Phosphatase Subfamily Ptp69D

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Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily Ptp69D

PTP69D is a receptor PTP family involved in metazoan neural development.


PTP69D is found in bilateral metazoans, but appears to be lost in vertebrates, though the vertebrate PTPRA family is highly similar in phosphatase domain sequence to PTP69D.

Domain Structure

These have dual intracellular PTP phosphatases domains and extracllular Ig and FN3 repeats. Phosphatase domains are most similar to PTPRA, a vertebrate-specific family with a shorter extracellular region with an endomucin-like domain.


C. elegans clr-1 is involved in the FGFR signaling pathway, where it suppresses the egl-15 RTK [1] and is involved in netrin-dependent axonal guidance [2]. Drosophila Ptp69D is also involved in axonal guidance [3], in part by antagonizing Abl kinase signaling [4].


  1. Kokel M, Borland CZ, DeLong L, Horvitz HR, and Stern MJ. clr-1 encodes a receptor tyrosine phosphatase that negatively regulates an FGF receptor signaling pathway in Caenorhabditis elegans. Genes Dev. 1998 May 15;12(10):1425-37. DOI:10.1101/gad.12.10.1425 | PubMed ID:9585503 | HubMed [Kokel]
  2. Chang C, Yu TW, Bargmann CI, and Tessier-Lavigne M. Inhibition of netrin-mediated axon attraction by a receptor protein tyrosine phosphatase. Science. 2004 Jul 2;305(5680):103-6. DOI:10.1126/science.1096983 | PubMed ID:15232111 | HubMed [Chang]
  3. Marlo JE and Desai CJ. Loss of phosphatase activity in Ptp69D alleles supporting axon guidance defects. J Cell Biochem. 2006 Aug 1;98(5):1296-307. DOI:10.1002/jcb.20862 | PubMed ID:16514605 | HubMed [Marlo]
  4. Song JK, Giniger E, and Desai CJ. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech Dev. 2008 Mar-Apr;125(3-4):247-56. DOI:10.1016/j.mod.2007.11.005 | PubMed ID:18160268 | HubMed [Song]
All Medline abstracts: PubMed | HubMed