Difference between revisions of "Phosphatase Subfamily PTPDC1"
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===Evolution=== | ===Evolution=== | ||
| − | PTPDC1 is found in holozoans but lost from Drosophila and most other insects. Distant homologs are also seen in a number of protist genomes. | + | PTPDC1 is found in holozoans but lost from Drosophila and most other insects. Distant homologs are also seen in a number of protist genomes. The pattern is near-identical to other cilia-associated proteins (the ciliome) that are lost in species that lack cilia. |
===Domain Structure=== | ===Domain Structure=== | ||
Revision as of 00:37, 26 October 2016
Phosphatase Classification: Superfamily CC1: Family DSP: Subfamily PTPDC1
Evolution
PTPDC1 is found in holozoans but lost from Drosophila and most other insects. Distant homologs are also seen in a number of protist genomes. The pattern is near-identical to other cilia-associated proteins (the ciliome) that are lost in species that lack cilia.
Domain Structure
PTPDC1 typically has an N-terminal phosphatase domain and usually an extended, poorly-conserved C-terminal region. The Monosiga homolog has an N-terminal PH domain extension.
Functions
Mouse PTPDC1 has been proposed as a cilia gene by tissue-specific expression [1] and RNAi knockdown [2] and implicated in centriole duplication and cytokinesis [3]
References
Error fetching PMID 17971504:
Error fetching PMID 21289087:
Error fetching PMID 19284988:
Error fetching PMID 21289087:
Error fetching PMID 19284988:
- Error fetching PMID 17971504:
- Error fetching PMID 21289087:
- Error fetching PMID 19284988:
