Difference between revisions of "Phosphatase Subfamily CTDSPL2"
m (Mark moved page Phosphatase Subfamily HSPC129 to Phosphatase Subfamily CTDSPL2) |
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| − | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[ | + | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Family_FCP|FCP]]: [[Phosphatase_Subfamily_CTDSPL2|CTDSPL2]] |
__NOTOC__ | __NOTOC__ | ||
| − | + | CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes. | |
===Evolution=== | ===Evolution=== | ||
| − | + | CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called CTSDPL2, HSPC058, HSPC129, or SCP4 | |
===Domain Structure=== | ===Domain Structure=== | ||
| + | Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension | ||
===Catalytic activity=== | ===Catalytic activity=== | ||
| + | Human CTDSPL2 has experimentally-shown activity <cite>qian</cite> and orthologs are also predicted to be active. | ||
| − | === | + | ===Functions=== |
| + | Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway <cite>Zhao</cite> | ||
===Related Kinases=== | ===Related Kinases=== | ||
| Line 19: | Line 22: | ||
<biblio> | <biblio> | ||
#qian pmid=17487459 | #qian pmid=17487459 | ||
| + | #Zhao pmid=25100727 | ||
</biblio> | </biblio> | ||
Revision as of 06:41, 30 December 2014
Phosphatase Classification: FCP: CTDSPL2
CTDSPL2 (CTD small phosphatase like 2) is a poorly-studied RNA polymerase CTD phosphatase which is found in most eukaryotes.
Evolution
CTDSPL2 is found as a single copy gene in most eukaryotes. It is absent from all but a few basal fungi, and is also lost in Drosophilids. The human gene is called CTSDPL2, HSPC058, HSPC129, or SCP4
Domain Structure
Usually a C-terminal phosphatase domain with a relatively poorly conserved N-terminal extension
Catalytic activity
Human CTDSPL2 has experimentally-shown activity [1] and orthologs are also predicted to be active.
Functions
Human CTDSPL2 binds and dephosphorylates Smad1/5/8, and attenuates signaling through the BMP pathway [2]
Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
Error fetching PMID 25100727:
- Error fetching PMID 17487459:
- Error fetching PMID 25100727:
Links
Human HSPC129 from NCBI Gene
