Difference between revisions of "Phosphatase Subfamily FCP1"
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Revision as of 03:59, 1 January 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1
F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1, prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].
Evolution
FCP1 is conserved from yeast to human, usually one copy per genome.
Domain Structure
In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region that binds regulatory TFIIF.
Catalytic activity
Substrates and Related Kinases
See Phosphorylation of RNA polymerase II C-terminal domain.
References
Error fetching PMID 15304220:
- Error fetching PMID 15304220:
Links
Human FCP1 from NCBI Gene
