Phosphatase Subfamily PXYLP1

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Phosphatase Classification: Fold HP: Superfamily HP: Family HP, branch 2: Subfamily PXYLP1


PXYLP1 is found in bilateria.


PXYLP1 has a N-terminal transmembrane region and C-terminal phosphatase domain.


Human PXYLP1 dephosphorylates xylose, a sugar, in the glycosaminoglycan-protein linkage region of proteoglycans . In collaboration with kinase FAM20B, it regulates the transient phosphorylation of the Xyl residue in the glycosaminoglycan-protein linkage region, which controls the formation of glycosaminoglycan chains of proteoglycans [1].

Related kinase



  1. Koike T, Izumikawa T, Sato B, and Kitagawa H. Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans. J Biol Chem. 2014 Mar 7;289(10):6695-708. DOI:10.1074/jbc.M113.520536 | PubMed ID:24425863 | HubMed [koike14]