Difference between revisions of "Phosphatase Superfamily Cys-based III"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
  
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The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and SSU72 families. Although human exhibits low sequence identity with proteins from any of the cysteine-based phosphatase family, except the existence of the PTP motif, the fold of the core domain is highly identical with that of LMWPTP (Figure 1E). A -CX5R- signature motif is located at the N-terminus of the protein. With the primary sequence consensus of only 15%, the overall fold of Ssu72 exhibits a Z score of 11.6 in a DALI search [36] and an rmsd (root mean square deviation) of 1.7 Å when superimposed with the main chain of LMWPTP (PDB code 1XWW) (Ssu72 6–195 excluding residues 41–96; LMWPTP 1–157 excluding residues 50–67).
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The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.
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== Reference ==
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<biblio>
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#zhangy11 pmid=21204787
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</biblio>

Revision as of 17:03, 30 April 2014


Phosphatase Classification: Superfamily Cys-based III

The superfamily consists of two member families present in human low molecular weight PTP (LWMPTP) and SSU72. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) [1].

Reference

  1. Zhang Y, Zhang M, and Zhang Y. Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem J. 2011 Mar 15;434(3):435-44. DOI:10.1042/BJ20101471 | PubMed ID:21204787 | HubMed [zhangy11]
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