Difference between revisions of "Phosphatase Family SSU72"
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(Created page with "==Phosphatase Classification: SSU72== == Function == The phosphatase activity of Ssu72 is important for Pol II tr...") |
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| + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]: [[Phosphatase_Family_LMWPTP|Family LMWPTP]] | ||
== Function == | == Function == | ||
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing <cite>Krish04</cite> <cite>Xiang10</cite>. | The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing <cite>Krish04</cite> <cite>Xiang10</cite>. | ||
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== Evolution == | == Evolution == | ||
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). | Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). | ||
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Revision as of 16:46, 30 April 2014
Phosphatase Classification: Superfamily Cys-based III: Family LMWPTP
Function
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing [1] [2].
Evolution
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania).
Reference
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Error fetching PMID 20861839:
Error fetching PMID 20861839:
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- Error fetching PMID 20861839:
