Gene PPM1D in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP185_AA protein Get Run
SpurP185_AA_0-306 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 1-306 3.4e-134 439.8 In-house 16-308 (309) alignment
Range on Protein: 1-306
Range on HMM: 16-308/309.0
MEDMICIVFDREQEA---DYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAINEAFRVTQEGMWKERSSWPKTLSGYPSTAGSTCSMV
|||...||...|..|   ..|..|||||||||||| .||.|||..||.|..|.|.||..|..||.|||  |.| |.|....|||| ||..||||.|.|.|
meDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllstaGttasvv

IICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvTSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPitrnTELTDIPF
||.....|.||||||.||||..||           . .|.....||.||||...|| |||||.||.|..|.||.||||.||.|.|.||    |....|||
iirreklyvahvGDsaivlgvkep...........kekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngp....tvideiPF

LAVARSLGDLWSYNFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSsETVSHQLVKRGMDLWNYHLLRADN
||||||||||||||..||...||||||...|..||..|.|.||.||||||..|.|..|..|||......|..||| ..|...|||.... |... |||||
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealqrwrskklraDn

ISVICVFFE
.|||.|..|
vsvivvile

PP2C Protein phosphatase 2C 13-283 1.4e-57 188.2 Pfam-A 30-245 (255) alignment
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . |   |  |....|.  .. .....   .|. .  ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS

RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||...                     .||.|||||| .|.||||||||.|..   ..||..|                     |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk

RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
   ...||.|||. .. .... . ||||.|||||......  |..|..  .|..      | .... .||. 
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde

PP2C Protein phosphatase 2C 13-283 1.4e-57 188.2 In-house 30-245 (255) alignment
Range on Protein: 13-283
Range on HMM: 30-245/255.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVtQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDS
.. . | ||||||||| ||| ||| ||.. .|.|. | . |   |  |....|.  .. .....   .|. .  ||. |||.....| |...|.|.||||
gkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.epsksGstavvalirgkklyvAnvGDS

RIVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNF
|.||...                     .||.|||||| .|.||||||||.|..   ..||..|                     |||.|.|||......
ravLcrkdnak................keltedHkpsdedEreRIeeaggsvsn...ngrvngs.....................LavsRalGdfelkpk

RsgKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY-DKTRilqgeqSSETVSHQLVKR
   ...||.|||. .. .... . ||||.|||||......  |..|..  .|..      | .... .||. 
e..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvde

PPM_PTC7 14-261 1.8e-57 187.7 In-house 31-233 (259) alignment
Range on Protein: 14-261
Range on HMM: 31-233/259.0
EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREpnAVMSAINEAFRVTQEGMWKERsswPKTLSgYPSTAGSTCSMVIICGNDMYTAHVGDSR
. . | ||||||||| ||| ||| ||.. .|..  | . |   .  |....|.  .  .....   ... .  ||| |||.....| |...|.|.|||||
kdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.epstsGstAvvalitgsklyvAnvGDSr

IVLGKSEPRGlnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNFR
.||..|.                    .||.|||||. .|.||||.|||.| .. |..||...                     |||.|..||...... 
avLcrsgnav................kqltedHkpsnedEreRiegaggsvsnv.gngrvngv.....................lavsRafGdfelkpke

SGKYIVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKY
...  ||.|||| .. ||.. . ||||.|||||..|...  |..| . 
teeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrse

PP2Cc_SM00332 1-303 4.6e-53 173.4 In-house 24-274 (274) alignment
Range on Protein: 1-303
Range on HMM: 24-274/274.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSRE-PNAVMSAINEAFRVTQEGMWKERSSW-PKTlsgypSTAGSTCSMVI
||| ...|.|  .|.| . |.|||||||.|.| .....|....|..  . ..|  ..|  |...||. |.| ...| .|. ..      ...|||.....
meDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen.....alsGstavval

ICGNDMYTAHVGDSRIVLGKSEPrglnttnvygvtshkivTETLTVDHKPSDIEEIERIEEAGGrvqdkagvqrvvwsrpkldhtgpITRNTelTDIPFL
. ..|.| |.|||||.||....                     |.|||||.| .|..||..|||                        ...        |
lkkedlyvanvGDSravlcrngk.................avqlsvdhkpedederkRikkagg.......................vvekg..rvnggl

AVARSLGDLWSYN-FRSGKYIVSPEPDIMHRVIdPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTRilqG----EQSSETVSHQLVKRgmdlwnyhLL
|| |..|| .  .   . . ....|||. .  .  ....|||| |||||......  |.||.|  ...        .. .| .  .. .|          
avsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr........gg

RADNISVICV
 .|||.|..|
seDniTvvvv

0034914 PP2C-like 1-306 1.3e-52 171.5 In-house 35-291 (295) alignment
Range on Protein: 1-306
Range on HMM: 35-291/295.0
MEDMICIVFDREQ-EADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ----DGFFSREPNAVMSAINEAFRVTQEGMWKERSSWpktlsGYPSTAGSTCS
.|| ...|..    . |...|.||||||| .|| .|...|.......    . . . ... ...|. .||  ..| ....  ..      . .. |.|..
neDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr.....pelagsGtTav

MVIICGNDMYTAHVGDSRIVLGKSEPRglnttnvygvtshkivtETLTVDHKPSDIEEIERIEEAGGRVQDkagvQRVVwsrpkldhtgpitrnteltdi
...|.|| .|.|.|||||.|| ..                    . |||||||.. .|.|||..|||.|..     ||                      
valirgnklyvanvGDSravllrngel.................vqltvdhkpvnelererilsaggavsh....grvn.....................

PFLAVARSLGDLWSY---NFRSGKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKtrilqGEQSSETVSHQLVKRGMDlwnyhL
..||| |.||| . .   ..   ...||.|||.... .....  ||.|.|||||.....|  |.|| .. .     . .. | ....||.. ..      
gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.....kgldleeaaeeLvdlAla.....r

LRADNISVICVFFE
   |||.|..|...
gsrDNiTvvvvrln

subfamily_PPM1A_pd Subfamily PPM1A 1-306 3.6e-41 134.4 In-house 26-281 (282) alignment
Range on Protein: 1-306
Range on HMM: 26-281/282.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFF-----SREPNAVMSAINEAFRVTQEGMWKErSSWpktLSGYpSTAGSTCS
|||  ..| . .. .| . |||||||.|.|.| |. .|| .|| ... .      ..| ..| .|....|  ..| . .. |..   |..    .|||. 
mEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairel.std...lkta.dksGsTav

MVIICGNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVQdkagVQRVVWSrpkldhtgpitrnteltdi
.|..  . ...|..||||.|| . .                  .. || |||||. .| .|||.||| |     |.||  .                   
tvlvsekhliianlGDsRavlcrng.................kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa...................

pfLAVARSLGDLWSYN---FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVEKydktRILQGeQSSETVSHQLVKRGmdlwnYHL
  |||.|.|||    .    .. .  ||.||...   .. . . ||.| .||.| ....|  |..|.|    |. .. .  |.|...||..      .. 
..LAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrk....rleva.deleevakalvdka.....lek

LRADNISVICVFFE
   ||.||. |.|.
gsrDNlsvlvvlfa

0049733 PP2C-like 1-306 8.3e-39 126.3 In-house 18-234 (235) alignment
Range on Protein: 1-306
Range on HMM: 18-234/235.0
MEDMICIvfdreqeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQdgFFSREPNAVMSAINEAFRVTQEGMWKERSSWPktlsgYPSTAGSTCSMVIIC
.|| ...        ....|||.||||| .|. .|...|.......  . . ..  .. |. .||. ..| ....  ..|       .. |.|.......
neDavlv........glllfavaDGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp.....elagmgtTavvalld

GNDMYTAHVGDSRIVLGKSEprglnttnvygvtshkiVTETLTVDHKPSDIEEIERIEEAGGRVqdkagvqrvvwsrpkldhtgpitrntelTDIPFLAV
|. .|.|.|||||..| ...                   . ||.||.|.. .| .||..|||.|                            . .. ||.
ggklyvanvGDsrayllrdg.................klvqltedhspvnelerqriitaggav............................rvpgrlal

ARSLGDLWSYnfrsgkyivspePDIMHRVIDPKSerFLILGSDGLWNMVTSEASVQIVEKydktrilqgeQSSETVSHQLVKRGMDLWNYhllraDNISV
 |.||||.              ||...  ..|    ||.| |||||.....|  |... .          .. | . ..||.. .. . .     |||.|
tralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelalarggr.....DNiTv

ICVFFE
..|...
vvvrld

subfamily_PPM1G2_pd Subfamily PPM1G2 2-305 1e-35 116.1 In-house 34-286 (287) alignment
Range on Protein: 2-305
Range on HMM: 34-286/287.0
EDMICI---VFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFsrePNAVMSAINEAFRVTQEGMWKErsswpKTLSGypSTAGSTCSMVI
||   .   ....... . | |||||||||...| ||  .| . |.... |     .|.  ....||  | | . |.     ..|.   ..||||. .|.
eDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.....eklkd..esaGstavvvl

ICGNDMYTAHVGDSRIVLgkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRPKLDHTGPITRNteltdipfl
|  ...| | .|||| ||                 |.|. ...|..||||....| .||..||| |. .   . .  ||   |..   . .         
ikeeklyvanaGDsravl.................sskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvk.........

avarslgdlwsynFRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVekydKTRILQGeQSSETVSHQLVKRGMDLWNY-HLLRADN
              ..   ||  .||.. . .| ... ||.|  ||.|...|..  |..|    ..|. .| .. ......|.....   .    . .||
.............kkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlv....rerlvsg.akldeiieelldkclapdssntgvGcDn

ISVICVFF
..|. | .
mtvvivvl

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1-284 5.9e-33 107.2 In-house 20-241 (255) alignment
Range on Protein: 1-284
Range on HMM: 20-241/255.0
MEDMICIV--FDREQEADYacFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPnavMSAINEAFRVTQEGMwkersswpktlSGYPSTAGSTCSMVI
||| . |   |  ... ||  .|.||||||..|| .| ..| . ...    .. .|   . ....|.. ..  .           | .|   |.|   |.
medelviyGsfrdksdedy..yalfdGhgGraaakfaseelykilaelldlnnanP...vkslkkaykeistqi...........serpkfiGttaasvl

ICGNDMYTAHVGDSRIVLGkseprglnttnvygvtSHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKagvqrvvwsrpkldhtgpitRNTELTDiPFL
|... .| | |||||.||.                 .. ... |..|||||. .| .||.|.|| |  .                    . |   .   |
iiedkvyianvGdsrvvlc................qkdgtakrlsldhkPseeseekriselGGtvvst....................vvtsrvn.Gtl

AVARSLGDLWSYNFrsgkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEKYDKTrilqgEQSSETVSHQLVKRG
||.|.||| .   |      | |.||. . .   |...||||  ||.|.... | .|.|| .  ..     |...|..  .  ..|
avsralGdsflePf......vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdp.....ekaaeklrdlayssG

PPM_PTC7_SpoIIE 19-258 5.2e-26 84.9 In-house 36-205 (230) alignment
Range on Protein: 19-258
Range on HMM: 36-205/230.0
CFAVFDGHGGKEaaVYARDHLWQNIKNQDgFFSRE-PNAVMSAINEAF-RVTQEGmwkersswpktlsgyPSTAGSTCSMVIICGND--MYTAHVGDSRI
 ....||||| .   .|. .|.. ....  | . | |.......|.|. . ...                ||. |.|.. ..| ...  .|.|..|||..
vvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede...............psssgaTavvalidpstgklyvanaGdspp

VLGKSEPRglnttnvygvtshkivtetltvdhkpsdieEIERIeEAGGRVQdK-AGVQRVVWSrpkldhtgpitrnteltdipfLAVARSLGDLWSYNfr
.| .....                              |.||| .||| .    .. .||...                     |||... |||. .   
llvrddgg..............................ereri.vagglps.lGilpgrvfgv.....................lavslapGdlllly..

sGKYIVSPEPDiMHRVIDPKSERFLILGSDGLWNMVTSEASVQIV
    .|..|||   . ...  ..||||.|||||......  |..|
.tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlv

subfamily_PPM1E_pd Subfamily PPM1E 7-173 1e-22 73.6 In-house 30-167 (265) alignment
Range on Protein: 7-173
Range on HMM: 30-167/265.0
IVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfSREPNavmSAINEAFRVTQEGMWKErSSWpKTLsgypsTAGSTCSMVIICGNDMYT
 .|. ..| ..| ||||||||| ||| ||  ||.... .|  .  ..|    .|..|||..| | . .  .   ..|     ..|||  .|.| .. .| 
elfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa...ealkeafkltDerflqk.aer.ekl.....ksGstavvvliekdqlyv

AHVGDSRIVLgkseprglnttnvygVtsHKIVTETLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
| .|||. .|               |  .|. . .|.  |||.. .| .||||||| |    |. ||
aWlGDsqall...............v..rkgeavqlmkpHkPeredEkkRieeagGlvvvi.gawRv

subfamily_ILKAP_pd Subfamily ILKAP 17-167 1.7e-21 69.6 In-house 43-179 (293) alignment
Range on Protein: 17-167
Range on HMM: 43-179/293.0
YACFAVFDGHGGKEAAVYARDHLWQNIKNQ---DGFFSREpNAVMSAINEAFRVTQEGMWKERSSwpktlsGYPS-TAGSTCSMVIICGNDMYTAHVGDS
 . .||||||.|. |. .| ..| ..|...   . . ..| . .  .. ..|. | | . |. |.      . |.   |||  .|..  | .|.| .|||
vsyyavfdGhaGsrasefaaeklhkkileklpksdvsake.keikkclvdsfkktdeefLklask......akPvWkdGstatvvlvldnvlyvanlGds

RIVLGKSEPRGLNttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
. || . .. | .           |.. .||.||.| . || .||. ||| |.| 
kavlvrkkeegdk...........iasvvLtkdhtpvkyeerkriqkaGgvvrdg

subfamily_PPM1L_pd Subfamily PPM1L 1-173 4.1e-17 55.3 In-house 19-172 (269) alignment
Range on Protein: 1-173
Range on HMM: 19-172/269.0
MEDMICIVFDREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFFSREPNAvMSAINEAFRVTQEGMWKERSSWPKTLSGYpSTAGSTCSMVIIC
||| . |  | .....   |||||||||. || .|.| | ..|||.   . .. .     || .  .|.| .  ..    |. . .  .||.|. . .. 
medrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadken.tepinfsklltdeilsvdekllekakrae.diaGttalialvq

GNDMYTAHVGDSRIVLGKSEprGlnttnvygvtsHKIvteTLTVDHKPSDIEEIERIEEAGGRVQDKaGVQRV
..|.  | ||||| ||   .  |           . |    |. |||| ...|  ||..||| .  . || ||
esdlivanvGdsrGvlydkr..G...........kai...plsfdhkpqqvkerkrikkaGGfiafr.Gvwrv

subfamily_PPM1K_pd Subfamily PPM1K 2-260 3.3e-15 48.9 In-house 19-227 (263) alignment
Range on Protein: 2-260
Range on HMM: 19-227/263.0
EDMICIvfdREQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNqdgFFSREPNaVMSAINEAFRVTQEGMWKER-SSWPKTlsgYPSTAGSTCSMVII-
|| |..   .| . .   .||||||.|  || .. |.| . .|.   .. .| . .   ...||   .. . .    |....      ..|.| ..... 
edrikl...keldpellyvavfdGhaGsaaadfvhdklekilkr...llekekd.leivlknafeeldkklkrylefsvaea...ellssGttatvsllr

CGNDMYTAHVGDSRIVLGKseprglNttnvyGVtshkivTETLTVDHKPSDIEEIERIEEAGGRVQDKAGVQRVVWSRpkldhtgpitrnteltdipfLA
 |...  | .|||| .| .      |     |       .. || ||.|.  || ||| .|||.|. ..  .  | .|                    ||
dGtelvlaslGdsrailcr......n.....Gk......akkltrdhdPeleeekerikaagGsvewnslgkplvngr....................la

VARSLGDLwsyNFRsgKYIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK
..||||||   ...  .| |  .|.  .  .| ... ||.| .||. ..|.|.   ..|..
mtrslGdl...dlk..ryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrl

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 19-167 4.4e-14 45.7 In-house 21-151 (292) alignment
Range on Protein: 19-167
Range on HMM: 21-151/292.0
CF--AVFDGHG--GKEAAVYARDHLWQNIKNQDGFFSREPNAVMSAIneafrVTQEGMWKErSSWPKTLSGypsTAGSTCSMViICGNDMYTAHVGDSRI
 |  ||.||||  |.. | .| |.| ... .        ..|..  |     .     ... .   . .|.   |.  .|..|   .  .. |.||||| 
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllri.....ldiaakldk.ltidaresa...ttavvcarv.rddralilanvGdsra

VLGKSeprglnttnvYGVTSHKivTETLTVDHKPSDIEEIERIEEAGGRVQDK
.||.            | . ..     |. ||||.| .| .||  |||||.  
llgrc..........lggsdye..liPlsrdhkPedPderarilraGGrvept

subfamily_PPM1G_pd Subfamily PPM1G 89-167 1.3e-12 40.5 In-house 295-356 (473) alignment
Range on Protein: 89-167
Range on HMM: 295-356/473.0
TAGSTCSMVIICGNDMYTAHVGDSRIVLGKSeprglnttnvygvtshkIVTETLTVDHKPSDIEEIERIEEAGGRVQDK
 .|.|  .... ..... | .|||| || ..                  .   | .|||| | .| ||||.|||.|.  
dsGttAvvaLlkekklivAnaGDsRcvlsrn.................GkAldlslDHkPeDevEleRiekAGGkvded

subfamily_PPM1E_pd Subfamily PPM1E 198-306 2.3e-12 39.7 In-house 171-263 (265) alignment
Range on Protein: 198-306
Range on HMM: 171-263/265.0
LAVARSLGDlwsynfRSGKYIVSPEPDIMHRVIDpKSERFLILGSDGLWNMVTSEASVQIVEKYdktrILQGEQSSETVSHQLVKRGMDLwnyhlLRADN
|.|.|..||      .. |  || |.|...  .| .|| .|||..||||..|. |  |..||..    . .|......|...||.   .        .||
LsvsRaiGD......vklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveef....ladgaedlsevakllveaakea.....gssDn

ISVICVFFE
|.|. ||..
itvvvvfld

subfamily_PPM1G_pd Subfamily PPM1G 1-66 6e-11 35.0 In-house 33-93 (473) alignment
Range on Protein: 1-66
Range on HMM: 33-93/473.0
MEDMICIVFDREQeaDYACFAVFDGHGGKEAAVYARDHLWQNIKNQDGFfsrEPNAVMSAINEAFR
.|| .  . | ..  | ..|||.||||||| |.|  ..| . .|.| |.   . . | .|..||| 
qEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgy...kegdvekaleeafl

subfamily_PDP_pd Subfamily PDP 219-274 3.2e-10 32.7 In-house 270-324 (398) alignment
Range on Protein: 219-274
Range on HMM: 270-324/398.0
VSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEKYDKTRILQGEQSSE
.. ||..... . .. ..||.|..||||.....|. |..|... . .  . . ..|
ltaePevtshklren.dkFLvlatDGLwdllsneevvslVgehlakkkekepvkve

PP2C_SIG_SM00331 15-304 4.3e-10 32.5 In-house 28-216 (217) alignment
Range on Protein: 15-304
Range on HMM: 28-216/217.0
ADYACFAVFDGHG-GKEAAVYARD--HLWQNIKNQDgffsREPNAVMSAINEAFRVTqegmwkersswpktlsGYPSTAGSTCSMVII--CGNDMYTAHV
...  ..|.||.| |..||....   .. ... ...     |.  .....|.|..                     .  . |. . ..   .. .. |..
egrlllvvaDgmGkGlaAaaassqlrtalrellseg....eelsqalkrlnraiyee................keekgmfaTlllalydfssgklsyana

GDSRIVLGKSEPRGLNTTNvygvtshkivtetltvdhkpsdieeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdlws
||||..|  .. .   ..                                                                                  
Gdsrpyllrdgklveilkd.................................................................................

ynfrSGKYIVSPEPDIM--HRVIDPKSERFLILGSDGLWNMVTSEAsvqIVEKYDKTRILQgEQssETVSHQLVKRGMD-LWNYHLLR--ADNISVICVF
       .... ||...   | .. . . .|.| .|||.......    . |. ... . .  .  .. . .| .. .. | ..   .   |.|.|. |.
....vegaplGlepevsvdirelelekgdllllytDGltearsekg...faeerleeiled.lv..dseaqelaqkiveellelakgsngeDdiTvvvvk





subfamily_PPM1L_pd Subfamily PPM1L 197-260 1.8e-09 30.3 In-house 175-235 (269) alignment
Range on Protein: 197-260
Range on HMM: 175-235/269.0
FLAVARSLGDlwsYNFRSGKyIVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVE-K
 ||..|.|||   | ..  . .| ..|||.   .| .  .|||| |||||.  . | .|. .  .
vlatsralGd...yplkdkn.lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfiker

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 186-303 8e-09 27.8 In-house 169-274 (276) alignment
Range on Protein: 186-303
Range on HMM: 169-274/276.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
||   . | |  |||.|.||| .  .   |   .. || .  |..    ..|||. |||||.... . ....|.  ||.      ..... ..  |..  
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta

MDlwnyHLLRADNISVICV
..      .  ||.||| |
iq....sikakdnvsvivv

subfamily_KAPP-like_pd Subfamily KAPP-like 186-303 8e-09 27.9 In-house 159-264 (266) alignment
Range on Protein: 186-303
Range on HMM: 159-264/266.0
ITRNTELTDIPFLAVARSLGDLWSYNFRSGkyiVSPEPDIMHRVIDPKSERFLILGSDGLWNMVTSEASVQIVEK-YDKtrilqgEQSSETVSHQLVKRG
||   . | |  |||.|.||| .  .   |   .. || .  |..    ..|||. |||||.... . ....|.  ||.      ..... ..  |..  
itlsdnqtrinGlavsralGdhfikelniG...lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq......qatedkmasslleta

MDlwnyHLLRADNISVICV
..      .  ||.||| |
iq....sikakdnvsvivv

subfamily_PDP_pd Subfamily PDP 58-159 9.7e-08 24.5 In-house 116-209 (398) alignment
Range on Protein: 58-159
Range on HMM: 116-209/398.0
MSAINEAFRVTQEGMWKERS-SWPKTL---SGYPSTAGSTCSMVIICGNDMYTAHVGDSRIVLGKSEPRGlnttnvygvtshKIVTETLTVDHKPSDIEE
 .|...||    . . .|   . ...    .  ....|... .. | |.... | .||.| |||..|..|            .  . .|. |.  .  ||
kealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeeg............sweavkLskdqtadneeE

IERIEE
.|||..
veRikk

subfamily_ILKAP_pd Subfamily ILKAP 179-303 1.3e-07 24.1 In-house 168-290 (293) alignment
Range on Protein: 179-303
Range on HMM: 168-290/293.0
KLDHTGPITRNTELTDIpfLAVARSLGDLwsyNFRSGKyiVSPEPDIMHRVIDPKsERFLILGSDGLWNMVTSEASVQIVEK----YDKTRILQGEQSSE
... .|   |.  .. .  | |.||.||    .|..    |.  ||...  ...  ..|..|  ||||. .. .. |. . |     .. | ...|.. .
riqkaGgvvrdgrvlGv..levsrsiGdg...rfkrlG..vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekks

T--VSHQLVKRGMDLWNYHLLRADNISVICV
.  | ....   .     .   .||..|. |
keevrfevacnrlaseavkrgssdnvtvllv

PP2C_2 Protein phosphatase 2C 13-252 5.2e-07 22.2 Pfam-A 20-184 (212) alignment
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.|  . .  .   . ...      ...  .. . . .....| ..... .... . .       ..  ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi

GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||.    .| . |..  . . ..    |  || .   ..                                                         
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................

wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
                   .| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke

PP2C_2 Protein phosphatase 2C 13-252 5.2e-07 22.2 In-house 20-184 (212) alignment
Range on Protein: 13-252
Range on HMM: 20-184/212.0
QEADYACFAVFDGHGGKEAAVYARDHLWQNIknqDGFFSREPNAVMSA-INEAFRVTQEGMWKERSSWPKTL--SGYPSTAGSTCSMVIICGNDMYTAHV
...|. ..|| ||.|  . .  .   . ...      ...  .. . . .....| ..... .... . .       ..  ..|.....|... .. ...
easdgwllaVADGaGsakrSdkGarlaveaa...gealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqi

GDSRIVLG--KSEPRGLNTTNVYGVTSHkivTETLTVDHKPSDIeeierieeaggrvqdkagvqrvvwsrpkldhtgpitrnteltdipflavarslgdl
||..||.    .| . |..  . . ..    |  || .   ..                                                         
GDgaivvrdrdgevqllgepdsgeyane...ttfltsedaeeel........................................................

wsynfrsgkyivspepdiMHRVIDPKSERFLILGSDGLWNMVTSE
                   .| .. .. . |.| .||.......|
..................rirrlklepgdalllmTDGvsdslrke

subfamily_PPM1G_pd Subfamily PPM1G 200-280 6.3e-07 21.7 In-house 365-444 (473) alignment
Range on Protein: 200-280
Range on HMM: 365-444/473.0
VARSLGDlWSYN----FRSGKYIVSPEPDIMHRVIDPKSErFLILGSDGLWNMVTSEASVQIVekydKTRILQGEQS-SETVSHQL
..| ||| ..|           ..|  |||  ... .. | ||.| .||.||...|.  |. |    .... .||.|  ... ..|
lsRAlGD.haYkkneeLplkeqmisAlPDikvltlteede.FlvlAcDGiWnvmesqevvdfv....raklkkgeesvlseiveeL

PPM_PTC7_motif 239-261 1.8e-06 21.4 In-house 1-23 (51) alignment
Range on Protein: 239-261
Range on HMM: 1-23/51.0
ILGSDGLWNMVTSEASVQIVEKY
||.|||||......  |..| . 
iLAsDGLWDvlsdqeavdlvrdq

subfamily_PPM1H_pd Subfamily PPM1H 11-46 3.3e-06 19.1 In-house 56-91 (404) alignment
Range on Protein: 11-46
Range on HMM: 56-91/404.0
REQEADYACFAVFDGHGGKEAAVYARDHLWQNIKNQ
.|.....|.|..||||.|. ||. |   | . .|..
eeeklplayfglfDGhaGsgaalvaskllhkhlkek

Subfamily Dicty-PPM1L-like 15-46 4.2e-06 18.8 In-house 35-65 (305) alignment
Range on Protein: 15-46
Range on HMM: 35-65/305.0
ADYACFAVFDGHGGKEAAVYARDHLwQNIKNQ
 .   | |||||.|. || |.. .|  .| |.
qelslfGvfdGhnGdiaaeyvkkkl.veivnk