Gene TIGAR-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily TIGAR
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP171_AA protein Get Run
SpurP171_AA_1-225 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_TIGAR_pd Subfamily TIGAR 4-226 4.1e-86 280.2 In-house 1-220 (222) alignment 
Range on Protein: 4-226
Range on HMM: 1-220/222.0
FILSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSNEKIDYVYTSDLLRATQTTDIILKSLRAPPCD-VIEEVGLRERNFGDKEGITISEYR
|||..|||||...|..|..||||..||||.|| ||....||||||||.|...||||||.||..||||.|..  .. |...  ||||..|..||....|.|
filivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

AFLLSEGfTFRSHVPKGGESFQVARQRVVKAFHDICNKQLELEKDAT-TSADGNLTHVLVVGHGLLFKELLAYFIEELNVeipgGKERVMKDSSNSSLSR
..| ..| ...|.||.||||......|.|.|....|.|.|.||.|.. ..|.|.|||||||.||| ..|||.....||.|    ||.|..|.|.|..||.
ellkaag.nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhvelsv....gklrlakgsrntdlst

FEIECAANVAPKITCQFIYDVSHLS
...|..............|...||.
lvveierdgkqsvqvaclylkehln
0049178 Phosphoglycerate mutase-like 2-177 2.3e-42 137.6 In-house 2-195 (243) alignment 
Range on Protein: 2-177
Range on HMM: 2-195/243.0
VKFILSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLS--NEKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITIS
 .  | ||||||. .|.....||.|.|||.| |. ||. | ..|.  . |.|.||.|.|.|| || .|||. |  | ..|. . .||||.||. ||.|..
mmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka

EYRAFLLSEGFTF----RSHVP-----------------------KGGESFQVARQRVVKAFHDICNKQLelekdattsadGNLTHVLVVGHGLLFKELL
| .|    | . .      ..|                        ||||..  ..||..|........|            .  .||||.||  .. ||
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell...........hdgktvlvVaHggvirall

AYFIE
|..  
alllg
0043909 Phosphoglycerate mutase-like 6-225 2.5e-42 137.4 In-house 5-240 (249) alignment 
Range on Protein: 6-225
Range on HMM: 5-240/249.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLS--NEKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISEYRA
| ||||||. .|.....||...|||.| |. ||. | ..|.  . ..|.||.|.|.|| ||  |||. |  . ..|. . .||||.||. ||.|..| ..
lyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaeiae

FLLSEGFTFRS---------------------------------HVPKGGESFQVARQRVVKAFHDICNKQLelekdattsadGNLTHVLVVGHGLLFKE
    | . ..                                  . | ||||..  ..||..|. ......|            .  .||.|.||   . 
kypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll...........kdggnvliVaHggvlra

LLAYFIeELNVEIPGGKervmkDSSNSSLSRFEIecAANVAPKITCQFIYDVSHL
||||.   |..| . .        .|.|....|.   ..  | ...... |.|||
llayll.glsledilrl.....nlpngsitvlel..ddggkpvvvlvllndtshl
0036777 Phosphoglycerate mutase-like 6-205 2.1e-41 134.5 In-house 5-218 (247) alignment 
Range on Protein: 6-205
Range on HMM: 5-218/247.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISEYRA
| ||||||. .|.....||....||.| |. ||. | ..|..   ..|.||.|.|||| || .|||. |  . ..|. . .||||..|. || |..| ..
lyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaeiae

FLLSEGFTFR----SHVP-------------------------KGGESFQVARQRVVKAFHDICNKQLelekdattsadGNLTHVLVVGHGLLFKELLAY
    | . ..     ..|                          ||||..  ..||..|........|            .  .||||.||   . ||||
kypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll...........kdgenvlvVsHggvlrallay

FIeELNVEIPGGKervmkDSSNSSLSRFEIE
.   |..|            .|.|....|..
ll.glsledilrl.....nlpngsitvleld
0037864 Phosphoglycerate mutase-like 5-176 6.9e-41 132.3 In-house 9-175 (211) alignment 
Range on Protein: 5-176
Range on HMM: 9-175/211.0
ILSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISEYR
 | ||||||. .|.....||....||.| |. ||. | ..| .   ..|.||.|.|||| || .|||. |  | ..|. . .||||.||. ||.|..| .
rlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltleeia

AFLLSEGFTFR----SHVPKGGESFQVARQRVVKAFHDICNKQLelekdattsadGNLTHVLVVGHGLLFKELLAYFI
..   | . .      ..| ||||..  ..||..|........|           ..  .||||.||   . ||||. 
ekypeelvawlrdpydfrppggEsladvvaRvlpaleellarll...........kdgenvlvVsHggvlrallayll
0051064 Phosphoglycerate mutase-like 5-181 1.6e-40 131.9 In-house 5-200 (241) alignment 
Range on Protein: 5-181
Range on HMM: 5-200/241.0
ILSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISEYR
 | ||||||| .| ....||.|..||.| |. ||. | .||..   |.|.||.|.|||| || .||.. |  | ..|. . .|||..||. || |..| .
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltleeia

AFLLSEGFTF----RSHVP-------------------------KGGESFQVARQRVVKAFHDICNKQLELEKDattsadgnlthVLVVGHGLLFKELLA
. .  | . .      . |                          ||||.. ...||..|........|  .|.           ||||.||   . |||
ekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgkn...........vlvVsHggviralla

YFIEeLNV
|..  |..
yllg.lpl
0048955 Phosphoglycerate mutase-like 6-177 5.1e-40 130.2 In-house 3-194 (240) alignment 
Range on Protein: 6-177
Range on HMM: 3-194/240.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISEYRA
| ||||||| .| ....||.|..||.| |. ||. | .||..   |.|.||.|.|||| || .||.. |  | ..|. . .||||.||. || |..|...
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

FLLSEGFTFRSHVP-----------------------------KGGESFQVARQRVVKAFHDICNKQLElekdattsaDGnlTHVLVVGHGLLFKELLAY
 .  | . .  . .                              ||||.. ...||..|........|.         .|   .||||.||   . ||||
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk.........pg..knvlvVsHggvirallay

FIE
.. 
llg
0036887 Phosphoglycerate mutase-like 6-177 1.1e-38 125.2 In-house 4-163 (202) alignment 
Range on Protein: 6-177
Range on HMM: 4-163/202.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSNEKIDYVYTSDLLRATQTTDIILKSLRappCDVIEEVGLRERNFGDKEGITISEYRAFL
| ||||||. .|.....||....||.| |. ||. | .||.. ..|.||.|.|||| || .||.. |    ..|| . .|||..||. ||.|..|.... 
lyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleeiaeky

LSEGFTF----RSHVPKGGESFQVARQRVVKAFHDICNKQlelekdattsadgNLTHVLVVGHGLLFKELLAYFIE
  | . .      . | ||||..  ..||..|........             .  .||||.||     ||||.  
peelaawlrdpydfrppggEsladvvaRvlaaleellarl.............dggnvlvVsHggvlrallayllg
0050036 Phosphoglycerate mutase-like 6-176 2e-38 123.7 In-house 3-145 (171) alignment 
Range on Protein: 6-176
Range on HMM: 3-145/171.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLsneKIDYVYTSDLLRATQTTDIILkslrappCDVIEEVGLRERNFGDKEGITISEYRAFL
| ||||||. .| ....||.|..||.| |. ||. | ..|   ..|.||.|.|||| || ..||       ..|| . .||||.||. ||.|..| .|  
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell...pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeiaaky

LSEGFTFRSHVPKGGESFQVARQRVVKAFHDICnkqlelekdattsadgnlTHVLVVGHGLLFKELLAYFI
    ...  ..| ||||..  ..||..|.....                   .||||.||   . |||...
pewlldlldlappggEsladvlaRvlpaleell..................gnvlvvaHggvirallalll
0039931 Phosphoglycerate mutase-like 7-178 6.5e-38 122.6 In-house 3-154 (219) alignment 
Range on Protein: 7-178
Range on HMM: 3-154/219.0
SLVRHGESKYNQQKLVQGqtNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIIlkslrapPCDVIEEVGLRERNFGDKEGITISEYRAF
 ||||||. .| ....||  .|||.| |. ||. | .||..   ..|.||.|.|||| || .||       ...|. . .|||..||| ||.|..|....
yLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeiaek

LLSEGFTF----RSHVPKGGESFQVARQRVVKAFHDICNkqlelekdattsadgnLTHVLVVGHGLLFKELLAYFIeE
   | . .      ..| ||||..  ..||..|......                  .||||.||   . ||||.   
ypeelaawlrdpydyrppggEsladvvaRvlpaleella................genvlvVsHggvirallayll.g
0035570 Phosphoglycerate mutase-like 7-177 3.9e-37 120.2 In-house 3-154 (219) alignment 
Range on Protein: 7-177
Range on HMM: 3-154/219.0
SLVRHGESKYNQQKLVQGqtNSPLSEDGVLQAESLSKRLSN--EKIDYVYTSDLLRATQTTDIIlkslrapPCDVIEEVGLRERNFGDKEGITISEYRAF
 ||||||. .| ....||  ..||.| |. ||. | ..|..   ..|.||.|.|||| || .||        ..|. . .|||..||| || |..|....
yLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeiaek

LLSEGFTFR----SHVPKGGESFQVARQRVVKAFHDIcnkqlelekdattsadGNLTHVLVVGHGLLFKELLAYFIE
   | . ..     ..| ||||..  ..||..|....                 .  .||||.||   . ||||.  
ypeelaawlrdpydyrppggEsladvvaRvlpaleel................edgenvlvVsHggvirallayllg
0053607 Phosphoglycerate mutase-like 6-176 5.5e-37 119.5 In-house 4-155 (191) alignment 
Range on Protein: 6-176
Range on HMM: 4-155/191.0
LSLVRHGESKYNQQKLVQGqtNSPLSEDGVLQAESLSKRLS--NEKIDYVYTSDLLRATQTTDIIlkslrapPCDVIEEVGLRERNFGDKEGITISEYRA
| ||||||. .| ....||  ..||.| |. ||. | ..|   . |.|.||.|.|||| || .||        ..|. . .|||..||| ||.|..|...
lyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleelae

FLLSEGFTFRSH----VPKGGESFQVARQRVVKAFHDICNkqlelekdattsadgnLTHVLVVGHGLLFKELLAYFI
 .  | . .. .    .| ||||..  ..||..|......                  .||||.||   . ||||. 
kypeelaawlrdpldyrppggEsladvaaRvlpaleella................ggnvlvVaHggvirallayll
His_Phos_1 Histidine phosphatase superfamily (branch 1) 7-167 2.3e-32 105.1 Pfam-A 3-154 (158) alignment 
Range on Protein: 7-167
Range on HMM: 3-154/158.0
SLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLS--NEKIDYVYTSDLLRATQTTDIILKSLRappCDVIEEVGLRERNFGDKEGITISEYRAF
 |||||||..|... .||....||.| |  ||..| |.|.  ...|| ||||.|.|| ||..|.|..|.   ...|.| .||||.||. || . .| .. 
ylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevkee

LLSEGFTFRS----HVPKGGESFQVARQRVVKAFHDICNkqlelekdattsADGNLTHVLVVGHGLL
.  |   ...      |..|||..  ..|| ... .. .            |. . . ||.|.||  
fpeeyekwkrdkkefrppegesladvyeRvapfleelie............akdkgenvlivsHggv
His_Phos_1 Histidine phosphatase superfamily (branch 1) 7-167 2.3e-32 105.1 In-house 3-154 (158) alignment 
Range on Protein: 7-167
Range on HMM: 3-154/158.0
SLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLS--NEKIDYVYTSDLLRATQTTDIILKSLRappCDVIEEVGLRERNFGDKEGITISEYRAF
 |||||||..|... .||....||.| |  ||..| |.|.  ...|| ||||.|.|| ||..|.|..|.   ...|.| .||||.||. || . .| .. 
ylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevkee

LLSEGFTFRS----HVPKGGESFQVARQRVVKAFHDICNkqlelekdattsADGNLTHVLVVGHGLL
.  |   ...      |..|||..  ..|| ... .. .            |. . . ||.|.||  
fpeeyekwkrdkkefrppegesladvyeRvapfleelie............akdkgenvlivsHggv
subfamily_PGAM_pd Subfamily PGAM 6-100 5.9e-21 66.9 In-house 3-99 (248) alignment 
Range on Protein: 6-100
Range on HMM: 3-99/248.0
LSLVRHGESKYNQQKLVQGQTNSPLSEDGVLQAESLSKRLSNEKI--DYVYTSDLLRATQTTDIILKSLRAPPCDVIEEVGLRERNFGDKEGITISE
| |.|||||..|...  .| .   ||| |. .|. ..| | ....  | ||||.| || ||...||..|      | ..  |.||..|. .|.  .|
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkae
subfamily_PFKFB_pd Subfamily PFKFB 6-184 1.8e-17 55.5 In-house 9-169 (198) alignment 
Range on Protein: 6-184
Range on HMM: 9-169/198.0
LSLVRHGESKYNQQKLVQGQTNspLSEDGVLQAESLSKRLSNEKID--YVYTSDLLRATQTTDIIlkslRAPPCDVIEevgLRERNFGDKEGITISEYRA
. |||||||..|... . |...  |.|.|| .|..|.| ...|...   |.|| | |..||....    ..|  .. .   |.|.. |. .|.| .| . 
iylvRhGeseknkkgriggdse..LterGveyakklakfikeenlkelrvwtselkrtiqTaell....glpkeqwka...LdeldaGkcdgltyeeike

F-----LLSEGFTFRSHVPkGGESFQVARQRVVKAFhdicnkqLELEKDATTsadgnlthVLVVGHGLLFKELLAYFIEELNVEIP
        ..   .|   | .|||..   ||. . .       ||||.   .        ||.. |    . ||||. ..   |.|
kfpeefkerkkdkyryryp.rgEsyedlvqRlepvi.......leLereqen........vliiaHqavlrvllaylldksaeelp
subfamily_PGAM5_pd Subfamily PGAM5 7-77 2.2e-09 28.7 In-house 5-72 (189) alignment 
Range on Protein: 7-77
Range on HMM: 5-72/189.0
SLVRHGEskYNQQKLVQGqtnSPLSEDGVLQAESLSKRLSNEKID--YVYTSDLLRATQTTDIILKSLRAPPC
 |||||.  |.... ..    . |.| |  ||| . ||| . ...   ...| . ||..|.|||.| |   | 
ilvrhgq..yvldddsdk...kiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpk
subfamily_STS_pd Subfamily STS 24-164 2.3e-09 29.0 In-house 49-186 (245) alignment 
Range on Protein: 24-164
Range on HMM: 49-186/245.0
GQTNSPLSEDGVLQAESLSKRL--SNEKIDYVYTSDLLRATQTTDIILKSLRaPPCDVIEEVGLRERNFGDKEG----ITISEYRAFLLSEGFTFRSHVP
 . ..||.| || ||. | ..|  .. ||.... |  ||  ||.  |||.|      .  | || |    |..     .. .|   | ..   .......
yksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlkldrkpipellspeelkkffpqidedYkpvls

KG----GESFQVARQRVVKAFHDICNKQlelekdattsadGNLTHVLVVGH
.     .|| .   .|. |... |..|              . ...|.|.|
lselkskeseeelyeRikkvvkeiiekv............pedgniliVah
0053031 Phosphoglycerate mutase-like 3-79 9.6e-08 24.9 In-house 4-97 (342) alignment 
Range on Protein: 3-79
Range on HMM: 4-97/342.0
KFILSLVRHG----ESKYNQQKLVQGQTN---SPLSEDGVLQAESLSKRLS-----------NEKIDYVYTSDLLRATQTTDIILKSLRaPPCDV
|..  |||||    .||..   | . ...   ..|.. |..||  | .||            | .. ||..||  |. |.   .|..|  ||.. 
kqvivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlf.ppegt
0046349 Phosphoglycerate mutase-like 3-77 2.4e-06 20.1 In-house 8-107 (409) alignment 
Range on Protein: 3-77
Range on HMM: 8-107/409.0
KFILSLVRHGE----------SKYNQQKLVQGQTN-SPLSEDGVLQAESLSKRL---------------SNEKIDYVYTSDLLRATQTTDIILKSLRaPP
|..  |.|||.           ... ..  .|... ..|.. |. ||  | |||                | .. ||..||  |. |.   .|. |  ||
kqvqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYvdlgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlf.pp

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