Gene PPM1K-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1K
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP191_AA protein Get Run
SpurP191_AA_162-423 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1K_pd Subfamily PPM1K 165-424 2.7e-151 495.0 In-house 5-263 (263) alignment 
Range on Protein: 165-424
Range on HMM: 5-263/263.0
RIGKDSLIGRRAENEDRICIKELHPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHDLQIVLKNAFEDLNNKLTRYLYFHYPEAEYENSGSTATV
 .|||||||.||||||||..|||.|.||||..|||||||.|.|.||..||..|...||.|.||.||||||||.|..||.|||.|...|||...||.||||
svGkdsliGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatv

SLLRNGNELVLANLGDSRAILCRNGKAKRLTDDHDPEYNTaEKERIKAAGGSFTWNSLGKPLVNSVLTMTRSFGDVTLKRYGVIATPETRSLEVKHGRDS
||||.|.|||||.|||||||||||||||.||.|||||... |||||||||||..||||||||||..|.||||.||..||||||||||||.||.|.|..||
sllrdGtelvlaslGdsrailcrnGkakkltrdhdPelee.ekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaads

FLVFCTDGVHFVMNDQEMCDSISLCHNPQEAASFICDQALQFGSEDNASVIVVPLGQWGR
|||..|||..||.|.||.||...|||.|.|||.....||||.||||||...|||||.||.
flvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvplgawgk
0034914 PP2C-like 163-423 1.2e-65 214.2 In-house 20-294 (295) alignment 
Range on Protein: 163-423
Range on HMM: 20-294/295.0
VGRIGKDSLIGRRAENEDRICIKE----LHPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFW--------LEREHDLQIVLKNAFEDLNNKLTRYLYFhy
. |.|  | .||| .|||....      |...||..|.|||| |. | ......|  .|  .         . ..|.. .|..||  ....| ....   
llrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall..

pEAEYENSGSTATVSLLrNGNELVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWnslgkPLVNSVLTMTRSFGDVTLK-------
 . |. .||.||.| |.  || |..||.|||||.|.|||....|| ||.|  |  |.|||..|||  ..     . || || .||..||. ||       
.rpelagsGtTavvali.rgnklyvanvGDSravllrngelvqltvdhkpv.nelererilsaggavsh.....grvngvlavtRalGdfdlklllslll

-RYGVIATPETRSLEVKHGRDSFLVFCTDGVHFVMNDQEMCDSISL----CHNPQEAASFICDQALQFGSEDNASVIVVPLGQWG
 ...|.|.|....||.... | ||....||.. |....|..| ..     .....|||  ..|.||. || || .|.|| |...|
leplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlnglg
PP2Cc_SM00332 167-417 8.7e-53 172.4 In-house 13-274 (274) alignment 
Range on Protein: 167-417
Range on HMM: 13-274/274.0
GKDSLIGRRAENEDRICIKEL---HPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHD-----LQIVLKNAFEDLNNKLTRYLYFHYPEAeyENS
||.|  |.| ..||.....     . . |..|.||||.|| ....|  .|  .|.  |. . |      . .||.||........     . .|   ..|
gkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen..als

GSTATVSLLRNGNeLVLANLGDSRAILCRNGKAKRLTDDHDPeYNTAEKERIKAAGGSFTWNslgkpLVNSVLTMTRSFGDVTLKR------YGVIATPE
||||.|.||.... |..||.|||||.|||||||..|. || |  .  |..|||.|||.  ..      || .| ..|.|||. ||.       ...|.|.
Gstavvallkked.lyvanvGDSravlcrngkavqlsvdhkp.edederkRikkaggvvekg.....rvngglavsrafGdhflkknkklkepyitaepd

TRSLEVkHGRDSFLVFCTDGVHFVMNDQEMCDSISLCH------NPQEAASFICDQALQF-GSEDNASVIVV
.  ...    | ||....||.. |...||..| .  .       .|||||  ....|..  ||||| .|.||
vkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
PP2C Protein phosphatase 2C 171-411 3e-50 164.2 Pfam-A 8-254 (255) alignment 
Range on Protein: 171-411
Range on HMM: 8-254/255.0
LIGRRAENEDRICIKE------LHPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHD--LQIVLKNAFED-LNNKLTRylyfHYPEAEYENSGST
| |.| ..||.... .         .  ....||||.|..| .| . .|| .|.   . . .  .. .|...|.  ....|..    .   .| ..||||
lqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks....skantepsksGst

ATVSLLRNGNeLVLANLGDSRAILCRNGKAK-RLTDDHDPEyNTAEKERIKAAGGSFTWnslgKPLVNSVLTMTRSFGDVTLKR---YGVIATPETRSLE
|.|.|.|. . | .||.|||||.|||...|| .|| ||.|. .. |.|||..||||. .    .  || .| ..|..||. ||.   . |.| |...| .
avvalirgkk.lyvAnvGDSravLcrkdnakkeltedHkps.dedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

VKHGrDSFLVFCTDGVHFVMNDQEMCDSISLCHN----PQEAASFICDQALQFGSEDN
 .   |.||. ..||.  |..|||..| .  . .    |.|||  ..|.|.. |||||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
PP2C Protein phosphatase 2C 171-411 3e-50 164.2 In-house 8-254 (255) alignment 
Range on Protein: 171-411
Range on HMM: 8-254/255.0
LIGRRAENEDRICIKE------LHPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHD--LQIVLKNAFED-LNNKLTRylyfHYPEAEYENSGST
| |.| ..||.... .         .  ....||||.|..| .| . .|| .|.   . . .  .. .|...|.  ....|..    .   .| ..||||
lqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelks....skantepsksGst

ATVSLLRNGNeLVLANLGDSRAILCRNGKAK-RLTDDHDPEyNTAEKERIKAAGGSFTWnslgKPLVNSVLTMTRSFGDVTLKR---YGVIATPETRSLE
|.|.|.|. . | .||.|||||.|||...|| .|| ||.|. .. |.|||..||||. .    .  || .| ..|..||. ||.   . |.| |...| .
avvalirgkk.lyvAnvGDSravLcrkdnakkeltedHkps.dedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvk

VKHGrDSFLVFCTDGVHFVMNDQEMCDSISLCHN----PQEAASFICDQALQFGSEDN
 .   |.||. ..||.  |..|||..| .  . .    |.|||  ..|.|.. |||||
ltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
0049733 PP2C-like 167-419 7.2e-50 162.4 In-house 6-233 (235) alignment 
Range on Protein: 167-419
Range on HMM: 6-233/235.0
GKDSLIGR-RAENEDRICIkelhpNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLERE--HDLQIVLKNAFEDLNNKLTRYLYFHYpeaEYENSGSTAT
|  | ||| | .|||....     .||.....||| |. | ... ..|  .|  .|..   .||. .|..||. .|. | .. . ..   |.  .|.||.
gaasdigrvrkvneDavlv.....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp...elagmgtTav

VSLLRnGNELVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFtwnslgkpLVNSVLTMTRSFGDVTLKrygviatPETRSLEVKHGRd
| ||. |. |..||.|||||.|.|.||. .|| || |  |  |..||..||| .         |. .| .||..|| .||       |....||...|  
valld.ggklyvanvGDsrayllrdgklvqltedhspv.nelerqriitaggav........rvpgrlaltralGdlllk.......pdvtvlelepgd.

sFLVFCTDGVHFVMNDQEMCDSISLcHNPQEAASFICDQALQFGSEDNASVIVVPL
 ||....||.. |..|.|..| ..  ....|||......||. |. || .|.|| |
.flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
PPM_PTC7 173-411 1.6e-48 158.4 In-house 10-258 (259) alignment 
Range on Protein: 173-411
Range on HMM: 10-258/259.0
GRRAENEDRICIKE------LHPNLLYVGIFDGHAGSMAVDYVHHNLEfhlNFWLEREHD-----LQIVLKNAFED--LNNKLTRylyfHYPEAEYENSG
|.| ..||. ...          .  ....||||.|..| .|.. .||   ... ||. .     |. .|...|.   ....|..    .   .| ..||
gfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle...eilkerksfeeleklekalrksflaldtdeelks....seantepstsG

STATVSLLRNGNeLVLANLGDSRAILCRNGKAK-RLTDDHDPEyNTAEKERIKAAGGSFTWNslGKPLVNSVLTMTRSFGDVTLKR-----YGVIATPET
|||.| |... . |  ||.|||||.|||.|.|. .|| ||.|. |. |.|||..||||. .   |.  || || ..|.|||. ||.       |.|.|..
stAvvalitgsk.lyvAnvGDSravLcrsgnavkqltedHkps.nedEreRiegaggsvsnv..gngrvngvlavsRafGdfelkpketeeqlvsaePdi

RSLEVKHGrDSFLVFCTDGVHFVMNDQEMCDSISLCHN---PQEAASFICDQALQFGSEDN
 | .     | ||. ..||.  |..||| .| .  . .   |.|||  ..| |.. |||||
sstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedn
subfamily_PPM1A_pd Subfamily PPM1A 165-419 2.6e-48 157.8 In-house 13-280 (282) alignment 
Range on Protein: 165-419
Range on HMM: 13-280/282.0
RIGKDSLIGRRAENEDRICIKELHPNL---LYVGIFDGHAGSMAVDYVHHNLEFHLNF---------WLEREHDLQIVLKNAFEDLNNKLTRyLYFHYPE
|.| .|  |.|.|.||. ..    ..|    .  .||||||| ...||...|  ..             . ..... .|...| .|.... . |  .. .
rygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire.lstdlkt

AeyENSGSTATVSLLRnGNELVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTwnslgKPLVNSVLTMTRSFGDVTLKR--------
|  ..|||||.. |..  ..|..||||||||.|||||||..||.|| |. .. ||.||..|||| .     .  ||  | ..|..|| ..|.        
a..dksGsTavtvlvs.ekhliianlGDsRavlcrngkaaflteDHkps.rpkEkkRieqAGGsvv.....vsRvnGaLAvsRalGDyeykeeeekkaee

YGVIATPETRSLEVKHGRDsFLVFCTDGVHFVMNDQEMCDSISLC----HNPQEAASFICDQALQFGSEDNASVIVVPL
  |.| ||..|.| ..  | ||| . ||.. |..|.|... .       ....| |. . |.||. ||.|| ||.|| .
qlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 165-419 1.1e-42 139.1 In-house 7-253 (255) alignment 
Range on Protein: 165-419
Range on HMM: 7-253/255.0
RIGKDSLIGRRAENEDRICIKEL---HPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHD-LQIVLKNAFEDLNNKLtrylyfhypeAEYE-NSG
..|.  .||||.  ||.. |      ...  |. .||||.|. | ..  ..|.  |.  |. ..   . .||.|..... ..          .|.    |
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi..........serpkfiG

STATvSLLRNGNELVLANLGDSRAILC-RNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWNsLGKPLVNSVLTMTRSFGDVTLKRYgVIATPETRSLEV
.||. |.|  ..  ..||.||||..|| ..| ||||. || |  .  |..||...||    .      ||  |...|..||. |. . |.. |.  .   
ttaa.svliiedkvyianvGdsrvvlcqkdgtakrlsldhkPs.eeseekriselGGtvvst.vvtsrvnGtlavsralGdsflePf.vvpdPdlsqsle

KHGRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQEAASFICDQALQFGSEDNASVIVVPL
.. .| ||.   ||.  .. |.| .. .    .|..||  . |.| . ||.|| ||||. |
iskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1E_pd Subfamily PPM1E 189-419 2.8e-40 131.2 In-house 38-262 (265) alignment 
Range on Protein: 189-419
Range on HMM: 38-262/265.0
PNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEREHDLQIVLKNAFEDLNNKLTRYlyfhyPEAEYENSGSTATVSLLRNgNELVLANLGDSRAILCRN
..  . ..||||.|. | .|  ..|  .|    . ..| .  ||.||. .......       | |  .||||| | |... ..| .| ||||.|.|.|.
keraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqk.....aereklksGstavvvliek.dqlyvaWlGDsqallvrk

GKAKRLTDDHDPEyNTAEKERIKAAGGSFTWNslGKPLVNSVLTMTRSFGDVTLKRYgVIATPETRSLEVKhGRDSFLVFCTDGVHFVMNDQEMCDSISL
|.| .|.. | || .  ||.||..|||   .   |.  || ||...|. |||.||.| |.. ... ..|.. | . .|.  .||.. |.|..|... .. 
geavqlmkpHkPe.redEkkRieeagGlvvvi..gawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveld.gseeylilacDGlwDvvneeevvklvee

CHN-----PQEAASFICDQALQFGSEDNASVIVVPL
  .      .|.| .....| . ||.|| .|.|| |
fladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1G2_pd Subfamily PPM1G2 167-407 7e-33 106.8 In-house 22-264 (287) alignment 
Range on Protein: 167-407
Range on HMM: 22-264/287.0
GKDSLIGRRAENEDRICI------KELHPNLLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLER-EHDLQIVLKNAFEDLNNKLTRYlyfhyPEAEYENSG
|  .. | | . ||   .      |. ...| ....|||| |. .  |. ..|   ..   .  |  |. .||.|| .....|..       . . |..|
gssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkd.....eklkdesaG

STATVSLLRNGNeLVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWNSlgkplVNSVLTMTRSFGDVTLKRYG--------VIATP
|||.| |... . |. || |||||.|. .|..| |. || |. ...||.||.||||    |      || .| . |..|| . |.          | |.|
stavvvlikeek.lyvanaGDsravlsskgnvkalsfDhkPq.eesekkriiaagGfvelnr.....vngnLalsralgDfefkknvkkkpeeqivtavP

ETRSLEVKhGRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQEAASFICDQALQFG
.    ...  .| |||   ||.  |....|..| .      . . . |... |. .
Dvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkc
subfamily_PPM1L_pd Subfamily PPM1L 170-419 9.4e-33 106.6 In-house 11-266 (269) alignment 
Range on Protein: 170-419
Range on HMM: 11-266/269.0
SLIGRRAENEDRICIKELHPN---LLYVGIFDGHAGSMAVDYVHHNLEFHLNFWL-----EREHDLQIVLKNAFEDLNNKLTRYLyFHYPEAEYENSGST
|. ||| . |||. |.|   |     ....|||| | .| ..... |   .   |     ..|. . |  .. ..|    . . |  .  ..... .|.|
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekl.lekakraediaGtt

ATVSLLRnGNELVLANLGDSRAILC-RNGKAKRLTDDHDPeYNTAEKERIKAAGGSFTWNslGKPLVNSVLTMTRSFGDVTLKRYG-VIATPETRSLEVK
| ..|.. ...|..||.|||| .|. ..|||  |. || | ..  |. ||| |||  ...  |   |. ||...|..||  ||    |||.|.  .....
alialvq.esdlivanvGdsrGvlydkrGkaiplsfdhkp.qqvkerkrikkaGGfiafr..GvwrvaGvlatsralGdyplkdknlviadpdiltfdld

HGRDSFLVFCTDGVHFVMNDQEMCDSIS-LCHNPQEAASFICDQALQFGSEDNASVIVVPL
. .  ||.. .||.   . ..| .  |    ..|.  |  .  .. . || || .|.|| |
dhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl
subfamily_ILKAP_pd Subfamily ILKAP 191-395 2.5e-27 88.8 In-house 43-248 (293) alignment 
Range on Protein: 191-395
Range on HMM: 43-248/293.0
LLYVGIFDGHAGSMAVDYVHHNLEFHLNFWLEReHDLQI---VLKNAFEDL-NNKLTRYLYFHYPEAEYENSGSTATVSLLRNgNELVLANLGDSRAILC
. | ..||||||| | ... ..|. ..   | . .|..     .|... |  ...   .|     .      |||||| |  . | |  ||||||.|.|.
vsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvld.nvlyvanlGdskavlv

RNGKAKR------LTDDHDPEyNTAEKERIKAAGGSFTWNSlgkplVNSVLTMTRSFGDVTLKRYGVIATPETRSLEVKHGrDSFLVFCTDGVHFVMNDQ
|. .. .      || ||.|  .  |..||. |||. . .      |. || ..|| ||   || |||.||... .|...  | |.| . ||.. |.. .
rkkeegdkiasvvLtkdhtpv.kyeerkriqkaGgvvrdgr.....vlGvlevsrsiGdgrfkrlGvistPdvkkceLten.dlfvvlaCdGLwkvfsad

EMCDSISLCHNPQEA
|. . |. . . .| 
evvkfilkvledeed
subfamily_PPM1G_pd Subfamily PPM1G 252-402 1.7e-26 86.2 In-house 290-443 (473) alignment 
Range on Protein: 252-402
Range on HMM: 290-443/473.0
EAEYENSGSTATVSLLRnGNELVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWNSlgKplVNSVLTMTRSFGDVTLKRYG-----
|.. |.||.||.| ||. ...|. || ||||..|.|||||  |  || || .  |.|||..|||  . .   .  ||  | . | .|| . |.       
eepGedsGttAvvaLlk.ekklivAnaGDsRcvlsrnGkAldlslDHkPe.DevEleRiekAGGkvdedg..R..vnGGLnlsRAlGDhaYkkneeLplk

---VIATPETRSLEVKHgRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQE--AASFICDQ
   . | |. . |.. .  | |||  .||.  ||. ||. | .    . .|    | |...
eqmisAlPDikvltlte.edeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseivee
PPM_PTC7_SpoIIE 173-386 4.1e-24 78.7 In-house 10-205 (230) alignment 
Range on Protein: 173-386
Range on HMM: 10-205/230.0
GRRAENEDRICIKE------LHPNLLYVGIFDGHAGSMavDYVHHNLEFHLNFWLEREHD-LQIVLKNAFEDLNNKLTRYlyfhypeaeYENSGSTATVS
|.| ..||. ...        .   |.||..||| |..   ...  |   |.    .... .  .|..... |. .|. .          ..||.||.| 
garksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede.........psssgaTavva

LLRNGN-ELVLANLGDSRAILCRN-GKakrltddhdpeyntaEKERIkAAGGSFTwNSLGKPLVNSVLTMTRSFGDVTLKR--YGVIATPEtrS-LEVKH
|... . .| .||.|||...|.|. |.               |.||| .|||     ...   |. ||......||. |.     | | |.  .  .   
lidpstgklyvanaGdsppllvrddgg...............ereri.vagglps.lGilpgrvfgvlavslapGdllllytDGvveaepd..tsdgelf

GRDSFLVFCTDGVHFVMNDQEMCDSI
|.| ||. ..||.  |...||..| .
gkdeflilasdglwdvlspqelvdlv
subfamily_PPM1D_pd Subfamily PPM1D 173-419 3e-22 72.1 In-house 11-307 (309) alignment 
Range on Protein: 173-419
Range on HMM: 11-307/309.0
GRRAENEDRICIKELH------PNLLYVGIFDGHAGSMAVDYVHHNLEFHL----NFWLEREHDLQIVLKNAFEDLNNKLTRYLYfHYPE---AEYENSG
| |   ||...|.  .       .  .|..|||| |  |  .....|   .    .|. . ..|..  ...|| ...... . |  ..|.    ..  .|
GgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkle.eWpktksgllstaG

STATVSLLRNgNELVLANLGDSRAILCRNGK------AKRLTDDHDPEYnTAEKERIKAAGGSFT---------WNS-----LGKPLVNSV--LTMTRSF
.||.| ..|. ..| .|. |||...|  . .      || ||.|| ||   .|||||. .||. .         |.       |.  ....  |...|| 
ttasvviirr.eklyvahvGDsaivlgvkepkekklrakeltkdHkPes.peekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaRsl

GDV-----TLKRYGVIATPETRSLEVKHGRDSFLVFCTDGVHFVMNDQEMCDSISL------CH--NPQEAASFICDQALQFGSE-----DNASVIVVPL
||.     . ... |   |..   ...  .. |... .||.  |.. ..  . ..       ..  . .. |. . ..|||. ..     || ||||| |
GDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsvivvil
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 174-353 3.1e-22 72.5 In-house 3-196 (292) alignment 
Range on Protein: 174-353
Range on HMM: 3-196/292.0
RRAENEDRICIKELHPNLLY-VGIFDGHA--GSMAVDYVHHNLEFHLNFWLEREHDLQIVLKNAFEDLNNKLTRYlYFhypEAeYENSGSTATVSLLRNG
 . ||.|| .. |    | .   ..|||   |    ..   .|| .|     .  .|   | .   |.  || .  .    .|  |....... .  |..
nkkenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaakldkl.ti...da.resattavvcarvrdd

NELVLANLGDSRAILCR-----NGKAKRLTDDHDPEyNTAEKERIKAAGGSFT------WNSLGKPLV------NSVLTMTRSFGDVTLKRYGVIATPET
 .|.|||.|||||.| |     . . . |. || || .  |..||..|||  .      |   | . |      .  |...|. ||. |.  ||.| || 
ralilanvGdsrallgrclggsdyeliPlsrdhkPe.dPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel
subfamily_PP2D1_pd Subfamily PP2D1 270-383 2.2e-21 69.1 In-house 187-299 (492) alignment 
Range on Protein: 270-383
Range on HMM: 187-299/492.0
GNELVLANLGDSRAILCRNGKAKRLTDDHDPeYNTAEKERIKAAGGSFTWNSlGKPLVNSVLTMTRS---FGDVTLKRyGVIATPETRSLEVKHgRDSFL
   | .|| |. .|.|||.|||..|| .|.| .|. |..|.. ||.. . .   . ||| .|. ||    .||  ||.  ||  |.|.| .. . .. ||
lgvlyianaGnvqAvLcreGkaiiLtreHtp.rnkkERtRvekagsvvvkse.knglvnGildttRGLGnyGdpkLkk.svipePkttsvklde.aaqfl

VFCTDGVHFVMNDQEMC
|. . |.  |....|. 
vlAsnGlWevlseeevl
subfamily_KAPP-like_pd Subfamily KAPP-like 192-418 4.9e-20 64.6 In-house 35-265 (266) alignment 
Range on Protein: 192-418
Range on HMM: 35-265/266.0
LYVGIFDGHAGSMAVDYVHHNLEFHLNFWLER---------EHDLQIVLKNAFEDLNNKLTRYlyfhypeaEYEnsGSTATVSLL-RNGNELVL--ANLG
   ..||||||  | |  .. ..  |.  |..          .| . .|.|||.....||  .        |||  |.|||..|. ..|.   |  ||.|
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdf........eye..GatatlalvwsdGqqrylqvanvG

DSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWNslgKPLVNSVlTMTRSFGDVTLKR--YGVIATPETRSLEVKHGRDSFLVFCTDGVHFVM
|| |.|.|  ..  |. ||  . .  || |||  | . . |   .  .| . ...|..||  .|.   |.|..|   .  .    |.||.  .||.  |.
dssaflsrGneslelskdhkak.dpeekqrikddGitlsdn...qtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvi

NDQEMCDSISLCHNPQEAA----SFICDQALQF-GSEDNASVIVVP
. ..  . ..  .. |...    | . . |.|   . || ||||| 
sGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
PP2C_SIG_SM00331 179-418 3.2e-16 52.5 In-house 18-216 (217) alignment 
Range on Protein: 179-418
Range on HMM: 18-216/217.0
EDRICIKELHPNLLYVGIFDGHA-GSMAVDYVHHNLEFHLNFWLERehdlqivlkNAFEDLNNKLTR----YlyfhypeAEYENSGSTATVSLL-RNGNE
.|  .. .|.   | . ..||.  |  |  .    ..   ... |.         ...... ..| |            .| .... |... |.  ....
GDyydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee.......keekgmfaTlllalydfssgk

LVLANLGDSRAILCRNGKAKRLTDDhdpeyntaekerikaaggsftwnslgkplvnsvltmtrsfgdVTLKRYGVIATP--ETRSLEVKHgrDSFLVFCT
| .||.|||| .| |.|| .  ..|                                          |. .  |.. ..  ..|.||..   ...|...|
lsyanaGdsrpyllrdgklveilkd..........................................vegaplGlepevsvdirelelek..gdllllyt

DGVHFVMNDQE---------MCDSIslCHNPQEAAS----FICDQALQFGSEDNASVIVVP
||.. ......         ..|.   .. .|| |.     .. .| . . ||...|.|| 
DGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 222-418 4e-16 51.7 In-house 64-275 (276) alignment 
Range on Protein: 222-418
Range on HMM: 64-275/276.0
E--------------REHDLQIVLKNAFEDLNNKLTRYlyfhypeaEYEnsGSTATVSLL-RNGN--------ELVLANLGDSRAILCRNGKAKRLTDDH
.                .| . .|...|.....||  .        |||  |.|||..|. ..|.         |  ||.||| |.|.|  ..  |. ||
ksgnysltkqddGGdniydqskllldlfkevdaklkdf........eye..GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdh

DPEyNTAEKERIKAAGGSFTWNslgKPLVNSVlTMTRSFGDVTLKR--YGVIATPETRSLEVKHGRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQEAA
  . .  ||.|||  | . . |   .  .| . ...|..||  .|.   |.|..|   .  .    |.||.  .||.  |.. ..  . ..  .. |...
kat.dpeekqrikddGitlsdn...qtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqate

----SFICDQALQF-GSEDNASVIVVP
    | . . |.|   . || ||||| 
dkmasslletaiqsikakdnvsvivvk
subfamily_PHLPP_pd Subfamily PHLPP 259-418 2e-13 42.8 In-house 86-244 (246) alignment 
Range on Protein: 259-418
Range on HMM: 86-244/246.0
GSTATVSLLRNGN-------ELVLANLGDSRAILCRNGKAKRLTDDHDPEYNtaEKERIKAAGGSFTWNSlgKplVNSVLTMTRSFGDVTLKRyGVIATP
||.| . |.|. .        | .|. |   |.|.||||  ||.  .  | .  | .||| | .  | ..  |  .|.|.. || .| . |    |. .|
gsaallilirhdkvdPaksfsLevAsvGtlqavliRngkklrlsksyviekd..elkrikeakaiitedn..k..ingviestrllGytflfP.vvlPkp

ETRSLEVKHgRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQEAASFICDQALQFGSEDNASVIVVP
. |.. ...  | .|.   . .  |.. .|. ...   ..|  ||  ..|.|  .| .|. ||.|| 
hvrevlLte.qdellivGnkalWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvr
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 259-407 3e-11 35.1 In-house 135-299 (317) alignment 
Range on Protein: 259-407
Range on HMM: 135-299/317.0
GSTATVSLLRNGNELVLANLGDSRAIL-CRNGKAKRLTDDHDPEY--------NTAEKERIKAA---GGSFTWNS----LGKPLVNSVLTMTRSFGDVTL
|.||.|... .   .| || ||. |..  |.   .  .|  . |.          ||..|.. .    . .| .     | . | .  | .|.|.|   |
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkll

KRYGVIATPETRSLEVKHGRDSFLVFCTDGVHFVMNDQEMCDSISLCHNPQEAASFICDQALQFG
||.|||| || ||  .. .    .| ..||.   .. ... | .  .   .||.  .|| | .. 
kraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdyl
Subfamily Dicty-PPM1L-like 305-420 6.8e-11 34.5 In-house 181-304 (305) alignment 
Range on Protein: 305-420
Range on HMM: 181-304/305.0
AEKERIKAAGGSFTwnSLGKPLVNSVLTMTRSFGDVTLKRYgVIATPETRSLEVKHGRDSFLVFCTDGVHFVMNDQEMCDSISLC-----------HNPQ
 .. ||  ....      |. ||| .|   || ||  || . ||  ..   | | .  |.||| .|||.  |.. |.. . .               ...
eiririeslqaaly..nygellvnrllkksrskGdknlkel.viPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfn

EAASFICDQALQFGSEDNASVIVVPLG
|  . |  .|.. ||.||. .....| 
eisrviveeavkrgsgDnitlviiklk
subfamily_PDP_pd Subfamily PDP 230-343 1.9e-09 30.1 In-house 118-241 (398) alignment 
Range on Protein: 230-343
Range on HMM: 118-241/398.0
VLKNAFEDLNNKLTRYLYFHYPEAEYE------NSGSTATVSLLrNGNELVLANLGDSRAILCRN---G--KAKRLTDDHDPEyNTAEKERIKAAGGSFT
.||.||..| . ..     . .| . .       ||..|...|. .|.|| .|| ||.||.|...   |  .|..|. |.  . |..| ||||..  .  
alkkaFlklDkdistealkklkekslreallvalsGacallali.egtelhvAntGDcravlgvqeeegsweavkLskdqtad.neeEveRikkeHPgee

W-NSLGKPLVNSVLTMTRSFGDVTLK
    . .  . . |. .| |||| .|
sktvirngRlLgeLqPlRAFGdvryK
subfamily_TAB1_pd Subfamily TAB1 258-343 5.4e-09 28.3 In-house 129-213 (333) alignment 
Range on Protein: 258-343
Range on HMM: 129-213/333.0
SGSTATVSLLRNgNELVLANLGDSRAILCR---NGKAKRLTDDHDPEyNTAEKERIKAAGgsFTWNSLGKPLVNSVLTMTRSFGDVTLK
 |.|| | |. | |.|  || |||||.|..   . | | |  ||. . |  | .|.|  |  .  . . .  . .    ||| || ..|
gGttAvvalifn.nkLyVaNvGdsrAllvkrkesekvkqLsvdHttd.NedEllRlkdLG..ldieqikrnkrlgskentRsiGdykvk
subfamily_PPM1H_pd Subfamily PPM1H 231-311 7.9e-09 27.7 In-house 140-211 (404) alignment 
Range on Protein: 231-311
Range on HMM: 140-211/404.0
LKNAFEDLNNKLTRYlyfhypEAEYENS-GSTATVSLLrNGNELVLANLGDSRAILCRNGKAKRLTDDHDPEyntAEKERIK
| .|| .......|       . .|. . | || |.|.   . | .|| |||||||.|... . |  |. ||   .|..|..
lesaflemDeqiare......reayrikGGCtalvalv.llgklYvanaGDsRailvrkdeiiplsadftPe...teRqRlq
PP2C_2 Protein phosphatase 2C 174-381 5.6e-08 25.3 Pfam-A 8-179 (212) alignment 
Range on Protein: 174-381
Range on HMM: 8-179/212.0
RRAENEDRICIKELHPNLLYVgIFDGHAGS----MAVDYVHHNLEFHLNFWLEREHDLQivLKNAFEDLNNKLTRYL----YFHYPEAEYENSGSTATVS
... ..|.. |.| .   | . . ||.        .  .. ...  .|  .||.|   .   . ......|.. . .      .  ..| .. ..| .. 
kgkpcqDalaireasdgwlla.VADGaGsakrSdkGarlaveaagealeklleeeseqe..eeallrqieneilasvklkqeaeaqqeelkdyatTllla

LlRNGNELVLANLGDSRA-ILCRNGKAKRLTDDHDPEYNtAEKERIKAAGGSFTWnslgkplvnsvltmtrsfgdvtlkrygviatpetRSLEVKHGRDS
. ....|.|....||... .  |.|....|....  ||   |  ... .  . ..                                  |  ..|    .
v.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel..................................rirrlklepgd

FLVFCTDGVHfvmndqE
 |. .||||       .
alllmTDGvs......d
PP2C_2 Protein phosphatase 2C 174-381 5.6e-08 25.3 In-house 8-179 (212) alignment 
Range on Protein: 174-381
Range on HMM: 8-179/212.0
RRAENEDRICIKELHPNLLYVgIFDGHAGS----MAVDYVHHNLEFHLNFWLEREHDLQivLKNAFEDLNNKLTRYL----YFHYPEAEYENSGSTATVS
... ..|.. |.| .   | . . ||.        .  .. ...  .|  .||.|   .   . ......|.. . .      .  ..| .. ..| .. 
kgkpcqDalaireasdgwlla.VADGaGsakrSdkGarlaveaagealeklleeeseqe..eeallrqieneilasvklkqeaeaqqeelkdyatTllla

LlRNGNELVLANLGDSRA-ILCRNGKAKRLTDDHDPEYNtAEKERIKAAGGSFTWnslgkplvnsvltmtrsfgdvtlkrygviatpetRSLEVKHGRDS
. ....|.|....||... .  |.|....|....  ||   |  ... .  . ..                                  |  ..|    .
v.itpgeivffqiGDgaivvrdrdgevqllgepdsgeya.nettfltsedaeeel..................................rirrlklepgd

FLVFCTDGVHfvmndqE
 |. .||||       .
alllmTDGvs......d
PPM_PTC7_motif 369-411 9.3e-07 22.3 In-house 3-50 (51) alignment 
Range on Protein: 369-411
Range on HMM: 3-50/51.0
CTDGVHFVMNDQEMCDSISLCHN-----PQEAASFICDQALQFGSEDN
..||.  |..||| .| .  . .     |||||. ..|.||. |||||
AsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn
PPM_PTC7_SpoIIE_motif 362-417 1.7e-06 21.6 In-house 11-78 (81) alignment 
Range on Protein: 362-417
Range on HMM: 11-78/81.0
RDSFLVFCTDGVH-------FVMNDQEMCDSIS--LCHNPQEAASFICDQALQFG---SEDNASVIVV
 .. |...|||.         .....| .. ..    ...||.|  ..|..|. |   .||.....|.
pgdvllLyTDGltEardsdgelfgkeellrladraegkslqeladklvdevlengsgereDDitllvl
Subfamily Dicty-PPM1L-like 273-320 5.6e-06 18.4 In-house 229-275 (305) alignment 
Range on Protein: 273-320
Range on HMM: 229-275/305.0
LVLANLGDSRAILCRNGKAKRLTDDHDPEyNTAEKERIKAAGGSFTWN
||.|. .|.. .|...|... |  .. .| .  |. |.|  ..   |.
lvvakanDqflvlatdGlwevlsyqdvve.evkellrdkssqkkiewd