Phosphatase Subfamily PPIP5K

Phosphatase Classification: Fold HP: Superfamily HP (histidine phosphatase): Family HP, branch 2: PPIP5K

Evolution

PPIP5K is conserved across opisthokont. Human genome has three copies.

Functions

Human PPIP5K1 and PPIP5K2 mediates phosphorylation of InsP6 and 5-InsP7 to 1-InsP7 and InsP8, which are multifunctional signaling molecules that regulate diverse cellular activities [1, 2].