Difference between revisions of "Phosphatase Subfamily PRL"
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PRL3 is implicated in cancer. For instance, deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice <cite>Cramer15</cite>. PRL3 (PTP4A3) independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy <cite>Yeh15</cite>. | PRL3 is implicated in cancer. For instance, deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice <cite>Cramer15</cite>. PRL3 (PTP4A3) independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy <cite>Yeh15</cite>. | ||
| − | PTP4A3 has a number of protein substrates including ezrin <cite>Forte<cite> and p130cas <cite>Matter</cite>. All three human genes have activity against tyrosine-phosphorylated peptides <cite>Pathak</cite>. | + | PTP4A3 has a number of protein substrates including ezrin <cite>Forte</cite> and p130cas <cite>Matter</cite>. All three human genes have activity against tyrosine-phosphorylated peptides <cite>Pathak</cite>. |
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Revision as of 16:16, 27 October 2016
Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily PRL (PTP4A)
Evolution
PRL subfamily is present in animals, amoeba, and many basal eukaryotes, but is absent from fungi and plants (unpublish data from gOrtholog).
Domain
PRL has a CC1 fold phosphatase domain followed by a consensus prenylation motif.
Function
PRL is short for Phosphatases of Regenerating Liver. There are three PRLs in human, PRL1, PRL2, PRL3 (PTP4A1-3), all of which have been identified as key contributors to metastasis in several human cancers [1, 2]. The molecular mechanisms of PRL phosphatases has been reviewed [3] in 2012.
PRL3 is implicated in cancer. For instance, deletion of PRL3 reduces clonogenicity and tumor-initiation ability of colitis-associated cancer cells in mice [4]. PRL3 (PTP4A3) independently predicts metastasis and survival in upper tract urothelial carcinoma treated with radical nephroureterectomy [5].
PTP4A3 has a number of protein substrates including ezrin [6] and p130cas [7]. All three human genes have activity against tyrosine-phosphorylated peptides [8].
References
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