Phosphatase Family HP2
The histidine phosphatase, branch 2 (HP2) family is found throughout eukaryotes. It has subfamilies that are protein phosphatases, non-protein phosphatases, and pseudophosphatases. See also Pfam PF00328. All subfamilies other than PPIP5K encode an N-terminal signal peptide or signal anchor, and many have a C-terminal transmembrane domain. One of its subfamily ACP2 can function as tyrosine protein phosphatase.
ACP2: pTyr and small molecule phosphatase
The ACP2 subfamily is a protein phosphatase subfamily that usually has multiple copies per genome. Human has three copies with different tissue specificity. It is found in holozoa, ameobozoa, and some protists.
ACP6: lysophosphatidic acid-specific phosphatase
MINPP1: Ins5P and Ins6P phosphatase
A non-protein phosphatase found in a broad of eukaryotes, including most metazoa and amoebozoa. Known substrates include InsP6 and 2,3-BPG.
PXYLP1 (ACPL2): xylose phosphatase
PPIP5K: pseudophosphatase domain binding to PtdIns(3,4,5)P3
The PPIP5K subfamily has two domains: a pseudophosphatase domain which binds PtdIns(3,4,5)P3, and a kinase domain of the RimK superfamily, which converts InsP6 and 5-InsP7 to 1-InsP7 and InsP8. PPIP5K is found throughout eukaryotes; vertebrates usually have two copies per genome.
Cf60 is a pseudophosphatase found in many amoebozoa. The Dictyostelium discoideum cf60 encodes a secreted 450-kDa complex of proteins called counting factor (CF), through which Dictyostelium discoideum cells sense and regulate the size of groups and fruiting bodies.
- Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-708. DOI:10.1074/jbc.M113.520536 |
- Zhang XQ, Lee MS, Zelivianski S, and Lin MF. Characterization of a prostate-specific tyrosine phosphatase by mutagenesis and expression in human prostate cancer cells. J Biol Chem. 2001 Jan 26;276(4):2544-50. DOI:10.1074/jbc.M006661200 |
- Meng TC and Lin MF. Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells. J Biol Chem. 1998 Aug 21;273(34):22096-104.