Gene PPM1G2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1Z
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP188_AA protein Get Run
SpurP188_AA_2-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G2_pd Subfamily PPM1G2 4-287 1.1e-141 463.8 In-house 1-287 (287) alignment 
Range on Protein: 4-287
Range on HMM: 1-287/287.0
TLSEPVTAKETSGCENHLCKVGASCMQGWRINMEDAHTQ---ILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRGEISTAIRESFLKI
||||||.|||.. |.|.|.|||.|.|||.|.||||||..   .|. .|||. |.|||.|||||||||.|||..|..|.|.....|.|.........||..
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DEDMLKDEAMKDELAGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFNRVNGNLALSRALGDFVFKRNLSKGP
||..||||..||| ||.||.....|..|.|..|.|||| |.|..|..| |||||||..|.|.||||||||.||.||||||||||||||||.||.| .|.|
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp

EEQIVTAVPDVTETEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKICEDLMTRCLAPDCQMGGLGCDNMTVVLVCLL
|||||||||||. ... .|.|||.||||||||||||.||||.||.|. .......|.|.|...|||||....|.||||||||.|.||
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
PP2Cc_SM00332 22-284 6.1e-89 291.0 In-house 10-274 (274) alignment 
Range on Protein: 22-284
Range on HMM: 10-274/274.0
CKVGASCMQGWRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRG----EISTAIRESFLKIDEDMLKDEAMKDE---L
.  | |.||||| .||||| ...  .  .| .||.|.|||||..||... ..|.. |...  .| .    ..  |....||..||..|..| .| .   |
lsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenal

AGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFNRVNGNLALSRALGDFVFKRNLskGPEEQIVTAVPDVTET
.|.||.. ..|....|. |||||| |.. .| |..|| ||||..|.|.||| .|||.||..||||.||.|||.||. .|.|   ...|...|| |||. .
sGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvv

EIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRI--GNKMDPEKICEDLMTRCLAPdcqmgGLGCDNMTVVLV
.. .. |||.||.||.||||.||||||.||...  |...||....|.|.  ...      | ..||.|||.|
tltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr.....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 18-286 1.3e-88 290.1 In-house 8-280 (282) alignment 
Range on Protein: 18-286
Range on HMM: 8-280/282.0
ENHLCKVGASCMQGWRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTY--------KRGEISTAIRESFLKIDEDMLKDEA
|..  ..| | |||||..|||||| .  .   || .||||.|||.|..||.|. .||.... .....        .. |.. |.|..||..||.. ....
egnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelst

MKD--ELAGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFNRVNGNLALSRALGDFVFKRNLSKGPEEQIVTA
 ..  . .|.||.  ......... |.||||.|..  |.|. |. |||||...| ||| .||| |  .||||.||.||||||. .|.. .|..||| |.|
dlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsa

VPDVTETEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKICEDLMTRCLAPDCQmgglgcDNMTVVLVCL
.|.|| .|.. . .||.||||||||||...|||..||.|.. . ..|.....|. ..|  . .      ||..|..|..
epevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
PP2C Protein phosphatase 2C 23-269 1.1e-85 280.3 Pfam-A 2-251 (255) alignment 
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KVGASCMQGWRINMEDAHTQILAI---DDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRG-EISTAIRESFLK-IDEDMLKDEAM-KDELAG
.||||..||.| .|||||. .      ..... |||||.||||| ..|.||..||. .|..|.. . . . . |.|.|||. .|| . ...|. ...  |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

TTALITVMKNNKIYCGNVGDSRGVMSISGHAK-PLSFDHKPSNENESKRIIAAGGWVE-FNRVNGNLALSRALGDFVFKRNLskgpeEQIVTAVPDVTET
.||........|.|. |||||| |......||  |..|||||.|.| .|| .|||.|. ..||||.||.||||||| .|..      ||.|.| ||||..
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

EIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKICEDLMTRCLAPDC
.. .. |||.||.||.||||..||.||.|||..  | .|....|.|.. ..|. .
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PP2C Protein phosphatase 2C 23-269 1.1e-85 280.3 In-house 2-251 (255) alignment 
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KVGASCMQGWRINMEDAHTQILAI---DDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRG-EISTAIRESFLK-IDEDMLKDEAM-KDELAG
.||||..||.| .|||||. .      ..... |||||.||||| ..|.||..||. .|..|.. . . . . |.|.|||. .|| . ...|. ...  |
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksG

TTALITVMKNNKIYCGNVGDSRGVMSISGHAK-PLSFDHKPSNENESKRIIAAGGWVE-FNRVNGNLALSRALGDFVFKRNLskgpeEQIVTAVPDVTET
.||........|.|. |||||| |......||  |..|||||.|.| .|| .|||.|. ..||||.||.||||||| .|..      ||.|.| ||||..
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

EIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKICEDLMTRCLAPDC
.. .. |||.||.||.||||..||.||.|||..  | .|....|.|.. ..|. .
klteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
PPM_PTC7 23-269 2e-85 279.4 In-house 2-255 (259) alignment 
Range on Protein: 23-269
Range on HMM: 2-255/259.0
KVGASCMQGWRINMEDAHTQILAI---DDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRG-EISTAIRESFLK--IDEDMLKDEAM-KDELA
..|||..||.| .|||||.        ..... |||||.||||| ..|.||..||. .|..... . . . . |.|.|||.  .|| . ..||. ...  
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepsts

GTTALITVMKNNKIYCGNVGDSRGVMSISGHAK-PLSFDHKPSNENESKRIIAAGGWVE---FNRVNGNLALSRALGDFVFKRNLSkgpEEQIVTAVPDV
|.||.. .  ..|.|. |||||| |...||.|. .|..|||||||.| .|| .|||.|.   ..||||.||.|||.||| .|.. .   ||| |.| ||.
GstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdi

TETEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKmDPEKICEDLMTRCLAPDC
..|.| .. |||.||.||.|||...||.||.|||..  | ||....|.|.. ..|...
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
0034914 PP2C-like 3-286 2e-84 275.7 In-house 2-290 (295) alignment 
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTAKETSGCENHLCKVGASCMQGWRINMEDAHTQILAIDD-DKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQ-------STYKRGEISTAIR
..|| |.. . ..  .. | .||....||.| ..|||.. .| .   ..| ..|.|.||||| ..|..| ..|.. |...       .|.    | .|.|
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr

ESFLKIDEDMLKDEAM--KDELAGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFNRVNGNLALSRALGDFVF
..||..||..|.   .  ..   ||||.. ....||.|..|||||| |.. .|....|..||||.|| | .||..|||.| ..||||.||..|||||| .
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KRNLSKGPEEQIVTAVPDVTETEII-PDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKICEDLMTRCLApdcqmgGLGCDNMTVVLVCL
|..||  ..|..|.|.|||| .|.  .| .|||||.||.||||.|.|.||.|||.. . .|.|...| |. ..||      . ..||.|||.|.|
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
subfamily_PPM1G_pd Subfamily PPM1G 115-286 3.4e-67 220.5 In-house 296-470 (473) alignment 
Range on Protein: 115-286
Range on HMM: 296-470/473.0
AGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVE-FNRVNGNLALSRALGDFVFKRNLSKGPEEQIVTAVPDVTE
.|||| ....|..|..  |.|||| |.| .|.|  || |||| .|.| .|| .||| |.   |||| | |||||||...|.| . ...||...|.||.  
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv

TEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDP--EKICEDLMTRCLAPDCQMGGLGCDNMTVVLVCL
... .. ||| |||||||.|.. ||||||||... .. .   ..|.|.|.  ||||| .  | |||||||..|.|
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
0049733 PP2C-like 23-286 8e-60 194.9 In-house 4-233 (235) alignment 
Range on Protein: 23-286
Range on HMM: 4-233/235.0
KVGASCMQGW-RINMEDAHTQilaidddkDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQ-STYKRGEISTAIRESFLKIDEDMLKDEAM--KDELAGTT
.|||....|. | ..|||.          . ..|||.|||||. ....| ..|.. |...  ..   .. .|.|..||...| .|.      .    |||
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgtT

ALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVefnRVNGNLALSRALGDFVFKrnlskgpeeqivtavPDVTETEIIP
|.. .. ..|.|. |||||| ..  .|.. .|..||.|.|| | .|||.|||.|   ||.| |||.|||||. .|               ||||..|. |
avvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlelep

DSeFLLLACDGIWDVLTNQEVVDFVRSrignkMDPEKICEDLMTRCLApdcqmgGLGCDNMTVVLVCL
.  |||||.||.||||...|.||..||     .|.|...| |. ..||      . |.||.|||.|.|
gd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvrl
subfamily_PPM1E_pd Subfamily PPM1E 24-286 3.8e-55 179.9 In-house 6-262 (265) alignment 
Range on Protein: 24-286
Range on HMM: 6-262/265.0
VGASCMQGWRINMEDAHTQI------LAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRGEIsTAIRESFLKIDEDMLKDEAMKDELAGT
| . .... |  ||| |  .      . ..|.|. |||||.||||| . |.|| .|||. |..|.. |.    .|..|.| ..|| .|.  . .   .|.
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklksGs

TALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWV---EFNRVNGNLALSRALGDFvfkrnlskgPEEQIVTAVPDVTET
|| .........| . .|||....   |.|  |   |||..|.| ||| .||| |   .  ||||.|..|||.||           ... |.. .||.|.
tavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDv.........klkpyvsgeadvaev

EIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKM-DPEKICEDLMTRCLAPDCQmgglgcDNMTVVLVCL
|.  ..|.|.|||||.|||....|||. |.. . ..  | ... . |..     . .      ||.|||.| |
eldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvvfl
subfamily_PPM1L_pd Subfamily PPM1L 23-249 3.8e-52 170.2 In-house 6-238 (269) alignment 
Range on Protein: 23-249
Range on HMM: 6-238/269.0
KVGASCMQGWRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQS----TYKRGEI----STAIRESFLKIDEDMLKDEAMKDEL
.| . ...| | .|||  .    |... .  ||||.|||||   |..| . | ... |.     . |. ..    |. . .  | .||..|.    . ..
qvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi

AGTTALITVMKNNKIYCGNVGDSRGVMS-ISGHAKPLSFDHKPSNENESKRIIAAGGWVEFN---RVNGNLALSRALGDFVFKrnlskgpEEQIVTAVPD
|||||||........   ||||||||.   .|.| |||||||| . .| |||  |||.. |.   ||.| || ||||||. .|       ....| | ||
aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadpd

VTETEIIP-DSEFLLLACDGIWDVLTNQEVVDFVRSRIGN
.   ..   . |||.||.||.|| ..|.| | |.. |...
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 22-284 5.1e-49 159.8 In-house 6-251 (255) alignment 
Range on Protein: 22-284
Range on HMM: 6-251/255.0
CKVGASCMQGWRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRGEISTAIRESFLKIDEDMlkdeAMKDELAGTTALI
 ||| | | | |  |||  .   .  |..|. ..|..||||| . |..| ..|.. ||.    .. .   ...... .|.  .    . .    ||||  
fkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGttaas

TVMKNNKIYCGNVGDSRGVMS-ISGHAKPLSFDHKPSNENESKRIIAAGGWVEFN----RVNGNLALSRALGDFVFkrnlskgpeEQIVTAVPDVT-ETE
 .. ..|.|  |||||| |..   | || ||.|||||.|.| ||| ..|| |  .    ||||.||.||||||  .         |  |.. ||.. . |
vliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfl.........ePfvvpdPdlsqsle

IIPDSEFLLLACDGIWDVLTNQEVVDFVRsrigNKMDPEKICEDLMTRCLApdcqMGglGCDNMTVVLV
|  . .||.||||||||.....| |. |     .  |||| .| |           |    ||..|...
iskkdkflilacdGiwdlisdeeaveiva....gisdpekaaeklrdlays....sG..stdnisvivi
PPM_PTC7_SpoIIE 23-265 1.6e-45 148.7 In-house 2-222 (230) alignment 
Range on Protein: 23-265
Range on HMM: 2-222/230.0
KVGASCMQGWRINMEDAHTQILAI---DDDKDSAFFAVYDGHGGAKvaQYAGQHLHRKLANQStYKRGE-ISTAIRESFLKIDEDMLKDeamkDELAGTT
..|||..||.| .|||||.        ...   ......|||||    ..|  .|. .|.... .. .|  . ..|...|... |. ..    ..  |.|
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaT

ALITVMKNNK--IYCGNVGDSRGVMSISgHAKplsfdhkpsnenESKRIiAAGGWVE----FNRVNGNLALSRALGDFVFKRnlskgpEEQIVTAVPDvT
|.. .  ...  .|. |.|||. ... . ...            | .|| .|||...    ..||.|.||.|.| ||. ..       ....|.| || |
avvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.t

ETEIIPD-SEFLLLACDGIWDVLTNQEVVDFVRSRIGNKmdpekICEDLMTRCL
.... ..  ||| ||.||.||||..||.||.||.... .     ..|.|.. ..
sdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDi
subfamily_ILKAP_pd Subfamily ILKAP 26-257 3.1e-43 141.0 In-house 9-253 (293) alignment 
Range on Protein: 26-257
Range on HMM: 9-253/293.0
ASCMQGWRINMEDAHTQILAIDDD--------KDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQ----S-TYKRGEISTAIRESFLKIDEDMLKDEAMKD
 .. .| | .|.|||. .  .|..        .  ...||.|||.| . ...| ..||.|. ..    . . |  ||  .. .|| | ||..||  . . 
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskak

E--LAGTTALITVMKNNKIYCGNVGDSRGVMSI-SGHAK-----PLSFDHKPSNENESKRIIAAGGWVEFNRVNGNLALSRALGDFVFKRNlskGpeeqi
     |.|| . .. .| .| .|.|||. |.   . ...     .|. ||.| ...| |||  ||| |. .||.| |  ||..||  |||    |     
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl...G.....

VTAVPDVTETEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKIC
|...|||.  |. ..  |..|||||.|.|....|||.|. . .... | .|| 
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkik
subfamily_PPM1K_pd Subfamily PPM1K 23-286 4.9e-36 117.2 In-house 5-258 (263) alignment 
Range on Protein: 23-286
Range on HMM: 5-258/263.0
KVGASCMQGWRINMEDAhTQILAIDDdkDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQStYKRGEISTAIRESFLKIDEDMLKDEAMK-----DELAGT
.||   ..| | . ||   ... .|.  .  ..||.|||.|.  |... ..|.. | .    |  .. . ....|...|... .   ..      . .||
svGkdsliGkraenedr.iklkeldp..ellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGt

TALITVMKN-NKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFN-----RVNGNLALSRALGDFVFKRNlskGpeeqiVTAVPDV
|| ...... ...   ..|||| ..   |.|| |. ||.|. |.| .|| |||| ||.|     .||| ||..|.|||. .||    |     | | |. 
tatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry...G.....viatPet

TETEI-IPDSEFLLLACDGIWDVLTNQEVVDFVRSrignKMDPEKICEDLMTRCLapdcQMGGlgCDNMTVVLVCL
 . ..   .  ||.|  ||| .|...||. |.||       |||.  . | .  |    | |    || |.|.| |
kslkvdhaadsflvlitdgisfvvnsqelcdlvrl....chdpeeaahalteqal....qygs..ednatavvvpl
subfamily_PPM1G_pd Subfamily PPM1G 5-112 8.9e-33 107.0 In-house 2-107 (473) alignment 
Range on Protein: 5-112
Range on HMM: 2-107/473.0
LSEPVTAKETSGCENHLCKVGASCMQGWRINMEDAHTQILAIDDdkDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRGEISTAIRESFLKIDEDM
||.| . ||..   |. ...||| ||||| ..||||. |. .|.  | ..|||||||||..||.|  ..|   | .| .|| |....|..|.||..|| .
lskpkvekesedesneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl

LKDEAMKD
 ..|..|.
kaeeslke
subfamily_PPM1D_pd Subfamily PPM1D 23-174 1.2e-31 102.9 In-house 3-173 (309) alignment 
Range on Protein: 23-174
Range on HMM: 3-173/309.0
KVGASCMQGWRINMEDAHTQILAIDD---DKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYK---RGEISTAIRESFLKIDEDMLKDEAM-----K
.| ... || |  |||  .. |. ..   ... ||.||.||||| . |..| .||  .. .|. .      .. .||||.||.. | | |  .      .
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

--DELAGTTALITVMKNNKIYCGNVGDSRGVMSISGH------AKPLSFDHKPSNENESKRIIAAGGWVEF
     ||||| . .....|.| ..||||. |.... .      ||.|  ||||.. .| .||  .|| |  
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
subfamily_KAPP-like_pd Subfamily KAPP-like 31-286 2e-26 85.6 In-house 7-266 (266) alignment 
Range on Protein: 31-286
Range on HMM: 7-266/266.0
GWRINMEDAHTQILAIDDDKD------SAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTY--------KRGEISTAIRESFLKIDEDMLKDEAmkDELAG
|  ..||| .  |  . ..|.       |.|||.||| |  .|. | . . ..| ..           .  . |  ....| ..|. . . |   .  . 
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfey..eGata

TTALITVMKNNK-IYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEF--NRVNGnLALSRALGDFVFKRnLSKGpeeqiVTAVPDVTE
| ||.    . . . ..|||||   .|    .  ||.|||  ...| .||   |  .     |.|| ||.||||||   |. |  |     ... | |..
tlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfike.lniG.....lisepyvsn

-TEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNkmdpeKICEDLMTRCLApDCQMG-GLGCDNMTVVLVCL
   . |  .||..| ||.|||.. .. .. |.|   .     .  || |. .|  .. ..  .  ||..|..| |
rilltpfdkflivasdGlwdvisGkdaiekvkslydq.....qatedkmassll.etaiqsikakdnvsvivvkl
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 44-192 1.5e-24 80.1 In-house 12-185 (292) alignment 
Range on Protein: 44-192
Range on HMM: 12-185/292.0
LAIDDDKDSAF-FAVYDGHG--GAKVAQYAGQHLHRKLANqSTYKRGEISTAIRESFLKIDEDMLKDEAMKDELAGTTALITVMKNN-KIYCGNVGDSRG
| ..  .  .|  ||.||||  | ||||.| ..|  .| . .| .  |.| |.    |.|   . |  . . | |.|..  ...... ...  |||||| 
llvegsealtflaavldGhGvnGdkvaqlaedtlevelle.ltrqlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsra

VMSI-----SGHAKPLSFDHKPSNENESKRIIAAGGWVE-----------FNRV------NGNLALSRALGDFVF
..         . .||| ||||.. .| .|| .||| ||             ||      .|.|||||||||| .
llgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
subfamily_PDP_pd Subfamily PDP 78-256 2.8e-23 75.7 In-house 104-321 (398) alignment 
Range on Protein: 78-256
Range on HMM: 104-321/398.0
LANQSTYKRGEISTAIRESFLKIDEDMLKDE-----------AMKDELAGTTALITVMKNNKIYCGNVGDSRGVMSIS---G--HAKPLSFDHKPSNENE
| ..   . .... |....|||.|.|. ..            |..  |.|..||..........  |.||.| |.  .   |  .|..|| |.  .||.|
lqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeE

SKRIIAAGG------WVEFNRVNGNLALSRALGDFVFKRNL--SKGPEEQ---------------IVTAVPDVTETEIIPDSEFLLLACDGIWDVLTNQE
 .|| ..         .  .|. |.|. .|| ||. .| .   .| . |.                .|| |.||. .. ..  ||.|| ||.||.|.|.|
veRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsnee

VVDFVRSRIGNKMDPEKI
||. |   . .|.. |..
vvslVgehlakkkekepv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-286 1.9e-22 72.4 In-house 6-276 (276) alignment 
Range on Protein: 31-286
Range on HMM: 6-276/276.0
GWRINMEDAHTQILAIDDDKD------SAFFAVYDGHGGAKVAQYAGQHLHRKLA---NQ---STYKRGEISTAIREsFLKIDEDMLK--DEAMKD-ELA
|  ..||| .  |  . |.||       |.|||.||| |  .|. | . . ..|    .    |  |. .    | .   |.  |..|  |. .|| |  
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniyd.qskllldlfkevdaklkdfeye

GTTALITVMKNNK----------IYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEF--NRVNGnLALSRALGDFVFKRnLSKGpeeq
|.|| .... ..           . ..|||||   .|    .  ||.||| .. .| .||   |  .     |.|| ||.||||||   |. |  |    
GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfike.lniG....

iVTAVPDVTE-TEIIPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNkmdpeKICEDLMTRCLApDCQMG-GLGCDNMTVVLVCL
 ... | |..   . |  .||..| ||.|||.. .. .. |.|   .     .  || |. .|  .. ..  .  ||..|..| |
.lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydq.....qatedkmassll.etaiqsikakdnvsvivvkl
PPM_PTC7_motif 224-269 2.9e-18 59.1 In-house 1-47 (51) alignment 
Range on Protein: 224-269
Range on HMM: 1-47/51.0
LLACDGIWDVLTNQEVVDFVRSRIG--NKmDPEKICEDLMTRCLAPDC
.||.||.||||..||.||.||...   .. .|....|.|....||. .
iLAsDGLWDvlsdqeavdlvrdqlskkgl.spqeaAeklvdealargs
subfamily_PP2D1_pd Subfamily PP2D1 122-247 3.5e-16 52.0 In-house 183-306 (492) alignment 
Range on Protein: 122-247
Range on HMM: 183-306/492.0
TVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGGWVE----FNRVNGNLALSRALGDFVfKRNLskgpeEQIVTAVPDVTETEII
  ..   .|  |.|. . |.   |.|. |  .| | |..| .|.  ||. |       .||| |   | || .    .|     .. |   | .| ... 
hleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG.dpkL.....kksvipePkttsvkld

PDSEFLLLACDGIWDVLTNQEVVDFVRSRI
  . ||.||  |.|.||...||.  |.. .
eaaqflvlAsnGlWevlseeevlsLvkqtl
subfamily_TAB1_pd Subfamily TAB1 108-236 9.4e-16 50.5 In-house 121-262 (333) alignment 
Range on Protein: 108-236
Range on HMM: 121-262/333.0
EAMKDELA-GTTALITVMKNNKIYCGNVGDSRGVMSI---SGHAKPLSFDHKPSNENESKRIIAAG---GWVEFNRVNGNLALSRALGDFVFKRN-----
. ...|.. ||||.. .. |||.|  |||||| ..     | . | || ||.  ||.| .|.   |     .. |.. |.    |..||.  |       
qeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvd

-LSKGpEEQIVTAVPDVTET-EIIPDSEFLLLACDGIWDVLTN
 ||.  ... | | ||.. . .| .   ||.|  ||.   | .
ilssa.kgePviaePdiqgaypiddityflvlmSdGvyktLee
PP2C_SIG_SM00331 46-284 6.9e-14 44.9 In-house 24-215 (217) alignment 
Range on Protein: 46-284
Range on HMM: 24-215/217.0
IDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKrGEISTAIRESFLKIDEDmlkdeaMKDELAGTTALITV--MKNNKIYCGNVGDSRGVMSI
....... ...| ||.|. . |. |   |. .| .... .  |.|.|...    |.|        ...  ..|.|...  ....|..  |.|||| ..  
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.eelsqalkrlnraiyee......keekgmfaTlllalydfssgklsyanaGdsrpyllr

-SGHAKPLSFdhkpsneneskriiaaggwvefnrvngnlalsralgdfVFKRNLSKGPEEQivtavPDVTETEIIPdSEFLLLACDGIWDVL-----TNQ
 ..  ..|..                                      |  . |. .||..     .|..|.|. .  ..|||. ||....       ..
dgklveilkd......................................vegaplGlepevs.....vdirelelek.gdllllytDGltearsekgfaee

EVVDFVRSRIgnKMDPEKICEDLMTRCLA----PDCqmgglgCDNMTVVLV
.. .....    .. .... .. ... |.    .         |..|||.|
rleeiledlv..dseaqelaqkiveellelakgsng......eDdiTvvvv
subfamily_PPM1D_pd Subfamily PPM1D 181-286 1.5e-13 43.5 In-house 201-307 (309) alignment 
Range on Protein: 181-286
Range on HMM: 201-307/309.0
LALSRALGDFVfkrNLSKGPEEQIVTAVPDVTETEIIPDSE-FLLLACDGIWDVLTNQEVVDFVRSRIGNKMD----PEKICEDLMTRCLAPdCQMGGLG
||..|.|||.      ..  .| .|  .|||..... |..| |..|| ||.|.||| ...|..|..    |.      ... . |... |    .   | 
LavaRslGDlW...synaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqr.wrskklr

CDNMTVVLVCL
.||..|..|.|
aDnvsvivvil
subfamily_PPM1H_pd Subfamily PPM1H 90-162 2.7e-13 42.5 In-house 137-209 (404) alignment 
Range on Protein: 90-162
Range on HMM: 137-209/404.0
STAIRESFLKIDEDMLKDEAMKDELAGTTALITVMKNNKIYCGNVGDSRGVMSISGHAKPLSFDHKPSNENES
  |. ..||..|| . ...       | |||.... ..|.|  | |||| ... ... .|||.|. |  | . 
iGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqR
PP2C_2 Protein phosphatase 2C 35-246 3.2e-12 39.2 Pfam-A 11-194 (212) alignment 
Range on Protein: 35-246
Range on HMM: 11-194/212.0
NMEDAHTqilaIDDDKDSAFFAVYDGHGGAKV----AQYAGQHLHRKLANQSTYKRGE-ISTAIRESFLKIDEDM-LKDE----AMKDELAGTTALITVM
. .||..    | ...|  ..|| ||.| ||     |..| . . . |... . .. . .....|.   .|.... ||.|     .. .  .|| |..|.
pcqDala....ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavi

KNNKIYCGNVGDSRG-VMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFnrvngnlalsralgdfvfkrnlskgpeeqivtavpdvtETEI--IPDSE
....|.....||..  |.. .| ...|. ...   .||  ..  .  . |.                                      ....   .. .
tpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgd

FLLLACDGIWDVLTNQE-VVDFVRSR
 |||  ||..| |...| . .... .
alllmTDGvsdslrkeepfrellael
PP2C_2 Protein phosphatase 2C 35-246 3.2e-12 39.2 In-house 11-194 (212) alignment 
Range on Protein: 35-246
Range on HMM: 11-194/212.0
NMEDAHTqilaIDDDKDSAFFAVYDGHGGAKV----AQYAGQHLHRKLANQSTYKRGE-ISTAIRESFLKIDEDM-LKDE----AMKDELAGTTALITVM
. .||..    | ...|  ..|| ||.| ||     |..| . . . |... . .. . .....|.   .|.... ||.|     .. .  .|| |..|.
pcqDala....ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavi

KNNKIYCGNVGDSRG-VMSISGHAKPLSFDHKPSNENESKRIIAAGGWVEFnrvngnlalsralgdfvfkrnlskgpeeqivtavpdvtETEI--IPDSE
....|.....||..  |.. .| ...|. ...   .||  ..  .  . |.                                      ....   .. .
tpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgd

FLLLACDGIWDVLTNQE-VVDFVRSR
 |||  ||..| |...| . .... .
alllmTDGvsdslrkeepfrellael
PPM_PTC7_SpoIIE_motif 214-286 1.7e-10 34.4 In-house 6-80 (81) alignment 
Range on Protein: 214-286
Range on HMM: 6-80/81.0
TEIIPDSEFLLLACDGIW-------DVLTNQEVVDFVRSRigNKMDPEKICEDLMTRCLApdcQMGGLGCDNMTVVLVCL
.. ..  . |||..||..       ......|........   ......... |. ..|.   . .|   |..|......
efqLkpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlrv
subfamily_PP2D1_pd Subfamily PP2D1 32-83 7.2e-10 31.2 In-house 13-64 (492) alignment 
Range on Protein: 32-83
Range on HMM: 13-64/492.0
WRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQST
|. .|||..|      .| .|.||..|||. ||  |. | ..||. |...  
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevlleele
subfamily_PPM1H_pd Subfamily PPM1H 176-251 1.9e-08 26.5 In-house 276-355 (404) alignment 
Range on Protein: 176-251
Range on HMM: 276-355/404.0
RVNGNLALSRALGDFVFKRNLSKGPEEQIVTAVPDVTETEI-----IPDSeFLLLACDGIWDVLTNQEVVDFVRSRIGNKM
|. . .. .| |||   |   ..     ....||.|. ...     ..|   |.|| ||.||||.|.||   ||. . .  
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDd.vlilatDGLWdvlsneevaeivrevlskve
subfamily_PHLPP_pd Subfamily PHLPP 41-246 3e-08 25.9 In-house 24-215 (246) alignment 
Range on Protein: 41-246
Range on HMM: 24-215/246.0
TqilaidddKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQSTYKRgEISTAIRESFLKIDEDMlkdeAMKDELAGTTALITVMKNNK--------IYCG
         .. | . ..||.   ....   . ..  |... . .. .    ..  .|..  ..     .. |  |..||.. ....|        .   
l........svealyGlfdGdrneelssllqrlmkdvlkeevqkdk.neeeymkntllvaqrkl....GeaGeklgsaallilirhdkvdPaksfsLevA

NVGDSRGVMSISGHAKPLSFDHKPSNEnESKRIIAAGGWV-EFNRVNGNLALSRALGDFVFKrnlskgPeeqIVTAVPDVTETEIIPDSEFLLLACDGIW
.||    |.   |.  .||  .. ... | |||  | . . | |..|| .. .| || .         |   .|   | | |. . .. |.|..  . .|
svGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflf......P...vvlPkphvrevlLteqdellivGnkalW

DVLTNQEVVDFVRSR
.||  .|.|. ||  
evlsideaveavrke
Subfamily Dicty-PPM1L-like 28-74 3.4e-07 22.4 In-house 13-59 (305) alignment 
Range on Protein: 28-74
Range on HMM: 13-59/305.0
CMQGWRINMEDAHTQILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHL
  .. | . || .   ... ....  .| |.|||.| . |.|. ..|
vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkkl
Subfamily Dicty-PPM1L-like 177-257 7.4e-07 21.3 In-house 201-273 (305) alignment 
Range on Protein: 177-257
Range on HMM: 201-273/305.0
VNGNLALSRALGDFVFKRNLSkGPEEQIVTAVPDvteteiiPDSEFLLLACDGIWDVLTNQEVVDFVRSRIGNKMDPEKIC
||. |  ||  ||   |  .   .... .  | .       .. .||.|| ||.|.|| .|.||..|.  . .|.  .|| 
vnrllkksrskGdknlkelvi.Pnndspllvvak.......anDqflvlatdGlwevlsyqdvveevkellrdkssqkkie
PAP1 Transcription factor PAP1 195-262 1.6e-06 14.3 Pfam-A 263-324 (347) alignment 
Range on Protein: 195-262
Range on HMM: 263-324/347.0
NLSKGPEEQIVTAVPD--VTETEIIPDSEFLLLACDGIWDVLTNQEVVdfvrsrigNKMDPEKICEDLMT
. ........  ....    | |..|  |  || |  ||| .|. . .        . .| .  | .|..
sqkakekkdladeidnddedeeevvpskekslLkCskiWDritshpkf........geiDiDgLCseLra
Subfamily Dicty-PPM1L-like 116-189 6.7e-06 18.1 In-house 215-294 (305) alignment 
Range on Protein: 116-189
Range on HMM: 215-294/305.0
GTTALITVMKNNKIY-CGNVGDSRGVMSISGHAKPLSFDHKPSNENESKRIIAAGG---W--VEFNRVNGNLALSRALGD
... |.   ......   . .|...|..  | .. ||..... . .|  |.   ..   |   |  || ...|..|  ||
nlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_TAB1_pd Subfamily TAB1 43-106 7.8e-06 17.9 In-house 18-84 (333) alignment 
Range on Protein: 43-106
Range on HMM: 18-84/333.0
ILAIDDDKDSAFFAVYDGHGGAKVAQYAGQHLHRKLANQST---YKRGEISTAIRESFLKIDEDMLK
.. .  ..|   .||.||. |.|.|... |.|  .| ..      .. |.   ... | .... .|.
vflfktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfle