Difference between revisions of "Phosphatase Subfamily PPP4C Functions"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme) - Functions notes | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_PPPL|Fold PPPL]]: [[Phosphatase_Superfamily_PPPL|Superfamily PPPL]]: [[Phosphatase_Family_PPPc|Family PPPc]]: [[Phosphatase_Subfamily_PPP4C|Subfamily PPP4C]] (catalytic subunit of PP4 holoenzyme) - Functions notes | ||
| + | === Mammals === | ||
PP4 negatively regulates [https://en.wikipedia.org/wiki/Interferon_type_I type I IFN] Production and antiviral innate immunity by dephosphorylating and deactivating TANK-binding kinase 1 (TBK1) of TK group, ACK family according to KinBase classification <cite>Zhan15</cite>. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. Type I IFNs are found in all mammals, and homologous (similar) molecules have been found in birds, reptiles, amphibians and fish species. The mammalian types are designated IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta), IFN-ε (epsilon), IFN-τ (tau), IFN-ω (omega), and IFN-ζ (zeta, also known as limitin). Non-mammalian types are discussed at [https://en.wikipedia.org/wiki/Interferon_type_I#Non-mammalian_types here]. | PP4 negatively regulates [https://en.wikipedia.org/wiki/Interferon_type_I type I IFN] Production and antiviral innate immunity by dephosphorylating and deactivating TANK-binding kinase 1 (TBK1) of TK group, ACK family according to KinBase classification <cite>Zhan15</cite>. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. Type I IFNs are found in all mammals, and homologous (similar) molecules have been found in birds, reptiles, amphibians and fish species. The mammalian types are designated IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta), IFN-ε (epsilon), IFN-τ (tau), IFN-ω (omega), and IFN-ζ (zeta, also known as limitin). Non-mammalian types are discussed at [https://en.wikipedia.org/wiki/Interferon_type_I#Non-mammalian_types here]. | ||
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PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX. | PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX. | ||
| + | === C. elegans === | ||
PP4 in ''C. elegans'' is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene <cite>sato-carlton14</cite>. | PP4 in ''C. elegans'' is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene <cite>sato-carlton14</cite>. | ||
| + | |||
| + | === Fungi === | ||
| + | In budding yeast, the PP4 phosphatase has been shown to play a key role in preventing hyperactivation of the checkpoint kinase Rad53 <cite>Jablonowski15</cite>. | ||
=== References === | === References === | ||
<biblio> | <biblio> | ||
#chen14 pmid=25215539 | #chen14 pmid=25215539 | ||
| + | #Jablonowski15 pmid=26362319 | ||
#Li15 pmid=25927939 | #Li15 pmid=25927939 | ||
#sato-carlton14 pmid=25340746 | #sato-carlton14 pmid=25340746 | ||
#Zhan15 pmid=26363053 | #Zhan15 pmid=26363053 | ||
</biblio> | </biblio> | ||
Revision as of 16:53, 14 September 2015
Phosphatase Classification: Fold PPPL: Superfamily PPPL: Family PPPc: Subfamily PPP4C (catalytic subunit of PP4 holoenzyme) - Functions notes
Contents
Mammals
PP4 negatively regulates type I IFN Production and antiviral innate immunity by dephosphorylating and deactivating TANK-binding kinase 1 (TBK1) of TK group, ACK family according to KinBase classification [1]. Interferons bind to interferon receptors. All type I IFNs bind to a specific cell surface receptor complex known as the IFN-α receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains. Type I IFNs are found in all mammals, and homologous (similar) molecules have been found in birds, reptiles, amphibians and fish species. The mammalian types are designated IFN-α (alpha), IFN-β (beta), IFN-κ (kappa), IFN-δ (delta), IFN-ε (epsilon), IFN-τ (tau), IFN-ω (omega), and IFN-ζ (zeta, also known as limitin). Non-mammalian types are discussed at here.
PPP4C is implicated in cancer. For instance, high expression of PPP4C is associated with the aggressive malignant behavior of colorectal carcinoma [2].
PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
C. elegans
PP4 in C. elegans is involved in M prophase, perhaps through dephosphorylate SUN-1 protein that is normally phosphorylated during the transition zone and early pachytene [3].
Fungi
In budding yeast, the PP4 phosphatase has been shown to play a key role in preventing hyperactivation of the checkpoint kinase Rad53 [4].
References
Error fetching PMID 26362319:
Error fetching PMID 25927939:
Error fetching PMID 25340746:
Error fetching PMID 26363053:
- Error fetching PMID 26363053:
- Error fetching PMID 25927939:
- Error fetching PMID 25340746:
- Error fetching PMID 26362319:
- Error fetching PMID 25215539:
