Phosphatase Subfamily CG42327
CG42327 is a receptor PTP found in metazoa, of unknown function and distribution.
CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon (AquePTP-Un-2), Monosiga (MbrePTP-Un-8) and S. purpuratus (SpurPTP-Un-2), as well as other varied metazoa such as Lingula anatina (Lingula anatina) and Crassostrea gigas (XP_011444263.1).
Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain. The signal peptide - TM - phosphatase architecture is also seen in many arthropod orthologs and in Amphimedon AquePTP-Un-2, and the signal peptide is also seen in an alternate isoform of (XP_011669700.1) the S. purpuratus gene, along with it's closest ortholog, Saccoglossus kowalevskii XP_006811223.1. The Monosiga putative ortholog has a PDZ domain C-terminal to the phosphatase domain but not signal peptide or TM region, and it's close orthologs in S. rosetta or Monosiga ovata have the same architecture.
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- Kokel M, Borland CZ, DeLong L, Horvitz HR, and Stern MJ. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 1998 May 15;12(10):1425-37. DOI:10.1101/gad.12.10.1425 |
- Marlo JE and Desai CJ. Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects. J Cell Biochem. 2006 Aug 1;98(5):1296-307. DOI:10.1002/jcb.20862 |
- Song JK, Giniger E, and Desai CJ. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech Dev. 2008 Mar-Apr;125(3-4):247-56. DOI:10.1016/j.mod.2007.11.005 |