Difference between revisions of "Phosphatase Superfamily PPPL"

PPPL is short for PPP like. It is used to name as MTDP, standing for MeTallo-Dependent Phosphatases, by referring to Pfam family Metallophos. But, this is not a clear naming, since the phosphatases of [[Phosphatase_Fold_PPM|PPM fold]] also require metal ion for catalytic activity. PPPL is found in both eukaryotes and prokaryotes. It is named after the [http://scop.berkeley.edu/sunid=56299 fold] and superfamily [http://scop.berkeley.edu/sunid=56300 superfamily] in SCOP database. Members of the superfamily can be detected by corresponding HMMs of [http://pfam.xfam.org/family/PF00149 Pfam] and [http://supfam.cs.bris.ac.uk/SUPERFAMILY/cgi-bin/scop.cgi?sunid=56300 SUPERFAMILY]. The superfamilies consists of [http://scop.berkeley.edu/sunid=56300 multiple families as shown in SCOP database]. Not all of the families are protein phosphatases or even phosphatases. Here, we focus on two families that dephosphorylate proteins: