Gene PPM1D in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP185_AA protein Get Run
SpurP185_AA_0-306 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 1-306 3.4e-134 439.8 In-house 16-308 (309) alignment 
Range on Protein: 1-306
Range on HMM: 16-308/309.0
MEDMICIVFDREQEA---DYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAINEAFRVTQEGMWKERSSWPKTLSGYPSTAGSTCSMV
|||...||...|..|   ..|..|||||||||||| .||.|||..||.|..|.|.||..|..||.|||  |.| |.|....|||| ||..||||.|.|.|
meDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvv

IICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvTSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPitrnTELTDIPF
||.....|.||||||.||||..||           . .|.....||.||||...|| |||||.||.|..|.||.||||.||.|.|.||    |....|||
iirreklyvahvGDsaivlgvkep...........kekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngp....tvideiPF

LAVARSLGDLWSYNFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSsETVSHQLVKRGMDLWNYHLLRADN
||||||||||||||..||...||||||...|..||..|.|.||.||||||..|.|..|..|||......|..||| ..|...|||.... |... |||||
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealqrwrskklraDn

ISVICVFFE
.|||.|..|
vsvivvile
PP2C Protein phosphatase 2C 13-283 1.4e-57 188.2 Pfam-A 30-245 (255) alignment 
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . |   |  |....|.  .. .....   .|. .  ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS

RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||...                     .||.|||||| .|.||||||||.|..   ..||..|                     |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk

RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
   ...||.|||. .. .... . ||||.|||||......  |..|..  .|..      | .... .||. 
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde
PP2C Protein phosphatase 2C 13-283 1.4e-57 188.2 In-house 30-245 (255) alignment 
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . |   |  |....|.  .. .....   .|. .  ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS

RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||...                     .||.|||||| .|.||||||||.|..   ..||..|                     |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk

RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
   ...||.|||. .. .... . ||||.|||||......  |..|..  .|..      | .... .||. 
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde
PPM_PTC7 14-261 1.8e-57 187.7 In-house 31-233 (259) alignment 
Range on Protein: 14-261
Range on HMM: 31-233/259.0
EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVTQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDSR
. . | ||||||||| ||| ||| ||.. .|..  | . |   .  |....|.  .  .....   ... .  ||| |||.....| |...|.|.|||||
kdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.epstsGstAvvalitgsklyvAnvGDSr

IVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNFR
.||..|.                    .||.|||||. .|.||||.|||.| .. |..||...                     |||.|..||...... 
avLcrsgnav................kqltedHkpsnedEreRiegaggsvsnv.gngrvngv.....................lavsRafGdfelkpke

SGKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY
...  ||.|||| .. ||.. . ||||.|||||..|...  |..| . 
teeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrse
PP2Cc_SM00332 1-303 4.6e-53 173.4 In-house 24-274 (274) alignment 
Range on Protein: 1-303
Range on HMM: 24-274/274.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSRE-PNAVMSAINEAFRVTQEGMWKERSSW-PKTlsgypSTAGSTCSMVI
||| ...|.|  .|.| . |.|||||||.|.| .....|....|..  . ..|  ..|  |...||. |.| ...| .|. ..      ...|||.....
meDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.....alsGstavval

ICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvtshkivTETLTVDHKPSDIEEIERIEEAGGrvqdkagvqrvvwsrpkldhtgpITRNTelTDIPFL
. ..|.| |.|||||.||....                     |.|||||.| .|..||..|||                        ...        |
lkkedlyvanvGDSravlcrngk.................avqlsvdhkpedederkRikkagg.......................vvekg..rvnggl

AVARSLGDLWSYN-FRSGKYIVSPEPDIMHRVIdPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRilqG----EQSSETVSHQLVKRgmdlwnyhLL
|| |..|| .  .   . . ....|||. .  .  ....|||| |||||......  |.||.|  ...        .. .| .  .. .|          
avsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr........gg

RADNISVICV
 .|||.|..|
seDniTvvvv
0034914 PP2C-like 1-306 1.3e-52 171.5 In-house 35-291 (295) alignment 
Range on Protein: 1-306
Range on HMM: 35-291/295.0
MEDMICIVFDREQ-EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ----DGFFSREPNAVMSAINEAFRVTQEGMWKERSSWpktlsGYPSTAGSTCS
.|| ...|..    . |...|.||||||| .|| .|...|.......    . . . ... ...|. .||  ..| ....  ..      . .. |.|..
neDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr.....pelagsGtTav

MVIICGNDMYTAHVGDSRIVLGKSEPRglnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagvQRVVwsrpkldhtgpitrnteltdi
...|.|| .|.|.|||||.|| ..                    . |||||||.. .|.|||..|||.|..     ||                      
valirgnklyvanvGDSravllrngel.................vqltvdhkpvnelererilsaggavsh....grvn.....................

PFLAVARSLGDLWSY---NFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKtrilqGEQSSETVSHQLVKRGMDlwnyhL
..||| |.||| . .   ..   ...||.|||.... .....  ||.|.|||||.....|  |.|| .. .     . .. | ....||.. ..      
gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.....kgldleeaaeeLvdlAla.....r

LRADNISVICVFFE
   |||.|..|...
gsrDNiTvvvvrln
subfamily_PPM1A_pd Subfamily PPM1A 1-306 3.6e-41 134.4 In-house 26-281 (282) alignment 
Range on Protein: 1-306
Range on HMM: 26-281/282.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFF-----SREPNAVMSAINEAFRVTQEGMWKErSSWpktLSGYpSTAGSTCS
|||  ..| . .. .| . |||||||.|.|.| |. .|| .|| ... .      ..| ..| .|....|  ..| . .. |..   |..    .|||. 
mEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel.std...lkta.dksGsTav

MVIICGNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVQdkagVQRVVWSrpkldhtgpitrnteltdi
.|..  . ...|..||||.|| . .                  .. || |||||. .| .|||.||| |     |.||  .                   
tvlvsekhliianlGDsRavlcrng.................kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa...................

pfLAVARSLGDLWSYN---FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVEKydktRILQGeQSSETVSHQLVKRGmdlwnYHL
  |||.|.|||    .    .. .  ||.||...   .. . . ||.| .||.| ....|  |..|.|    |. .. .  |.|...||..      .. 
..LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrk....rleva.deleevakalvdka.....lek

LRADNISVICVFFE
   ||.||. |.|.
gsrDNlsvlvvlfa
0049733 PP2C-like 1-306 8.3e-39 126.3 In-house 18-234 (235) alignment 
Range on Protein: 1-306
Range on HMM: 18-234/235.0
MEDMICIvfdreqeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQdgFFSREPNAVMSAINEAFRVTQEGMWKERSSWPktlsgYPSTAGSTCSMVIIC
.|| ...        ....|||.||||| .|. .|...|.......  . . ..  .. |. .||. ..| ....  ..|       .. |.|.......
neDavlv........glllfavaDGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp.....elagmgtTavvalld

GNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVqdkagvqrvvwsrpkldhtgpitrntelTDIPFLAV
|. .|.|.|||||..| ...                   . ||.||.|.. .| .||..|||.|                            . .. ||.
ggklyvanvGDsrayllrdg.................klvqltedhspvnelerqriitaggav............................rvpgrlal

ARSLGDLWSYnfrsgkyivspePDIMHRVIDPKSerFLILGSDGLWNMVTSEASVQIVEKydktrilqgeQSSETVSHQLVKRGMDLWNYhllraDNISV
 |.||||.              ||...  ..|    ||.| |||||.....|  |... .          .. | . ..||.. .. . .     |||.|
tralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelalarggr.....DNiTv

ICVFFE
..|...
vvvrld
subfamily_PPM1G2_pd Subfamily PPM1G2 2-305 1e-35 116.1 In-house 34-286 (287) alignment 
Range on Protein: 2-305
Range on HMM: 34-286/287.0
EDMICI---VFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFsrePNAVMSAINEAFRVTQEGMWKErsswpKTLSGypSTAGSTCSMVI
||   .   ....... . | |||||||||...| ||  .| . |.... |     .|.  ....||  | | . |.     ..|.   ..||||. .|.
eDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.....eklkd..esaGstavvvl

ICGNDMYTAHVGDSRIVLgkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPITRNteltdipfl
|  ...| | .|||| ||                 |.|. ...|..||||....| .||..||| |. .   . .  ||   |..   . .         
ikeeklyvanaGDsravl.................sskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvk.........

avarslgdlwsynFRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVekydKTRILQGeQSSETVSHQLVKRGMDLWNY-HLLRADN
              ..   ||  .||.. . .| ... ||.|  ||.|...|..  |..|    ..|. .| .. ......|.....   .    . .||
.............kkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlv....rerlvsg.akldeiieelldkclapdssntgvGcDn

ISVICVFF
..|. | .
mtvvivvl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1-284 5.9e-33 107.2 In-house 20-241 (255) alignment 
Range on Protein: 1-284
Range on HMM: 20-241/255.0
MEDMICIV--FDREQEADYacFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPnavMSAINEAFRVTQEGMwkersswpktlSGYPSTAGSTCSMVI
||| . |   |  ... ||  .|.||||||..|| .| ..| . ...    .. .|   . ....|.. ..  .           | .|   |.|   |.
medelviyGsfrdksdedy..yalfdGhgGraaakfaseelykilaelldlnnanP...vkslkkaykeistqi...........serpkfiGttaasvl

ICGNDMYTAHVGDSRIVLGkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKagvqrvvwsrpkldhtgpitRNTELTDiPFL
|... .| | |||||.||.                 .. ... |..|||||. .| .||.|.|| |  .                    . |   .   |
iiedkvyianvGdsrvvlc................qkdgtakrlsldhkPseeseekriselGGtvvst....................vvtsrvn.Gtl

AVARSLGDLWSYNFrsgkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTrilqgEQSSETVSHQLVKRG
||.|.||| .   |      | |.||. . .   |...||||  ||.|.... | .|.|| .  ..     |...|..  .  ..|
avsralGdsflePf......vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdp.....ekaaeklrdlayssG
PPM_PTC7_SpoIIE 19-258 5.2e-26 84.9 In-house 36-205 (230) alignment 
Range on Protein: 19-258
Range on HMM: 36-205/230.0
CFAVFDGHGGKEaaVYARDHLWQNIKNQDgFFSRE-PNAVMSAINEAF-RVTQEGmwkersswpktlsgyPSTAGSTCSMVIICGND--MYTAHVGDSRI
 ....||||| .   .|. .|.. ....  | . | |.......|.|. . ...                ||. |.|.. ..| ...  .|.|..|||..
vvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede...............psssgaTavvalidpstgklyvanaGdspp

VLGKSEPRglnttnvygvtshkivtetltvdhkpsdieEIERIeEAGGRVQdK-AGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNfr
.| .....                              |.||| .||| .    .. .||...                     |||... |||. .   
llvrddgg..............................ereri.vagglps.lGilpgrvfgv.....................lavslapGdlllly..

sGKYIVSPEPDiMHRVIDPKSERFLILGSDGLWNMVTSEASVQIV
    .|..|||   . ...  ..||||.|||||......  |..|
.tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlv
subfamily_PPM1E_pd Subfamily PPM1E 7-173 1e-22 73.6 In-house 30-167 (265) alignment 
Range on Protein: 7-173
Range on HMM: 30-167/265.0
IVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfSREPNavmSAINEAFRVTQEGMWKErSSWpKTLsgypsTAGSTCSMVIICGNDMYT
 .|. ..| ..| ||||||||| ||| ||  ||.... .|  .  ..|    .|..|||..| | . .  .   ..|     ..|||  .|.| .. .| 
elfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa...ealkeafkltDerflqk.aer.ekl.....ksGstavvvliekdqlyv

AHVGDSRIVLgkseprglnttnvygVtsHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
| .|||. .|               |  .|. . .|.  |||.. .| .||||||| |    |. ||
aWlGDsqall...............v..rkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRv
subfamily_ILKAP_pd Subfamily ILKAP 17-167 1.7e-21 69.6 In-house 43-179 (293) alignment 
Range on Protein: 17-167
Range on HMM: 43-179/293.0
YACFAVFDGHGGKEAAVYARDHLWQNIKNQ---DGFFSREpNAVMSAINEAFRVTQEGMWKERSSwpktlsGYPS-TAGSTCSMVIICGNDMYTAHVGDS
 . .||||||.|. |. .| ..| ..|...   . . ..| . .  .. ..|. | | . |. |.      . |.   |||  .|..  | .|.| .|||
vsyyavfdGhaGsrasefaaeklhkkileklpksdvsake.keikkclvdsfkktdeefLklask......akPvWkdGstatvvlvldnvlyvanlGds

RIVLGKSEPRGLNttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
. || . .. | .           |.. .||.||.| . || .||. ||| |.| 
kavlvrkkeegdk...........iasvvLtkdhtpvkyeerkriqkaGgvvrdg
subfamily_PPM1L_pd Subfamily PPM1L 1-173 4.1e-17 55.3 In-house 19-172 (269) alignment 
Range on Protein: 1-173
Range on HMM: 19-172/269.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAvMSAINEAFRVTQEGMWKERSSWPKTLSGYpSTAGSTCSMVIIC
||| . |  | .....   |||||||||. || .|.| | ..|||.   . .. .     || .  .|.| .  ..    |. . .  .||.|. . .. 
medrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadken.tepinfsklltdeilsvdekllekakrae.diaGttalialvq

GNDMYTAHVGDSRIVLGKSEprGlnttnvygvtsHKIvteTLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
..|.  | ||||| ||   .  |           . |    |. |||| ...|  ||..||| .  . || ||
esdlivanvGdsrGvlydkr..G...........kai...plsfdhkpqqvkerkrikkaGGfiafr.Gvwrv
subfamily_PPM1K_pd Subfamily PPM1K 2-260 3.3e-15 48.9 In-house 19-227 (263) alignment 
Range on Protein: 2-260
Range on HMM: 19-227/263.0
EDMICIvfdREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNqdgFFSREPNaVMSAINEAFRVTQEGMWKER-SSWPKTlsgYPSTAGSTCSMVII-
|| |..   .| . .   .||||||.|  || .. |.| . .|.   .. .| . .   ...||   .. . .    |....      ..|.| ..... 
edrikl...keldpellyvavfdGhaGsaaadfvhdklekilkr...llekekd.leivlknafeeldkklkrylefsvaea...ellssGttatvsllr

CGNDMYTAHVGDSRIVLGKseprglNttnvyGVtshkivTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRpkldhtgpitrnteltdipfLA
 |...  | .|||| .| .      |     |       .. || ||.|.  || ||| .|||.|. ..  .  | .|                    ||
dGtelvlaslGdsrailcr......n.....Gk......akkltrdhdPeleeekerikaagGsvewnslgkplvngr....................la

VARSLGDLwsyNFRsgKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK
..||||||   ...  .| |  .|.  .  .| ... ||.| .||. ..|.|.   ..|..
mtrslGdl...dlk..ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 19-167 4.4e-14 45.7 In-house 21-151 (292) alignment 
Range on Protein: 19-167
Range on HMM: 21-151/292.0
CF--AVFDGHG--GKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAIneafrVTQEGMWKErSSWPKTLSGypsTAGSTCSMViICGNDMYTAHVGDSRI
 |  ||.||||  |.. | .| |.| ... .        ..|..  |     .     ... .   . .|.   |.  .|..|   .  .. |.||||| 
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllri.....ldiaakldk.ltidaresa...ttavvcarv.rddralilanvGdsra

VLGKSeprglnttnvYGVTSHKivTETLTVDHKPSDIEEIERIEEAGGRVQDK
.||.            | . ..     |. ||||.| .| .||  |||||.  
llgrc..........lggsdye..liPlsrdhkPedPderarilraGGrvept
subfamily_PPM1G_pd Subfamily PPM1G 89-167 1.3e-12 40.5 In-house 295-356 (473) alignment 
Range on Protein: 89-167
Range on HMM: 295-356/473.0
TAGSTCSMVIICGNDMYTAHVGDSRIVLGKSeprglnttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
 .|.|  .... ..... | .|||| || ..                  .   | .|||| | .| ||||.|||.|.  
dsGttAvvaLlkekklivAnaGDsRcvlsrn.................GkAldlslDHkPeDevEleRiekAGGkvded
subfamily_PPM1E_pd Subfamily PPM1E 198-306 2.3e-12 39.7 In-house 171-263 (265) alignment 
Range on Protein: 198-306
Range on HMM: 171-263/265.0
LAVARSLGDlwsynfRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVEKYdktrILQGEQSSETVSHQLVKRGMDLwnyhlLRADN
|.|.|..||      .. |  || |.|...  .| .|| .|||..||||..|. |  |..||..    . .|......|...||.   .        .||
LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveef....ladgaedlsevakllveaakea.....gssDn

ISVICVFFE
|.|. ||..
itvvvvfld
subfamily_PPM1G_pd Subfamily PPM1G 1-66 6e-11 35.0 In-house 33-93 (473) alignment 
Range on Protein: 1-66
Range on HMM: 33-93/473.0
MEDMICIVFDREQeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfsrEPNAVMSAINEAFR
.|| .  . | ..  | ..|||.||||||| |.|  ..| . .|.| |.   . . | .|..||| 
qEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgy...kegdvekaleeafl
subfamily_PDP_pd Subfamily PDP 219-274 3.2e-10 32.7 In-house 270-324 (398) alignment 
Range on Protein: 219-274
Range on HMM: 270-324/398.0
VSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSSE
.. ||..... . .. ..||.|..||||.....|. |..|... . .  . . ..|
ltaePevtshklren.dkFLvlatDGLwdllsneevvslVgehlakkkekepvkve
PP2C_SIG_SM00331 15-304 4.3e-10 32.5 In-house 28-216 (217) alignment 
Range on Protein: 15-304
Range on HMM: 28-216/217.0
ADYACFAVFDGHG-GKEAAVYARD--HLWQNIKNQDgffsREPNAVMSAINEAFRVTqegmwkersswpktlsGYPSTAGSTCSMVII--CGNDMYTAHV
...  ..|.||.| |..||....   .. ... ...     |.  .....|.|..                     .  . |. . ..   .. .. |..
egrlllvvaDgmGkGlaAaaassqlrtalrellseg....eelsqalkrlnraiyee................keekgmfaTlllalydfssgklsyana

GDSRIVLGKSEPRGLNTTNvygvtshkivtetltvdhkpsdieeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdlws
||||..|  .. .   ..                                                                                  
Gdsrpyllrdgklveilkd.................................................................................

ynfrSGKYIVSPEPDIM--HRVIDPKSERFLILGSDGLWNMVTSEAsvqIVEKYDKTRILQgEQssETVSHQLVKRGMD-LWNYHLLR--ADNISVICVF
       .... ||...   | .. . . .|.| .|||.......    . |. ... . .  .  .. . .| .. .. | ..   .   |.|.|. |.
....vegaplGlepevsvdirelelekgdllllytDGltearsekg...faeerleeiled.lv..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_PPM1L_pd Subfamily PPM1L 197-260 1.8e-09 30.3 In-house 175-235 (269) alignment 
Range on Protein: 197-260
Range on HMM: 175-235/269.0
FLAVARSLGDlwsYNFRSGKyIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVE-K
 ||..|.|||   | ..  . .| ..|||.   .| .  .|||| |||||.  . | .|. .  .
vlatsralGd...yplkdkn.lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfiker
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 186-303 8e-09 27.8 In-house 169-274 (276) alignment 
Range on Protein: 186-303
Range on HMM: 169-274/276.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
||   . | |  |||.|.||| .  .   |   .. || .  |..    ..|||. |||||.... . ....|.  ||.      ..... ..  |..  
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta

MDlwnyHLLRADNISVICV
..      .  ||.||| |
iq....sikakdnvsvivv
subfamily_KAPP-like_pd Subfamily KAPP-like 186-303 8e-09 27.9 In-house 159-264 (266) alignment 
Range on Protein: 186-303
Range on HMM: 159-264/266.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
||   . | |  |||.|.||| .  .   |   .. || .  |..    ..|||. |||||.... . ....|.  ||.      ..... ..  |..  
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta

MDlwnyHLLRADNISVICV
..      .  ||.||| |
iq....sikakdnvsvivv
subfamily_PDP_pd Subfamily PDP 58-159 9.7e-08 24.5 In-house 116-209 (398) alignment 
Range on Protein: 58-159
Range on HMM: 116-209/398.0
MSAINEAFRVTQEGMWKERS-SWPKTL---SGYPSTAGSTCSMVIICGNDMYTAHVGDSRIVLGKSEPRGlnttnvygvtshKIVTETLTVDHKPSDIEE
 .|...||    . . .|   . ...    .  ....|... .. | |.... | .||.| |||..|..|            .  . .|. |.  .  ||
kealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeeg............sweavkLskdqtadneeE

IERIEE
.|||..
veRikk
subfamily_ILKAP_pd Subfamily ILKAP 179-303 1.3e-07 24.1 In-house 168-290 (293) alignment 
Range on Protein: 179-303
Range on HMM: 168-290/293.0
KLDHTGPITRNTELTDIpfLAVARSLGDLwsyNFRSGKyiVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEK----YDKTRILQGEQSSE
... .|   |.  .. .  | |.||.||    .|..    |.  ||...  ...  ..|..|  ||||. .. .. |. . |     .. | ...|.. .
riqkaGgvvrdgrvlGv..levsrsiGdg...rfkrlG..vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekks

T--VSHQLVKRGMDLWNYHLLRADNISVICV
.  | ....   .     .   .||..|. |
keevrfevacnrlaseavkrgssdnvtvllv
PP2C_2 Protein phosphatase 2C 13-252 5.2e-07 22.2 Pfam-A 20-184 (212) alignment 
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.|  . .  .   . ...      ...  .. . . .....| ..... .... . .       ..  ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi

GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||.    .| . |..  . . ..    |  || .   ..                                                         
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................

wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
                   .| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke
PP2C_2 Protein phosphatase 2C 13-252 5.2e-07 22.2 In-house 20-184 (212) alignment 
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.|  . .  .   . ...      ...  .. . . .....| ..... .... . .       ..  ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi

GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||.    .| . |..  . . ..    |  || .   ..                                                         
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................

wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
                   .| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke
subfamily_PPM1G_pd Subfamily PPM1G 200-280 6.3e-07 21.7 In-house 365-444 (473) alignment 
Range on Protein: 200-280
Range on HMM: 365-444/473.0
VARSLGDlWSYN----FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVekydKTRILQGEQS-SETVSHQL
..| ||| ..|           ..|  |||  ... .. | ||.| .||.||...|.  |. |    .... .||.|  ... ..|
lsRAlGD.haYkkneeLplkeqmisAlPDikvltlteede.FlvlAcDGiWnvmesqevvdfv....raklkkgeesvlseiveeL
PPM_PTC7_motif 239-261 1.8e-06 21.4 In-house 1-23 (51) alignment 
Range on Protein: 239-261
Range on HMM: 1-23/51.0
ILGSDGLWNMVTSEASVQIVEKY
||.|||||......  |..| . 
iLAsDGLWDvlsdqeavdlvrdq
subfamily_PPM1H_pd Subfamily PPM1H 11-46 3.3e-06 19.1 In-house 56-91 (404) alignment 
Range on Protein: 11-46
Range on HMM: 56-91/404.0
REQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ
.|.....|.|..||||.|. ||. |   | . .|..
eeeklplayfglfDGhaGsgaalvaskllhkhlkek
Subfamily Dicty-PPM1L-like 15-46 4.2e-06 18.8 In-house 35-65 (305) alignment 
Range on Protein: 15-46
Range on HMM: 35-65/305.0
ADYACFAVFDGHGGKEAAVYARDHLwQNIKNQ
 .   | |||||.|. || |.. .|  .| |.
qelslfGvfdGhnGdiaaeyvkkkl.veivnk