Difference between revisions of "Phosphatase Subfamily PPP4C"
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=== Evolution === | === Evolution === | ||
| − | PPP4C is found in [[Phosphatase_Glossary#Opisthokonta|opisthokonta]] and amoebazoa, often one copy per genome. | + | PPP4C is found in [[Phosphatase_Glossary#Opisthokonta|opisthokonta]] and amoebazoa, often one copy per genome. |
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| + | === Domain === | ||
| + | PPP4C has a single domain - phosphatase domain. | ||
=== Functions === | === Functions === | ||
Revision as of 17:38, 5 January 2015
Phosphatase Classification: Fold MTDP: Superfamily MTDP: Family PPP: Subfamily PPP4C
Contents
Evolution
PPP4C is found in opisthokonta and amoebazoa, often one copy per genome.
Domain
PPP4C has a single domain - phosphatase domain.
Functions
PPP4C, catalytic subunit of Protein Phosphatase 4 (PP4) holoenzyme, is closely related to PPP2C, the catalytic subunit of PP2A holoenzyme. Like PP1 and PP2A, holoenzyme PP4 consists of the catalytic subunit and one or two regulatory subunits. At least 6 different holoenzyme complexes have been found.
PP4 dephoshorylate the phophorylated histone 2A variant, γ-H2AX, a marker for DNA damage and cell-cycle arrest. Interestingly, PP2A also dephosphorylates γ-H2AX.
