Gene PPM1G in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP187_AA protein Get Run
SpurP187_AA_2-340 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 152-341 6.1e-115 377.9 In-house 285-472 (473) alignment
Range on Protein: 152-341
Range on HMM: 285-472/473.0
G--GKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTSLPPEE
|  .|||||.|||.|||||||..|.|.|||.|||||||||.|.|||.|.||||||.|||.|||||||||. |||||||||||||.|||.||....||..|
gseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplke

QMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESdqsnKLSKICEELFDFCLSPDTSGDGTGCDNMTCVIVQFHS
|||||.||||..||||.|.|.|.|||||||.|.||.|.|||...|....||    .||.|.|||.| ||.||||||||||||||..||....
qmisAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtviivllkk

PP2Cc_SM00332 18-337 8.5e-90 293.8 In-house 6-274 (274) alignment
Range on Protein: 18-337
Range on HMM: 6-274/274.0
SCEELSYGASAMQGWRVGMEDSHNCITKLT--EDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG----DIDAAFEEAFMTFDASLKQKAIIEKL
|  .|||| |.|||||. ||| |.....|   ||...|.|.|||||.||| ......|. | . ...|..    |. .| ..||  .|  . ...  ..|
snlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskel

RRiagmeegeekeedgetetlleeaelpleqlvarymqlpggkeepgSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRI
..                                             ..||||||||||....| |||.||||.||.|.| |...|.|||||| .|..||
en.............................................alsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRi

EKAGGKVTPDgRVNGGLNLSRAFGDHCYKMTTslPPEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdQSNKLSKICE
.||||.|  . ||||||..|||||||..|     ...|..|.| ||.|. |||..|.|...|.||.|. ...|.|.|.|. .|..     . |. ....|
kkaggvvekg.rvngglavsrafGdhflkknk..klkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg....ktndpqeaae

ELFDFCLSPdtsgdGTGCDNMTCVIV
.| . ...      |...||.|.|.|
lldeeairr.....ggseDniTvvvv

0034914 PP2C-like 3-340 1.9e-78 256.1 In-house 2-291 (295) alignment
Range on Protein: 3-340
Range on HMM: 2-291/295.0
AYLSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNCITKL---TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNL-------KSFKDGDIDAAFE
..|| |..|...   .   |..|.. .||.|  .||.. ... |   .||..||.|.||||| ..| . .. ...|| .|        .. . ||  |..
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

EAFMTFDASLKQKAIIEklrriagmeegeekeedgetetlleeaelpleqlvarymqlpggkeEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGV
.||.  |  | ..|. .                                                 . ||.||||||.||..|.|||.||||.||.|.|.
kaflaadeellelallr..............................................pelagsGtTavvalirgnklyvanvGDSravllrnge

ALDMSYDHKPEDDVELRRIEKAGGKVTPdGRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLT-EQDDFMVVACDGIWNAMTSQDVIDFVT
.. ...|||| .  | .||..||| |.  |||||.|...||.||...|.  ||...|...||.||... .|| |.|||...|.||.|. .......|.|.
lvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivr

HRLEnsresdQSNKLSKICEELFDFCLSpdtsgdGTGCDNMTCVIVQFH
..|.      ... |....||| |..|.      . ..||.|.|.|...
slla......kgldleeaaeeLvdlAla......rgsrDNiTvvvvrln

subfamily_PPM1A_pd Subfamily PPM1A 15-340 4.8e-76 248.8 In-house 5-281 (282) alignment
Range on Protein: 15-340
Range on HMM: 5-281/282.0
DDGSCEELSYGASAMQGWRVGMEDSHNCITKLTE--DTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKD--------GDIDAAFEEAFMTFDASLKQ
.... ..| || |.|||||| |||.|.....|..  | |.|||.|||.|.||| |....... ... ...|.         ..  |....|...| ....
sqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

KAIIEKLRR-IagmeegeekeedgetetlleeaelpleqlvarymqlpggkeepgsdsGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPE
.    | .                                                  |||||..|.. |.| .||.|||| ||.|.| |  ...||||.
lstdlktadks...............................................GsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkps

DDVELRRIEKAGGKVTpDGRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqs
.. | .|||.|||.|.  .|||| | .|||.||. || ......|||..|| |....   .|.|||.|.||||||  .....|...|..||| .      
rpkEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrleva......

NKLSKICEELFDFCLSPDTSgdgtgcDNMTCVIVQFH
..|......| | .|. ..       ||.....| |.
deleevakalvdkalekgsr......DNlsvlvvlfa

PPM_PTC7 24-323 2.5e-68 223.3 In-house 3-256 (259) alignment
Range on Protein: 24-323
Range on HMM: 3-256/259.0
YGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDidaafeeafmtfdaslkqkaiieklrriagme
.||||.||.|. |||.| .  .|      .. ..|||.||||| |.| |....... | . |||....                                
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele................................

egeekeedgETETLLEEAELPL-------EqlvarymqlpgGK--EePGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVEL
         ..|  | .. | |                    .  .   |.|||||||||..|..| |||.||||.||.|.| |   ...||||..  | 
.........klekalrksflaldtdeelks...........seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEr

RRIEKAGGKVTP--DGRVNGGLNLSRAFGDHCYKMTTSlppEEQMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsnKL
.|||.|||.|    .||||| |..||||||...|   .   |||..|| |||......|.|.|...|.||.|. ...|...|.|. .|.         ..
eRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.......dp

SKICEELFDFCLSPDTS
....|.| |........
meaaeklvdeaiargse

subfamily_PPM1G2_pd Subfamily PPM1G2 157-339 1.9e-64 210.4 In-house 111-286 (287) alignment
Range on Protein: 157-339
Range on HMM: 111-286/287.0
PGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDgRVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFP
  ...||||||.|.. . | |||.||||.||| .| .  .|.||||..  | .||..||| |  . |||| | ||||.||...| .....||||.. |.|
kdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkknvkkkpeeqivtavP

DIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsNKLSKICEELFDFCLSPDTSGDGTGCDNMTCVIVQF
|. .  |.|.|.|.|.||||||. .|...|.|.| .|| .        ||..|.|||.| ||.||.|  | ||||||.||| .
DvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsg......akldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_PPM1G_pd Subfamily PPM1G 4-147 3.1e-59 194.2 In-house 1-150 (473) alignment
Range on Protein: 4-147
Range on HMM: 1-150/473.0
YLSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNCITKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFDASLK
|||.|.|||.|.|.|.|||||||||||||||..||.|||||.|.||||||||||||||.|||.|.|...|.||.. |..|.||...|.||||...|..||
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklk

QKAIIEKLRRIAGMEEGEEKE------EDGETETLLEEAELPLEQLVARY
.......|..||..||.|..|      .. |.|.| ||||.||..|..|.
aeeslkelkeiaeaeededeeeeddeededeiellteeaeipldellkrl

PP2C Protein phosphatase 2C 159-323 9.6e-59 192.0 Pfam-A 98-252 (255) alignment
Range on Protein: 159-323
Range on HMM: 98-252/255.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTslppeEQMISAFPD
|.|||||||||.|||.| |||.||||.||.|.. |   ...||||.|. | .|||.|||.|   ||||| |..|||.||...|  .     ||..|| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSResdqsnKLSKICEELFDFCLSPDTS
.....|||.|.|...|.||.|. ...|...|.|. .|.  .      ......||| |..... ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 159-323 9.6e-59 192.0 In-house 98-252 (255) alignment
Range on Protein: 159-323
Range on HMM: 98-252/255.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVAL-DMSYDHKPEDDVELRRIEKAGGKVTPDGRVNGGLNLSRAFGDHCYKMTTslppeEQMISAFPD
|.|||||||||.|||.| |||.||||.||.|.. |   ...||||.|. | .|||.|||.|   ||||| |..|||.||...|  .     ||..|| ||
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSResdqsnKLSKICEELFDFCLSPDTS
.....|||.|.|...|.||.|. ...|...|.|. .|.  .      ......||| |..... ..
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk......spmeaaeelvdeaiargse

0049733 PP2C-like 22-340 4.3e-53 172.9 In-house 3-234 (235) alignment
Range on Protein: 22-340
Range on HMM: 3-234/235.0
LSYGASAMQGW-RVGMEDSHNCitklteDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNL-KSFKDGDIDAAFEEAFMTFDASLKQKaiieklrriagmee
||.||. ..|. |  .||.. .      ...||||.|||||.... . .......| .| ...   |. .|...||.. .. | ..              
lsvgaasdigrvrkvneDavlv......glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallel..............

geekeedgetetlleeaelpleqlvarymqlpGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVt
                                . .... . .|.|||||||.|..|.|||.||||..| ||| .. ...||.| .. | .||..||| | 
................................alaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav.

pdgRVNGGLNLSRAFGDHCYKmttslppeeqmisafPDIKTATLTEQDdFMVVACDGIWNAMTSQDVIDFVTHrlensresdqsNKLSKICEELFDFCLS
   ||.|.| |.||.||...|               ||. . .|...| |...|.||.|. .......|....           . |....|.|....|.
...rvpgrlaltralGdlllk...............pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs...........ldleeaaerlvelala

pdtsgdGTGCDNMTCVIVQFH
      . |.||.|.|.|...
......rggrDNiTvvvvrld

subfamily_PPM1L_pd Subfamily PPM1L 26-297 1.5e-39 128.8 In-house 9-239 (269) alignment
Range on Protein: 26-297
Range on HMM: 9-239/269.0
ASAMQGWRVGMEDSHNCITKLTEDT--SLFAVYDGHGGAEVAVYTAQQFPKLLTN-LKSFkdgdidaafeeafmtfdaslkqkaiieklrriagmeegee
. ...| |  |||  .  ......|  |.|||.|||||   | .. . ..| . | |. .                                        
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel........................................

kEEDGETETLLEEAELPLEQLVARYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLS-RDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD
 ..| | .. .. ..|  .....   .|    .     .|.||..||.... |.|||.|||| ||  ..| |. .|.||||..  | .||.|||| .. .
.dadkentepinfsklltdeilsvdekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafr

G--RVNGGLNLSRAFGDHCYKmttslppEEQMISAFPDIKTATLTE-QDDFMVVACDGIWNAMTSQDVIDFVTHRLENS
|  ||.| |  |||.||.  |       ..... | ||| |  | . . .|...|.||.|.... .. . |.  ||.. 
GvwrvaGvlatsralGdyplk.......dknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlkep

PPM_PTC7_SpoIIE 24-309 2.4e-38 125.2 In-house 3-213 (230) alignment
Range on Protein: 24-309
Range on HMM: 3-213/230.0
YGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEvaVYTAQQFPKLLTNLKsFKDGD-IDAAFEEAFMTFDASLKQKaiieklrriagm
.||||.||.| .|||.| .  ..          .....||||| .   ... .. ..| .|. |....  ........  ..| |. .            
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede............

eegeekeedgetetlleeaelpleqlvarymqlpggkeepGSDSGSTAVVALLRGKT--LTVANIGDSRCVLSRD-GValdmsydhkpeddvELRRIeKA
                                         |.||.||||||... |  |.||| |||...|.|| |               | .|| .|
........................................psssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.va

GGKVT---PDGRVNGGLNLSRAFGDHCYKMttslppEEQMISAFPDiKTATLTEQ-DDFMVVACDGIWNAMTSQDVIDFVTHRLENSresdqsnklskI
|| .     .|||.| |..|.|.||  ..       ......| ||   ...... |.|...|.||.|. ...|...|.|  .||             .
gglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp...........a

subfamily_PPM1E_pd Subfamily PPM1E 159-339 2.7e-36 118.1 In-house 100-262 (265) alignment
Range on Protein: 159-339
Range on HMM: 100-262/265.0
SDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPDG--RVNGGLNLSRAFGDHcykmttslpPEEQMISAFP
  |||||||.|.....| || .|||. .| |.| |. .   ||||.. | .|||.||| |   |  |||| |..||| ||           .....|. .
lksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDv.........klkpyvsgea

DIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENsresdQSNKLSKICEELFDFCLSPDTSgdgtgcDNMTCVIVQF
|. . .|.........||||.|. .. ..|.. |.. |..     ....||.. ..| .   . . |      ||.| |.| .
dvaeveldgseeylilacDGlwDvvneeevvklveeflad.....gaedlsevakllveaakeagss......Dnitvvvvfl

subfamily_ILKAP_pd Subfamily ILKAP 154-311 7.1e-33 107.0 In-house 106-260 (293) alignment
Range on Protein: 154-311
Range on HMM: 106-260/293.0
KEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDG------VALDMSYDHKPEDDVELRRIEKAGGKVTpDGRVNGGLNLSRAFGDHCYKMTTslpp
|..|    ||||.| |   ..| |||.|||..|| |        ... .. ||.| .  | .||.||||.|. ||||.| |. ||. ||  .| .     
kakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr.dgrvlGvlevsrsiGdgrfkrlG....

eeqmISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNKLSKICE
    ... ||.|  .||| | |.|.||||.|.... ..|..|... ||. ..... ..  |. .
....vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekksk

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 139-293 2.4e-32 105.2 In-house 73-223 (255) alignment
Range on Protein: 139-293
Range on HMM: 73-223/255.0
PLEQLVARYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLS-RDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD---GRVNGGLNLSRAF
|.. |   | ..    .| .   |.||...|. ..   .||.|||| ||. .||.|  .|.|||| .. | .||...||.|  .    |||| | .|||.
PvkslkkaykeistqiserpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsral

GDHCykMTTSLPPEeqmisafPDIK-TATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHR
||    ..  . |.       ||.. . . ...| |...||||||. .. .. .. |   
Gdsf..lePfvvpd.......PdlsqsleiskkdkflilacdGiwdlisdeeaveivagi

subfamily_PPM1K_pd Subfamily PPM1K 124-293 3.5e-28 91.4 In-house 62-228 (263) alignment
Range on Protein: 124-293
Range on HMM: 62-228/263.0
EEDGETETLLEEAELPLEQLVARYMQLPGGKEePGSDSGSTAVVALLR-GKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-
|.. . |..| .| . |.. . ||...   ..     ||.|| |.||| |. | .|..|||| .| |.| |  .. ||.|| . | .|| .|||.|. . 
ekekdleivlknafeeldkklkrylefsvaea.ellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewns

---GRVNGGLNLSRAFGDHCYKMTTslppeeqmISAFPDIKTATL-TEQDDFMVVACDGIWNAMTSQDVIDFVTHR
    .||| | ..|..||   |           . | |. |.  .  ..| |.|.  ||| . ..||.. |.|.  
lgkplvngrlamtrslGdldlkryG........viatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc

subfamily_PPM1G2_pd Subfamily PPM1G2 5-108 3.1e-26 85.0 In-house 2-110 (287) alignment
Range on Protein: 5-108
Range on HMM: 2-110/287.0
LSEPNVEKISDDGSCEELSYGASAMQGWRVGMEDSHNC---ITKL--TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFD
|||| |.| |. .. .    |.|||||.|. |||.|     . ..  .....||||.||||||.|| |..... | ... ||||.| .. ....||...|
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletD

ASLKQKAII
 .| ..  .
eellkdekl

subfamily_PDP_pd Subfamily PDP 161-303 3.4e-25 82.0 In-house 152-321 (398) alignment
Range on Protein: 161-303
Range on HMM: 152-321/398.0
SGSTAVVALLRGKTLTVANIGDSRCVLSR---DG--VALDMSYDHKPEDDVELRRIEKAGGK-----VTPDGRVNGGLNLSRAFGDHCYKMTTSL-----
||..|..||..|..| |||.||.|.|| .   .|   |  .| |.  .   |..||.|.  .     |  .||. | |  .|||||  ||... |     
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl

--------PPEE----QMISAFPDIKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQS
        .|..      ..| |.. .. |.|.| |.|.| ||.|. .....|.. |.. |... |... 
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv

subfamily_PP2D1_pd Subfamily PP2D1 161-306 2.3e-21 69.0 In-house 176-318 (492) alignment
Range on Protein: 161-306
Range on HMM: 176-318/492.0
SGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGG---KVTPDGRVNGGLNLSRAFGDHCYKMttsLppeEQMISAFPD
. ..  | |    .| .||.|. . || |.|.|  .  .| |..  | .|.||||.   |  . |.||| |.  |  | .       |   .. .   | 
esngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpk...L...kksvipePk

IKTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNKL
... .|.|.. |.|.|  |.|. .. ..|.  |.. |.  ... .....
ttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenv

subfamily_KAPP-like_pd Subfamily KAPP-like 162-301 2e-20 66.0 In-house 101-239 (266) alignment
Range on Protein: 162-301
Range on HMM: 101-239/266.0
GSTAVVALL----RGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-GRVNgGLNLSRAFGDHCYKMTTSlppeeQMISaFP
|.|| .||.    . . | |||.|||   |||   .| .|.||| .|. | .|| . |  .. .  |.| || .|||.|||  |          .||  |
GatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni.....Glis.ep

DI-KTATLTEQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESD
 . .  .|| .|.|..|| ||.|. .. .| |. |    .. . .|
yvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqated

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 173-301 2.1e-19 62.5 In-house 126-249 (276) alignment
Range on Protein: 173-301
Range on HMM: 126-249/276.0
KTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVTPD-GRVNgGLNLSRAFGDHCYKMTTSlppeeQMISaFPDI-KTATLTEQDDFM
. | |||.|||   |||   .| .|.||| .|  | .|| . |  .. .  |.| || .|||.|||  |          .||  | . .  .|| .|.|.
rylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikelni.....Glis.epyvsnrilltpfdkfl

VVACDGIWNAMTSQDVIDFVTHRLENSRESD
.|| ||.|. .. .| |. |    .. . .|
ivasdGlwdvisGkdaiekvkslydqqated

PP2C_SIG_SM00331 41-339 2.6e-18 59.4 In-house 21-217 (217) alignment
Range on Protein: 41-339
Range on HMM: 21-217/217.0
NCITKLTEDTSLFAVYDGHG-GAEVAVYTAQQFPKLLTNLKSFkdgdidAAFEEAFMTFDASLKQKaiieklrriagmeegeekeedgetetlleeaelp
 ...|| |.. |..| ||.| |.. |....|  ..| . |..        ....|.   .  ....                                  
ydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee..................................

leqlvarymqlpggkeEPGSDSGSTAVVALL--RGKTLTVANIGDSRCVLSRDG-VALDMSYdhkpeddvelrriekaggkvtpdgrvngglnlsrafgd
                .  .... |...||.  ....| .||.||||..| |||    . .                                       
................keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd......................................

hCYKMTTSLPPEEQmisafPDIKTATLTEqDDFMVVACDGIWNAMTSQDvidFVTHRLENSRESDQSNKLSK----ICEELFDFCLSPDTsgdgtgCDNM
    . ..| ||..     .||.. .| . .|... . ||...|.....   | . |||.  |. ... . .    | |||. .   . .       |..
.vegaplGlepevs.....vdirelelek.gdllllytDGltearsekg...faeerleeiledlvdseaqelaqkiveellelakgsng......eDdi

TCVIVQF
| |.|..
Tvvvvkv

PP2C Protein phosphatase 2C 23-104 4.6e-15 48.9 Pfam-A 2-90 (255) alignment
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG-DIDAAFEEAFMT-FDASLKQ
 .|||..||.|  |||.| .. .|      .. ..|||.||||| |.| |.... ...| . |||... . ..|. ..|.  .| .||.
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

PP2C Protein phosphatase 2C 23-104 4.6e-15 48.9 In-house 2-90 (255) alignment
Range on Protein: 23-104
Range on HMM: 2-90/255.0
SYGASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDG-DIDAAFEEAFMT-FDASLKQ
 .|||..||.|  |||.| .. .|      .. ..|||.||||| |.| |.... ...| . |||... . ..|. ..|.  .| .||.
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 158-236 6.3e-15 48.5 In-house 82-182 (292) alignment
Range on Protein: 158-236
Range on HMM: 82-182/292.0
GSDSGSTAVVALLRGK-TLTVANIGDSRCVLSR-----DGVALDMSYDHKPEDDVELRRIEKAGGKVTP----------DGRV------NGGLNLSRAFG
.  .....| |  |    | .||.||||..| |     |     .| ||||||  | .|| .|||.|.|            ||      .|.| |||| |
resattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralG

D
|
d

subfamily_PHLPP_pd Subfamily PHLPP 173-292 2.6e-14 45.7 In-house 105-214 (246) alignment
Range on Protein: 173-292
Range on HMM: 105-214/246.0
KTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDvELRRIEKAGGKVTPDGRVNGGLNLSRAFGdHCYKMTTSLPPeeqmisafPDIKTATLTEQDDFMVV
 .|.||..|    || |.|  | .|  .. |.| ||.|| .| . .| |...|| .. .| .| . .   . ||         | ..  .|||||....|
fsLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllG.ytflfPvvlPk........phvrevlLteqdelliv

ACDGIWNAMTSQDVIDFVTH
  . .|. .  ... . | .
GnkalWevlsideaveavrk

subfamily_PPM1H_pd Subfamily PPM1H 15-206 6.7e-14 44.5 In-house 29-207 (404) alignment
Range on Protein: 15-206
Range on HMM: 29-207/404.0
DDGSCEELSYGASAMQGWRVGMEDSHNCITKLteDTSLFAVYDGHGGAEVAVYTAQQFPKLLT-NLKSFKDGDIDAAFEEAFMTFDASlkqkaiIEKLRR
| .... |    .. . .   .. ...  .||  .. .|...|||.|  .|. ..... | |. .|.. ..   . . ||   | . |       |.   
Dqaaakvlllkkekkeksvtskpkekseeekl..playfglfDGhaGsgaalvaskllhkhlkekledvlellleksaeeeenteess......kespss

IAGMEEGEEKEEDGETETLLEEAELPLEQLVARymqlpgGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGVALDMSYDHKPEDDV
   . | .| ...      ||.| | .....||       .|.     | ||.|||.  . | ||| |||| .|.| .   ..| |. || . 
vseiyeekeiskeeLviGalesaflemDeqiar......ereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR

subfamily_PPM1E_pd Subfamily PPM1E 26-112 8.1e-14 44.4 In-house 8-101 (265) alignment
Range on Protein: 26-112
Range on HMM: 8-101/265.0
ASAMQGWRVGMEDSHNCITKL--------TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIdAAFEEAFMTFDASLKQKAIIEKLR
. |... |  ||| | .. .|        ..... |||.||||| | | |.|.. ..|| . ...|.     |..||| . | .. |||. |||.
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklk

PPM_PTC7_motif 271-323 8.2e-13 41.6 In-house 1-48 (51) alignment
Range on Protein: 271-323
Range on HMM: 1-48/51.0
VVACDGIWNAMTSQDVIDFVTHRLENSREsdqsnKLSKICEELFDFCLSPDTS
. |.||.|. ...|...|.|. .|.  ..     .. ...|.| |..|.. ..
iLAsDGLWDvlsdqeavdlvrdqlskkgl.....spqeaAeklvdealargse

subfamily_PPM1D_pd Subfamily PPM1D 147-220 1e-12 40.8 In-house 94-173 (309) alignment
Range on Protein: 147-220
Range on HMM: 94-173/309.0
YMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRCVLSRDGV------ALDMSYDHKPEDDVELRRIEKAGGKVTP
. . |  |.   | .|.|| | ..|.. | ||..|||. ||. .        |  .  |||||.  | .|||..||.|. 
leeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa

subfamily_TAB1_pd Subfamily TAB1 161-314 1.3e-12 40.2 In-house 129-296 (333) alignment
Range on Protein: 161-314
Range on HMM: 129-296/333.0
SGSTAVVALLRGKTLTVANIGDSRCVLSR---DGVALDMSYDHKPEDDVELRRIEKAG---GKVTPDGRVnGGLNLSRAFGDHC----YKMTTSLP-PEE
 |.||||||.  . | |||.|||| .| .         .| ||. . . || |... |    ..   .|. |. .  |. ||..    || .. |   ..
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakg

QMISAFPDIKTA-TLTEQDDFMVVACDGIWNAMTSQ---DVIDFVTHRLENSRESDQSNKLSKICEELF
. . | |||. |  ...   |.|.  ||. ...      .  .     || . |  .. .|... ... 
ePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavv

subfamily_PPM1D_pd Subfamily PPM1D 228-340 2e-11 36.5 In-house 201-308 (309) alignment
Range on Protein: 228-340
Range on HMM: 201-308/309.0
LNLSRAFGDH-CYKMTTslppEEQMISAFPDIKTATLTEQDD-FMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSNklSKICEELFDFCLSPdTSGD
|...|. ||   |....    .| ..|  ||.|  ||. ... |...| ||.|| .|..|....|..  | .   ....  ... . | .  |.  ..  
LavaRslGDlWsynaks....gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealqr.wrsk

GTGCDNMTCVIVQFH
   .||.. ..| ..
klraDnvsvivvile

PP2C_2 Protein phosphatase 2C 39-309 2.4e-11 36.3 Pfam-A 15-210 (212) alignment
Range on Protein: 39-309
Range on HMM: 15-210/212.0
SHNciTKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLtnLKSFKDGD-------IDAAFEEAFMTFDASLKqkaiieklrriagmeegeekeedgetet
..    . ..| .|.|| ||.| |. .   |. . . .  ......         ..|.....    .||.|                            
ala..ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvk............................

lleeaelpleqlvarYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRC-VLSRDGVALDMSYDHKPEDDVELRRIEKA--GGKVtpdgrvnggl
               . |    ..|. .| ..| ..|....... ...|||... | .||| .  .. ... |   |.... ..  ....          
...............lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........

nlsrafgdhcykmttslppeeqmisafpDIKTATlTEQDDFMVVACDGIWNAMT-SQDVIDFVTHRLENSRESDQSNKLSKI
                            .|.. . .|. |  ..  ||...... ...........||. .| .....|...
............................rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeegaaeeLaef

PP2C_2 Protein phosphatase 2C 39-309 2.4e-11 36.3 In-house 15-210 (212) alignment
Range on Protein: 39-309
Range on HMM: 15-210/212.0
SHNciTKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLtnLKSFKDGD-------IDAAFEEAFMTFDASLKqkaiieklrriagmeegeekeedgetet
..    . ..| .|.|| ||.| |. .   |. . . .  ......         ..|.....    .||.|                            
ala..ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvk............................

lleeaelpleqlvarYMQLPGGKEEPGSDSGSTAVVALLRGKTLTVANIGDSRC-VLSRDGVALDMSYDHKPEDDVELRRIEKA--GGKVtpdgrvnggl
               . |    ..|. .| ..| ..|....... ...|||... | .||| .  .. ... |   |.... ..  ....          
...............lkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........

nlsrafgdhcykmttslppeeqmisafpDIKTATlTEQDDFMVVACDGIWNAMT-SQDVIDFVTHRLENSRESDQSNKLSKI
                            .|.. . .|. |  ..  ||...... ...........||. .| .....|...
............................rirrlk.lepgdalllmTDGvsdslrkeepfrellaelletleeegaaeeLaef

subfamily_PPM1H_pd Subfamily PPM1H 223-313 6.8e-11 34.5 In-house 276-369 (404) alignment
Range on Protein: 223-313
Range on HMM: 276-369/404.0
RVNGGLNLSRAFGDHCYKMTTSLPPEEQMISAFPDIKTATLTE----QDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESDQSnKLSKICEEL
|. . .  .| .|||  |.. .      ..|..|....  ||.    .|| ...| ||.|. .. ..|   |.. |..  ..|.. . ... .||
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkk.rytavaqeL

subfamily_PPM1D_pd Subfamily PPM1D 26-105 7.8e-10 31.3 In-house 6-93 (309) alignment
Range on Protein: 26-105
Range on HMM: 6-93/309.0
ASAMQGWRVGMEDSHNCITKL-----TEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSF---KDGDIDAAFEEAFMTFDASLKQK
..| || |  |||     ..      . . . .||.||||| | | .. ..  . ... | |   .. |. .| .|||..   ..|.|
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkk

subfamily_PPM1K_pd Subfamily PPM1K 25-106 1.4e-09 30.4 In-house 7-86 (263) alignment
Range on Protein: 25-106
Range on HMM: 7-86/263.0
GASAMQGWRVGMEDShNCITKLTEDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKsFKDGDIDAAFEEAFMTFDASLKQKA
|  ...| |   ||   ....|...   .||.|||.|.  | .. ... | |..|.  |. |..  . .||   |  ||. .
GkdsliGkraenedr.iklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkryl

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 23-105 2.8e-09 29.6 In-house 7-91 (255) alignment
Range on Protein: 23-105
Range on HMM: 7-91/255.0
SYGASAMQGWRVGMEDSHNCITKLT--EDTSLFAVYDGHGGAEVAVYTAQQFPKLLTNLKSFKDGDIDAAFEEAFMTFDASLKQK
  | | | | |  |||.     .    .|  ..|..||||| . | .......|.|..|   .. .   ....|. . .  ....
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiser

Subfamily Dicty-PPM1L-like 209-312 3.5e-09 28.9 In-house 184-285 (305) alignment
Range on Protein: 209-312
Range on HMM: 184-285/305.0
RRIEKAGGKVTPDGRV--NGGLNLSRAFGDHCYKMTTSlPPEEQMISAfpdIKTAtlteQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESD----Q
 ||| ... .   |..  |. |. ||  ||   |     |.... .     .  |    .|.|.|.| ||.|...  |||...| . |...  .      
irieslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllv...vaka....nDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewd

SNKLSKICEE
 | .|..  |
fneisrvive

PPM_PTC7_SpoIIE_motif 265-339 8.3e-08 25.8 In-house 10-80 (81) alignment
Range on Protein: 265-339
Range on HMM: 10-80/81.0
EQDDFMVVACDGIWNAMTSQDVIDFVTHRLENSRESdQSNKLSKICEELFDFCLSpdtSGDGTGCDNMTCVIVQF
. .| .....||.. |..|.. .  . ..|.  ..  ....| .....|.| .|.    |.|   |..| .....
kpgdvllLyTDGltEardsdgelfgkeellrladra.egkslqeladklvdevle...ngsgereDDitllvlrv

subfamily_PP2D1_pd Subfamily PP2D1 32-82 2.1e-07 23.0 In-house 13-66 (492) alignment
Range on Protein: 32-82
Range on HMM: 13-66/492.0
WRVGMEDSHNCITKLTEDT--SLFAVYDGHGGAEVAVYTAQQFPKLLT-NLKSF
|.  ||| .    . ..|.  . |..|||. ||  |  .|......|. .|...
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleelekv

subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 159-328 2.8e-07 22.0 In-house 132-310 (317) alignment
Range on Protein: 159-328
Range on HMM: 132-310/317.0
SDSGSTAVVALLRGKT-LTVANIGD-------SRC--VLSRDGVALD-MSYDHKPEDDVELRRIEKA---GGKVTPDGRVNgglNLSRAFGDHCYKMTTS
 | |.|||||..  .| ..||| ||        ..   . |||. .. .|  |. .   |  |....    ..|| || .     |  |. ..  ..| |
ldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgyla...ildealaayelqltks

LPPE---EQMISAFPDIKTATLTEQDDFMVVAC-DGIWNAMTSQDVIDFVTHrLENSRESDQsnklsKICEELFDFCLSPDTSGDGTG
|         ..| |.... .|  .. | ||.. ||| . .  .||.| | .    ..|. .     ..|..  |..|. ... | | 
lGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlr.aatalease.....vlcddaqdylldetsiddata

Subfamily Dicty-PPM1L-like 174-219 7.8e-07 21.2 In-house 228-273 (305) alignment
Range on Protein: 174-219
Range on HMM: 228-273/305.0
TLTVANIGDSRCVLSRDGVALDMSYDHKPEDDVELRRIEKAGGKVT
 | ||. .|.. ||..||..  .||....|.  || |... ..|. 
llvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkie