Phosphatase Subfamily DCR2

Phosphatase Classification: Fold MTDP:Superfamily MTDP: Family PAP: DCR2

Evolution

The DCR2 subfamily is found in most fungi, most plants and a few chromalveolates.

Domain Structure

DCR2 has a single phosphatase domain.

Function

DCR2 dephosphorylates Ire1, a conserved endoplasmic reticulum transmembrane UPR sensor in Saccharomyces cerevisiae [1].

References

1. Guo J and Polymenis M. Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae. EMBO Rep. 2006 Nov;7(11):1124-7. DOI:10.1038/sj.embor.7400813 |