Phosphatase Subfamily PTPDC1
PTPDC1 is found in holozoans but lost from Drosophila and most other insects. Distant homologs are also seen in a number of protist genomes. The pattern is near-identical to other cilia-associated proteins (the ciliome) that are lost in species that lack cilia.
PTPDC1 typically has an N-terminal phosphatase domain and usually an extended C-terminal region that includes a novel conserved domain most similar to the RhoGAP family (unpublished). The Monosiga homolog has an N-terminal PH domain extension.
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