGHPEef
..|| ||||...| .||. |  | .|.|.|. . | |||..     .   |..| |.|..|||  | . ..... | |.| |...|||..||.. .||  
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..

alRDQDKFHYRYPMGESYQDLVARLEPVIMELErqKNVLVICHQGVMRCLLAYFLDKNSDELPYLKCPLHTVIKL
  ...|......| |||..|..||. |.. ||   .||||..|.||.|.|||..|. . .|...|..| ..|. |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl

His_Phos_1 Histidine phosphatase superfamily (branch 1) 280-427 8e-38 122.8 Pfam-A 1-158 (158) alignment
Range on Protein: 280-427
Range on HMM: 1-158/158.0
TIYLTRHGESMHNQNGRIGGDAN--LSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDV----AIEQWKSLDELDAGVCDGLTYEEIQKGH
..||.||||| .|..||. |. .  |.|.|.   |.||.... ..|.  .|.||.|||..||| ..       |.. . | |.|.|...||..||... .
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELE----RQKNVLVICHQGVMRCL
|||.. ...||...|.| |||..|...|..|...||     ...|||...|.||.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

His_Phos_1 Histidine phosphatase superfamily (branch 1) 280-427 8e-38 122.8 In-house 1-158 (158) alignment
Range on Protein: 280-427
Range on HMM: 1-158/158.0
TIYLTRHGESMHNQNGRIGGDAN--LSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDV----AIEQWKSLDELDAGVCDGLTYEEIQKGH
..||.||||| .|..||. |. .  |.|.|.   |.||.... ..|.  .|.||.|||..||| ..       |.. . | |.|.|...||..||... .
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef

PEEFALRDQDKFHYRYPMGESYQDLVARLEPVIMELE----RQKNVLVICHQGVMRCL
|||.. ...||...|.| |||..|...|..|...||     ...|||...|.||.|.|
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral

AAA_33 AAA domain 59-168 9.3e-12 35.5 Pfam-A 1-98 (143) alignment
Range on Protein: 59-168
Range on HMM: 1-98/143.0
VIVMVGLPARGKTYIAKKLARYLNWIGINTKVfnvgeyRRKAVSGeishdfFRHDNAEAYKIRLQCAKEALEDMANWLDEDGEVAVFDATNTTRDRRQTI
....||||. ||.. |..|.. | .. ... .       |... |        ... . |  .|. . ..|...| .  ..|  ...||||..|..|. .
lvllvGlpGsGKstlaerllkklgyvrlsqdt......lrrrlfg......tdqqsltdytrvlkrlyqilnklarkalsagrsvivdatnlsreerarf

LEFLGERHIK
.... . . .
vklakrlgvp

subfamily_TIGAR_pd Subfamily TIGAR 281-432 1.1e-11 36.8 In-house 3-174 (222) alignment
Range on Protein: 281-432
Range on HMM: 3-174/222.0
IYLTRHGESMHNQNGRIGGD--ANLSERGWSYSRSLGEYMSTQNLQdlKVWTSRLKRTVQTASSI--------DVAIEQWKSLDELDAGVCDGLTYEEIQ
... ||||.. |... . |     |||.|     .... .| ....   . .| |.|. |||. |        . |.|. | | | . ||  | ...|..
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

KGHPEEFalrdqdKFHYR-YPMGESYQDLVARLEPVIMEL-----ERQ------------KNVLVICHQGVMRCLLAYFL
.    .       ...    . ||| . | .|| . . ||     ...             .|||..|. ..| ||....
ellkaag......nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlh

subfamily_PGAM_pd Subfamily PGAM 280-347 1.7e-11 35.9 In-house 2-71 (248) alignment
Range on Protein: 280-347
Range on HMM: 2-71/248.0
TIYLTRHGESMHNQNGRIGG--DANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAI
.. | ||||| .|.. .. |  ||.|||.| .  . .|...  .||.  .|.||.|||..||.. |  ..
klvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileel

AAA_17 AAA domain 59-168 1.8e-10 32.3 Pfam-A 1-91 (121) alignment
Range on Protein: 59-168
Range on HMM: 1-91/121.0
VIVMVGLPARGKTYIAKKLARYLNWIgintkVFNVGE-YRRKAVSgEISHDFFrhdnaEAYKIRLQCAKEALEDMANwlDEDGEVAVFDAtnttrdrrqt
||. .| |. ||...||.||..|...     |.. .. .|....  |. ....     |.. . ..  .. |...|.   .|... |.|           
viaitGppGsGKsTlakeLaerlglp.....vlslddllreeglk.elddger.....eskdadadllaaildglaa..kkdtlswvidg..........

ileflgE---------RHIK
                 ...
......aleveldlrleead

subfamily_TFC7_pd Subfamily TFC7 280-425 5.6e-08 23.6 In-house 2-171 (255) alignment
Range on Protein: 280-425
Range on HMM: 2-171/255.0
TIYLTRHGE-------SMHNQNGR-IGGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSI----------DVAIEQWKSLDELDaGVC
|||..|||          ...  . |  |. |||||   .. |..|... .|.   . .| |.| ..|. .|          |  . .|   |.    . 
tiyiarhGyrsnwlpkgpypdpltgidsdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeeleiPvyvdrGvgewykpdrrP.vil

DGLTYEEIQKGHPEEFAlRDQDKFHYRYPMGESYQDLVARLE---PVIM-----ELERQKNVLVICHQGVMR
. ...|...| .|.    .| .      . ||. ..|  |..   || .     . . .. .|.. |   . 
ePasnevlskffPsvis.ldyestltpsekgeteeelyertkkfwpvfidrvekkfknvetilivthaatki

subfamily_STS_pd Subfamily STS 298-427 1.4e-07 23.2 In-house 50-193 (245) alignment
Range on Protein: 298-427
Range on HMM: 50-193/245.0
GGDANLSERGWSYSRSLGEYMSTQNLQDLKVWTSRLKRTVQTASSIDVAIEqWKSLDELDAGVCDGLTYEEIQ-K--GHPE---EFALRDQDKF---HYR
  |  |.|||   .. ||.... ....   .. |   |..|||. |  ...  |   ... |... | ... . .   .||   .| .. . ..   .  
ksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvlsl

YPM--GESYQDLVARLEPVIMEL----ERQKNVLVICHQGVMRCL
...  .||...|..| . |. |.    ....|.|.. |   .  |
selkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal

0053031 Phosphoglycerate mutase-like 279-343 2.8e-07 23.3 In-house 5-87 (342) alignment
Range on Protein: 279-343
Range on HMM: 5-87/342.0
RTIYLTRHG----ESMHNQNGRI-----GGDANLSERGWSYSRSLGEYMSTQ---------NLQDLKVWTSRLKRTVQTASSI
..|.|.|||    .|... . ..      |.  |...|.  .. ||... .          | ....|..|   ||.|.| ..
qvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaf

0049059 Phosphoglycerate mutase-like 279-343 1.1e-06 21.0 In-house 45-143 (435) alignment
Range on Protein: 279-343
Range on HMM: 45-143/435.0
RTIYLTRHGE--------------------SMHNQNGR---------IGGDANLSERGWSYSRSLGEYMST-----QNLQDLKVWTSRLKRTVQTASSI
....|.|||.                    .... ||          . |.  |...|.   . ||...        | ....|..|   ||.|.| . 
qvqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqaf

KTI12 Chromatin associated protein KTI12 59-114 5.4e-06 15.7 Pfam-A 3-51 (270) alignment
Range on Protein: 59-114
Range on HMM: 3-51/270.0
VIVMVGLPARGKTYIAKKLARYLNWIGINTKVFNVGEYRrkavsgeISHDFFRHDN
 .|. |||. ||. .||.||..|.  |..  | .  ...       |..| ... .
LvvltGlPssGKstvakeLakaleeegrsvvvisdeslg.......iekdsykdsk

0047369 Phosphoglycerate mutase-like 280-342 7e-06 18.6 In-house 47-143 (438) alignment
Range on Protein: 280-342
Range on HMM: 47-143/438.0
TIYLTRHGE----------------SMHNQNGRIGGD-------------ANLSERGWSYSRSLGEYMSTQ----NLQDL-KVWTSRLKRTVQTASS
...|.|||.                 . | .....|.               |...|.   . ||... .     | .|. .|..|   ||.|.| .
vqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrYglLnpedvlyvrssdvdRtlqSAqa

AAA_28 AAA domain 60-146 9.1e-06 12.1 Pfam-A 2-79 (163) alignment
Range on Protein: 60-146
Range on HMM: 2-79/163.0
IVMVGLPARGKTYIAKKLARYlnwigiNTKVFnvGEYRRKAVSGEIshdFFRHDNAE----AYKIRLQCAKEALEDMANWldEDGEVAVFD
||..| |  ||| ....||..      ...|.   |. |. .. .    . ......    . ...... ...||. |.   ..... ..|
ivitGgpstGKTtlleaLaar......gypvv..pEvarevleekl...akgeealpweedllafaeavleaqleqeaaa..aaskllfcD

subfamily_PGAM_pd Subfamily PGAM 383-438 9.8e-06 17.0 In-house 141-200 (248) alignment
Range on Protein: 383-438
Range on HMM: 141-200/248.0
DKFHYRYPMGESYQDLVARLEPVIME-----LERQKNVLVICHQGVMRCLLAYfLDKNSDE
.. . ..|  || ...|.||.||. |     ....|.||.. | ...|.|| . |.. |||
elkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkv.legisde