Difference between revisions of "Phosphatase Subfamily CG42327"
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_ CG42327 |Subfamily CG42327]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_CC1|Superfamily CC1]]: [[Phosphatase_Family_PTP|Family PTP]]: [[Phosphatase_Subfamily_ CG42327 |Subfamily CG42327]] | ||
| − | |||
CG42327 is a receptor PTP found in metazoa, of unknown function and distribution. | CG42327 is a receptor PTP found in metazoa, of unknown function and distribution. | ||
| Line 11: | Line 10: | ||
Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain. | Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain. | ||
| + | The putative Monosiga homolog (MbrePTP-Un-8) has a Sec14 upstream of the phosphatase domain, but this is not conserved in choanoflagellate orthologs. It also has a C-terminal PDZ domain which is conserved in both Monosiga ovata and S. rosetta. | ||
===Functions=== | ===Functions=== | ||
Revision as of 01:30, 20 December 2016
Phosphatase Classification: Superfamily CC1: Family PTP: Subfamily CG42327
CG42327 is a receptor PTP found in metazoa, of unknown function and distribution.
Evolution
CG42327 is defined by the Drosophila melanogaster CG42327 gene. Clear orthologs exist in most arthropods. Possible orthologs exist in several other metazoa, including Amphimedon (AquePTP-Un-2), Monosiga (MbrePTP-Un-8) and S. purpuratus (SpurPTP-Un-2). The Amphimedon protein also encodes a signal peptide.
Domain Structure
Drosophila CG42327 has a strong signal peptide and single TM region. The extracellular region is low complexity with no known domains, and the intracellular region contains a PTP phosphatase domain.
The putative Monosiga homolog (MbrePTP-Un-8) has a Sec14 upstream of the phosphatase domain, but this is not conserved in choanoflagellate orthologs. It also has a C-terminal PDZ domain which is conserved in both Monosiga ovata and S. rosetta.
Functions
Unknown
References
Error fetching PMID 9585503:
Error fetching PMID 16514605:
Error fetching PMID 18160268:
- Error fetching PMID 15232111:
- Error fetching PMID 9585503:
- Error fetching PMID 16514605:
- Error fetching PMID 18160268:
