Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PPM1A_pd | Subfamily PPM1A | 12-299 | 7.1e-128 | 418.8 | In-house | 2-282 (282) | alignment | ||
Range on Protein: 12-299
Range on HMM: 2-282/282.0
KENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkvDGKLNPSTDAVKEGIRTGFL
| .....|||||||.||||||||||||||..|. |. .||||||||||||||||.|||....|.|..|... |. . . ..|.|||..|.|||
kpksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke....aaleasekdevkealrqgfL
SIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKN
..|...|.........||||||||.|..|.|||..||.||||.||.|.| | .|.|||||| .|||.||||.|||||...||||.||||||||||.||.
aldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng..kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeyke
NPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQN
...|...|||||.|||||..||..|..|..|||||||||.|.||.....|.|| ..|.|||.........|.||||||.|...|||..
eeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 5-297 | 2e-89 | 292.3 | In-house | 2-286 (287) | alignment | ||
Range on Protein: 5-297
Range on HMM: 2-286/287.0
LEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPH--GLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSnpeflgspkvdgKLNPSTDAV
|..| ..||.. .. . . | |.|||.|..||||| . | . |. ..||||||| |.||||...... . |.. | . . .|.
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak............kksfkegal
KEGIRTGFLSIDSKMRTDFARTDssDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdKPTFsTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSR
.. .. .||..|.... | . | ...||||| |.|. ..|. ||.||||.||| ||. .. . |||| . .| |||..||| | ..||||.||.||
eqilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgn.vkal.sfDhkPqeesekkriiaagGfvelnrvngnLalsr
ALGDYDYKNNPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSR------DNMSIVIVL
||||. .|.| |.| ||.| .|.|.| ......||..|||||||||..|.|.....|.||. .|.||.......||.. |. |||..|||
algDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv
F
.
l
|
|||||||||
PP2C | Protein phosphatase 2C | 23-290 | 1.1e-87 | 286.8 | Pfam-A | 2-255 (255) | alignment | ||
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| | | | ....||||||||.|...|| ..||. . ....||.. |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks
DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....
EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.| .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
|
|||||||||
PP2C | Protein phosphatase 2C | 23-290 | 1.1e-87 | 286.8 | In-house | 2-255 (255) | alignment | ||
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| | | | ....||||||||.|...|| ..||. . ....||.. |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks
DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....
EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.| .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
|
|||||||||
PPM_PTC7 | 23-290 | 6.5e-87 | 284.2 | In-house | 2-259 (259) | alignment | |||
Range on Protein: 23-290
Range on HMM: 2-259/259.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS--IDSKMR
..| |..||.|..||||| | .| | ....||||||||.|...|| ..||. . ....| . .....|..||. .|....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele...........klekalrksflaldtdeelk
TDFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM---IERVNGSLAVSRALGDYDYKNNPDk
.. |.| ...|||||| ..|....|..||.|||| ||.|.|... .. |||||| ...|..|||.|||||. ||||.||||||.||...|...
sseant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket.
ppTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITdNLEEICNQVIETCLQKGSRDNM
.|||||.||.... ....|.||.|||.||.|||.|..|.....||.|. . ..|............||.||.
..eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
|
|||||||||
0034914 | PP2C-like | 4-300 | 2.5e-86 | 281.9 | In-house | 3-293 (295) | alignment | ||
Range on Protein: 4-300
Range on HMM: 3-293/295.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkvDGKLNPSTDAVK
.|..|..|. . . . . ||.| .|.||.| ..|||...|..|...|.|...|.||||| |...|...||...... .. | | . | .|.. ..
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.....lllltlsledie
EGIRTGFLSIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRA
| .|..||..| .... . . . . ||.||| ..| ...|..||.|||| ||.|.| .... |.|||| . |..||..||| |. .||||.|||.||
ealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng..elvqltvdhkpvnelererilsaggavshgrvngvlavtRa
LGDYDYKNNPDKPPTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQNA
|||.|.|... ...|.|||.||.|||.|.| .. .|..||.||.|||.||||.....||.|| ...|||....... .|..|||||...|.| ...
lGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
|
|||||||||
PP2Cc_SM00332 | 14-295 | 8.4e-85 | 277.5 | In-house | 2-274 (274) | alignment | |||
Range on Protein: 14-295
Range on HMM: 2-274/274.0
NERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpsTDAVKEGIRTGFLSI
.| ||..||.||.|||||||..||||| |. | .||.||.|||||.||.||| .|... . . ..... . . |.|.| ....|||.
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel........eddveealkkaflst
DSKMRTDFARTDSS-DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdkPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNN
|...... . .|||||| .... ..|..||.|||| ||.|.|. . ..|||| ...|.|||..|||.|. .||||.||||||.||...|.|
deeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngk..avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkkn
PdkPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRL--AITDNLEEICNQVIETCLQK-GSRDNMSIVIV
...|. ...||.|.| . |.|.||.|||.||.|||.||.|.....|..| | . .|......| .... ||.||...|.|
k..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
|
|||||||||
0049733 | PP2C-like | 22-298 | 1.9e-59 | 193.7 | In-house | 3-234 (235) | alignment | ||
Range on Protein: 22-298
Range on HMM: 3-234/235.0
LRYGLSSMQGW-RVEMEDAHSAvtglphglkDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnPSTDAVKEGIRTGFLSIDSKMRTD
|..| .|..|. | ..|||. . ....|||.||| |. .....||.... . . . ... ..| .| || ... ..
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle...........lllldleealrkaflaaneallel
FARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDHKPGKPKEMKRIEDAGGSVmieRVNGSLAVSRALGDYDYKnnpdkppteq
. . . .|.||| ... ...|..||.|||| .| | ..| .. ||||.| . |..||..||| | ||.|.||..|||||...|
alaspelagmgtTavvalldggklyvanvGDsrayllr..dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk..........
lvspePEVTVFERTDEEeFIILACDGIWDVMSNEELCQFIRSrlaitDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
|.|||.| .... |..||.||.|||.|.||.....|| ..|||......|..|..|.|||...|.| ..
.....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 27-298 | 1.2e-55 | 181.6 | In-house | 9-263 (265) | alignment | ||
Range on Protein: 27-298
Range on HMM: 9-263/265.0
SSMQGWRVEMEDAHSAVTGLPHG-----LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpstdavkEGIRTGFLSIDSKMRTDF
.... | ||| | |. | . |. .||||||||.|.. ||. ..|. . . ..... .|. | .. .| .|... .
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.............ealkeafkltDerflqka
ARtdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI---ERVNGSLAVSRALGDYDYKnnpdkppt
.| . ||||||| |.|. ..|. | |||...| |||| .. ||| ...| ||||.||| |. ||||.|.||||.||...|
er..eklksGstavvvliekdqlyvaWlGDsqallvrkgeav..qlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk........
eQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD-NLEEICNQVIETCLQKGSRDNMSIVIVLFQ
. || |..|. .| ...||..||||||.|||. .||... ... || . .|.|. ....|. ..||.||...|.|...
.pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 126-299 | 5.8e-52 | 170.2 | In-house | 292-472 (473) | alignment | ||
Range on Protein: 126-299
Range on HMM: 292-472/473.0
SSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFStEDHKPGKPKEMKRIEDAGGSVMI-ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSP
.||.||| ... |.|. || ||||.||||.|. .| .|||| ..|..||| ||| | |||| | .||||||. ||.| . |. ||..|
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAld.ls.lDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA
EPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD--NLEEICNQVIETCLQKGS------RDNMSIVIVLFQN
|.. | . |.|.||..|||||||.||. .| .|.|..|. .. |.||.......|| . |||...|||...
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
|
|||||||||
PPM_PTC7_SpoIIE | 23-282 | 8.1e-47 | 152.9 | In-house | 2-222 (230) | alignment | |||
Range on Protein: 23-282
Range on HMM: 2-222/230.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKvaKHCSEHILHEITSNPeFLGSPkvdgklnpstdAVKEGIRTGFLSIDSKMRTD
..| |..||.| .||||| . .. | . .....||| |. . ..... . .. | |.. ..| .| ..| .. .....
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle...........kpeeilrrlnlalaadlede
fartdsSDKSGSTAVGVIISPKH--LFFANCGDSRSVLSRKgEDKptfstedhkpgkpkEMKRIeDAGGSVM----IERVNGSLAVSRALGDYDYKNnpd
..||.||| ..| | . | .||.|||. .|.|. ... | .|| .||| .. .||.|.||||.| ||. ..
......psssgaTavvalidpstgklyvanaGdsppllvrd.dgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly...
kppTEQLVSPEPEvTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITdnleeICNQVIETCL
|...|..||. |. ..... .||.|||.||.|||.|..||....|..| .... .| ..
...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDi
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 22-297 | 1.5e-46 | 151.8 | In-house | 6-253 (255) | alignment | ||
Range on Protein: 22-297
Range on HMM: 6-253/255.0
LRYGLSSMQGWRVEMEDAHSAVtGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLgspkvdgKLNPStdAVKEGIRTGFLSIDSKMrtdf
.. | | | | | ||| .. | .. .| ..|.||||.|.. ||..||.. . | |.| .||.. . .. .. . .|. ..
fkvgfsdmiGrrptmedelviy.GsfrdksdedyyalfdGhgGraaakfaseel.ykila..ell.......dlnna..nPvkslkkaykeistqi....
arTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTEDHKPGKPKEMKRIEDAGGSVMIE----RVNGSLAVSRALGDYdYKNnPdkpp
.. . |.||. |.| .. . || |||| ||..| . |||| ...| |||...|| |. . |||| ||||||||| . . |
..serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtak.rlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle.P....
teqLVSPEPEVT-VFERTDEEEFIILACDGIWDVMSNEELCQFIrsrLAITDnLEEICNQVIETCLQKGSRDNMSIVIVLF
| |.|... .| . ...|.|||||||||..|.|| .. . ..|.| |. .... . ..|| ||.|.... .
...fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv...agisd.pekaaeklrdlayssGstdnisvivikl
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 28-299 | 4.4e-45 | 147.0 | In-house | 11-268 (269) | alignment | ||
Range on Protein: 28-299
Range on HMM: 11-268/269.0
SMQGWRVEMEDAHSAVTGLPHGLKdWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkVDGKLNPSTDAVKEGIRTGFLSIDSKMRTDFARtdSS
|..| | .||| ... .. . ||||||||| | |... . . ..| .. | | | . .. . ||.| |. . | .
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknkliel....dadkentepinfsklltdeilsvdekllekakr..ae
DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTFsTEDHKPGKPKEMKRIEDAGGSVMIE---RVNGSLAVSRALGDYDYKNNpdkppteQLVSP
| .|.||. ... ..| || |||| || | . . |||| ..|| |||..||| . .. ||.| ||.||||||| |.. .|| .
diaGttalialvqesdlivanvGdsrGvlydkrGkaipl.sfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlvia
EPEVTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITDNleeICNQVIETCLQKGSRDNMSIVIVLFQN
.|.. |. | ||.|||.||.|| .|||| ..||. || | .. . ..|| ||.....| ..|
dpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdf...GakslvlesfkrGsvdnitvlvvklkn
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 29-296 | 4e-44 | 143.9 | In-house | 12-291 (293) | alignment | ||
Range on Protein: 29-296
Range on HMM: 12-291/293.0
MQGWRVEMEDAHSAVTGLP-------HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNpefLgsPKvdGKLNPSTDAVKEGIRTGFLSIDSKMRTDF
.| | ||.||| . | .. |..|||||||||. .....|.. ..| .. | || .... . .| . | |... .
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek...l..pk..sdvsakekeikkclvdsfkktdeefLkla
ARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTF----STEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNNPdkpp
... . | ||||. |.. . |. || |||..|| || |. .. | ||.| | .| |||. |||.| ||.| | |||..|| .|.
skakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG....
teqlVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD----------------NLEEICNQVIETCLQKGSRDNMSIVIVL
|. |.|. | |. . |..|||||.|.|.|..| .|| . | . ..| .||.. ...|| ||.....|
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 25-298 | 8.5e-35 | 113.1 | In-house | 7-259 (263) | alignment | ||
Range on Protein: 25-298
Range on HMM: 7-259/263.0
GLSSMQGWRVEMEDAHSaVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITsnpeflgspkvdgKLNPSTDAVKEGIRTGFLSIDSKMRTDFART
| |..| | | || . .. | .. ..||||||||| |... ... . .. .| . . ... .. |. .| |.. .
GkdsliGkraenedrik.lkeld...pellyvavfdGhaGsaaadfvhdklekilk.............rllekekdleivlknafeeldkklkrylefs
---DSSDKSGSTAVGV-IISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI-----ERVNGSLAVSRALGDYDYKNNPdk
. .||.|| . . ..| |. ||||..| |.|. | |.||.| . .| .|| ||||| .||| ||..|.||| | |.
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkak..kltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG..
ppteqlVSPEPEVTVFER-TDEEEFIILACDGIWDVMSNEELCQFIRsrlaITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
| .|| .. ... |..| ||| .|....|||...| . . || . . |. || || || ..|.| ..
......viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 27-192 | 1.9e-31 | 102.3 | In-house | 7-174 (309) | alignment | ||
Range on Protein: 27-192
Range on HMM: 7-174/309.0
SSMQGWRVEMEDAHSAVTGLPHGL--KDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRT---DF
.. || | ||| . |. . . ....|.|||||| | . ||. .||....|. . .| |. . ..| | || .||.. ..|. ..
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.........lssepedvleAireaflatheamkkkleeW
ARTDSSDK--SGSTAVGVIISPKHLFFANCGDSRSVLSRKGE----DKPTFSTEDHKPGKPKEMKRIEDAGGSVMIE
..| | . .|.|| ||| ..|. |. |||. ||. | . ... |.|||| .|.| .|||..||.|...
pktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
|
|||||||||
PP2C_C | Protein serine/threonine phosphatase 2C, C-terminal domain | 291-368 | 3.1e-26 | 80.9 | Pfam-A | 1-80 (81) | alignment | ||
Range on Protein: 291-368
Range on HMM: 1-80/81.0
SIVIVLFQNAPEVSQDALTKEKELDVLLEEKVKEVMENFGDQTQLDL--VMHVLRMADIPGLPPGGGLSAKKGTIEEILN
||..|.| .||.||..|. ||.||| ||..|.|..|. . . . || |...| |||.|||||||..|. ||. .
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavyk
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 35-295 | 1.3e-25 | 83.0 | In-house | 11-264 (266) | alignment | ||
Range on Protein: 35-295
Range on HMM: 11-264/266.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEITsnpEFLGSPKVDGKLNPSTDAvKEGIRTGFLSIDSKMRtDFartdssDK
|||| . |. | . | . ..||||||||| .|. .. . .|. . | | | | .. | .. .. | ..|.|.. || .
emedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkele...kllkstkqddGGdniydq.skllenafkevdaklk.df......ey
SGSTAVGVII----SPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTEQLVS
|.|| ... ..| || ||| . ||| | . . ||| .|.| .|| | | .. |.|| |||||||||. |. .| ||
eGatatlalvwsdGqqrylqvanvGdssaflsrGnes..lelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvs
PEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
.. .| | ..|.|.| ||.|||.| .. . ..| . ..... ..|| .| ..||.|...|
nrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 4-119 | 8.7e-25 | 80.6 | In-house | 1-101 (473) | alignment | ||
Range on Protein: 4-119
Range on HMM: 1-101/473.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnpSTDAVK
.|.||..|||.| .| ..|.|| |.||||||..|||| ..| | .|.|.|||.||| |..|||........ .. . . . |.
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgy............kegdve
EGIRTGFLSIDSKMRT
.... ||..|.|...
kaleeaflalDeklka
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 93-286 | 1.1e-23 | 77.0 | In-house | 106-334 (398) | alignment | ||
Range on Protein: 93-286
Range on HMM: 106-334/398.0
GKLNPSTDAVKEGIRTGFLSIDSKMRTDFA---RTDSSD------KSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDK---PTFSTEDHKPGKPKEMK
.|. ... ||| ....||..|. ..|. . |.. ||..|. . |....|. || ||.|.|| .. |. . ..|. ..|..
elleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEve
RIEDAG------GSVMIERVNGSLAVSRALGDYDYKNNP--DK-----------PP----TEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELC
||. . .. .|. |.|. .|| ||. || . .| .| | .. ||||| . . .. |..|| ||.||..||||
RikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevv
QFIRSRLAITDNLEEICNQVIETCLQKGS
. . || ... |.. . .. |.. .
slVgehlakkkekepvkveeakltlkqvv
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 35-295 | 5.1e-23 | 74.3 | In-house | 10-274 (276) | alignment | ||
Range on Protein: 35-295
Range on HMM: 10-274/276.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEIT----SNPEFLGSPKVDGklNPSTDaVKEGIRTGFLSIDSKMRtDFARTD
|||| . |. | . . . ..||||||||| .|. .. . .|. | | . | .. | .. . | .|.|.. ||
emedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGG..dniyd.qskllldlfkevdaklk.dfeyeG
-SSDKSGSTAVG---VIISPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTE
.. . | ..| || ||| . ||| | . . ||| |.|..|| | | .. |.|| |||||||||. |. .|
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes..lelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise
QLVSPEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
||.. .| | ..|.|.| ||.|||.| .. . ..| . ..... ..|| .| ..||.|...|
pyvsnrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 128-267 | 1.7e-20 | 66.2 | In-house | 175-309 (492) | alignment | ||
Range on Protein: 128-267
Range on HMM: 175-309/492.0
DKSGSTAVGVIiSPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVM----IERVNGSLAVSRALGDYDyknnpdKPPTEQLVS
..| .. | . . |. || |. . || |.| | | .| |. .|| .|.| ||..|. .||| | . | || | | .. |
kesngsevhle.elgvlyianaGnvqAvLcreG..kaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG......dpkLkksvi
PEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAIT
|||..| . ... |..|| |.|.|.|.|| . ... |||
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 23-298 | 3.3e-20 | 65.1 | In-house | 8-304 (305) | alignment | ||
Range on Protein: 23-298
Range on HMM: 8-304/305.0
RYGLSSMQGWRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLGSPKVD--GKLNPSTDAVKEGIRTGFLSIDSKmRTD
.|.| .. | || . .| .. |.| ||||| | . |.. .. || ... || | . . | | |. ..|| |. |
kyelyvsansrkyqedrnkvkisless.qelslfGvfdGhnGdiaaeyvkkkl.veivn..kyvkenkvGysaknlnvddlpleaiksaslstdks.sld
FARTDSSdKSGSTA----VGVIISPKHLFFANCGDSRSVLSRKGEDKPTFSTEDHK------PG-------------KPKEMKRIEDAGGSVMIE---RV
.| .|. |.|.| ||. . . .. .|. .||| . .. . . | || . .. ||| ...... .|
saesdnk.kaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellv
NGSLAVSRALGDYDyknnpdkppTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNL-------EEICNQVIETCLQKGS
|. | .|| || . ...|| |... .. . ...|..|| ||.|.|.|.... .... | .. .|| . . | ...||
nrllkksrskGdkn.........lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgs
RDNMSIVIVLFQ
.||. .||. ..
gDnitlviiklk
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 48-206 | 1.2e-18 | 60.6 | In-house | 15-182 (292) | alignment | ||
Range on Protein: 48-206
Range on HMM: 15-182/292.0
HGLKDWSF-FAVFDGHA--GSKVAKHCSEHILHEITSnpeflgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRTDFArtDSSDKSGSTAVGVIISPK-H
.| . .| ||.||| | |||. ... .|... | . .. | . . |.| .|.. .. | ......| ..
egsealtflaavldGhGvnGdkvaqlaedtlevelle.............ltrqlqelsealllrildiaakldklti..daresattavvcarvrddra
LFFANCGDSRSVLSR---KGEDKPTFSTEDHKPGKPKEMKRIEDAGGSVMI-----------ERV------NGSLAVSRALGD
|. || ||||..| | . .. . |||| | | .|| ||| | || .| ||.||||||
lilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
|
|||||||||
PPM_PTC7_motif | 241-290 | 1.1e-17 | 57.3 | In-house | 1-51 (51) | alignment | |||
Range on Protein: 241-290
Range on HMM: 1-51/51.0
ILACDGIWDVMSNEELCQFIRSRLAI-TDNLEEICNQVIETCLQKGSRDNM
|||.||.|||.|..|.....|..|. . ..|.........|..|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 198-298 | 2.5e-15 | 49.4 | In-house | 201-308 (309) | alignment | ||
Range on Protein: 198-298
Range on HMM: 201-308/309.0
LAVSRALGDY-DYKNNpdkpPTEQLVSPEPEVTVFERTDEEE-FIILACDGIWDVMSNEELCQFIRSRLAITDNL----EEICNQVIETCLQKGSR----
|||.|.||| |... | .|||||.|.|.... .|| ||||| ||.|.|.. |. ..... ... ... ...... ||. ..
LavaRslGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr
-DNMSIVIVLFQ
||.|...|...
aDnvsvivvile
|
|||||||||
PP2C_SIG_SM00331 | 82-295 | 1e-13 | 44.4 | In-house | 63-215 (217) | alignment | |||
Range on Protein: 82-295
Range on HMM: 63-215/217.0
NpeflgspkvdgklnpstdavkEGIRTGFLSIDSKMRTDfartDSSDKSGSTAVGVI--ISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDhkpgkpkem
. | . . . ... .. . . .. |.. . .| ..| .||.|||| .| | ..| .. ..|
g.....................eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsyanaGdsrpyllr..dgklveilkd.........
kriedaggsvmiervngslavsralgdydyknnpdkpPTEQLVSPEPEVT--VFERT-DEEEFIILACDGIWDVM-----SNEELCQFIRSRLaiTDNLE
.. .... ||||. . |.. .......|. ||..... .|.|...... . .. ..
.....................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv..dseaq
EICN----QVIETCLQKGSRDNMSIVIV
|. . ...|. ... .|....|.|
elaqkiveellelakgsngeDdiTvvvv
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 192-269 | 8.2e-12 | 37.6 | In-house | 275-356 (404) | alignment | ||
Range on Protein: 192-269
Range on HMM: 275-356/404.0
ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSPEPEVTVFERT----DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDN
|. . ..|.| |||.. | . ..||.|||.|.. | .|.. .||| ||.|||.|||| . .|. |. ...
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvep
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 130-251 | 3.6e-11 | 35.4 | In-house | 129-260 (333) | alignment | ||
Range on Protein: 130-251
Range on HMM: 129-260/333.0
SGSTAVGVIISPKHLFFANCGDSRSVLSR-KGEDKPTFSTEDHKPGKPKEMKRIEDAGGS-VMI--ERVNGSLAVSRALGDYDYKNNPD-----KPPTEQ
|.||| ..| ..|. ||.|||| .| . | ..| . ||. ..|..|..| | | .. || |..||| |. . . ...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge
LVSPEPEVTVF-ERTDEEEFIILACDGIWDVM
| ||... . .| . |..| ||. .
PviaePdiqgaypiddityflvlmSdGvyktL
|
|||||||||
PPM_PTC7_SpoIIE_motif | 236-295 | 6.7e-11 | 35.7 | In-house | 11-78 (81) | alignment | |||
Range on Protein: 236-295
Range on HMM: 11-78/81.0
EEEFIILACDGIW-------DVMSNEELCQFIRSRlaITDNLEEICNQVIETCLQKG---SRDNMSIVIV
. . ..|..||.. .....|||....... .|.|.. ......|. | ..|.......
pgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvl
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 143-296 | 2.2e-09 | 29.6 | In-house | 106-244 (246) | alignment | ||
Range on Protein: 143-296
Range on HMM: 106-244/246.0
HLFFANCGDSRSVLSRKGEdKPTFSTEDHKPGKpkEMKRIEDAGGSVMIE-RVNGSLAVSRALGDYdYkNNPdkppteqLVSPEPEVTVFERTDEEEFII
| |. | .|| |.|. | ..| .. |.||| .| . . . ..|| .. .| || . . | | |.|.| |...|..|
sLevAsvGtlqavliRngk.klrlsksyviekd..elkrikeakaiitednkingviestrllGyt.f.lfP.......vvlPkphvrevlLteqdelli
LACDGIWDVMSNEELCQFIRSRlaiTDNLeEICNQVIETCLQKGSRDNMSIVIVL
. . .|.|.| .|. . .| | | . .... | .|..|...|
vGnkalWevlsideaveavrke...edpl.vaAkklvdlaqsygaadsvsvlvvr
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 102-173 | 3.5e-08 | 25.6 | In-house | 136-203 (404) | alignment | ||
Range on Protein: 102-173
Range on HMM: 136-203/404.0
VKEGIRTGFLSIDSKMRTDfaRTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTeDHKP
|. . . ||..|.... . |.. .| | ||. ... . |. || ||||..|.||.| .| .|. |. |
viGalesaflemDeqiare..reayrikGGCtalvalvllgklYvanaGDsRailvrkdeiip.lsa.dftP
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 50-263 | 6.7e-07 | 21.8 | Pfam-A | 21-194 (212) | alignment | ||
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
.|....|| ||. | ... .. . ... | | ..... ..|. . |... | . . . |. . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq
CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. | .| || .. .. . .. | .. .. .... .. .. ... . ..| |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD
GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 50-263 | 6.7e-07 | 21.8 | In-house | 21-194 (212) | alignment | ||
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
.|....|| ||. | ... .. . ... | | ..... ..|. . |... | . . . |. . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq
CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. | .| || .. .. . .. | .. .. .... .. .. ... . ..| |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD
GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 32-79 | 6.5e-06 | 18.1 | In-house | 13-58 (492) | alignment | ||
Range on Protein: 32-79
Range on HMM: 13-58/492.0
WRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHiLHEI
|. .|||.. . . .||...||. |. |. .... |||.
WKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaake.lhev
|