Difference between revisions of "Phosphatase Subfamily PAPL"
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[[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]:[[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PAP|Family PAP]]: [[Phosphatase_Subfamily_PAPL|PAPL]] | [[Phosphatase classification|Phosphatase Classification]]: [[Phosphatase_Fold_MTDP|Fold MTDP]]:[[Phosphatase_Superfamily_MTDP|Superfamily MTDP]]: [[Phosphatase_Family_PAP|Family PAP]]: [[Phosphatase_Subfamily_PAPL|PAPL]] | ||
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=== Evolution === | === Evolution === | ||
| − | PAPL subfamily is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members. Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny (see [http://www.genomicus.biologie.ens.fr/genomicus-metazoa-25.01/cgi-bin/phyloview.pl?root=1004984&id=1005002&xhide=2:41:9:59:1:55:29:24:25:45:27:42:13:4:58:-1004984:49:56:7:33:38:51&xcollapse=-1004984& Genomicus] and/or search the genes in genome browsers). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga. | + | PAPL subfamily is found in [[Phosphatase_Glossary#Holozoa|holozoa]] but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members. Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny (see [http://www.genomicus.biologie.ens.fr/genomicus-metazoa-25.01/cgi-bin/phyloview.pl?root=1004984&id=1005002&xhide=2:41:9:59:1:55:29:24:25:45:27:42:13:4:58:-1004984:49:56:7:33:38:51&xcollapse=-1004984& Genomicus] and/or search the genes in genome browsers). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga. In sum, the multiple copies arose through different duplication events. |
=== Domain Structure === | === Domain Structure === | ||
Revision as of 18:20, 13 May 2015
Phosphatase Classification: Fold MTDP:Superfamily MTDP: Family PAP: PAPL
Evolution
PAPL subfamily is found in holozoa but lost from most arthropods. Humans have a single member, PAPL, but many invertebrates have multiple members. Each of sea urchin, nematostella, sponge and monosiga has three members, but there is no evidence that supports they belong to any double-conserved synteny (see Genomicus and/or search the genes in genome browsers). The sponge copies arrange as a tandem of three PAPLs, while the copies locate in different scaffolds in sea urchin, nematostella and monosiga. In sum, the multiple copies arose through different duplication events.
Domain Structure
PAPL has a phosphatase domain and a signal peptide cleavage site on N-terminus. Though predicted to be secreted, human PAPL is found mostly in the cytoplasm (http://www.proteinatlas.org/ENSG00000183760-PAPL/tissue).
Function
Unclear.
