Difference between revisions of "Phosphatase Subfamily PAPL"
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[ | + | __NOTOC__ |
| − | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PAP|Family PAP]]: [[Phosphatase_Subfamily_PAPL|PAPL]] | |
| − | + | ||
=== Evolution === | === Evolution === | ||
| − | PAPL | + | PAPL is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL (aka ACP7, PAPL1), but many invertebrates have multiple members, including 3 members each in Monosiga, Nematostella, sponge, and sea urchin. These appear to be independent expansions by protein sequence similarity, and in sea urchin, they form a tandem duplication cluster. |
=== Domain Structure === | === Domain Structure === | ||
| − | PAPL has a phosphatase domain and | + | PAPL has a phosphatase domain and most members have an N-terminal signal peptide cleavage site. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue). |
=== Function === | === Function === | ||
| − | + | PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins. The structural similarity between PAPL and ACP5 has been explored <cite>Flanagan</cite>. | |
| + | |||
| + | ===References=== | ||
| + | <biblio> | ||
| + | #Flanagan pmid=16793224 | ||
| + | </biblio> | ||
Latest revision as of 01:16, 26 October 2016
Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PAP: PAPL
Evolution
PAPL is found in holozoa but lost from most arthropods. Humans have a single member, PAPL (aka ACP7, PAPL1), but many invertebrates have multiple members, including 3 members each in Monosiga, Nematostella, sponge, and sea urchin. These appear to be independent expansions by protein sequence similarity, and in sea urchin, they form a tandem duplication cluster.
Domain Structure
PAPL has a phosphatase domain and most members have an N-terminal signal peptide cleavage site. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).
Function
PAPL function is unclear. There may be some confusion in the literature, as PAPL/ACP7 may be confused with another PAP family member, ACP5, both of which are putative secreted proteins. The structural similarity between PAPL and ACP5 has been explored [1].
