Phosphatase Subfamily MINPP1
MINPP1 is a non-protein phosphatase found in a broad of eukaryotes, including most metazoan and amoebazoan.
MINPP1 is found broadly in eukaryotes but absent from many genomes, such as C elegans. Human has a single copy, but yeast have as many as five copies.
MINPP1 has a phosphatase domain, N-terminal signal peptide. A C-terminal xDEL has been hypothesized as an ER-retention signal, similar to KDEL . However, the xDEL at the C-terminal is found only in vertebrates.
Human MIPP1 does not display any phosphoglycerate mutase activity. MINPP1 is the only hitherto known InsP6 (aka phytate) phosphatase  and is involved in cancer metabolism . It has been shown to be predominantly localized in the lumen of the ER (endoplasmatic reticulum) [2, 4].
Human MIPP1 has biologically significant 2,3-BPG phosphatase activity . Dictyostelium Mipp1 also shows 2,3-BPG phosphatase activity in vitro and in vivo . TIGAR of HP2 family also dephosphorylates 2,3-BPG .
Yeast has as many as five MINPP1s, including PHO3, PHO5, PHO11, PHO12 and DIA3. The first four have been known to be involved in phosphate metabolism.
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