Difference between revisions of "Phosphatase Subfamily PPM1E"
From PhosphataseWiki
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The subfamily has some potent inhibitors <cite>Ishida07</cite>. | The subfamily has some potent inhibitors <cite>Ishida07</cite>. | ||
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| + | The subfamily also dephosphorylate 5'-AMP-activated protein kinase (AMPK) <cite>Voss12</cite>. The activation of AMPK is related to the treatment of type 2 diabetes. | ||
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#Takeuchi04 pmid=15496589 | #Takeuchi04 pmid=15496589 | ||
#Takeuchi01 pmid=11726284 | #Takeuchi01 pmid=11726284 | ||
| + | #Voss12 pmid=20801214 | ||
</biblio> | </biblio> | ||
Revision as of 04:27, 6 May 2014
Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E
The subfamily is named named after two human PPMs, PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N) and PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g [1, 2, 3] and PAK [4], and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
The subfamily has some potent inhibitors [5].
The subfamily also dephosphorylate 5'-AMP-activated protein kinase (AMPK) [6]. The activation of AMPK is related to the treatment of type 2 diabetes.
References
Error fetching PMID 11864573:
Error fetching PMID 17897624:
Error fetching PMID 15680915:
Error fetching PMID 15496589:
Error fetching PMID 11726284:
Error fetching PMID 20801214:
Error fetching PMID 17897624:
Error fetching PMID 15680915:
Error fetching PMID 15496589:
Error fetching PMID 11726284:
Error fetching PMID 20801214:
- Error fetching PMID 11726284:
- Error fetching PMID 15496589:
- Error fetching PMID 15680915:
- Error fetching PMID 11864573:
- Error fetching PMID 17897624:
- Error fetching PMID 20801214:
