Gene PPM1E in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP186_AA protein Get Run
SpurP186_AA_103-379 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1E_pd Subfamily PPM1E 116-379 4.9e-126 412.3 In-house 4-264 (265) alignment 
Range on Protein: 116-379
Range on HMM: 4-264/265.0
HTVSLHAVRNTRRKMEDKHVVLQDINTMFKSrlkdPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIESPTNALKKAFNETDDAFIQKAGREG
..||..||.|.||||||.||.|.|.|..|.      |.|.|||.||.||||||.|..||||||| ..|.|....|.|..|||.||..||..|.||| ||.
yevsiaavknkrrkmEDrhvaledlnelfel....kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqkaerek

LRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWFGAWRVNGSLAVSRSIGDPDYKPYVSSEADTAILPLDG
|.||||.|.|.|| |....||||||||.|.|... | .|.||||.|||||||||..||.||..|||||||.|.|||.|||...|||||.|||.| ..|||
lksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaeveldg

TEECIIIACDGLWDVITPEGACTAIQEFIESGA-DLSGMAPTLVTMAKEAGSSDNITVMVVFLNP
.||..|.||||||||...| ......||...|| ||| .| .||..||||||||||||.||||.|
seeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfldp
0034914 PP2C-like 104-379 6.6e-70 228.1 In-house 9-292 (295) alignment 
Range on Protein: 104-379
Range on HMM: 9-292/295.0
TSMPPVNVGPGIHTVSLHAVRNTRRKMEDKHVVLQDINTMFKSrlkdpddkpRAFYAVYDGHGGVDASYYAAAHLHLHTVS--------QPDFIESPTNA
...  ..  . ...|. . ... |...|| ..|. ........          ....|.||||| .|. .|. .|. . ..         ....|.. .|
lellllsslllllrvgvasdqGrrksneDavlvvlnllslled.........lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieea

LKKAFNETDDAFIQKAGR--EGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWfgaWRVNGSLAVSRSI
|.||| ..| .....| .  | ..||.| |...| ......|..|||.|||.|. ..| .   |||..|.|..||...||.|..   .||||.|||.|..
lrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRal

GDPDYK---------PYVSSEADTAILPLD-GTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMAPTLVTMAKEAGSSDNITVMVVFLNP
|| |.|         |.||.| |. .|.|. .  .....|.||||||...| ... .......| ||. .|  || .| ..||.|||||.||.||.
GdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
PP2C Protein phosphatase 2C 118-370 3e-65 213.3 Pfam-A 3-255 (255) alignment 
Range on Protein: 118-370
Range on HMM: 3-255/255.0
VSLHAVRNTRRKMEDKHVVLQDINTMfksrlkdPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIES--PTNALKKAFNE-TDDAFIQKAGR-
|. ..... |..|||.|. |.. . .        .....||.||.||||| .|. ||. ||. .  .|..| |.    .||.|.| . ||. . ... . 
vgaselqgarksmedahialknleks.......sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant

EGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPV-IIMDPHKPDREDEKKRIEDLGGCVVWfgAWRVNGSLAVSRSIGDPDYKP----YVSSEADT
| ..|||| | ..| ......|..|||.|||.|. ...  ..  |||..|||..|||..|| | .   .||||||||||..|| ..||    .||.| |.
epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdv

AILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMAPTLVTMAKEAGSSDNI
   .|.  .|..|.|.||||||.... |.  ........ ... .|  ||. |.. ||.|||
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 118-370 3e-65 213.3 In-house 3-255 (255) alignment 
Range on Protein: 118-370
Range on HMM: 3-255/255.0
VSLHAVRNTRRKMEDKHVVLQDINTMfksrlkdPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIES--PTNALKKAFNE-TDDAFIQKAGR-
|. ..... |..|||.|. |.. . .        .....||.||.||||| .|. ||. ||. .  .|..| |.    .||.|.| . ||. . ... . 
vgaselqgarksmedahialknleks.......sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskant

EGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPV-IIMDPHKPDREDEKKRIEDLGGCVVWfgAWRVNGSLAVSRSIGDPDYKP----YVSSEADT
| ..|||| | ..| ......|..|||.|||.|. ...  ..  |||..|||..|||..|| | .   .||||||||||..|| ..||    .||.| |.
epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdv

AILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMAPTLVTMAKEAGSSDNI
   .|.  .|..|.|.||||||.... |.  ........ ... .|  ||. |.. ||.|||
tsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2Cc_SM00332 121-375 2.2e-63 207.2 In-house 15-274 (274) alignment 
Range on Protein: 121-375
Range on HMM: 15-274/274.0
HAVRNTRRKMEDKHVVLQDINtmfksrlkdpDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIES-----PTNALKKAFNETDDAFIQKAGREG
..  . |..||| |||  | .            .  .|..|.||||| ... .....|. .  ... . ..     ...||||||..||... ... .. 
ssmqgwrksmeDahvvvvdlv..........eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqske

L---RSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGcvvWFGAWRVNGSLAVSRSIGDPDYK-------PYVSSE
|   .|||| | ...  .....|..|||.|||.|. | | .   |||..|||.|||.. ||   .   .||||.|||||..|| ..|       ||...|
lenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg...vvekgrvngglavsrafGdhflkknkklkepyitae

ADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGA--DLSGMAPTLVTMAKEA-GSSDNITVMVV
 |. .. |.  .|..|.|.||||||.... ..  .......|.  | . .|  |. .| .. ||.|||||.||
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PPM_PTC7 118-370 5e-63 206.0 In-house 3-259 (259) alignment 
Range on Protein: 118-370
Range on HMM: 3-259/259.0
VSLHAVRNTRRKMEDKHVVLQDINTMfksrlkdPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIES--PTNALKKAFNE--TDDAFIQKAGR
.. .| .. |..|||.|..|.. . .        .....||.||.|||||  |. ||. ||. .  ....| |.  . .||.|.| .  ||. . ... .
ggasafqgfrksmedahialanless.......sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelkssean

-EGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPV-IIMDPHKPDREDEKKRIEDLGGCVVWFGAWRVNGSLAVSRSIGDPDYKP------YVSSE
 | ..|||| | ..| ..... |..|||.|||.|. ..|      |||..|||..|||..|| | . | .||||.|||||..|| ..||      .||.|
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae

ADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGaDLSGMAPTLVTMAKEAGSSDNI
 |.   ..|  .|..|.|.||||||.... |.  ........ |..  |  ||. |.. ||.|||
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
subfamily_PPM1A_pd Subfamily PPM1A 118-378 3.1e-59 193.6 In-house 14-281 (282) alignment 
Range on Protein: 118-378
Range on HMM: 14-281/282.0
VSLHAVRNTRRKMEDKHVVLQDINTMfksrlKDpddkpRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFI---------ESPTNALKKAFNETDDAFI
... .... |..|||.|.| ......     ||      .|.||.|||.| ... |.. ||. . ... ..          ..  .||...| ..|.|  
ygvssmqgwrvemEDahtvvaslgal.....kd.....wsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeair

QKAGREG--LRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVwfgAWRVNGSLAVSRSIGDPDYKP------
..  .    ..|||| |.|....... .| |||| |||.|. | ..  . |||.|..||||||. || ||     ||||.|||||..|| .||       
elstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykeeeekka

---YVSSEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMAPTLVTMAKEAGSSDNITVMVVFLN
    ||.|......  .  .. ...||||.|||.. | ..  ... .| . .|. .| .||  | |.|| ||..|.||...
eeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
0049733 PP2C-like 121-378 9.9e-52 168.5 In-house 8-234 (235) alignment 
Range on Protein: 121-378
Range on HMM: 8-234/235.0
HAVRNT-RRKMEDKHVVlqdintmfksrlkdpddkPRAFYAVYDGHGGVDASYYAAAHLHLHTVS--QPDFIESPTNALKKAFNETDDAFIQKAGR--EG
. ...  |. .|| ..|                   ....||.|||||  |. .|. .|. . ..  .. .......||.||| ....|....| .  | 
asdigrvrkvneDavlv..................glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspel

LRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVvwfgawRVNGSLAVSRSIGDPDYKpyvsseADTAILPLDG
 ..|.| |.... ......|..||| |.|.|| | | .  .|.| .|.|..||...|| |      ||.|.||..|..||...|      .|. .|.|. 
agmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pdvtvlelep

TEeCIIIACDGLWDVITPEGACTAIQEfiesgADLSGMAPTLVTMAKEAGSSDNITVMVVFLN
 . ....|.||||||...| ..  ...      ||. .| .|| .| ..|. |||||.||.|.
gd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1G2_pd Subfamily PPM1G2 118-378 9.8e-48 155.5 In-house 21-287 (287) alignment 
Range on Protein: 118-378
Range on HMM: 21-287/287.0
VSLHAVRNTRRKMEDKHVVLQDintmfksRLKDPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIE-SPTNALKKAFNETDDAFIQKAGREGL
|.  |..  |..||| |.. ..        |. .|||  |..||.||||| ... ||. .|.   .....| | . ...||.|| |||  ....   .  
vgssamqGyrlnmeDahilene.......lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklkde

RSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVwfgAWRVNGSLAVSRSIGDPDYKPYV---------SSEAD
 .||| |.|.|. . .  |  |||.|||  . .   .   |||..|.|||||.. || |      ||||.||.||..||  .|  |           . |
saGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtavPD

TAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMAPTLVTMAKEAGSS------DNITVMVVFLN
  .  ||  .| ...||||.|||.| .  .  ..| . |||.|. .. .|.. .    ||      ||.||..| |.
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 126-377 2.8e-45 147.6 In-house 16-253 (255) alignment 
Range on Protein: 126-377
Range on HMM: 16-253/255.0
TRRKMEDKHVVLQDintmFKsrlKDPDDKPrafYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIES-PTNALKKAFNETDDAFiqkaGREGLRSGSTGVA
 |  |||. |.       |.   ...|..    ||..||||| .|. .|. .|.    .  |  .. | ..||||..|..  .    .  . . |.| ..
rrptmedelviyGs....fr...dksdedy...yalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaas

VVIEPDTIHLAWLGDSQAVLM-RDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWF-GAWRVNGSLAVSRSIGDPDYKPYVSSEADTA-ILPLDGTEECII
|.|  | . .| .|||..||  .|   . .   |||  |.|.|||..||| ||    . |||| |||||..||   .|.| .. |    |    ... .|
vliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdPdlsqsleiskkdkfli

IACDGLWDVITPEGACTAIQEFiesgADLSGMAPTLVTMAKEAGSSDNITVMVVFL
.||||.||.|. | |.  . .     .|    | .|  .| . ||.|||.|.|. |
lacdGiwdlisdeeaveivagi....sdpekaaeklrdlayssGstdnisvivikl
subfamily_ILKAP_pd Subfamily ILKAP 120-375 2.2e-39 128.4 In-house 8-290 (293) alignment 
Range on Protein: 120-375
Range on HMM: 8-290/293.0
LHAVRN-TRRKMEDKHVVLQDINTMfkSRLKDPDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQ---PDFIE---SPTNALKKAFNETDDAFIQKAG
 .| |.  | .|.|.||.|.|...   .||..   .  ..|||.|||.|  || .|| .|| . ...    |.     .  ..| ..|..||. |...| 
ayaerkGereemqdahviledldeq..lrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklas

RE--GLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRD------CKPVIIMDPHKPDREDEKKRIEDLGGCVvWFGawRVNGSLAVSRSIGDPDYKPY-VS
..    . ||| . |..  .... | ||||.|||.|        . | .   |.| ...|.|||.  || | . |  ||.| | |||||||  .|   |.
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdg..rvlGvlevsrsiGdgrfkrlGvi

SEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGAD----------------LSGMAPTLVTMAKEAGSSDNITVMVV
|  |.  . |.  .  ...||||||.|.. . .   |.. .|.  |                .   .  | . | . |||||.||..|
stPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllv
subfamily_PPM1L_pd Subfamily PPM1L 116-377 9e-36 116.5 In-house 5-266 (269) alignment 
Range on Protein: 116-377
Range on HMM: 5-266/269.0
HTVSLHAVRNTRRKMEDKHVVLQDINtmfksrlkdpDDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQP------DFIESPT---NALKKAFNETDDA
. |. ..|.  | .|||.  . .||.          ..    |.||.|||||  |. .|   |     ..          . |    . |..     |  
qqvavysvlGrrprmedrfeieedik..........nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdek

FIQKAGREGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLM-RDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWFGAWRVNGSLAVSRSIGDPDYKPYVSSE
...|| |.   .|.| .  ... . . .| .|||. ||. .. | . .   ||| .  |.|||.. || . . |.|||.| ||.||..||   |      
llekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlvi

ADTAILPLDGT---EECIIIACDGLWDVITPEGACTAIQEFIESGaDLSgmAPTLVTMAKEAGSSDNITVMVVFL
||  || .|      | .|.|.||||| .. | |.. |.| ..   |.   | .||  .   || |||||.|| |
adpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkep.dfG..akslvlesfkrGsvdnitvlvvkl
PPM_PTC7_SpoIIE 119-374 1.4e-34 112.9 In-house 4-226 (230) alignment 
Range on Protein: 119-374
Range on HMM: 4-226/230.0
SLHAVRNTRRKMEDKHVVLQDINTMfksrlkdPDDKPRAFYAVYDGHGGVDasYYAAAHLHLHTVSQPdFIES--PTNALKKAFNETDDAFIQKagreGL
. .| .. |..|||.|..... . .       ...  .......|||||     .|...|.    ..  | ..  | ..|.... . ....  .      
gasaaqgarksmedahispanseks.......sggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....ps

RSGSTGVAVVIEPDT--IHLAWLGDSQAVLMRDcKPViimdphkpdredEKKRIeDLGGCV-VWFGAWRVNGSLAVSRSIGDPDYKP---YVSSEADTAI
 ||.| | ..|.|.|  ...|..||| ..|.|| ..             |..|| ..|| . . .. .||.|.||||...||  ...   .|..|.||  
ssgaTavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepdtsd

LPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGadlsgmaptlvtmAKEAGSSDNITVMV
  |.| .| .|.|.|||||| .|. .. .... .|.              | |.. .| ||. |
gelfgkdeflilasdglwdvlspqelvdlvrdelekp.............aaeglleDDitllv
subfamily_PPM1K_pd Subfamily PPM1K 158-380 1.6e-34 112.3 In-house 33-261 (263) alignment 
Range on Protein: 158-380
Range on HMM: 33-261/263.0
FYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIESPTNALKKAFNETDDAFIQK-----AGREGLRSGSTG-VAVVIEPDTIHLAWLGDSQAVLMRDCKPV
..||.|||.|. |  ..  .|. .     .  .     ||.||.| |... .      | .| | ||.|  |... .   . || ||||.|.| |. |. 
yvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkak

IIMDPHKPDREDEKKRIEDLGGCVVW--FGAWRVNGSLAVSRSIGDPDYKPY-VSSEADTAILPLDGTEE-CIIIACDGLWDVITPEGACTaiqeFIESG
 . . |.|..|.||.||   || | |   |  .||| ||..||.|| | |.| | .. .|  | .| ...  ...  ||. .|.. .  |     ...  
kltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcd....lvrlc

ADLSGMAPTLVTMAKEAGSSDNITVMVVFLNPF
 |    | .|...| . || || |..|| |. .
hdpeeaahalteqalqygsednatavvvplgaw
subfamily_PPM1D_pd Subfamily PPM1D 119-378 6.3e-29 94.0 In-house 5-308 (309) alignment 
Range on Protein: 119-378
Range on HMM: 5-308/309.0
SLHAVRNTRRKMEDKHVVLQDINTMFKsrlkdpdDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIESPT----NALKKAFNETDDAFIQKA---
. .| .  |. |||  ..  . .   .       ..  || ||.||||| .|. .|  ||      | .|. |.     .|...|| .|  |  .|    
tseadqGgrkymeDvvaivleeeesae.......elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW

--GREGLR--SGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCK------PVIIMDPHKPDREDEKKRIEDLGGCVVWF-GAWR---------VNGS-----
   ..||   .|.|   |.|  . ...|  |||..||  . .      .  ... |||.  .||.|||.||| |    |  |          ||      
pktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvide

---LAVSRSIGD-----PDYKPY-VSSEADTAILPLDGTEE-CIIIACDGLWDVITPEGACTAIQEFIESGADL----SGMAPTLVTMAKEAGSS-----
   |||.||.||        . . || | |.    ||. || .||.| ||||.|.||| | . ...  | .       . .|..||. | .  .|     
iPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNITVMVVFLN
||..|.||.|.
Dnvsvivvile
subfamily_PPM1G_pd Subfamily PPM1G 210-379 1.1e-22 73.7 In-house 288-472 (473) alignment 
Range on Protein: 210-379
Range on HMM: 288-472/473.0
KAGREGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWFGawRVNGSLAVSRSIGDPDYKPY--------
..  .|  ||.| | .... ...  |  ||| .|| |. | . .   |||. | |..|||  || |   |  |||| | .|| .||  ||          
ekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeq

-VSSEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGA--DLSGMAPTLV--TMAKEA---G-SSDNITVMVVFLNP
 .|   |  .| |   .| ...||||.|.|.. .     ... .. |    || .  .|.  ..|..    |   || ||..| |..
misAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_KAPP-like_pd Subfamily KAPP-like 157-376 6.7e-18 57.7 In-house 35-265 (266) alignment 
Range on Protein: 157-376
Range on HMM: 35-265/266.0
AFYAVYDGHGGVDASYYAAAHLH---LHTVSQ------PDFIESPTNALKKAFNETDdAFIQKAGREGLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMRD
|..||.||| |  |.  |   .     . . .       | |    . |..||.| | | ...   ||  .  . |    .   .  | .||| | | | 
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevd.aklkdfeyeGatatlalvwsdGqqrylqvanvGdssaflsrG

CKPVIIMDPHKPDREDEKKRIEDLGgCVVWFGAWRVNGsLAVSRSIGDPDYKPY---VSSEAD-TAILPLDGTEECIIIACDGLWDVITPEGACTAIQEF
 . . .   || . ..||.|| | |   .  .  |.|| |||||..||   |     ..||   .  . |   .. .|.| |||||||. . |   .. .
neslelskdhkakdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvksl

IESGADLSGMAPTLVTMAKEA-GSSDNITVMVVF
 . .|    || .|.  | ..  . ||..|.|| 
ydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PP2D1_pd Subfamily PP2D1 207-344 2.1e-17 56.0 In-house 164-306 (492) alignment 
Range on Protein: 207-344
Range on HMM: 164-306/492.0
FIQKAGREGLRSGSTGVAV-VIEPDTIHLAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGGCVVWFGA-WRVNGSLAVSRS---IGDPDYKPY
  .|  .|||   | |  |  .|. ....|  |. ||||.|. | .|.   | |  . |..|.|  |. ||  .   .||| | . |    .|||. |  
eekkdseeGlekesngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkks

VSSEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFI
|  |  |   .|| .   ...|  |||.|.. |   . .....
vipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 157-295 6.3e-17 55.0 In-house 21-182 (292) alignment 
Range on Protein: 157-295
Range on HMM: 21-182/292.0
AF-YAVYDGHG--GVDASYYAAAHLHLHTVSQPDFIESPTNALKKAFNETDDAFIQKAGREGLRSGSTGVAVVIEPD-TIHLAWLGDSQAVLMR-----D
.|  ||.||||  |   . .|. .|  . ..        ..|| .   ..   . .    ........ |  ..  |  . || .|||.|.| |     |
tflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsd

CKPVIIMDPHKPDREDEKKRIEDLGGCVV--------WFGAWRV------NGSLAVSRSIGD
 ... .   |||.  ||..||   || |         . |. ||      .| ||.||..||
yeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGd
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 234-376 7.4e-16 50.8 In-house 130-275 (276) alignment 
Range on Protein: 234-376
Range on HMM: 130-275/276.0
LAWLGDSQAVLMRDCKPVIIMDPHKPDREDEKKRIEDLGgCVVWFGAWRVNGsLAVSRSIGDPDYKPY---VSSEAD-TAILPLDGTEECIIIACDGLWD
 | .||| | | |  . . .   || .  .||.|| | |   .  .  |.|| |||||..||   |     ..||   .  . |   .. .|.| |||||
vanvGdssaflsrGneslelskdhkatdpeekqrikddG.itlsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwd

VITPEGACTAIQEFIESGADLSGMAPTLVTMAKEA-GSSDNITVMVVF
||. . |   .. . . .|    || .|.  | ..  . ||..|.|| 
visGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PHLPP_pd Subfamily PHLPP 209-377 3.1e-14 45.5 In-house 76-245 (246) alignment 
Range on Protein: 209-377
Range on HMM: 76-245/246.0
QKAGREGLRSGSTGVAVVIEPDT--------IHLAWLGDSQAVLMRDCKPVIIMDPHKPDREdEKKRIEDLGGCVVwfGAWRVNGSLAVSRSIGDPDYKP
.| | .| . ||. . . | .|.        ...|  |  ||||.|. |....  ... ... | ||| .  . .      ..|| .. .| .|     |
rklGeaGeklgsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiit..ednkingviestrllGytflfP

YVSSEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGAdlsgMAPTLVTMAKEAGSSDNITVMVVFL
.|  .     ..|   .| .|.  . ||.|.  . |  |...  .. .     |  ||..|.  | .|...|.|| |
vvlPkphvrevlLteqdellivGnkalWevlsideaveavrkeedplv....aAkklvdlaqsygaadsvsvlvvrl
PP2C_SIG_SM00331 151-376 1.5e-13 43.8 In-house 27-216 (217) alignment 
Range on Protein: 151-376
Range on HMM: 27-216/217.0
PDDkpRAFYAVYDGHG-GVDASYYAAAHLH-LHTVSQPDfiesptNALKKAFNETDDAFIQKagREGLRSGSTGVAVVI--EPDTIHLAWLGDSQAVLMR
...  | ...| ||.| |..|. ...  .. |.. .. .      ..|..|......|. ..   |  ... | .. ..  . .....| .|||  .|.|
neg..rlllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr

DCKPVIIMDPhkpdredekkriedlggcvvwfgawrvngslAVSRSIG-DPDYKpyvsseADTAILPLDGtEECIIIACDGLWDVITPEG-ACTAIQEFI
| | | | .                                  .. .|  |...      .|.. | |.  .. .... |||... ...| |   ..|..
dgklveilkd...............................vegaplGlepevs......vdirelelek.gdllllytDGltearsekgfaeerleeil

ESGADL--SGM----APTLVTMAKEAGSSDNITVMVVF
|. .|     .       |.. ||... .|.|||.||.
edlvdseaqelaqkiveellelakgsngeDdiTvvvvk
Subfamily Dicty-PPM1L-like 262-378 9.4e-13 40.6 In-house 180-304 (305) alignment 
Range on Protein: 262-378
Range on HMM: 180-304/305.0
EDEKKRIEDLGGCVVWFGAWRVNGSLAVSRSIGDPDYKPYVSSEADTAILPLDGT-EECIIIACDGLWDVITPEGACTAIQEFIE---SGA----DLSGM
.... ||| |..... .|  .||. | .|||.|| . | .|  . |  .| .  . .. ...| ||||.|.  .     ..| ..   |.     |   .
deiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfnei

APTLVTMAKEAGSSDNITVMVVFLN
    |  | . || ||||.....|.
srviveeavkrgsgDnitlviiklk
PPM_PTC7_motif 321-370 4.1e-11 36.2 In-house 1-51 (51) alignment 
Range on Protein: 321-370
Range on HMM: 1-51/51.0
IIACDGLWDVITPEGACTAIQEFIE-SGADLSGMAPTLVTMAKEAGSSDNI
|.|.||||||.... |.  ......  | ..   |  ||. | . ||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PPM_PTC7_SpoIIE_motif 319-375 2.6e-08 27.4 In-house 14-78 (81) alignment 
Range on Protein: 319-375
Range on HMM: 14-78/81.0
CIIIACDGLWDVITPEGAC----TAIqEFIE--SGADLSGMAPTLVTMAKEAG---SSDNITVMVV
 .....|||.. ....| .    ... ....  .| .|  .| .||  ..|.|   ..|.||..|.
vllLyTDGltEardsdgelfgkeell.rladraegkslqeladklvdevlengsgereDDitllvl
subfamily_PPM1G_pd Subfamily PPM1G 127-210 3.6e-08 25.8 In-house 30-102 (473) alignment 
Range on Protein: 127-210
Range on HMM: 30-102/473.0
RRKMEDKHVVLQDIntmfksrlkdpdDKPRAFYAVYDGHGGVDASYYAAAHLHLHTVSQPDFIESP-TNALKKAFNETDDAFIQK
| ..|| | .. |.            |.  ...|||||||| . . | |..|      |  . |   ..||..|| . |.   ..
rvsqEDahncitdl............dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkae
subfamily_TAB1_pd Subfamily TAB1 215-298 1e-06 20.8 In-house 126-212 (333) alignment 
Range on Protein: 215-298
Range on HMM: 126-212/333.0
GLRSGSTGVAVVIEPDTIHLAWLGDSQAVLMR---DCKPVIIMDPHKPDREDEKKRIEDLGGCVVWFGAWRVNGSLAVSRSIGDPDY
 .. |.| | ..|  . .. |  |||.|.|..     | . .   |. | ||| .|..|||  .      .. ||    |||||   
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykv
subfamily_PDP_pd Subfamily PDP 300-354 1.1e-06 21.0 In-house 268-322 (398) alignment 
Range on Protein: 300-354
Range on HMM: 268-322/398.0
PYVSSEADTAILPLDGTEECIIIACDGLWDVITPEGACTAIQEFIESGADLSGMA
||...| .    .|  ..  ...| |||||....| . . ..|.... .. . ..
PYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepvk