Gene PDP in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PDPc
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP182_AA protein Get Run
SpurP182_AA_34-433 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PDP_pd Subfamily PDP 36-434 4.6e-165 542.5 In-house 1-398 (398) alignment 
Range on Protein: 36-434
Range on HMM: 1-398/398.0
DSNQLFSNKPGEDRRAIAECMFTNGVLFGVFDGHGGTACAQAISERLFNYIVAETLPFQTLPKALARLQSGE-MNDLVKWHRHPNEYKLQATADLYKESL
||||| ||.| ||||..|... .|||||||||||||.|||.|.|.||..|..|..|. |.| .|...|.||. ...|.|...|..... .....|....|
dsnqLasNePiEDrrseakllesngvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslsel

IKYVQANLSVDVLdddDTADVLKTAFDRLDNDFSTEAMRATTEPLGIEPVLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGAWESIPLTVDHN
 ||.|..|...|    .....||.||..||.|.||||.....|   .| .|.|..|.||..|......|.|||.||||||||.... |.||...|. |..
skylqelleaeve...kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqt

VQNLDEVNRIKGGHPSHESTTVIKNGRLLGELMPLRAFGNIRFKWTAEMQRTLMRT-FIGYLPPKSFHTPPYLITTPEVTHHRLTSNDKFLILASDGLWD
..| .||.|||  ||..||.|||.||||||||.||||||..|.||..|.|...... ....|.||...|||||...||||.|.|..|||||.||.|||||
adneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwd

MLSSDKAVQLVGEHMKSMKASSSYGVQE-GAALKDVMKDLKERMDILKSLDTNSATHLIRYSLCGVGNDfDLNKLAEVLSLPDAIARQHRDDMTVTVIYF
.||....|.|||||....|......|.| ...||.|...||||.. ||..|.|.||||||..|.|.... | .|....||.|...||..|||.||||..|
llsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkredknaAthLirhalggneag.dkekvsallsiPeelaRmyRDDitvtVvff

DS
.|
ns
PP2Cc_SM00332 35-430 1.9e-67 220.5 In-house 14-274 (274) alignment 
Range on Protein: 35-430
Range on HMM: 14-274/274.0
YdSNQLFSNKPGEDRRAIAECMF--TNGVLFGVFDGHGGTACAQAISERLFNYIvAETLPFQTL-Pkalarlqsgemndlvkwhrhpneyklqatadlyk
. |..  ..|..||. ..  ...  ... .|||||||||...|. .|..|.... .|.| ...                                     
k.ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpeal.keelkkkkdel..................................

eslikyvqanlsvdvldDDDTADVLKTAFDRLDNDFSTEAMRATTEPlgiepvltAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGygaweSIPLTV
                 .||....||.|| ..|... .|. .   |         |  ||.|.||.....|||||||||.||||.|..      ...|.|
.................eddveealkkaflstdeeileeeqskelen........alsGstavvallkkedlyvanvGDSravlcrngk.....avqlsv

DHNVQNLDEVNRIKGGHPshesttVIKNGRLLGELMPLRAFGNIRFKWTAemqrtlmrtfigylppksFHTPPYLITTPEVTHHRLTSNDKFLILASDGL
||.... ||..|||  ..      |...||. | |.  ||||   .|.                     ...||.. .|.|....|||.|.|||||||||
dhkpedederkRikkagg......vvekgrvngglavsrafGdhflkknk..................klkepyitaepdvkvvtltsedeflilaSDGl

WDMLSSDKAVQLVGEHMKSMkasssygvqegaalkdvmkdlkermdilksldtnsaT-----------------Hliryslcgvgndfdlnklaevlslp
||.||....|..| ......                                                      .                         
wdvlsnqevvdivrkllakg....................................ktndpqeaaelldeeairr.........................

daiaRQHRDDMTVTVI
    ....|..|| |.
....ggseDniTvvvv
0034914 PP2C-like 43-433 2.3e-57 187.1 In-house 32-291 (295) alignment 
Range on Protein: 43-433
Range on HMM: 32-291/295.0
NKPGEDRRAIAECM---FTNGVLFGVFDGHGGTACAQAISERLFNYIVaetlpfqtlpkalarlqsgemN-----------Dlvkwhrhpneyklqatad
.|. ||.  .  ..   .....|||||||||| |.|. .||.|.....                     .           .                  
rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelll.....................ellekllllltls..................

lykeslikyvqanlsvdvldDDDTADVLKTAFDRLDNDFSTEAMRAtteplgiepVLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKgygawESIP
                    ..| ...|..|| ..|... ..|..             |. |..|.||.. .. ||||||||.|||| |..     | ..
....................ledieealrkaflaadeellelallr.........pelagsGtTavvalirgnklyvanvGDSravllrng.....elvq

LTVDHNVQNLDEVNRIKGGHPshesttVIKNGRLLGELMPLRAFGNIRFKWTaemqrtlmrtfigylpPKSFHTPPYLITTPEVTHHRLT-SNDKFLILA
|||||.. | .|. ||.  ..      .. .||..| |.  ||.|  ..|.                 .. ....|... .|.||...|| ..|.||.||
ltvdhkpvnelererilsagg......avshgrvngvlavtRalGdfdlkll................lslllleplvsaePdvtvleltledddfllLa

SDGLWDMLSSDKAVQLVGEHMKSMKAsssygvqegaalkdvmkdlkermdilkslDTNSATHLIRYSLCgvgndfdlnklaevlslpdaiaRQHRDDMTV
||||||.||.. .|..| ..... .                               .. |..|....|                       | .||..||
sDGlwdvlsneeivdivrsllakgld.............................leeaaeeLvdlAla......................rgsrDNiTv

TVIYFD
 |....
vvvrln
PPM_PTC7 148-354 1.4e-41 135.7 In-house 68-243 (259) alignment 
Range on Protein: 148-354
Range on HMM: 68-243/259.0
DDDDTADVLKTAFDR--LDNDFST-EAMratteplgiePvLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGawesIPLTVDHNVQNLDEVNRI
..... ..|...| .  .|. . . ||.            .    ||.| ||......||||||||.||||.||..       .||.||...| ||..||
eleklekalrksflaldtdeelkssean..........t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRi

KGGHPSHESTtviKNGRLLGELMPLRAFGNIRFKWTAEmqrtlmrtfigylppksfhTPPYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLV
.| . |...    .|||. | |   ||||  ..|                       ...... .|..... ....|.|||||||||||..|...||.||
egaggsvsnv...gngrvngvlavsRafGdfelkpket...................eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlv

GEHMKS---MKAS
 .....   |.|.
rselskkdpmeaa
PP2C Protein phosphatase 2C 148-352 1.9e-41 135.4 Pfam-A 68-233 (255) alignment 
Range on Protein: 148-352
Range on HMM: 68-233/255.0
DDDDTADVLKTAFDR-LDNDFSTeaM--RatteplgiePvLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGawesIPLTVDHNVQNLDEVNRI
....  ..|. .| . .|. . .  .  .           .    ||.| ||......||||||||.||||.|...        ||.|| ... ||..||
elekvekalrksfladtdeelks..skan.........t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRI

KGGHPSHESttvikNGRLLGELMPLRAFGNIRFKWTAemqrtlmrtfigylppksfhtPPYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLV
.. . |..      |||. | |   ||.|  ..|                        ... .  |.||...||..|.|||||||||||.||...||.||
eeaggsvsn.....ngrvngsLavsRalGdfelkpke.....................eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlv

GEHMKSMK
 ......|
rselskkk
PP2C Protein phosphatase 2C 148-352 1.9e-41 135.4 In-house 68-233 (255) alignment 
Range on Protein: 148-352
Range on HMM: 68-233/255.0
DDDDTADVLKTAFDR-LDNDFSTeaM--RatteplgiePvLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGawesIPLTVDHNVQNLDEVNRI
....  ..|. .| . .|. . .  .  .           .    ||.| ||......||||||||.||||.|...        ||.|| ... ||..||
elekvekalrksfladtdeelks..skan.........t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRI

KGGHPSHESttvikNGRLLGELMPLRAFGNIRFKWTAemqrtlmrtfigylppksfhtPPYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLV
.. . |..      |||. | |   ||.|  ..|                        ... .  |.||...||..|.|||||||||||.||...||.||
eeaggsvsn.....ngrvngsLavsRalGdfelkpke.....................eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlv

GEHMKSMK
 ......|
rselskkk
0049733 PP2C-like 43-433 6.7e-38 123.4 In-house 15-234 (235) alignment 
Range on Protein: 43-433
Range on HMM: 15-234/235.0
NKPGEDRRAIaecmftNGVLFGVFDGHGGTACAQAISERLFNYIVAETLPFQTLPkalarlqsgemndlvkwhrhpneyklqatadlykeslikyvqanl
.| .||. ..      ...||.|.||||| |...  ||.|....... |.. .|                                              
rkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllld.............................................

svdvlddddTADVLKTAFDRLDNDFSTEAMRATteplgiepvLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKgygawESIPLTVDHNVQNLDEVN
         ....|. || .... .  .|..             |. |..|.||.. .. ||||||||.||.| |..     . ..||.||.. | .|. 
.........leealrkaflaaneallelalasp.........elagmgtTavvalldggklyvanvGDsrayllrdg.....klvqltedhspvnelerq

RIKGGHPSHesttvikngRLLGELMPLRAFGNIRFKwtaemqrtlmrtfigylppksfhtppylittPEVTHHRLTSNDkFLILASDGLWDMLSSDKAVQ
||.  ..           | .| |. .||.|.  .|                               |.||...|...| ||.||||||||.||.. .|.
riitaggav.........rvpgrlaltralGdlllk...............................pdvtvlelepgd.flllasDGlwdvlsdeeivd

LVGEhmKSMkasssygvqegaalkdvmkdlkermdilksldT-----------NsathliryslcgvgndfdlnklaevlslpdaiaRQHRDDMTVTVIY
|. .  ...                                            .                                 |  ||..|| |..
llrs..ldl................................eeaaerlvelala.................................rggrDNiTvvvvr

FD
.|
ld
subfamily_PPM1A_pd Subfamily PPM1A 47-433 2.9e-34 111.7 In-house 27-281 (282) alignment 
Range on Protein: 47-433
Range on HMM: 27-281/282.0
EDRRAIAECM--FTNGVLFGVFDGHGGTACAQAISERLFNYIVAetlpfqtlpkalarlqsgemndlvkwhrhpneyklqatadlyK----Eslikyvqa
||. ... ..   ... .| |||||.|. .|.  .. | . |.                                           .    |        
EDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile..........................................eeelke........

nLSVDVLDDDDTADVLKTAFDRLDNDFSTEAMRATTEpL-GiepvltavtGSCACVAYVNDQDLYVANVGDCRAVLGRSKgygawESIPLTVDHNVQNLD
  . .  ..|.. ..|...| .||.. ...  ...|. .           || | .. |... |..||.||.|||| | .     ... || ||  .. .
.aaleasekdevkealrqgfLaldeairelstdlkta.dks.........GsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrpk

EVNRIKGG--HPShesttvikNGRLLGELMPLRAFGNIRFKWTAEMQRTLMrtfigylppksfhtppYLITTPEVTHHRLTSNDKFLILASDGLWDMLSS
| .||.    .          ..|. | |   ||.|   .| . |.. . .                 ... ||||  . ...|.||.||.||.||.||.
EkkRieqAGGsvv........vsRvnGaLAvsRalGDyeykeeeekkaeeq................lvsaepevtsierseeddflvlacDGiwDvlsd

DKAVQLVGEHMKSMKASSSYgvqegaalkdvmkdlkermdilksldtnsathliryslcgvgndfdlnklAEVLsLPDAIARQHRDDMTVTVIYFD
...|.|| ....  .  ..                                                   |. | .  |. .  || ..| |. |.
eevvelvrkrlevadeleev..................................................akal.vdkalekgsrDNlsvlvvlfa
subfamily_PPM1G2_pd Subfamily PPM1G2 60-352 1.1e-31 102.8 In-house 52-251 (287) alignment 
Range on Protein: 60-352
Range on HMM: 52-251/287.0
GVLFGVFDGHGGTACAQAISERLFNYIVAetlpfqtlpkalarlqsgemndlvkwhrhpneyklqatadlykeslikyvqanlsVDVLDDDDTADVLKTA
 .||.|||||||...|.  ...| ..|..                                                        . ....    .|| |
lalfavfDGhGGakvakyagkklikkiak.......................................................kksfkegaleqilkda

FDRLDNDFSTEamratteplgiEPVLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGygaweSIPLTVDHNVQNLDEVNRIKgghpshESTTVIKN
| ..|...  .           | .   ..|| | |. .....|||||.|| ||||  .       .  |..||  |. .| .||.      ..  ... 
fletDeellkd...........eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkrii......aagGfvel

GRLLGELMPLRAFGNIRFKWTAEmqrtlmrtfigylppksfHTP--PYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMK
.|  |.|   ||.|.  || . .                   .|      ..|.|. ..|...| ||.|| ||.||.|.... |.|| |...| .
nrvngnLalsralgDfefkknvk..................kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsga
PPM_PTC7_SpoIIE 60-351 5.4e-25 81.5 In-house 34-212 (230) alignment 
Range on Protein: 60-351
Range on HMM: 34-212/230.0
GVLFGVFDGHGGTAcaqAISERLFNYIVAETLpFQTLPkalarlqsgemndlvkwhrhpneyklqatadlykeslikyvqanlsvdvldddDTADVLKTA
....|..||||| |   |   .|.. ...|   |..|.                                                     . ...|. .
alvvgdvdGhGgra...alamgllrtalrela.fagle.....................................................kpeeilrrl

FDRLDNDFSTEamratteplgiepvlTAVTGSCACVAYVNDQD--LYVANVGDCRAVLGRSKGYgawesipltvdhnvqnldevnrikgghpshES----
...|. |. .|                .. |..|.||... ..  |||||.||....| |..|                               |     
nlalaadlede...............psssgaTavvalidpstgklyvanaGdsppllvrddgg..............................ereriv

-----------TtvikngrllgelmplrafgniRFKWTAEMQRTLMRTFIGYlppksfhTPPYLITTPEvTHHRLT-SNDKFLILASDGLWDMLSSDKAV
           .                     |  .......    ... |       |  .    |. | . .. ..|.|||||||||||.||.. .|
agglpslGilpg.....................rvfgvlavslapGdlllly.......tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelv

QLVGEHMKSM
.|| ..... 
dlvrdelekp
subfamily_PPM1G_pd Subfamily PPM1G 189-354 9.4e-24 77.2 In-house 296-435 (473) alignment 
Range on Protein: 189-354
Range on HMM: 296-435/473.0
TGSCACVAYVNDQDLYVANVGDCRAVLGRSkgygaWESIPLTVDHNVQNLDEVNRIKgghpsHESTTVIKNGRLLGELMPLRAFGNIRFKWTAEMQRTLM
 |. |.|| .....|.|||.||.|.|| |.      . . | .||  ..  | .||.     .   .| ..||. | |   ||.|.  .| ..|..    
sGttAvvaLlkekklivAnaGDsRcvlsrn.....GkAldlslDHkPeDevEleRie.....kAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeq

RtfigylppksfhtppyLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKAS
                 .   |..  . ||..|.||.||.||.|....|.. |. | ...|  . |
m................isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees
subfamily_TAB1_pd Subfamily TAB1 189-432 3.8e-18 58.4 In-house 129-331 (333) alignment 
Range on Protein: 189-432
Range on HMM: 129-331/333.0
TGSCACVAYVNDQDLYVANVGDCRAVLGRSKGygAWESIPLTVDHNVQNLDEVNRIKGGHpsHESTTvIKNGRLLGELMPLRAFGNIRFKWTAEMQRTLm
 |. | || .  ..|||||||| ||.| ..|     .   | |||...| ||. |.|.     .  . ||. ..||. .. |. |. . |   .    | 
gGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLG..ldieq.ikrnkrlgskentRsiGdykvkkgykdvdil.

rtfigylppKSFHTPPyLITTPEVTHH-RLTSNDKFLILASDGLWDMLSSDKAVQlvGEHMKSMKASSSYGVQEGAALKDVMKDLKERMDILKSLDTNSA
         .| . .|  |..|...    ..   .||.| |||.   |   .  .     .... .  .  ... | |.|| ... ... .  .    | 
.........ssakgeP.viaePdiqgaypiddityflvlmSdGvyktLeevtgpe..tsnvenillevitelekqatlqdvAqavvdkvkrkHkdaylss

ThliryslcgvgndfdlnklaevlsLPDAIARQHRDDMTVTVIYF
                            |   ..|||||. |. |
a........................seravicrkrddmtllvlkf
subfamily_PPM1L_pd Subfamily PPM1L 58-246 2.5e-15 49.5 In-house 33-159 (269) alignment 
Range on Protein: 58-246
Range on HMM: 33-159/269.0
TNGVLFGVFDGHGGTACAQAISERLFNYIVAETLPFqtlpkalarlqsgemndlvkwhrhpneyklqatadlykeslikyvqanlsvdvldDDDTADVLK
|.  .|.|||||||   |. . ..| . | .. . .                                                       | |  . . 
tgesffavfdGhGGefaaefakdvlvkaiknkliel.......................................................dadkentep

TAFDRLdndFSTEAMRATTEPLGIEPVLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGygawESIPLTVDHNVQNLDEVNRIKG
 .|..|   .  | . . .. |    . . ..|. | .| |...|| |||||| | ||   .|    ..|||. ||  |.. |  ||| 
infskl...ltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkrG....kaiplsfdhkpqqvkerkrikk
subfamily_ILKAP_pd Subfamily ILKAP 149-279 3.2e-15 49.0 In-house 82-198 (293) alignment 
Range on Protein: 149-279
Range on HMM: 82-198/293.0
DDDTADVLKTAFDRLDNDFSTEAMRATteplgiePVLTavTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGA-WESIPLTVDHNVQNLDEVNRIKgg
. .    |  .| . |..| ..| .|.       ||     || | |  | |. |||||.|| .||| | |  |    |..||.||.  ...| .||.  
ekeikkclvdsfkktdeefLklaskak.......PvWk..dGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriq..

hpshESTTVIKNGRLLGELMPLRAFGNIRFKW
     . .|...||.|| |   |. |. ||| 
....kaGgvvrdgrvlGvlevsrsiGdgrfkr
subfamily_PPM1H_pd Subfamily PPM1H 52-233 1e-12 40.5 In-house 54-201 (404) alignment 
Range on Protein: 52-233
Range on HMM: 54-201/404.0
IAECMFTNGVLFGVFDGHGGTACAQAISERLfNYIVAETLpfQTLPKALARLQSgemndlvkwH--------RhpneyklqatadlyKESLIKYVQANLS
 .|  . . ..||.||||.|.. | . |. | . .. | |  . . . |.. ..         .        .              |||  .  .    
kseeeklplayfglfDGhaGsgaalvaskll.hkhlkekl..edvlellleksa.........eeeenteess..............kespssvseiyee

VDVLDDDDTADVLKTAFDRLDNDFSTEAMRATTEplgiepvltavTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYgawesIPLTVDH
 ..  ..     | .|| ..|.  . |  . ...            | .|.|| | .. ||||| ||.||.| |..       |||  |.
keiskeeLviGalesaflemDeqiarereayrik...........GGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadf
subfamily_PPM1K_pd Subfamily PPM1K 148-278 4e-12 38.8 In-house 63-182 (263) alignment 
Range on Protein: 148-278
Range on HMM: 63-182/263.0
DDDDTADVLKTAFDRLDNDFSTEAMRATTEPlgiepvLTAVTGSCACVAYVND-QDLYVANVGDCRAVLGRSkGygawESIPLTVDHNVQNLDEVNRIKG
 ..|   ||| ||. ||....  .    .|        .  .|. | |. . | ..| .|..|| ||.| |  |    ..  || ||. .  .| .||| 
kekdleivlknafeeldkklkrylefsvaea......ellssGttatvsllrdGtelvlaslGdsrailcrn.G....kakkltrdhdPeleeekerika

GHPSHESTTViKNGRLLGELMPLRAFGNIRFK
   | |....  . .. | |   |..|.. .|
agGsvewnsl.gkplvngrlamtrslGdldlk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 190-246 4e-12 39.3 In-house 86-143 (292) alignment 
Range on Protein: 190-246
Range on HMM: 86-143/292.0
GSCACVAYVNDQ-DLYVANVGDCRAVLGRSKGYGAWESIPLTVDHNVQNLDEVNRIKG
....  | |.|.  |..||||| ||.|||  |    | |||. ||  .. || .||. 
ttavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilr
subfamily_PPM1D_pd Subfamily PPM1D 127-246 2.4e-11 36.3 In-house 50-166 (309) alignment 
Range on Protein: 127-246
Range on HMM: 50-166/309.0
ADLYKESLIKYVQANLSVDVLDDDDTADVLKTAFDRLDNDFSTEAMRATTEPLGiepvLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKG-YGAWE
|   .| |..... .  .   ...|  . .. ||  . .    .    . .  |    | . .|. | |  . ...||||.||| ..||| ..     ..
akfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg....llstaGttasvviirreklyvahvGDsaivlgvkepkekklr

SIPLTVDHNVQNLDEVNRIKG
. .||.||  ....|..||. 
akeltkdHkPespeekeriee
subfamily_PPM1E_pd Subfamily PPM1E 303-354 1.7e-10 33.5 In-house 183-234 (265) alignment 
Range on Protein: 303-354
Range on HMM: 183-234/265.0
PPYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKAS
 ||... ..|.. .|......||||.|||||..  ...|.|| |.... . .
kpyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaed
subfamily_ILKAP_pd Subfamily ILKAP 306-356 1.8e-10 33.4 In-house 201-251 (293) alignment 
Range on Protein: 306-356
Range on HMM: 201-251/293.0
LITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKASSS
.|.||.|.. .|| ||.|..|| ||||. .| |..|. . . ... . ...
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrk
subfamily_PPM1D_pd Subfamily PPM1D 309-356 2.3e-10 33.0 In-house 225-273 (309) alignment 
Range on Protein: 309-356
Range on HMM: 225-273/309.0
TPEVTHHRLTSNDK-FLILASDGLWDMLSSDKAVQLVGEHMKSMKASSS
 |.|....|. |.. |.||||||||..|....||..| .. .  .  ..
ePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkee
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 303-354 4e-10 32.4 In-house 178-230 (255) alignment 
Range on Protein: 303-354
Range on HMM: 178-230/255.0
PPYLITTPEVT-HHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKAS
 |.... |...   . . .||||||| ||.||..| ..||..| .  .. ||.
ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpekaa
PPM_PTC7_motif 325-352 1.2e-09 31.5 In-house 1-33 (51) alignment 
Range on Protein: 325-352
Range on HMM: 1-33/51.0
ILASDGLWDMLSSDKAVQLVGEHMKS-----MK
|||||||||.||...||.|| .....     ..
iLAsDGLWDvlsdqeavdlvrdqlskkglspqe
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 183-275 3e-09 29.5 In-house 92-175 (255) alignment 
Range on Protein: 183-275
Range on HMM: 92-175/255.0
PvltAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGAwesiPLTVDHNVQNLDEVNRIKG--GHPSHEsttvIKNGRLLGELMPLRAFGNI
|      |. | .... ..  |.||||| |.||.. .|        |..||. .. .| .||.   |    .     .  |. | |   ||.|..
p...kfiGttaasvliiedkvyianvGdsrvvlcqkdgtak....rlsldhkPseeseekriselGGtvvst....vvtsrvnGtlavsralGds
subfamily_PP2D1_pd Subfamily PP2D1 306-359 6.4e-09 28.0 In-house 264-317 (492) alignment 
Range on Protein: 306-359
Range on HMM: 264-317/492.0
LITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKASSSYGV
.|. |..|   |. ...||.||| |||..|| .  ..|| . .. .| .   ..
vipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraen
subfamily_PPM1H_pd Subfamily PPM1H 303-353 6.8e-09 27.9 In-house 302-356 (404) alignment 
Range on Protein: 303-353
Range on HMM: 302-356/404.0
PPYLITTPEVTHHRLT----SNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKA
 |.| ..|||.   ||    ..|. ||||.|||||.|| ... ..| | ..... 
kPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvep
subfamily_PPM1L_pd Subfamily PPM1L 305-350 7e-09 28.3 In-house 192-238 (269) alignment 
Range on Protein: 305-350
Range on HMM: 192-238/269.0
YLITTPEVTHHRLT-SNDKFLILASDGLWDMLSSDKAVQLVGEHMKS
 .|..|..    |   . .||||||||||| .| ..||. . |..| 
lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
PP2C_SIG_SM00331 61-430 2.1e-08 27.0 In-house 31-215 (217) alignment 
Range on Protein: 61-430
Range on HMM: 31-215/217.0
VLFGVFDGHGGTACAQAISERLFNYIVAETLPFQTLPKALARLQSgEMNDLvkwhrhpneyklqatadlykeslikyvqanlsvdvlddddtadvlktaf
.|. |.||.|. ..|.|.|..| . .  .    ..|..|| || .  ....                                                 
lllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnr.aiyee.................................................

drldndfsteamratteplgiepV--LTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRSKGYGAWESIpltvdhnvqnldevnrikgghpshesttvik
                              .  ....   ... |..||.||.| .| |....  . .                                
.......................keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd...............................

ngrllgelmplrafgnirfkwtaemqrtlmrtfigylppK-----------SfhtppylittPEVTHHRLTSnDKFLILASDGLWDMLSSDKavqL----
                                       .           |          ....   |   . .|.|..|||... |...   .    
.......................................vegaplGlepevs..........vdirelelek.gdllllytDGltearsekg...faeer

----VGEHMksmkassSYGVQEG--AALKDVMKDLKERMDilksldtnsathliryslcgvgndfdlnklaevlslpdaiarqhRDDMTVTVI
    . ...       .  .||   . .....  .|..                                              .||.|| |.
leeiledlv.......dseaqelaqkiveellelakgsng............................................eDdiTvvvv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 306-346 4.4e-08 25.3 In-house 199-240 (276) alignment 
Range on Protein: 306-346
Range on HMM: 199-240/276.0
LITTPEVTH-HRLTSNDKFLILASDGLWDMLSSDKAVQLVGE
||..| |.    ||  |||||.|||||||..| ..|.. |  
lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
subfamily_KAPP-like_pd Subfamily KAPP-like 306-346 4.4e-08 25.5 In-house 189-230 (266) alignment 
Range on Protein: 306-346
Range on HMM: 189-230/266.0
LITTPEVTH-HRLTSNDKFLILASDGLWDMLSSDKAVQLVGE
||..| |.    ||  |||||.|||||||..| ..|.. |  
lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvks
subfamily_PHLPP_pd Subfamily PHLPP 300-353 1.2e-07 23.9 In-house 168-221 (246) alignment 
Range on Protein: 300-353
Range on HMM: 168-221/246.0
FHTPPYLITTPEVTHHRLTSNDKFLILASDGLWDMLSSDKAVQLVGEHMKSMKA
... |... .|.| .  ||..| .||. .. ||..|| |.||. | .. ... |
tflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplva
subfamily_KAPP-like_pd Subfamily KAPP-like 125-257 9e-07 21.2 In-house 51-168 (266) alignment 
Range on Protein: 125-257
Range on HMM: 51-168/266.0
ATADLYKESLIKYVQANLSVDVLD-DDDTADVLKTAFDRLDNDFSTEAMRATTEPLGIepVLTAVtgscacvayvNDQDLYVANVGDCRAVLGRSKgyga
|. .|... | |...     |  |   |  ..|. ||. .|. ..      .|  | .  | ..           . . | ||||||  | | |      
aakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlal..vwsdG..........qqrylqvanvGdssaflsrGn....

wESIPLTVDHNVQNLDEVNRIKG-GHPSHESTTVI
 ||. |. ||. .. .|  |||  | .  .. | |
.eslelskdhkakdpeekqrikddGitlsdnqtri
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 125-257 9.1e-07 21.0 In-house 50-178 (276) alignment 
Range on Protein: 125-257
Range on HMM: 50-178/276.0
ATADLYKESLIKYVQA-NLSVDVLDD-----DDTADVLKTAFDRLDNDFSTEAMRATTEplgiepVLTAVTGSCACVAYVNDQDLYVANVGDCRAVLGRS
|. .|. . | |.... | |.   ||      |  ..|. .|. .|. ..      .|        |. |  .       ... | ||||||  | | | 
aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGata......tlalvwsdGeeqqqqqqrylqvanvGdssaflsrG

KgygawESIPLTVDHNVQNLDEVNRIKG-GHPSHESTTVI
      ||. |. ||. .. .|..|||  | .  .. | |
n.....eslelskdhkatdpeekqrikddGitlsdnqtri
subfamily_PPM1E_pd Subfamily PPM1E 148-246 9.3e-07 21.3 In-house 72-154 (265) alignment 
Range on Protein: 148-246
Range on HMM: 72-154/265.0
DDDDTADVLKTAFDRLDNDFSTEAMRATTEplgiepvltavTGSCACVAYVNDQDLYVANVGDCRAVLGRSKgygawESIPLTVDHNVQNLDEVNRIKG
. .|.|. || || ..|. | . |.| . .           .|| | |. .. . |||| .|| .|.| |       | . |.  |. .. || .||. 
lkedpaealkeafkltDerflqkaereklk...........sGstavvvliekdqlyvaWlGDsqallvrkg.....eavqlmkpHkPeredEkkRiee
subfamily_PP2D1_pd Subfamily PP2D1 201-275 2.5e-06 19.5 In-house 188-255 (492) alignment 
Range on Protein: 201-275
Range on HMM: 188-255/492.0
QDLYVANVGDCRAVLGRSkGygawESIPLTVDHNVQNLDEVNRIKGGHPSHESTTviKNGRLLGELMPLRAFGNI
  ||.||.|. .||| |  |    ..| || .|. .|  | .|..    .  ..   |||.  | |   |  ||.
gvlyianaGnvqAvLcre.G....kaiiLtreHtprnkkERtRvekagsvvvkse..knglvnGildttRGLGny