Difference between revisions of "Phosphatase Subfamily PPM1E"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_PPM|Superfamily PPM (PP2C)]]: [[Phosphatase_Family_PPM|Family PPM (PP2C)]]: [[Phosphatase_Subfamily_PPM1E|Subfamily PPM1E]] | ||
| − | + | The subfamily is named named after two human PPMs, [[Phosphatase_Gene_PPM1E|PPM1E]] (also known as [http://www.ncbi.nlm.nih.gov/gene/22843 POXP1, PP2CH, caMKN, CaMKP-N]) and [[Phosphatase_Gene_PPM1F|PPM1F]] (also known as [http://www.ncbi.nlm.nih.gov/gene/9647 POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase]). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g). | |
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| + | The subfamily has some potent inhibitors <cite>Ishida07</cite>. | ||
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| + | == References == | ||
| + | <biblio> | ||
| + | #Ishida07 pmid=17897624 | ||
| + | #Ishida05 pmid=15680915 | ||
| + | #Takeuchi2014 pmid=15496589 | ||
| + | </biblio> | ||
Revision as of 04:16, 6 May 2014
Phosphatase Classification: Superfamily PPM (PP2C): Family PPM (PP2C): Subfamily PPM1E
The subfamily is named named after two human PPMs, PPM1E (also known as POXP1, PP2CH, caMKN, CaMKP-N) and PPM1F (also known as POXP2, CAMKP, FEM-2, hFEM-2, CaMKPase). The subfamily has a single copy in most non-vertebrates from Monosiga to ciona, and duplicated when vertebrates emerged. Both PPM1E and PPM1F dephosphorylate kinases CaMK2g and PAK, and PPM1E can also dephosphorylate CaMK4 (of different families from CaMK2g).
The subfamily has some potent inhibitors [1].
References
Error fetching PMID 17897624:
Error fetching PMID 15680915:
Error fetching PMID 15496589:
Error fetching PMID 15680915:
Error fetching PMID 15496589:
- Error fetching PMID 17897624:
- Error fetching PMID 15680915:
- Error fetching PMID 15496589:
