Difference between revisions of "Phosphatase Family SSU72"
From PhosphataseWiki
| Line 8: | Line 8: | ||
== Evolution == | == Evolution == | ||
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). | Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania). | ||
| + | |||
| + | ==Domain Structure== | ||
| + | Most SSU72 consist almost entirely of the phosphatase domain. | ||
Revision as of 05:08, 1 May 2014
Phosphatase Classification: Superfamily Cys-based III: Family LMWPTP
Function
The phosphatase activity of Ssu72 is important for Pol II transcription and termination and for gene looping. It catalyzes CTD Serine-5 dephosphorylation in association with the Pta1 component of the CPF complex. In yeast, Ssu72 is required for pre-mRNA 3’-end cleavage, but so far no evidence exists implicating mammalian Ssu72 in that processing [1] [2].
Evolution
Ssu72 can be found in all the unikonts (animals, choanoflagellates, fungi, and amoebozoan), plants/algae, Heterokonts, Trichomonas vaginalis (but not Giardia or Trypanasoma or Leishmania).
Domain Structure
Most SSU72 consist almost entirely of the phosphatase domain.
Reference
Error fetching PMID 15125841:
Error fetching PMID 20861839:
Error fetching PMID 20861839:
- Error fetching PMID 15125841:
- Error fetching PMID 20861839:
