Difference between revisions of "Phosphatase Subfamily DSP14"

Revision as of 18:47, 13 March 2017

Phosphatase Classification: Fold CC1: Superfamily CC1: Family DSP: Subfamily DSP14

Eumetazoan-specific subfamily of MAPK phosphatases.

Evolution

DSP14 emerged in eumetazoa and duplicated in vertebrates, giving rise to four human members: DUSP14 (MKP6), DUSP18, DUSP21, and DUSP28 (VHP).

Domain

DSP14 consist of a single phosphatase domain.

Function

DUSP14 (MKP6) dephosphorylates TGF-beta-activated kinase 1 (TAK1), a member of MAPKKK, at Thr-187 within its activation loop. Thus, DUSP14 negatively regulates TNF- or IL-1-induced NF-kappaB activation [1]. DUSP14 is widely expressed in different tissues with highest expression in skin (see GTEx).

DUSP18 interacts with and dephosphorylates JNK in vitro and in vivo. It does not dephosphorylate p38 or ERK1 [2]. DUSP18 was widely expressed in different tissues [3]. RNA-seq from GTEx shows expression predominantly in testis and pituitary.

DUSP21 is almost exclusively expressed in testis, but has been reported as a cancer-testis (CT) antigen and required for survival in a hepatocellular carcinoma cell line by RNAi [4].

DUSP28 (VHP) is widely expressed in different tissues according to RNA-seq data from GTEx, but its function is unknown.

The single Drosophila member, CG15528, and the 4 C. elegans members have not been characterized.

References

1. Error fetching PMID 23229544: [Zheng13]
2. Error fetching PMID 16720344: [Wu06]
3. Error fetching PMID 12591617: [Wu03]
4. Error fetching PMID 23929653: [Deng14]