Gene PPM1G in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP187_AA protein Get Run
SpurP187_AA_2-340 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 152-341 6.1e-115 377.9 In-house 285-472 (473) alignment 
Range on Protein: 152-341
Range on HMM: 285-472/473.0
G--GKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTSLPPEE
|  .|||||.|||.|||||||..|.|.|||.|||||||||.|.|||.|.||||||.|||.|||||||||. |||||||||||||.|||.||....||..|
gseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplke

QMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESdqsnKLSKICEELFDFCLSPDTSGDGTGCDNMTCVIVQFHS
|||||.||||..||||.|.|.|.|||||||.|.||.|.|||...|....||    .||.|.|||.| ||.||||||||||||||..||....
qmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
PP2Cc_SM00332 18-337 8.5e-90 293.8 In-house 6-274 (274) alignment 
Range on Protein: 18-337
Range on HMM: 6-274/274.0
SCEELSYGASAMQGWRVGMEDSHNCITKLT--EDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG----DIDAAFEEAFMTFDASLKQKAIIEKL
|  .|||| |.|||||. ||| |.....|   ||...|.|.|||||.||| ......|. | . ...|..    |. .| ..||  .|  . ...  ..|
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

RRiagmeegeekeedgetetlleeaelpleqlvarymqlpggkeepgSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRI
..                                             ..||||||||||....| |||.||||.||.|.| |...|.|||||| .|..||
en.............................................alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRi

EKAGGKVTPDgRVNGGLNLSRAFGDHCYKMTTslPPEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdQSNKLSKICE
.||||.|  . ||||||..|||||||..|     ...|..|.| ||.|. |||..|.|...|.||.|. ...|.|.|.|. .|..     . |. ....|
kkaggvvekg.rvngglavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg....ktndpqeaae

ELFDFCLSPdtsgdGTGCDNMTCVIV
.| . ...      |...||.|.|.|
lldeeairr.....ggseDniTvvvv
0034914 PP2C-like 3-340 1.9e-78 256.1 In-house 2-291 (295) alignment 
Range on Protein: 3-340
Range on HMM: 2-291/295.0
AYLSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNCITKL---TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNL-------KSFKDGDIDAAFE
..|| |..|...   .   |..|.. .||.|  .||.. ... |   .||..||.|.||||| ..| . .. ...|| .|        .. . ||  |..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

EAFMTFDASLKQKAIIEklrriagmeegeekeedgetetlleeaelpleqlvarymqlpggkeEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGV
.||.  |  | ..|. .                                                 . ||.||||||.||..|.|||.||||.||.|.|.
kaflaadeellelallr..............................................pelagsGtTavvalirgnklyvanvGDSravllrnge

ALDMSYDHKPEDDVELRRIEKAGGKVTPdGRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLT-EQDDFMVVACDGIWNAMTSQDVIDFVT
.. ...|||| .  | .||..||| |.  |||||.|...||.||...|.  ||...|...||.||... .|| |.|||...|.||.|. .......|.|.
lvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivr

HRLEnsresdQSNKLSKICEELFDFCLSpdtsgdGTGCDNMTCVIVQFH
..|.      ... |....||| |..|.      . ..||.|.|.|...
slla......kgldleeaaeeLvdlAla......rgsrDNiTvvvvrln
subfamily_PPM1A_pd Subfamily PPM1A 15-340 4.8e-76 248.8 In-house 5-281 (282) alignment 
Range on Protein: 15-340
Range on HMM: 5-281/282.0
DDGSCEELSYGASAMQGWRVGMEDSHNCITKLTE--DTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKD--------GDIDAAFEEAFMTFDASLKQ
.... ..| || |.|||||| |||.|.....|..  | |.|||.|||.|.||| |....... ... ...|.         ..  |....|...| ....
sqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

KAIIEKLRR-IagmeegeekeedgetetlleeaelpleqlvarymqlpggkeepgsdsGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPE
.    | .                                                  |||||..|.. |.| .||.|||| ||.|.| |  ...||||.
lstdlktadks...............................................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkps

DDVELRRIEKAGGKVTpDGRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqs
.. | .|||.|||.|.  .|||| | .|||.||. || ......|||..|| |....   .|.|||.|.||||||  .....|...|..||| .      
rpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva......

NKLSKICEELFDFCLSPDTSgdgtgcDNMTCVIVQFH
..|......| | .|. ..       ||.....| |.
deleevakalvdkalekgsr......DNlsvlvvlfa
PPM_PTC7 24-323 2.5e-68 223.3 In-house 3-256 (259) alignment 
Range on Protein: 24-323
Range on HMM: 3-256/259.0
YGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDidaafeeafmtfdaslkqkaiieklrriagme
.||||.||.|. |||.| .  .|      .. ..|||.||||| |.| |....... | . |||....                                
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele................................

egeekeedgETETLLEEAELPL-------EqlvarymqlpgGK--EePGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVEL
         ..|  | .. | |                    .  .   |.|||||||||..|..| |||.||||.||.|.| |   ...||||..  | 
.........klekalrksflaldtdeelks...........seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEr

RRIEKAGGKVTP--DGRVNGGLNLSRAFGDHCYKMTTSlppEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsnKL
.|||.|||.|    .||||| |..||||||...|   .   |||..|| |||......|.|.|...|.||.|. ...|...|.|. .|.         ..
eRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dp

SKICEELFDFCLSPDTS
....|.| |........
meaaeklvdeaiargse
subfamily_PPM1G2_pd Subfamily PPM1G2 157-339 1.9e-64 210.4 In-house 111-286 (287) alignment 
Range on Protein: 157-339
Range on HMM: 111-286/287.0
PGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDgRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFP
  ...||||||.|.. . | |||.||||.||| .| .  .|.||||..  | .||..||| |  . |||| | ||||.||...| .....||||.. |.|
kdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtavP

DIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsNKLSKICEELFDFCLSPDTSGDGTGCDNMTCVIVQF
|. .  |.|.|.|.|.||||||. .|...|.|.| .|| .        ||..|.|||.| ||.||.|  | ||||||.||| .
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg......akldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1G_pd Subfamily PPM1G 4-147 3.1e-59 194.2 In-house 1-150 (473) alignment 
Range on Protein: 4-147
Range on HMM: 1-150/473.0
YLSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNCITKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFDASLK
|||.|.|||.|.|.|.|||||||||||||||..||.|||||.|.||||||||||||||.|||.|.|...|.||.. |..|.||...|.||||...|..||
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

QKAIIEKLRRIAGMEEGEEKE------EDGETETLLEEAELPLEQLVARY
.......|..||..||.|..|      .. |.|.| ||||.||..|..|.
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl
PP2C Protein phosphatase 2C 159-323 9.6e-59 192.0 Pfam-A 98-252 (255) alignment 
Range on Protein: 159-323
Range on HMM: 98-252/255.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTslppeEQMISAFPD
|.|||||||||.|||.| |||.||||.||.|.. |   ...||||.|. | .|||.|||.|   ||||| |..|||.||...|  .     ||..|| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSResdqsnKLSKICEELFDFCLSPDTS
.....|||.|.|...|.||.|. ...|...|.|. .|.  .      ......||| |..... ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 159-323 9.6e-59 192.0 In-house 98-252 (255) alignment 
Range on Protein: 159-323
Range on HMM: 98-252/255.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTslppeEQMISAFPD
|.|||||||||.|||.| |||.||||.||.|.. |   ...||||.|. | .|||.|||.|   ||||| |..|||.||...|  .     ||..|| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSResdqsnKLSKICEELFDFCLSPDTS
.....|||.|.|...|.||.|. ...|...|.|. .|.  .      ......||| |..... ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse
0049733 PP2C-like 22-340 4.3e-53 172.9 In-house 3-234 (235) alignment 
Range on Protein: 22-340
Range on HMM: 3-234/235.0
LSYGASAMQGW-RVGMEDSHNCitklteDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNL-KSFKDGDIDAAFEEAFMTFDASLKQKaiieklrriagmee
||.||. ..|. |  .||.. .      ...||||.|||||.... . .......| .| ...   |. .|...||.. .. | ..              
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel..............

geekeedgetetlleeaelpleqlvarymqlpGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVt
                                . .... . .|.|||||||.|..|.|||.||||..| ||| .. ...||.| .. | .||..||| | 
................................alaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.

pdgRVNGGLNLSRAFGDHCYKmttslppeeqmisafPDIKTATLTEQDdFMVVACDGIWNAMTSQDVIDFVTHrlensresdqsNKLSKICEELFDFCLS
   ||.|.| |.||.||...|               ||. . .|...| |...|.||.|. .......|....           . |....|.|....|.
...rvpgrlaltralGdlllk...............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala

pdtsgdGTGCDNMTCVIVQFH
      . |.||.|.|.|...
......rggrDNiTvvvvrld
subfamily_PPM1L_pd Subfamily PPM1L 26-297 1.5e-39 128.8 In-house 9-239 (269) alignment 
Range on Protein: 26-297
Range on HMM: 9-239/269.0
ASAMQGWRVGMEDSHNCITKLTEDT--SLFAVYDGHGGAEVAVYTAQQFPKLLTN-LKSFkdgdidaafeeafmtfdaslkqkaiieklrriagmeegee
. ...| |  |||  .  ......|  |.|||.|||||   | .. . ..| . | |. .                                        
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel........................................

kEEDGETETLLEEAELPLEQLVARYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLS-RDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD
 ..| | .. .. ..|  .....   .|    .     .|.||..||.... |.|||.|||| ||  ..| |. .|.||||..  | .||.|||| .. .
.dadkentepinfsklltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafr

G--RVNGGLNLSRAFGDHCYKmttslppEEQMISAFPDIKTATLTE-QDDFMVVACDGIWNAMTSQDVIDFVTHRLENS
|  ||.| |  |||.||.  |       ..... | ||| |  | . . .|...|.||.|.... .. . |.  ||.. 
GvwrvaGvlatsralGdyplk.......dknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkep
PPM_PTC7_SpoIIE 24-309 2.4e-38 125.2 In-house 3-213 (230) alignment 
Range on Protein: 24-309
Range on HMM: 3-213/230.0
YGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEvaVYTAQQFPKLLTNLKsFKDGD-IDAAFEEAFMTFDASLKQKaiieklrriagm
.||||.||.| .|||.| .  ..          .....||||| .   ... .. ..| .|. |....  ........  ..| |. .            
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede............

eegeekeedgetetlleeaelpleqlvarymqlpggkeepGSDSGSTAVVALLRGKT--LTVANIGDSRCVLSRD-GValdmsydhkpeddvELRRIeKA
                                         |.||.||||||... |  |.||| |||...|.|| |               | .|| .|
........................................psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.va

GGKVT---PDGRVNGGLNLSRAFGDHCYKMttslppEEQMISAFPDiKTATLTEQ-DDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsnklskI
|| .     .|||.| |..|.|.||  ..       ......| ||   ...... |.|...|.||.|. ...|...|.|  .||             .
gglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp...........a
subfamily_PPM1E_pd Subfamily PPM1E 159-339 2.7e-36 118.1 In-house 100-262 (265) alignment 
Range on Protein: 159-339
Range on HMM: 100-262/265.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDG--RVNGGLNLSRAFGDHcykmttslpPEEQMISAFP
  |||||||.|.....| || .|||. .| |.| |. .   ||||.. | .|||.||| |   |  |||| |..||| ||           .....|. .
lksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDv.........klkpyvsgea

DIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENsresdQSNKLSKICEELFDFCLSPDTSgdgtgcDNMTCVIVQF
|. . .|.........||||.|. .. ..|.. |.. |..     ....||.. ..| .   . . |      ||.| |.| .
dvaeveldgseeylilacDGlwDvvneeevvklveeflad.....gaedlsevakllveaakeagss......Dnitvvvvfl
subfamily_ILKAP_pd Subfamily ILKAP 154-311 7.1e-33 107.0 In-house 106-260 (293) alignment 
Range on Protein: 154-311
Range on HMM: 106-260/293.0
KEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDG------VALDMSYDHKPEDDVELRRIEKAGGKVTpDGRVNGGLNLSRAFGDHCYKMTTslpp
|..|    ||||.| |   ..| |||.|||..|| |        ... .. ||.| .  | .||.||||.|. ||||.| |. ||. ||  .| .     
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlG....

eeqmISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNKLSKICE
    ... ||.|  .||| | |.|.||||.|.... ..|..|... ||. ..... ..  |. .
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekksk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 139-293 2.4e-32 105.2 In-house 73-223 (255) alignment 
Range on Protein: 139-293
Range on HMM: 73-223/255.0
PLEQLVARYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLS-RDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD---GRVNGGLNLSRAF
|.. |   | ..    .| .   |.||...|. ..   .||.|||| ||. .||.|  .|.|||| .. | .||...||.|  .    |||| | .|||.
PvkslkkaykeistqiserpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsral

GDHCykMTTSLPPEeqmisafPDIK-TATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHR
||    ..  . |.       ||.. . . ...| |...||||||. .. .. .. |   
Gdsf..lePfvvpd.......PdlsqsleiskkdkflilacdGiwdlisdeeaveivagi
subfamily_PPM1K_pd Subfamily PPM1K 124-293 3.5e-28 91.4 In-house 62-228 (263) alignment 
Range on Protein: 124-293
Range on HMM: 62-228/263.0
EEDGETETLLEEAELPLEQLVARYMQLPGGKEePGSDSGSTAVVALLR-GKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-
|.. . |..| .| . |.. . ||...   ..     ||.|| |.||| |. | .|..|||| .| |.| |  .. ||.|| . | .|| .|||.|. . 
ekekdleivlknafeeldkklkrylefsvaea.ellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewns

---GRVNGGLNLSRAFGDHCYKMTTslppeeqmISAFPDIKTATL-TEQDDFMVVACDGIWNAMTSQDVIDFVTHR
    .||| | ..|..||   |           . | |. |.  .  ..| |.|.  ||| . ..||.. |.|.  
lgkplvngrlamtrslGdldlkryG........viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc
subfamily_PPM1G2_pd Subfamily PPM1G2 5-108 3.1e-26 85.0 In-house 2-110 (287) alignment 
Range on Protein: 5-108
Range on HMM: 2-110/287.0
LSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNC---ITKL--TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFD
|||| |.| |. .. .    |.|||||.|. |||.|     . ..  .....||||.||||||.|| |..... | ... ||||.| .. ....||...|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

ASLKQKAII
 .| ..  .
eellkdekl
subfamily_PDP_pd Subfamily PDP 161-303 3.4e-25 82.0 In-house 152-321 (398) alignment 
Range on Protein: 161-303
Range on HMM: 152-321/398.0
SGSTAVVALLRGKTLTVANIGDSRCVLSR---DG--VALDMSYDHKPEDDVELRRIEKAGGK-----VTPDGRVNGGLNLSRAFGDHCYKMTTSL-----
||..|..||..|..| |||.||.|.|| .   .|   |  .| |.  .   |..||.|.  .     |  .||. | |  .|||||  ||... |     
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl

--------PPEE----QMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQS
        .|..      ..| |.. .. |.|.| |.|.| ||.|. .....|.. |.. |... |... 
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PP2D1_pd Subfamily PP2D1 161-306 2.3e-21 69.0 In-house 176-318 (492) alignment 
Range on Protein: 161-306
Range on HMM: 176-318/492.0
SGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGG---KVTPDGRVNGGLNLSRAFGDHCYKMttsLppeEQMISAFPD
. ..  | |    .| .||.|. . || |.|.|  .  .| |..  | .|.||||.   |  . |.||| |.  |  | .       |   .. .   | 
esngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpk...L...kksvipePk

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNKL
... .|.|.. |.|.|  |.|. .. ..|.  |.. |.  ... .....
ttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenv
subfamily_KAPP-like_pd Subfamily KAPP-like 162-301 2e-20 66.0 In-house 101-239 (266) alignment 
Range on Protein: 162-301
Range on HMM: 101-239/266.0
GSTAVVALL----RGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-GRVNgGLNLSRAFGDHCYKMTTSlppeeQMISaFP
|.|| .||.    . . | |||.|||   |||   .| .|.||| .|. | .|| . |  .. .  |.| || .|||.|||  |          .||  |
GatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni.....Glis.ep

DI-KTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESD
 . .  .|| .|.|..|| ||.|. .. .| |. |    .. . .|
yvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqated
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 173-301 2.1e-19 62.5 In-house 126-249 (276) alignment 
Range on Protein: 173-301
Range on HMM: 126-249/276.0
KTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-GRVNgGLNLSRAFGDHCYKMTTSlppeeQMISaFPDI-KTATLTEQDDFM
. | |||.|||   |||   .| .|.||| .|  | .|| . |  .. .  |.| || .|||.|||  |          .||  | . .  .|| .|.|.
rylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni.....Glis.epyvsnrilltpfdkfl

VVACDGIWNAMTSQDVIDFVTHRLENSRESD
.|| ||.|. .. .| |. |    .. . .|
ivasdGlwdvisGkdaiekvkslydqqated
PP2C_SIG_SM00331 41-339 2.6e-18 59.4 In-house 21-217 (217) alignment 
Range on Protein: 41-339
Range on HMM: 21-217/217.0
NCITKLTEDTSLFAVYDGHG-GAEVAVYTAQQFPKLLTNLKSFkdgdidAAFEEAFMTFDASLKQKaiieklrriagmeegeekeedgetetlleeaelp
 ...|| |.. |..| ||.| |.. |....|  ..| . |..        ....|.   .  ....                                  
ydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee..................................

leqlvarymqlpggkeEPGSDSGSTAVVALL--RGKTLTVANIGDSRCVLSRDG-VALDMSYdhkpeddvelrriekaggkvtpdgrvngglnlsrafgd
                .  .... |...||.  ....| .||.||||..| |||    . .                                       
................keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd......................................

hCYKMTTSLPPEEQmisafPDIKTATLTEqDDFMVVACDGIWNAMTSQDvidFVTHRLENSRESDQSNKLSK----ICEELFDFCLSPDTsgdgtgCDNM
    . ..| ||..     .||.. .| . .|... . ||...|.....   | . |||.  |. ... . .    | |||. .   . .       |..
.vegaplGlepevs.....vdirelelek.gdllllytDGltearsekg...faeerleeiledlvdseaqelaqkiveellelakgsng......eDdi

TCVIVQF
| |.|..
Tvvvvkv
PP2C Protein phosphatase 2C 23-104 4.6e-15 48.9 Pfam-A 2-90 (255) alignment 
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG-DIDAAFEEAFMT-FDASLKQ
 .|||..||.|  |||.| .. .|      .. ..|||.||||| |.| |.... ...| . |||... . ..|. ..|.  .| .||.
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
PP2C Protein phosphatase 2C 23-104 4.6e-15 48.9 In-house 2-90 (255) alignment 
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG-DIDAAFEEAFMT-FDASLKQ
 .|||..||.|  |||.| .. .|      .. ..|||.||||| |.| |.... ...| . |||... . ..|. ..|.  .| .||.
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 158-236 6.3e-15 48.5 In-house 82-182 (292) alignment 
Range on Protein: 158-236
Range on HMM: 82-182/292.0
GSDSGSTAVVALLRGK-TLTVANIGDSRCVLSR-----DGVALDMSYDHKPEDDVELRRIEKAGGKVTP----------DGRV------NGGLNLSRAFG
.  .....| |  |    | .||.||||..| |     |     .| ||||||  | .|| .|||.|.|            ||      .|.| |||| |
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG

D
|
d
subfamily_PHLPP_pd Subfamily PHLPP 173-292 2.6e-14 45.7 In-house 105-214 (246) alignment 
Range on Protein: 173-292
Range on HMM: 105-214/246.0
KTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDvELRRIEKAGGKVTPDGRVNGGLNLSRAFGdHCYKMTTSLPPeeqmisafPDIKTATLTEQDDFMVV
 .|.||..|    || |.|  | .|  .. |.| ||.|| .| . .| |...|| .. .| .| . .   . ||         | ..  .|||||....|
fsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdelliv

ACDGIWNAMTSQDVIDFVTH
  . .|. .  ... . | .
GnkalWevlsideaveavrk
subfamily_PPM1H_pd Subfamily PPM1H 15-206 6.7e-14 44.5 In-house 29-207 (404) alignment 
Range on Protein: 15-206
Range on HMM: 29-207/404.0
DDGSCEELSYGASAMQGWRVGMEDSHNCITKLteDTSLFAVYDGHGGAEVAVYTAQQFPKLLT-NLKSFKDGDIDAAFEEAFMTFDASlkqkaiIEKLRR
| .... |    .. . .   .. ...  .||  .. .|...|||.|  .|. ..... | |. .|.. ..   . . ||   | . |       |.   
Dqaaakvlllkkekkeksvtskpkekseeekl..playfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteess......kespss

IAGMEEGEEKEEDGETETLLEEAELPLEQLVARymqlpgGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDV
   . | .| ...      ||.| | .....||       .|.     | ||.|||.  . | ||| |||| .|.| .   ..| |. || . 
vseiyeekeiskeeLviGalesaflemDeqiar......ereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR
subfamily_PPM1E_pd Subfamily PPM1E 26-112 8.1e-14 44.4 In-house 8-101 (265) alignment 
Range on Protein: 26-112
Range on HMM: 8-101/265.0
ASAMQGWRVGMEDSHNCITKL--------TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIdAAFEEAFMTFDASLKQKAIIEKLR
. |... |  ||| | .. .|        ..... |||.||||| | | |.|.. ..|| . ...|.     |..||| . | .. |||. |||.
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklk
PPM_PTC7_motif 271-323 8.2e-13 41.6 In-house 1-48 (51) alignment 
Range on Protein: 271-323
Range on HMM: 1-48/51.0
VVACDGIWNAMTSQDVIDFVTHRLENSREsdqsnKLSKICEELFDFCLSPDTS
. |.||.|. ...|...|.|. .|.  ..     .. ...|.| |..|.. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealargse
subfamily_PPM1D_pd Subfamily PPM1D 147-220 1e-12 40.8 In-house 94-173 (309) alignment 
Range on Protein: 147-220
Range on HMM: 94-173/309.0
YMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGV------ALDMSYDHKPEDDVELRRIEKAGGKVTP
. . |  |.   | .|.|| | ..|.. | ||..|||. ||. .        |  .  |||||.  | .|||..||.|. 
leeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_TAB1_pd Subfamily TAB1 161-314 1.3e-12 40.2 In-house 129-296 (333) alignment 
Range on Protein: 161-314
Range on HMM: 129-296/333.0
SGSTAVVALLRGKTLTVANIGDSRCVLSR---DGVALDMSYDHKPEDDVELRRIEKAG---GKVTPDGRVnGGLNLSRAFGDHC----YKMTTSLP-PEE
 |.||||||.  . | |||.|||| .| .         .| ||. . . || |... |    ..   .|. |. .  |. ||..    || .. |   ..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QMISAFPDIKTA-TLTEQDDFMVVACDGIWNAMTSQ---DVIDFVTHRLENSRESDQSNKLSKICEELF
. . | |||. |  ...   |.|.  ||. ...      .  .     || . |  .. .|... ... 
ePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavv
subfamily_PPM1D_pd Subfamily PPM1D 228-340 2e-11 36.5 In-house 201-308 (309) alignment 
Range on Protein: 228-340
Range on HMM: 201-308/309.0
LNLSRAFGDH-CYKMTTslppEEQMISAFPDIKTATLTEQDD-FMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNklSKICEELFDFCLSPdTSGD
|...|. ||   |....    .| ..|  ||.|  ||. ... |...| ||.|| .|..|....|..  | .   ....  ... . | .  |.  ..  
LavaRslGDlWsynaks....gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealqr.wrsk

GTGCDNMTCVIVQFH
   .||.. ..| ..
klraDnvsvivvile
PP2C_2 Protein phosphatase 2C 39-309 2.4e-11 36.3 Pfam-A 15-210 (212) alignment 
Range on Protein: 39-309
Range on HMM: 15-210/212.0
SHNciTKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLtnLKSFKDGD-------IDAAFEEAFMTFDASLKqkaiieklrriagmeegeekeedgetet
..    . ..| .|.|| ||.| |. .   |. . . .  ......         ..|.....    .||.|                            
ala..ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvk............................

lleeaelpleqlvarYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRC-VLSRDGVALDMSYDHKPEDDVELRRIEKA--GGKVtpdgrvnggl
               . |    ..|. .| ..| ..|....... ...|||... | .||| .  .. ... |   |.... ..  ....          
...............lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........

nlsrafgdhcykmttslppeeqmisafpDIKTATlTEQDDFMVVACDGIWNAMT-SQDVIDFVTHRLENSRESDQSNKLSKI
                            .|.. . .|. |  ..  ||...... ...........||. .| .....|...
............................rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeegaaeeLaef
PP2C_2 Protein phosphatase 2C 39-309 2.4e-11 36.3 In-house 15-210 (212) alignment 
Range on Protein: 39-309
Range on HMM: 15-210/212.0
SHNciTKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLtnLKSFKDGD-------IDAAFEEAFMTFDASLKqkaiieklrriagmeegeekeedgetet
..    . ..| .|.|| ||.| |. .   |. . . .  ......         ..|.....    .||.|                            
ala..ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvk............................

lleeaelpleqlvarYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRC-VLSRDGVALDMSYDHKPEDDVELRRIEKA--GGKVtpdgrvnggl
               . |    ..|. .| ..| ..|....... ...|||... | .||| .  .. ... |   |.... ..  ....          
...............lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........

nlsrafgdhcykmttslppeeqmisafpDIKTATlTEQDDFMVVACDGIWNAMT-SQDVIDFVTHRLENSRESDQSNKLSKI
                            .|.. . .|. |  ..  ||...... ...........||. .| .....|...
............................rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeegaaeeLaef
subfamily_PPM1H_pd Subfamily PPM1H 223-313 6.8e-11 34.5 In-house 276-369 (404) alignment 
Range on Protein: 223-313
Range on HMM: 276-369/404.0
RVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLTE----QDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSnKLSKICEEL
|. . .  .| .|||  |.. .      ..|..|....  ||.    .|| ...| ||.|. .. ..|   |.. |..  ..|.. . ... .||
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkk.rytavaqeL
subfamily_PPM1D_pd Subfamily PPM1D 26-105 7.8e-10 31.3 In-house 6-93 (309) alignment 
Range on Protein: 26-105
Range on HMM: 6-93/309.0
ASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSF---KDGDIDAAFEEAFMTFDASLKQK
..| || |  |||     ..      . . . .||.||||| | | .. ..  . ... | |   .. |. .| .|||..   ..|.|
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkk
subfamily_PPM1K_pd Subfamily PPM1K 25-106 1.4e-09 30.4 In-house 7-86 (263) alignment 
Range on Protein: 25-106
Range on HMM: 7-86/263.0
GASAMQGWRVGMEDShNCITKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKsFKDGDIDAAFEEAFMTFDASLKQKA
|  ...| |   ||   ....|...   .||.|||.|.  | .. ... | |..|.  |. |..  . .||   |  ||. .
GkdsliGkraenedr.iklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkryl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 23-105 2.8e-09 29.6 In-house 7-91 (255) alignment 
Range on Protein: 23-105
Range on HMM: 7-91/255.0
SYGASAMQGWRVGMEDSHNCITKLT--EDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFDASLKQK
  | | | | |  |||.     .    .|  ..|..||||| . | .......|.|..|   .. .   ....|. . .  ....
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiser
Subfamily Dicty-PPM1L-like 209-312 3.5e-09 28.9 In-house 184-285 (305) alignment 
Range on Protein: 209-312
Range on HMM: 184-285/305.0
RRIEKAGGKVTPDGRV--NGGLNLSRAFGDHCYKMTTSlPPEEQMISAfpdIKTAtlteQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESD----Q
 ||| ... .   |..  |. |. ||  ||   |     |.... .     .  |    .|.|.|.| ||.|...  |||...| . |...  .      
irieslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv...vaka....nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewd

SNKLSKICEE
 | .|..  |
fneisrvive
PPM_PTC7_SpoIIE_motif 265-339 8.3e-08 25.8 In-house 10-80 (81) alignment 
Range on Protein: 265-339
Range on HMM: 10-80/81.0
EQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESdQSNKLSKICEELFDFCLSpdtSGDGTGCDNMTCVIVQF
. .| .....||.. |..|.. .  . ..|.  ..  ....| .....|.| .|.    |.|   |..| .....
kpgdvllLyTDGltEardsdgelfgkeellrladra.egkslqeladklvdevle...ngsgereDDitllvlrv
subfamily_PP2D1_pd Subfamily PP2D1 32-82 2.1e-07 23.0 In-house 13-66 (492) alignment 
Range on Protein: 32-82
Range on HMM: 13-66/492.0
WRVGMEDSHNCITKLTEDT--SLFAVYDGHGGAEVAVYTAQQFPKLLT-NLKSF
|.  ||| .    . ..|.  . |..|||. ||  |  .|......|. .|...
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekv
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 159-328 2.8e-07 22.0 In-house 132-310 (317) alignment 
Range on Protein: 159-328
Range on HMM: 132-310/317.0
SDSGSTAVVALLRGKT-LTVANIGD-------SRC--VLSRDGVALD-MSYDHKPEDDVELRRIEKA---GGKVTPDGRVNgglNLSRAFGDHCYKMTTS
 | |.|||||..  .| ..||| ||        ..   . |||. .. .|  |. .   |  |....    ..|| || .     |  |. ..  ..| |
ldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgyla...ildealaayelqltks

LPPE---EQMISAFPDIKTATLTEQDDFMVVAC-DGIWNAMTSQDVIDFVTHrLENSRESDQsnklsKICEELFDFCLSPDTSGDGTG
|         ..| |.... .|  .. | ||.. ||| . .  .||.| | .    ..|. .     ..|..  |..|. ... | | 
lGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlr.aatalease.....vlcddaqdylldetsiddata
Subfamily Dicty-PPM1L-like 174-219 7.8e-07 21.2 In-house 228-273 (305) alignment 
Range on Protein: 174-219
Range on HMM: 228-273/305.0
TLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVT
 | ||. .|.. ||..||..  .||....|.  || |... ..|. 
llvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkie