Difference between revisions of "Phosphatase Superfamily Cys-based III"

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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
 
[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Superfamily_Cys-based_III|Superfamily Cys-based III]]
  
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The superfamily share the common CX5R motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]]. Although the member families have very divergent sequences, they have similar fold to each other and all of them has CX5R motif.
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This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, [[Phosphatase_Superfamily_Cys-based_I|superfamily Cys-based I]] and [[Phosphatase_Superfamily_Cys-based_II|superfamily Cys-based II]].  
  
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The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very close to each other. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.
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The superfamily consists of two member families present in human [[Phosphatase_Family_LMWPTP|low molecular weight PTP (LWMPTP)]] and [[Phosphatase_Family_SSU72|SSU72]]. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very similar. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) <cite>zhangy11</cite>.
  
 
The subfamily has an additional member only present in prokaryotes, arsenate reductase (ArsC). It has low sequence identity with LMWPTP and SSU72, 19% between Golden Staph ArsC (PDB ID: 1LJL) and mouse LMWPTP (PDB ID: 2P4U), 16% between Golden Staph ArsC and fruit fly SSU72 (PDB ID: 3FMV). But, ArsC has very similar structure with LMWPTP as shown in [http://scop.berkeley.edu/sunid=52789 SCOP database].
 
The subfamily has an additional member only present in prokaryotes, arsenate reductase (ArsC). It has low sequence identity with LMWPTP and SSU72, 19% between Golden Staph ArsC (PDB ID: 1LJL) and mouse LMWPTP (PDB ID: 2P4U), 16% between Golden Staph ArsC and fruit fly SSU72 (PDB ID: 3FMV). But, ArsC has very similar structure with LMWPTP as shown in [http://scop.berkeley.edu/sunid=52789 SCOP database].

Revision as of 01:16, 1 May 2014


Phosphatase Classification: Superfamily Cys-based III

This superfamily has a unique fold, but shares the common CX5R catalytic motif with another two cysteine-based superfamilies, superfamily Cys-based I and superfamily Cys-based II.

The superfamily consists of two member families present in human low molecular weight PTP (LWMPTP) and SSU72. Although human LMWPTP and SSU72 exhibit low sequence identity (15%), the overall folds are very similar. The rmsd (root mean square deviation) of 1.7 Å when superimposing SSU72 (PDB ID: 3OMW) with LMWPTP (PDB ID: 1XWW) [1].

The subfamily has an additional member only present in prokaryotes, arsenate reductase (ArsC). It has low sequence identity with LMWPTP and SSU72, 19% between Golden Staph ArsC (PDB ID: 1LJL) and mouse LMWPTP (PDB ID: 2P4U), 16% between Golden Staph ArsC and fruit fly SSU72 (PDB ID: 3FMV). But, ArsC has very similar structure with LMWPTP as shown in SCOP database.

Reference

Error fetching PMID 21204787:
  1. Error fetching PMID 21204787: [zhangy11]
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