Difference between revisions of "Phosphatase Subfamily FCP1"
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See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | See [[CTD_Phosphorylation|Phosphorylation of RNA polymerase II C-terminal domain]]. | ||
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=== References === | === References === | ||
Revision as of 15:06, 13 October 2015
Phosphatase Classification: Fold HAD: Superfamily HAD: Family FCP: Subfamily FCP1
F-cell production 1 (FCP1) also called TFIIF-stimulated CTD phosphatase 1 (CTDP1), prefers to dephosphorylate pSer2 of heptapeptide repeats at CTD of RNA polymerase II. The molecular function is mainly studied in yeast [1].
Evolution
FCP1 is conserved from yeast to human, usually one copy per genome.
Domain Structure
In additional to the catalytic domain, it has a breast cancer protein-related carboxy-terminal (BRCT) domain and a C-terminal region (FCP1_C) that binds regulatory TFIIF.
The FCP1_C domain is found widely in deuterosomes (from sea urchin to chordates). It is absent from most proteostomes, except some individual organisms. It is present in basal eumetazoan Nematostella. It is probably FCP1_C domain was gained in eumetazoa, but was lost in multiple independent events. See technical notes.
Functions
FCP1 preferentially hydrolyzes Ser2 in CTD repeats in budding yeast [1] and fission yeast [2].
See Phosphorylation of RNA polymerase II C-terminal domain.
Technical notes
References
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