Difference between revisions of "Phosphatase Gene PPM1E"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]: [[Phosphatase_Gene_PPM1E|Gene PPM1E]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]]: [[Phosphatase_Gene_PPM1E|Gene PPM1E]] | ||
| − | [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]). | + | [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]). |
PPM1E and another phosphatase of this subfamily [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]) dephosphorylate and regulate multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs). PPM1E dephosphorylates CaMKIV and nuclear CaMKII, whereas PPM1F dephosphorylates CaMKI and cytosolic CaMKII. their localizations are different <cite>Takeuchi01</cite>. PPM1E is localized in the nucleus, whereas PPM1F is localized in the cytosol. PPM1E contains two NLSs, NLS1 and NLS2, at the C-terminus. A cluster of basic residues in the NLSs is important for their function. NLS1 and NLS2 function independently, but mutagenesis analysis suggests that these NLSs interact with each other <cite>Takeuchi04</cite>. | PPM1E and another phosphatase of this subfamily [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]) dephosphorylate and regulate multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs). PPM1E dephosphorylates CaMKIV and nuclear CaMKII, whereas PPM1F dephosphorylates CaMKI and cytosolic CaMKII. their localizations are different <cite>Takeuchi01</cite>. PPM1E is localized in the nucleus, whereas PPM1F is localized in the cytosol. PPM1E contains two NLSs, NLS1 and NLS2, at the C-terminus. A cluster of basic residues in the NLSs is important for their function. NLS1 and NLS2 function independently, but mutagenesis analysis suggests that these NLSs interact with each other <cite>Takeuchi04</cite>. | ||
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| + | PPM1E and PPM1F also dephoshorylate p21 (Cdc42/Rac)- activated kinase PAK <cite>Koh02</cite>. | ||
| + | |||
| + | PPM1E and PPM1F also dephosphorylate 5'-AMP-activated protein kinase (AMPK) <cite>Voss12</cite>. The activation of AMPK is related to the treatment of type 2 diabetes. | ||
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| + | A [http://www.google.com/patents/US8574861 patent] shows PPM1E proteins and nucleic acids as targets for neurodegenerative diseases. | ||
== References == | == References == | ||
<biblio> | <biblio> | ||
| + | #Koh02 pmid=11864573 | ||
#Takeuchi04 pmid=15496589 | #Takeuchi04 pmid=15496589 | ||
#Takeuchi01 pmid=11726284 | #Takeuchi01 pmid=11726284 | ||
| + | #Voss12 pmid=20801214 | ||
</biblio> | </biblio> | ||
Latest revision as of 05:02, 6 May 2014
Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E: Gene PPM1E
PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N).
PPM1E and another phosphatase of this subfamily PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase) dephosphorylate and regulate multifunctional Ca(2+)/calmodulin-dependent protein kinases (CaMKs). PPM1E dephosphorylates CaMKIV and nuclear CaMKII, whereas PPM1F dephosphorylates CaMKI and cytosolic CaMKII. their localizations are different [1]. PPM1E is localized in the nucleus, whereas PPM1F is localized in the cytosol. PPM1E contains two NLSs, NLS1 and NLS2, at the C-terminus. A cluster of basic residues in the NLSs is important for their function. NLS1 and NLS2 function independently, but mutagenesis analysis suggests that these NLSs interact with each other [2].
PPM1E and PPM1F also dephoshorylate p21 (Cdc42/Rac)- activated kinase PAK [3].
PPM1E and PPM1F also dephosphorylate 5'-AMP-activated protein kinase (AMPK) [4]. The activation of AMPK is related to the treatment of type 2 diabetes.
A patent shows PPM1E proteins and nucleic acids as targets for neurodegenerative diseases.
References
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