Gene PPM1A in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP184_AA protein Get Run
SpurP184_AA_3-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1A_pd Subfamily PPM1A 12-299 7.1e-128 418.8 In-house 2-282 (282) alignment
Range on Protein: 12-299
Range on HMM: 2-282/282.0
KENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkvDGKLNPSTDAVKEGIRTGFL
| .....|||||||.||||||||||||||..|. |. .||||||||||||||||.|||....|.|..|... |.        . . ..|.|||..|.|||
kpksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke....aaleasekdevkealrqgfL

SIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKN
..|...|.........||||||||.|..|.|||..||.||||.||.|.|  | .|.|||||| .|||.||||.|||||...||||.||||||||||.||.
aldeairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrng..kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeyke

NPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQN
...|...|||||.|||||..||..|..|..|||||||||.|.||.....|.|| ..|.|||.........|.||||||.|...|||..
eeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfak

subfamily_PPM1G2_pd Subfamily PPM1G2 5-297 2e-89 292.3 In-house 2-286 (287) alignment
Range on Protein: 5-297
Range on HMM: 2-286/287.0
LEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPH--GLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSnpeflgspkvdgKLNPSTDAV
|..| ..||.. .. .  . | |.|||.|..|||||   . | .    |. ..||||||| |.||||...... . |..            | . . .|.
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak............kksfkegal

KEGIRTGFLSIDSKMRTDFARTDssDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdKPTFsTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSR
.. .. .||..|.... | .  |  ...||||| |.|. ..|. ||.||||.||| ||.   .. . |||| . .| |||..||| | ..||||.||.||
eqilkdafletDeellkdeklkd..esaGstavvvlikeeklyvanaGDsravlsskgn.vkal.sfDhkPqeesekkriiaagGfvelnrvngnLalsr

ALGDYDYKNNPDKPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSR------DNMSIVIVL
||||. .|.|  |.| ||.|  .|.|.| ......||..|||||||||..|.|.....|.||.   .|.||.......||.. |.      |||..||| 
algDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivv

F
.
l

PP2C Protein phosphatase 2C 23-290 1.1e-87 286.8 Pfam-A 2-255 (255) alignment
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| |   |    | ....||||||||.|...|| ..||.   . ....||..             |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...     
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....

EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.|  .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 23-290 1.1e-87 286.8 In-house 2-255 (255) alignment
Range on Protein: 23-290
Range on HMM: 2-255/255.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS-IDSKMRT
..| |..||.| .||||| |   |    | ....||||||||.|...|| ..||.   . ....||..             |....| .||. .|.....
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele...........kvekalrksfladtdeelks

DFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM-IERVNGSLAVSRALGDYDYKNNPdkppt
. |.| . .||||||| ..|..|.|..||.|||| ||.||...| .. |||||| ...|..|||.|||||. . ||||||||||||||...|...     
skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak.keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....

EQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNM
|||||.||.||....|.|.||.|||.||.|||.|..|.....||.|  .....|....... ....||.||.
eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 23-290 6.5e-87 284.2 In-house 2-259 (259) alignment
Range on Protein: 23-290
Range on HMM: 2-259/259.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPkvdgklnpstdAVKEGIRTGFLS--IDSKMR
..| |..||.|..||||| |  .|    | ....||||||||.|...|| ..||.   . ....|  .             .....|..||.  .|....
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele...........klekalrksflaldtdeelk

TDFARTdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKpTFSTEDHKPGKPKEMKRIEDAGGSVM---IERVNGSLAVSRALGDYDYKNNPDk
.. |.|  ...|||||| ..|....|..||.|||| ||.|.|... .. |||||| ...|..|||.|||||.     ||||.||||||.||...|...  
sseant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket.

ppTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITdNLEEICNQVIETCLQKGSRDNM
  .|||||.||.... ....|.||.|||.||.|||.|..|.....||.|. .  ..|............||.||.
..eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

0034914 PP2C-like 4-300 2.5e-86 281.9 In-house 3-293 (295) alignment
Range on Protein: 4-300
Range on HMM: 3-293/295.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkvDGKLNPSTDAVK
.|..|..|. . . . . ||.| .|.||.| ..|||...|..|...|.|...|.||||| |...|...||...... .. | |     .  | .|.. ..
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl.....lllltlsledie

EGIRTGFLSIDSKMRTDFARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRA
| .|..||..| .... . .  . . ||.||| ..| ...|..||.|||| ||.|.|  .... |.||||  . |..||..||| |. .||||.|||.||
ealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng..elvqltvdhkpvnelererilsaggavshgrvngvlavtRa

LGDYDYKNNPDKPPTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQNA
|||.|.|...  ...|.|||.||.|||.|.| .. .|..||.||.|||.||||.....||.|| ...|||....... .|..|||||...|.| ... 
lGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl

PP2Cc_SM00332 14-295 8.4e-85 277.5 In-house 2-274 (274) alignment
Range on Protein: 14-295
Range on HMM: 2-274/274.0
NERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpsTDAVKEGIRTGFLSI
.| ||..||.||.|||||||..|||||  |. |    .||.||.|||||.||.||| .|... . . .....  . .         |.|.| ....|||.
sesgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel........eddveealkkaflst

DSKMRTDFARTDSS-DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEdkPTFSTEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNN
|......  .      .|||||| .... ..|..||.|||| ||.|.|.   .  ..|||| ...|.|||..|||.|. .||||.||||||.||...|.|
deeileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngk..avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkkn

PdkPPTEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRL--AITDNLEEICNQVIETCLQK-GSRDNMSIVIV
   ...|. ...||.|.| . |.|.||.|||.||.|||.||.|.....|..|    | . .|......| .... ||.||...|.|
k..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

0049733 PP2C-like 22-298 1.9e-59 193.7 In-house 3-234 (235) alignment
Range on Protein: 22-298
Range on HMM: 3-234/235.0
LRYGLSSMQGW-RVEMEDAHSAvtglphglkDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnPSTDAVKEGIRTGFLSIDSKMRTD
|..| .|..|. | ..|||. .         ....|||.||| |. .....||.... . .  .            ...  ..| .|  || ... ..  
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle...........lllldleealrkaflaaneallel

FARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDHKPGKPKEMKRIEDAGGSVmieRVNGSLAVSRALGDYDYKnnpdkppteq
  .  . . .|.||| ... ...|..||.|||| .| |  ..| .. ||||.|  . |..||..||| |   ||.|.||..|||||...|          
alaspelagmgtTavvalldggklyvanvGDsrayllr..dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk..........

lvspePEVTVFERTDEEeFIILACDGIWDVMSNEELCQFIRSrlaitDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
     |.|||.| .... |..||.||.|||.|.||.....||     ..|||......|..|..|.|||...|.| ..
.....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld

subfamily_PPM1E_pd Subfamily PPM1E 27-298 1.2e-55 181.6 In-house 9-263 (265) alignment
Range on Protein: 27-298
Range on HMM: 9-263/265.0
SSMQGWRVEMEDAHSAVTGLPHG-----LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGSPKvdgklnpstdavkEGIRTGFLSIDSKMRTDF
 .... |  ||| | |.  | .       |. .||||||||.|.. ||. ..|. . . .....  .|.             | .. .|  .|... .  
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.............ealkeafkltDerflqka

ARtdSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI---ERVNGSLAVSRALGDYDYKnnpdkppt
.|   . ||||||| |.|. ..|. |  |||...| ||||      .. ||| ...| ||||.||| |.     ||||.|.||||.||...|        
er..eklksGstavvvliekdqlyvaWlGDsqallvrkgeav..qlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk........

eQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD-NLEEICNQVIETCLQKGSRDNMSIVIVLFQ
 . || |..|. .| ...||..||||||.|||. .||... ... || .  .|.|. ....|.  ..||.||...|.|...
.pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld

subfamily_PPM1G_pd Subfamily PPM1G 126-299 5.8e-52 170.2 In-house 292-472 (473) alignment
Range on Protein: 126-299
Range on HMM: 292-472/473.0
SSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFStEDHKPGKPKEMKRIEDAGGSVMI-ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSP
   .||.||| ...  |.|. || ||||.||||.|.    .| .||||  ..|..||| ||| |    |||| | .||||||. ||.| . |. ||..| 
pGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAld.ls.lDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

EPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD--NLEEICNQVIETCLQKGS------RDNMSIVIVLFQN
 |.. | . |.|.||..|||||||.||. .|  .|.|..|. ..   |.||.......|| .         |||...|||...
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk

PPM_PTC7_SpoIIE 23-282 8.1e-47 152.9 In-house 2-222 (230) alignment
Range on Protein: 23-282
Range on HMM: 2-222/230.0
RYGLSSMQGWRVEMEDAHSAVTGLP--HGLKDWSFFAVFDGHAGSKvaKHCSEHILHEITSNPeFLGSPkvdgklnpstdAVKEGIRTGFLSIDSKMRTD
..| |..||.| .||||| .  ..    |   . .....||| |.   . .....   . ..  | |..            ..| .| ..| .. .....
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle...........kpeeilrrlnlalaadlede

fartdsSDKSGSTAVGVIISPKH--LFFANCGDSRSVLSRKgEDKptfstedhkpgkpkEMKRIeDAGGSVM----IERVNGSLAVSRALGDYDYKNnpd
       ..||.||| ..| | .  | .||.|||. .|.|. ...              | .|| .||| ..     .||.|.||||.| ||. ..    
......psssgaTavvalidpstgklyvanaGdsppllvrd.dgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly...

kppTEQLVSPEPEvTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITdnleeICNQVIETCL
   |...|..||. |. ..... .||.|||.||.|||.|..||....|..|        .... .| ..
...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDi

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 22-297 1.5e-46 151.8 In-house 6-253 (255) alignment
Range on Protein: 22-297
Range on HMM: 6-253/255.0
LRYGLSSMQGWRVEMEDAHSAVtGLPHGLKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLgspkvdgKLNPStdAVKEGIRTGFLSIDSKMrtdf
.. | | | | |  |||  ..  |  .. .|  ..|.||||.|.. ||..||.. . |    |.|       .||..  . .. ..  . .|. ..    
fkvgfsdmiGrrptmedelviy.GsfrdksdedyyalfdGhgGraaakfaseel.ykila..ell.......dlnna..nPvkslkkaykeistqi....

arTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTEDHKPGKPKEMKRIEDAGGSVMIE----RVNGSLAVSRALGDYdYKNnPdkpp
  .. .   |.||. |.|  .. . || |||| ||..|        . |||| ...| |||...|| |. .    |||| |||||||||  . . |    
..serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtak.rlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.fle.P....

teqLVSPEPEVT-VFERTDEEEFIILACDGIWDVMSNEELCQFIrsrLAITDnLEEICNQVIETCLQKGSRDNMSIVIVLF
    | |.|...  .| . ...|.|||||||||..|.|| .. .   ..|.|  |. .... .   ..|| ||.|.... .
...fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv...agisd.pekaaeklrdlayssGstdnisvivikl

subfamily_PPM1L_pd Subfamily PPM1L 28-299 4.4e-45 147.0 In-house 11-268 (269) alignment
Range on Protein: 28-299
Range on HMM: 11-268/269.0
SMQGWRVEMEDAHSAVTGLPHGLKdWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLgspkVDGKLNPSTDAVKEGIRTGFLSIDSKMRTDFARtdSS
|..| | .|||     ... .. .  ||||||||| |   |... . . ..| ..   |       | |    . .. .    ||.| |. .   |  . 
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknkliel....dadkentepinfsklltdeilsvdekllekakr..ae

DKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTFsTEDHKPGKPKEMKRIEDAGGSVMIE---RVNGSLAVSRALGDYDYKNNpdkppteQLVSP
| .|.||.  ... ..|  || |||| ||  |      . . |||| ..|| |||..||| . ..   ||.| ||.|||||||  |..       .|| .
diaGttalialvqesdlivanvGdsrGvlydkrGkaipl.sfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlvia

EPEVTVFERTDE-EEFIILACDGIWDVMSNEELCQFIRSRLAITDNleeICNQVIETCLQKGSRDNMSIVIVLFQN
.|..  |.  |   ||.|||.||.|| .|||| ..||. ||   |        ..  . ..|| ||.....| ..|
dpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdf...GakslvlesfkrGsvdnitvlvvklkn

subfamily_ILKAP_pd Subfamily ILKAP 29-296 4e-44 143.9 In-house 12-291 (293) alignment
Range on Protein: 29-296
Range on HMM: 12-291/293.0
MQGWRVEMEDAHSAVTGLP-------HGLKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNpefLgsPKvdGKLNPSTDAVKEGIRTGFLSIDSKMRTDF
 .| | ||.|||  .  |          ..  |..|||||||||. .....|.. ..| ..   |  ||  ....  .  .|  .   |   |... .  
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek...l..pk..sdvsakekeikkclvdsfkktdeefLkla

ARTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPTF----STEDHKPGKPKEMKRIEDAGGSVMIERVNGSLAVSRALGDYDYKNNPdkpp
...  . | ||||. |..  . |. || |||..|| || |.  ..     | ||.| | .| |||. |||.|   ||.| | |||..||  .|.      
skakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG....

teqlVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAITD----------------NLEEICNQVIETCLQKGSRDNMSIVIVL
    |.  |.|.  | |. . |..|||||.|.|.|..|  .|| . |   .                ..| .||..    ...|| ||.....| 
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk

subfamily_PPM1K_pd Subfamily PPM1K 25-298 8.5e-35 113.1 In-house 7-259 (263) alignment
Range on Protein: 25-298
Range on HMM: 7-259/263.0
GLSSMQGWRVEMEDAHSaVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITsnpeflgspkvdgKLNPSTDAVKEGIRTGFLSIDSKMRTDFART
|  |..| | | ||  . .. |    ..  ..|||||||||  |... ... . ..             .| .  . ... ..  |. .| |..     .
GkdsliGkraenedrik.lkeld...pellyvavfdGhaGsaaadfvhdklekilk.............rllekekdleivlknafeeldkklkrylefs

---DSSDKSGSTAVGV-IISPKHLFFANCGDSRSVLSRKGEDKptFSTEDHKPGKPKEMKRIEDAGGSVMI-----ERVNGSLAVSRALGDYDYKNNPdk
    .  .||.||  . .   ..|  |. ||||..| |.|. |    |.||.| . .| .||  |||||        .||| ||..|.||| | |.    
vaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkak..kltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG..

ppteqlVSPEPEVTVFER-TDEEEFIILACDGIWDVMSNEELCQFIRsrlaITDNLEEICNQVIETCLQKGSRDNMSIVIVLFQ
      |  .||   ..   ... |..|  ||| .|....|||...|    .  . ||  . . |. || || || ..|.| ..
......viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvplg

subfamily_PPM1D_pd Subfamily PPM1D 27-192 1.9e-31 102.3 In-house 7-174 (309) alignment
Range on Protein: 27-192
Range on HMM: 7-174/309.0
SSMQGWRVEMEDAHSAVTGLPHGL--KDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRT---DF
.. || |  |||  . |.   . .  ....|.|||||| | . ||. .||....|. . .|         |. . ..| | || .||.. ..|.    ..
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.........lssepedvleAireaflatheamkkkleeW

ARTDSSDK--SGSTAVGVIISPKHLFFANCGDSRSVLSRKGE----DKPTFSTEDHKPGKPKEMKRIEDAGGSVMIE
..| | .   .|.||  |||  ..|. |. |||. ||. | .     ...  |.|||| .|.| .|||..||.|...
pktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak

PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 291-368 3.1e-26 80.9 Pfam-A 1-80 (81) alignment
Range on Protein: 291-368
Range on HMM: 1-80/81.0
SIVIVLFQNAPEVSQDALTKEKELDVLLEEKVKEVMENFGDQTQLDL--VMHVLRMADIPGLPPGGGLSAKKGTIEEILN
||..|.| .||.||..|. ||.|||  ||..|.|..|. . . . ||  |...|   |||.|||||||..|.  ||.  .
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasKrsvieavyk

subfamily_KAPP-like_pd Subfamily KAPP-like 35-295 1.3e-25 83.0 In-house 11-264 (266) alignment
Range on Protein: 35-295
Range on HMM: 11-264/266.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEITsnpEFLGSPKVDGKLNPSTDAvKEGIRTGFLSIDSKMRtDFartdssDK
|||| . |.  | .  |     . ..|||||||||  .|.  .. . .|.    . | | | |   ..  |  .. ..  | ..|.|.. ||      . 
emedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkele...kllkstkqddGGdniydq.skllenafkevdaklk.df......ey

SGSTAVGVII----SPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTEQLVS
 |.||  ...      ..|  || ||| . |||  |    . . |||  .|.| .|| | | ..     |.|| |||||||||.  |.      .|  ||
eGatatlalvwsdGqqrylqvanvGdssaflsrGnes..lelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvs

PEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
..  .| |     ..|.|.| ||.|||.| ..  . ..|     .  ..... ..|| .|   ..||.|...|
nrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_PPM1G_pd Subfamily PPM1G 4-119 8.7e-25 80.6 In-house 1-101 (473) alignment
Range on Protein: 4-119
Range on HMM: 1-101/473.0
FLEKPNTEKENERGSGNGLRYGLSSMQGWRVEMEDAHSAVTGLPhglKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFlgspkvdgklnpSTDAVK
.|.||..|||.| .| ..|.|| |.||||||..|||| ..| |    .|.|.|||.||| |..|||........ .. .  .              . |.
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgy............kegdve

EGIRTGFLSIDSKMRT
....  ||..|.|...
kaleeaflalDeklka

subfamily_PDP_pd Subfamily PDP 93-286 1.1e-23 77.0 In-house 106-334 (398) alignment
Range on Protein: 93-286
Range on HMM: 106-334/398.0
GKLNPSTDAVKEGIRTGFLSIDSKMRTDFA---RTDSSD------KSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDK---PTFSTEDHKPGKPKEMK
 .|. ... ||| ....||..|. ..|.     .  |..       ||..|. . |....|. || ||.|.|| .. |.     .  ..|.    ..|..
elleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEve

RIEDAG------GSVMIERVNGSLAVSRALGDYDYKNNP--DK-----------PP----TEQLVSPEPEVTVFERTDEEEFIILACDGIWDVMSNEELC
||. .         .. .|. |.|. .|| ||. || .   .|           .|    |   .. |||||  . . .. |..|| ||.||..||||  
RikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevv

QFIRSRLAITDNLEEICNQVIETCLQKGS
. .   || ... |..  .  .. |.. .
slVgehlakkkekepvkveeakltlkqvv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 35-295 5.1e-23 74.3 In-house 10-274 (276) alignment
Range on Protein: 35-295
Range on HMM: 10-274/276.0
EMEDAHSAVTGLPHGLK-----DWSFFAVFDGHAGSKVAKHCSEHILHEIT----SNPEFLGSPKVDGklNPSTDaVKEGIRTGFLSIDSKMRtDFARTD
|||| . |.  | .  .     . ..|||||||||  .|.  .. . .|.     |    |   .  |  ..  |  .. .   |  .|.|.. ||    
emedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGG..dniyd.qskllldlfkevdaklk.dfeyeG

-SSDKSGSTAVG---VIISPKHLFFANCGDSRSVLSRKGEDkpTFSTEDHKPGKPKEMKRIEDAGGSVM--IERVNGsLAVSRALGDYDYKNNPDKPPTE
 ..  .     |        ..|  || ||| . |||  |    . . |||   |.|..|| | | ..     |.|| |||||||||.  |.      .|
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes..lelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise

QLVSPEPEVTVFertdeEEFIILACDGIWDVMSNEELCQFIRSRLAITDNLEEICNQVIETCLQK-GSRDNMSIVIV
  ||..  .| |     ..|.|.| ||.|||.| ..  . ..|     .  ..... ..|| .|   ..||.|...|
pyvsnrilltpf.....dkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_PP2D1_pd Subfamily PP2D1 128-267 1.7e-20 66.2 In-house 175-309 (492) alignment
Range on Protein: 128-267
Range on HMM: 175-309/492.0
DKSGSTAVGVIiSPKHLFFANCGDSRSVLSRKGedKPTFSTEDHKPGKPKEMKRIEDAGGSVM----IERVNGSLAVSRALGDYDyknnpdKPPTEQLVS
..| .. |  .  .  |. || |. . || |.|  |    | .| |. .|| .|.| ||..|.      .||| | . | || |        |  .. | 
kesngsevhle.elgvlyianaGnvqAvLcreG..kaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG......dpkLkksvi

PEPEVTVFERTDEEEFIILACDGIWDVMSNEELCQFIRSRLAIT
|||..|  . ...  |..||  |.|.|.|.||  . ... ||| 
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiy

Subfamily Dicty-PPM1L-like 23-298 3.3e-20 65.1 In-house 8-304 (305) alignment
Range on Protein: 23-298
Range on HMM: 8-304/305.0
RYGLSSMQGWRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHIlHEITSnpEFLGSPKVD--GKLNPSTDAVKEGIRTGFLSIDSKmRTD
.|.|   .. |   || .    .|    .. |.| ||||| | . |..   ..  ||    ...   ||    | . . |   | |. ..|| |.    |
kyelyvsansrkyqedrnkvkisless.qelslfGvfdGhnGdiaaeyvkkkl.veivn..kyvkenkvGysaknlnvddlpleaiksaslstdks.sld

FARTDSSdKSGSTA----VGVIISPKHLFFANCGDSRSVLSRKGEDKPTFSTEDHK------PG-------------KPKEMKRIEDAGGSVMIE---RV
.| .|.  |.|.|       ||.  . .  .. .|. .|||  .  ..  . .  |      ||             . ..  ||| ......     .|
saesdnk.kaGttlngssasvilerertivstasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellv

NGSLAVSRALGDYDyknnpdkppTEQLVSPEPEVTVFERT-DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDNL-------EEICNQVIETCLQKGS
|. | .||  || .         ...|| |...  ..  .  ...|..|| ||.|.|.|.... ....  | ..          .|| . . |  ...||
nrllkksrskGdkn.........lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgs

RDNMSIVIVLFQ
.||. .||. ..
gDnitlviiklk

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 48-206 1.2e-18 60.6 In-house 15-182 (292) alignment
Range on Protein: 48-206
Range on HMM: 15-182/292.0
HGLKDWSF-FAVFDGHA--GSKVAKHCSEHILHEITSnpeflgspkvdgkLNPSTDAVKEGIRTGFLSIDSKMRTDFArtDSSDKSGSTAVGVIISPK-H
.| .  .|  ||.|||   | |||.   ... .|...             | .   .. | .  . |.| .|..  ..  |   ......|  ..     
egsealtflaavldGhGvnGdkvaqlaedtlevelle.............ltrqlqelsealllrildiaakldklti..daresattavvcarvrddra

LFFANCGDSRSVLSR---KGEDKPTFSTEDHKPGKPKEMKRIEDAGGSVMI-----------ERV------NGSLAVSRALGD
|. || ||||..| |     . ..   . ||||  | | .||  ||| |              ||      .| ||.||||||
lilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd

PPM_PTC7_motif 241-290 1.1e-17 57.3 In-house 1-51 (51) alignment
Range on Protein: 241-290
Range on HMM: 1-51/51.0
ILACDGIWDVMSNEELCQFIRSRLAI-TDNLEEICNQVIETCLQKGSRDNM
|||.||.|||.|..|.....|..|.   . ..|.........|..|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

subfamily_PPM1D_pd Subfamily PPM1D 198-298 2.5e-15 49.4 In-house 201-308 (309) alignment
Range on Protein: 198-298
Range on HMM: 201-308/309.0
LAVSRALGDY-DYKNNpdkpPTEQLVSPEPEVTVFERTDEEE-FIILACDGIWDVMSNEELCQFIRSRLAITDNL----EEICNQVIETCLQKGSR----
|||.|.|||   |...      | .|||||.|.|.... .|| ||||| ||.|.|.. |.  .....  ...       ... ...... ||. ..    
LavaRslGDlWsynak....sgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklr

-DNMSIVIVLFQ
 ||.|...|...
aDnvsvivvile

PP2C_SIG_SM00331 82-295 1e-13 44.4 In-house 63-215 (217) alignment
Range on Protein: 82-295
Range on HMM: 63-215/217.0
NpeflgspkvdgklnpstdavkEGIRTGFLSIDSKMRTDfartDSSDKSGSTAVGVI--ISPKHLFFANCGDSRSVLSRkgEDKPTFSTEDhkpgkpkem
.                     | . . .  ... ..      .  . .. |..  .  .| ..| .||.|||| .| |  ..| .. ..|         
g.....................eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsyanaGdsrpyllr..dgklveilkd.........

kriedaggsvmiervngslavsralgdydyknnpdkpPTEQLVSPEPEVT--VFERT-DEEEFIILACDGIWDVM-----SNEELCQFIRSRLaiTDNLE
                                     .. .... ||||.  . |.. .......|. ||.....      .|.|...... .  .. ..
.....................................vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv..dseaq

EICN----QVIETCLQKGSRDNMSIVIV
|. .    ...|.  ... .|....|.|
elaqkiveellelakgsngeDdiTvvvv

subfamily_PPM1H_pd Subfamily PPM1H 192-269 8.2e-12 37.6 In-house 275-356 (404) alignment
Range on Protein: 192-269
Range on HMM: 275-356/404.0
ERVNGSLAVSRALGDYDYKNNPDKPPTEQLVSPEPEVTVFERT----DEEEFIILACDGIWDVMSNEELCQFIRSRLAITDN
 |. . ..|.| |||.. |    .     ..||.|||.|.. |    .|.. .||| ||.|||.||||  . .|. |. ...
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvep

subfamily_TAB1_pd Subfamily TAB1 130-251 3.6e-11 35.4 In-house 129-260 (333) alignment
Range on Protein: 130-251
Range on HMM: 129-260/333.0
SGSTAVGVIISPKHLFFANCGDSRSVLSR-KGEDKPTFSTEDHKPGKPKEMKRIEDAGGS-VMI--ERVNGSLAVSRALGDYDYKNNPD-----KPPTEQ
 |.||| ..|  ..|. ||.|||| .| . | ..| .    ||.   ..|..|..| |     |   .. ||    |..|||  |.  .     .  ...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPEVTVF-ERTDEEEFIILACDGIWDVM
 |  ||...   . .| . |..|  ||.   .
PviaePdiqgaypiddityflvlmSdGvyktL

PPM_PTC7_SpoIIE_motif 236-295 6.7e-11 35.7 In-house 11-78 (81) alignment
Range on Protein: 236-295
Range on HMM: 11-78/81.0
EEEFIILACDGIW-------DVMSNEELCQFIRSRlaITDNLEEICNQVIETCLQKG---SRDNMSIVIV
. . ..|..||..       .....|||.......     .|.|.. ......|. |   ..|.......
pgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvl

subfamily_PHLPP_pd Subfamily PHLPP 143-296 2.2e-09 29.6 In-house 106-244 (246) alignment
Range on Protein: 143-296
Range on HMM: 106-244/246.0
HLFFANCGDSRSVLSRKGEdKPTFSTEDHKPGKpkEMKRIEDAGGSVMIE-RVNGSLAVSRALGDYdYkNNPdkppteqLVSPEPEVTVFERTDEEEFII
 |  |. |   .|| |.|. | ..| ..       |.||| .| . .  . ..|| .. .| || . .   |        | |.|.|     |...|..|
sLevAsvGtlqavliRngk.klrlsksyviekd..elkrikeakaiitednkingviestrllGyt.f.lfP.......vvlPkphvrevlLteqdelli

LACDGIWDVMSNEELCQFIRSRlaiTDNLeEICNQVIETCLQKGSRDNMSIVIVL
.  . .|.|.| .|. . .|      | |  .  ....     | .|..|...| 
vGnkalWevlsideaveavrke...edpl.vaAkklvdlaqsygaadsvsvlvvr

subfamily_PPM1H_pd Subfamily PPM1H 102-173 3.5e-08 25.6 In-house 136-203 (404) alignment
Range on Protein: 102-173
Range on HMM: 136-203/404.0
VKEGIRTGFLSIDSKMRTDfaRTDSSDKSGSTAVGVIISPKHLFFANCGDSRSVLSRKGEDKPtFSTeDHKP
|.  . . ||..|.... .  |..  .| | ||. ...  . |. || ||||..|.||.| .| .|. |. |
viGalesaflemDeqiare..reayrikGGCtalvalvllgklYvanaGDsRailvrkdeiip.lsa.dftP

PP2C_2 Protein phosphatase 2C 50-263 6.7e-07 21.8 Pfam-A 21-194 (212) alignment
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
 .|....|| ||.   | ... ..   . ...  | |     .....  ..|. . |... | . . .     |.  . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq

CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. |  .| || .. .. . ..     |  .. ..  ....                                     ..  .. ... . ..|  |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD

GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael

PP2C_2 Protein phosphatase 2C 50-263 6.7e-07 21.8 In-house 21-194 (212) alignment
Range on Protein: 50-263
Range on HMM: 21-194/212.0
LKDWSFFAVFDGHAGSKVAKHCSEHILHEITSNPEFLGspkVDGKLNPsTDAVKEGIRTGFLSI-DsKMRTDFARTDSSDKSGSTAVGVIISPKHLFFAN
 .|....|| ||.   | ... ..   . ...  | |     .....  ..|. . |... | . . .     |.  . .. ..| . ..|.|....|..
asdgwllaVADGaGsakrSdkGarlaveaagealekll...eeeseqe.eeallrqieneilasvk.lkqeaeaqqeelkdyatTlllavitpgeivffq

CGDSRSV-LSRKGEDKPTFSTEDHKPGkpKEMKRIEDA--GGSVmiervngslavsralgdydyknnpdkppteqlvspepEVTVFErTDEEEFIILACD
.||.. |  .| || .. .. . ..     |  .. ..  ....                                     ..  .. ... . ..|  |
iGDgaivvrdrdgevqllgepdsgeya..nettfltsedaeeel.....................................rirrlk.lepgdalllmTD

GIWDVMSNEE-LCQFIRSR
|..| ...|| . .... .
Gvsdslrkeepfrellael

subfamily_PP2D1_pd Subfamily PP2D1 32-79 6.5e-06 18.1 In-house 13-58 (492) alignment
Range on Protein: 32-79
Range on HMM: 13-58/492.0
WRVEMEDAHSAVTGLPHGlKDWSFFAVFDGHAGSKVAKHCSEHiLHEI
|. .|||..  .        . .||...||. |.  |. .... |||.
WKskmeDkrtlqdyfgnd.vnscFfgiyDGynGataAeiaake.lhev