Difference between revisions of "Phosphatase Subfamily egg"
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=== Evolution === | === Evolution === | ||
| − | The | + | The egg subfamily is nematode specific. ''C. elegans'' has three members: egg-3, egg-4, egg-5. |
=== Domain === | === Domain === | ||
Revision as of 21:26, 7 September 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family PTP: Subfamily Egg
Evolution
The egg subfamily is nematode specific. C. elegans has three members: egg-3, egg-4, egg-5.
Domain
The egg subfamily has a single structural domain: a CC1-fold phosphatase domain.
Function
All three C. elegans members are predicted to be catalytically inactive, due to loss of the cysteine or arginine of the Cx5R motif. The near-identical proteins, egg-4 and egg-5, control the oocyte- to-zygote transition by regulating signaling by the DYRK family kinase MBK-2. egg-4/egg-5 binds to MBK-2 at the substrate-binding groove of the kinase, and inhibits the ability of the kinase to bind and phosphorylate substrates, thereby inhibiting downstream signaling [1, 2, 3].
References
Error fetching PMID 19879842:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
Error fetching PMID 19879147:
Error fetching PMID 19879835:
- Error fetching PMID 19879842:
- Error fetching PMID 19879147:
- Error fetching PMID 19879835:
